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The map label for this gene is etfA-3 [H]

Identifier: 197117888

GI number: 197117888

Start: 1735677

End: 1737005

Strand: Direct

Name: etfA-3 [H]

Synonym: Gbem_1501

Alternate gene names: 197117888

Gene position: 1735677-1737005 (Clockwise)

Preceding gene: 197117887

Following gene: 197117889

Centisome position: 37.61

GC content: 66.29

Gene sequence:

>1329_bases
ATGACTGAAGCTGTGAAGAAACCGAAGAAGCCGCGCGGCAAAGCGGCAGTGCTGGAAGGGCGCTGCATCGCCTGCGGCGC
CCGCTGCCAGAGCGCCTGCCCGGTCGACGCCATCCAGATGAACGAGGCGGGAGAGCCGGTCATAGACGCGTCCAAGTGCA
TCGGCTGCGTCAAATGCGTCAAGGTCTGCCCCGCGCAGGCCATAGAGATGGCCTTCACCCCGGAAGAGAAGCGGATCCTG
GACGAGCTGGCGGCGGCTGCCGCGGGAGCTCCGCCCGAGGAGGAGCTCGACCCGGAGGAGGCCGCTTTAAGGGAGAAGCT
TGCCGCCTATCGCGGCGTCTGGGTCTTCATCGAGCAGACCGAGGGGGAGGCCGCCAAGGTCTCCTGGGAGCTCCTGGGGA
AGGGAAAGGAGCTGGCTGCGGCCCGTAACTGCCCGCTTTCCGCGGTGGTGATGGGGGACCAGGTGGAGCACCTCTGCCGC
CAGGCGATGGGGTACGGGGCCGAGACGGTCTACCTCATGGACGCGCCGGTCTTGCGCCACTACCGCACCGAGGCGTACCA
GAAGAGCCTTTGCGCGCTGGTCGAGAAGTACAAGCCGGAGGTGATCCTGATGGGCGCCACCGGGCTTGGGCGCGACCTCG
CGGGTGTGGTGGCCACCGTGCTCGCCACGGGTCTTACCGCCGACTGCACCGGCCTTTCCATCGATAAAGGGAACCTGATG
CAGACCCGCCCCGCTTTCGGCGGCAACATCATGGCCACCATCGTCTGCGACAAGTTCCGCCCCCAGATGTCCACGGTGAG
GCCGCACGTGATGCCGATGCCGGAATTCGACGCGAGCCTCAAGGGTGAGATCGTGCGCGAGCCGGTCCCGGTAGCCGAGG
ACGAAGTCCAGGTGAAGGTGCTCGACATCCTGATGGACAAAGGGGGCTCCAAGGTGGACATCGCCGGCGCCGAGTTCATC
ATCTCCGGCGGTAGGGGGATGATGGCGAAGGAAAACTTCGGACTGCTCGAGGAGCTGGCAGAGGTCTTGGGCGGGGTGGT
GGGCGCGTCCAGAAGCGCGGTCGACGCGGGGTGGATGCCCCAGGACCGGCAGGTGGGGCAGACCGGGAAGACCGTGCGCC
CCAAGGTCTACATCGCCTGCGGCATCTCCGGCGCCATCCAGCACCTGGTGGGGATGCAGGATTCCGACGTGGTGATCGCC
ATCAACCGCGATCCGGAGGCCCCCATCTTCGAGGTGGCAAGCTACGGGATCGTCGGCGACCTGTTCCAGGTGATCCCTTC
GCTGACCGCGAAGCTCAAAGCGCTCAAGGGAGCAAGGTCAGGGGCCTGA

Upstream 100 bases:

>100_bases
CAAGATGATGGAGAAGGACCTTCTCGCGCTCTAGCTTGATACCACGGTCGGGGTCCTCAAAGGCCACGCCGTGGAACAAA
TACCCAAACAGGAAAAGTTC

Downstream 100 bases:

>100_bases
TTCATCATACTTCCCGCGGCTTAAGGGCCGCATTTTTCAAAGAGGAAACATCCATGATGCCGCAAACCGCACTCTTCACG
ACGCTACTGGTCGCCTCGCT

Product: electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MTEAVKKPKKPRGKAAVLEGRCIACGARCQSACPVDAIQMNEAGEPVIDASKCIGCVKCVKVCPAQAIEMAFTPEEKRIL
DELAAAAAGAPPEEELDPEEAALREKLAAYRGVWVFIEQTEGEAAKVSWELLGKGKELAAARNCPLSAVVMGDQVEHLCR
QAMGYGAETVYLMDAPVLRHYRTEAYQKSLCALVEKYKPEVILMGATGLGRDLAGVVATVLATGLTADCTGLSIDKGNLM
QTRPAFGGNIMATIVCDKFRPQMSTVRPHVMPMPEFDASLKGEIVREPVPVAEDEVQVKVLDILMDKGGSKVDIAGAEFI
ISGGRGMMAKENFGLLEELAEVLGGVVGASRSAVDAGWMPQDRQVGQTGKTVRPKVYIACGISGAIQHLVGMQDSDVVIA
INRDPEAPIFEVASYGIVGDLFQVIPSLTAKLKALKGARSGA

Sequences:

>Translated_442_residues
MTEAVKKPKKPRGKAAVLEGRCIACGARCQSACPVDAIQMNEAGEPVIDASKCIGCVKCVKVCPAQAIEMAFTPEEKRIL
DELAAAAAGAPPEEELDPEEAALREKLAAYRGVWVFIEQTEGEAAKVSWELLGKGKELAAARNCPLSAVVMGDQVEHLCR
QAMGYGAETVYLMDAPVLRHYRTEAYQKSLCALVEKYKPEVILMGATGLGRDLAGVVATVLATGLTADCTGLSIDKGNLM
QTRPAFGGNIMATIVCDKFRPQMSTVRPHVMPMPEFDASLKGEIVREPVPVAEDEVQVKVLDILMDKGGSKVDIAGAEFI
ISGGRGMMAKENFGLLEELAEVLGGVVGASRSAVDAGWMPQDRQVGQTGKTVRPKVYIACGISGAIQHLVGMQDSDVVIA
INRDPEAPIFEVASYGIVGDLFQVIPSLTAKLKALKGARSGA
>Mature_441_residues
TEAVKKPKKPRGKAAVLEGRCIACGARCQSACPVDAIQMNEAGEPVIDASKCIGCVKCVKVCPAQAIEMAFTPEEKRILD
ELAAAAAGAPPEEELDPEEAALREKLAAYRGVWVFIEQTEGEAAKVSWELLGKGKELAAARNCPLSAVVMGDQVEHLCRQ
AMGYGAETVYLMDAPVLRHYRTEAYQKSLCALVEKYKPEVILMGATGLGRDLAGVVATVLATGLTADCTGLSIDKGNLMQ
TRPAFGGNIMATIVCDKFRPQMSTVRPHVMPMPEFDASLKGEIVREPVPVAEDEVQVKVLDILMDKGGSKVDIAGAEFII
SGGRGMMAKENFGLLEELAEVLGGVVGASRSAVDAGWMPQDRQVGQTGKTVRPKVYIACGISGAIQHLVGMQDSDVVIAI
NRDPEAPIFEVASYGIVGDLFQVIPSLTAKLKALKGARSGA

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=336, Percent_Identity=35.4166666666667, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI189181759, Length=287, Percent_Identity=39.3728222996516, Blast_Score=175, Evalue=6e-44,
Organism=Escherichia coli, GI1787990, Length=330, Percent_Identity=30.6060606060606, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1786226, Length=127, Percent_Identity=43.3070866141732, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87082157, Length=271, Percent_Identity=26.5682656826568, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17506929, Length=120, Percent_Identity=60.8333333333333, Blast_Score=161, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6325261, Length=195, Percent_Identity=40, Blast_Score=152, Evalue=8e-38,
Organism=Drosophila melanogaster, GI17136898, Length=270, Percent_Identity=39.6296296296296, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24652801, Length=270, Percent_Identity=39.6296296296296, Blast_Score=169, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 46929; Mature: 46798

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAVKKPKKPRGKAAVLEGRCIACGARCQSACPVDAIQMNEAGEPVIDASKCIGCVKCV
CCCHHCCCCCCCCCEEEECCCEEEECCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHH
KVCPAQAIEMAFTPEEKRILDELAAAAAGAPPEEELDPEEAALREKLAAYRGVWVFIEQT
HHCCHHHHHEECCCHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHCCEEEEEECC
EGEAAKVSWELLGKGKELAAARNCPLSAVVMGDQVEHLCRQAMGYGAETVYLMDAPVLRH
CCCCCEEEHHHHCCCHHHHHHCCCCEEEEEECHHHHHHHHHHHCCCCCEEEEECCHHHHH
YRTEAYQKSLCALVEKYKPEVILMGATGLGRDLAGVVATVLATGLTADCTGLSIDKGNLM
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCE
QTRPAFGGNIMATIVCDKFRPQMSTVRPHVMPMPEFDASLKGEIVREPVPVAEDEVQVKV
ECCCCCCCCEEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCHHHHE
LDILMDKGGSKVDIAGAEFIISGGRGMMAKENFGLLEELAEVLGGVVGASRSAVDAGWMP
EEHHHHCCCCEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
QDRQVGQTGKTVRPKVYIACGISGAIQHLVGMQDSDVVIAINRDPEAPIFEVASYGIVGD
CCCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
LFQVIPSLTAKLKALKGARSGA
HHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TEAVKKPKKPRGKAAVLEGRCIACGARCQSACPVDAIQMNEAGEPVIDASKCIGCVKCV
CCHHCCCCCCCCCEEEECCCEEEECCCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHH
KVCPAQAIEMAFTPEEKRILDELAAAAAGAPPEEELDPEEAALREKLAAYRGVWVFIEQT
HHCCHHHHHEECCCHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHCCEEEEEECC
EGEAAKVSWELLGKGKELAAARNCPLSAVVMGDQVEHLCRQAMGYGAETVYLMDAPVLRH
CCCCCEEEHHHHCCCHHHHHHCCCCEEEEEECHHHHHHHHHHHCCCCCEEEEECCHHHHH
YRTEAYQKSLCALVEKYKPEVILMGATGLGRDLAGVVATVLATGLTADCTGLSIDKGNLM
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEECCCCCE
QTRPAFGGNIMATIVCDKFRPQMSTVRPHVMPMPEFDASLKGEIVREPVPVAEDEVQVKV
ECCCCCCCCEEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCHHHHE
LDILMDKGGSKVDIAGAEFIISGGRGMMAKENFGLLEELAEVLGGVVGASRSAVDAGWMP
EEHHHHCCCCEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
QDRQVGQTGKTVRPKVYIACGISGAIQHLVGMQDSDVVIAINRDPEAPIFEVASYGIVGD
CCCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
LFQVIPSLTAKLKALKGARSGA
HHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA