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The map label for this gene is gcdA [H]

Identifier: 197117840

GI number: 197117840

Start: 1680035

End: 1681792

Strand: Direct

Name: gcdA [H]

Synonym: Gbem_1453

Alternate gene names: 197117840

Gene position: 1680035-1681792 (Clockwise)

Preceding gene: 197117839

Following gene: 197117841

Centisome position: 36.4

GC content: 63.94

Gene sequence:

>1758_bases
ATGGCACGAAAGCAAACACCGCTGCGCCCGTATTTCGAGAAGATGGCGGACATCGGCAAGGCGCTGAGCGATGCGGAAGT
GAAACGTTCGCAGGAAAACGTCGAACTCGTCAAGGAGCAGGTGCAGCTGATCGAAAAGGAGACCGAGCGGGTCAAAAACG
CCGGCATCCCCGCCAAGAAGGTCCACGAGCGCGGCGGCATGACCATCTACGACCGCCTCGATTACCTGGTGGACGCCGGG
ACCTGGGCACCCCTGCATACGCTCTACAACCCCAAGGAGAACGAGGAAGGGTGCACCGGCGTCGTCAACGGCATAGGGCG
CATCGAAGGTAGATGGGCGGTCGTCATCGGCTTCGACAACAAGGTCATGGCCGGTGCCTGGATCGCAGGGCAGTCGGAGA
ACATTCTCATGGTCACCGACATGGCCAAGCGCCTCAACGTCCCGCTGGTCTGGCTCACCAACTGTTCCGGCGTGAAGCTC
ATGGAGCAGGAAACCGTCTACGCCGGCCGCCGCTCCAGCGGCGCTCCCTTCTACCGCCACGCCGACCTGAACCATCTCGG
CATCCCCATCTTGAACGGCATCTACGGCACCAACCCCGCCGGCGGCGGCTACCAGGGGATCAGCCCGACCATCCTCCTCG
CCCATGACGGCGCCAACATCGCGGTAGGCGGAGCCGGCATCGTCGGCGGCATGAACCCCAAGGGGCACATCGACGTCGAG
GCCGCGCAGGCCCTCATCGACGCCACCCGCAACTTCAAGGCGAAAGATCCCGGCCGTGTCGAGACCCATTTCGACCAGAC
CGCCTACTTCCGCGAGGTCCACGACACGGAGACCGGTGTTCTCGACGGCATCAAGGATTACATGCGCATGATGCCCGCCT
ACGACCCCGCCATGTTCCGAGTCGCCGCTCCCGTTCCCCCGCGCTTCCCGGTCGAGGATCTCAACATGATCCTCCCGGCG
AACCAGAAGCGCCCCTACGACGCAATCCAGATCCTGGCGCGCCTTACCGACAACAGCGAATTCATGGAATACCGCCCCGA
CTACGGCCGCGAGGTCTACGCCGGCATCGCCAAGGTCGACGGCTTCCCGGTCGCCTTCATCGGCAACCGCCAGGGTGTCT
TCCCCGGCTACCCCGAGTACGCCAAGGGCGCCTACCCGGCGGTCGGCGGCAAGCACTACCGCGAGGGGCTCATCAAGCAG
GCCGAGTTCGTGACCCTGTGCGGTCGCGACAACCTCCCCATCGTCTGGATGCAGGACACAACAGGCATCGACGTCGGCGA
CCTCGCCGAGGAAGCCGAACTGTTGGCCCTGGGGCAGTCGCTCGTCTACTCAATCGAGCAGACCGATCTCTCCATGATGT
GCGTCGTGCTCAGGAAGGGGACCGCCGCGGCCCACTACATCATGTGCGGCCCGCAGGCGAACAACAACAACGCCTTCACC
CTAGGAACCCCTCTCACCGAGATCTACGTGATGCACGGCGAGACCGCGGCCGCCGCCTCCTACGCCCGCCGCCTGGTGAA
AGAGCAGGATTCCGGCAACGACCTGGGCCCGGTCATCGGCAAGATGAACCAGATGATCCAGGACTACCAGGAGAAGTCGC
GCCCGGCCTACTGCGCCATCAGCGGATTCGTGGACGAGATTGTCCAGCTTCCCGACCTGCGCAAGTACGTCCAGGCCTTT
GCCGGCGCCAACTACCAGAACCCGAAGTCGATCACCCCGGTGCACCAGATGCTCCTCCCGAGGATCATCAGGGGATAA

Upstream 100 bases:

>100_bases
GGAGCAATGACCGAAGTGACTGCCTGGTGCAGCGTGTGAAGCCATATGCGAAGCCTTGGCTGTCGAGTGTCTAATCCCAT
TTAATGAAAAGGAACCCACT

Downstream 100 bases:

>100_bases
GTCCTGAAGGCAAATCCCCCCTGTCCCCCCTTCGCAAAGGGGGGGACCCGGGGGCACCGGCAGCGCCACGTGGCAAATTA
CATTGTGGCCTTCCGGGATT

Product: glutaconyl-CoA decarboxylase

Products: NA

Alternate protein names: Carboxyltransferase [H]

Number of amino acids: Translated: 585; Mature: 584

Protein sequence:

>585_residues
MARKQTPLRPYFEKMADIGKALSDAEVKRSQENVELVKEQVQLIEKETERVKNAGIPAKKVHERGGMTIYDRLDYLVDAG
TWAPLHTLYNPKENEEGCTGVVNGIGRIEGRWAVVIGFDNKVMAGAWIAGQSENILMVTDMAKRLNVPLVWLTNCSGVKL
MEQETVYAGRRSSGAPFYRHADLNHLGIPILNGIYGTNPAGGGYQGISPTILLAHDGANIAVGGAGIVGGMNPKGHIDVE
AAQALIDATRNFKAKDPGRVETHFDQTAYFREVHDTETGVLDGIKDYMRMMPAYDPAMFRVAAPVPPRFPVEDLNMILPA
NQKRPYDAIQILARLTDNSEFMEYRPDYGREVYAGIAKVDGFPVAFIGNRQGVFPGYPEYAKGAYPAVGGKHYREGLIKQ
AEFVTLCGRDNLPIVWMQDTTGIDVGDLAEEAELLALGQSLVYSIEQTDLSMMCVVLRKGTAAAHYIMCGPQANNNNAFT
LGTPLTEIYVMHGETAAAASYARRLVKEQDSGNDLGPVIGKMNQMIQDYQEKSRPAYCAISGFVDEIVQLPDLRKYVQAF
AGANYQNPKSITPVHQMLLPRIIRG

Sequences:

>Translated_585_residues
MARKQTPLRPYFEKMADIGKALSDAEVKRSQENVELVKEQVQLIEKETERVKNAGIPAKKVHERGGMTIYDRLDYLVDAG
TWAPLHTLYNPKENEEGCTGVVNGIGRIEGRWAVVIGFDNKVMAGAWIAGQSENILMVTDMAKRLNVPLVWLTNCSGVKL
MEQETVYAGRRSSGAPFYRHADLNHLGIPILNGIYGTNPAGGGYQGISPTILLAHDGANIAVGGAGIVGGMNPKGHIDVE
AAQALIDATRNFKAKDPGRVETHFDQTAYFREVHDTETGVLDGIKDYMRMMPAYDPAMFRVAAPVPPRFPVEDLNMILPA
NQKRPYDAIQILARLTDNSEFMEYRPDYGREVYAGIAKVDGFPVAFIGNRQGVFPGYPEYAKGAYPAVGGKHYREGLIKQ
AEFVTLCGRDNLPIVWMQDTTGIDVGDLAEEAELLALGQSLVYSIEQTDLSMMCVVLRKGTAAAHYIMCGPQANNNNAFT
LGTPLTEIYVMHGETAAAASYARRLVKEQDSGNDLGPVIGKMNQMIQDYQEKSRPAYCAISGFVDEIVQLPDLRKYVQAF
AGANYQNPKSITPVHQMLLPRIIRG
>Mature_584_residues
ARKQTPLRPYFEKMADIGKALSDAEVKRSQENVELVKEQVQLIEKETERVKNAGIPAKKVHERGGMTIYDRLDYLVDAGT
WAPLHTLYNPKENEEGCTGVVNGIGRIEGRWAVVIGFDNKVMAGAWIAGQSENILMVTDMAKRLNVPLVWLTNCSGVKLM
EQETVYAGRRSSGAPFYRHADLNHLGIPILNGIYGTNPAGGGYQGISPTILLAHDGANIAVGGAGIVGGMNPKGHIDVEA
AQALIDATRNFKAKDPGRVETHFDQTAYFREVHDTETGVLDGIKDYMRMMPAYDPAMFRVAAPVPPRFPVEDLNMILPAN
QKRPYDAIQILARLTDNSEFMEYRPDYGREVYAGIAKVDGFPVAFIGNRQGVFPGYPEYAKGAYPAVGGKHYREGLIKQA
EFVTLCGRDNLPIVWMQDTTGIDVGDLAEEAELLALGQSLVYSIEQTDLSMMCVVLRKGTAAAHYIMCGPQANNNNAFTL
GTPLTEIYVMHGETAAAASYARRLVKEQDSGNDLGPVIGKMNQMIQDYQEKSRPAYCAISGFVDEIVQLPDLRKYVQAFA
GANYQNPKSITPVHQMLLPRIIRG

Specific function: Decarboxylase subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD) [H]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=550, Percent_Identity=25.2727272727273, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI119943100, Length=513, Percent_Identity=22.2222222222222, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI295821216, Length=533, Percent_Identity=21.7636022514071, Blast_Score=108, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17552936, Length=546, Percent_Identity=23.6263736263736, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25147362, Length=507, Percent_Identity=22.6824457593688, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI25147359, Length=507, Percent_Identity=22.6824457593688, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24586065, Length=489, Percent_Identity=24.7443762781186, Blast_Score=131, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =4.1.1.70 [H]

Molecular weight: Translated: 64349; Mature: 64218

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKQTPLRPYFEKMADIGKALSDAEVKRSQENVELVKEQVQLIEKETERVKNAGIPAKK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
VHERGGMTIYDRLDYLVDAGTWAPLHTLYNPKENEEGCTGVVNGIGRIEGRWAVVIGFDN
HHHCCCCCHHHHHHHHHCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCC
KVMAGAWIAGQSENILMVTDMAKRLNVPLVWLTNCSGVKLMEQETVYAGRRSSGAPFYRH
CEEEEEEEECCCCCEEEEEEHHHHCCCCEEEEECCCCCEEEHHHHHHCCCCCCCCCEEEE
ADLNHLGIPILNGIYGTNPAGGGYQGISPTILLAHDGANIAVGGAGIVGGMNPKGHIDVE
CCCCCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEECCCEEEECCCEEECCCCCCCCEEHH
AAQALIDATRNFKAKDPGRVETHFDQTAYFREVHDTETGVLDGIKDYMRMMPAYDPAMFR
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEE
VAAPVPPRFPVEDLNMILPANQKRPYDAIQILARLTDNSEFMEYRPDYGREVYAGIAKVD
EECCCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHCC
GFPVAFIGNRQGVFPGYPEYAKGAYPAVGGKHYREGLIKQAEFVTLCGRDNLPIVWMQDT
CCEEEEECCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHEEEEECCCCCCEEEEECC
TGIDVGDLAEEAELLALGQSLVYSIEQTDLSMMCVVLRKGTAAAHYIMCGPQANNNNAFT
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCCCCEEE
LGTPLTEIYVMHGETAAAASYARRLVKEQDSGNDLGPVIGKMNQMIQDYQEKSRPAYCAI
ECCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEH
SGFVDEIVQLPDLRKYVQAFAGANYQNPKSITPVHQMLLPRIIRG
HHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
ARKQTPLRPYFEKMADIGKALSDAEVKRSQENVELVKEQVQLIEKETERVKNAGIPAKK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
VHERGGMTIYDRLDYLVDAGTWAPLHTLYNPKENEEGCTGVVNGIGRIEGRWAVVIGFDN
HHHCCCCCHHHHHHHHHCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCC
KVMAGAWIAGQSENILMVTDMAKRLNVPLVWLTNCSGVKLMEQETVYAGRRSSGAPFYRH
CEEEEEEEECCCCCEEEEEEHHHHCCCCEEEEECCCCCEEEHHHHHHCCCCCCCCCEEEE
ADLNHLGIPILNGIYGTNPAGGGYQGISPTILLAHDGANIAVGGAGIVGGMNPKGHIDVE
CCCCCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEECCCEEEECCCEEECCCCCCCCEEHH
AAQALIDATRNFKAKDPGRVETHFDQTAYFREVHDTETGVLDGIKDYMRMMPAYDPAMFR
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEE
VAAPVPPRFPVEDLNMILPANQKRPYDAIQILARLTDNSEFMEYRPDYGREVYAGIAKVD
EECCCCCCCCHHHHHEECCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHCC
GFPVAFIGNRQGVFPGYPEYAKGAYPAVGGKHYREGLIKQAEFVTLCGRDNLPIVWMQDT
CCEEEEECCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHEEEEECCCCCCEEEEECC
TGIDVGDLAEEAELLALGQSLVYSIEQTDLSMMCVVLRKGTAAAHYIMCGPQANNNNAFT
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCCCCCEEE
LGTPLTEIYVMHGETAAAASYARRLVKEQDSGNDLGPVIGKMNQMIQDYQEKSRPAYCAI
ECCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEH
SGFVDEIVQLPDLRKYVQAFAGANYQNPKSITPVHQMLLPRIIRG
HHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8382157; 8365476; 7607244 [H]