Click here to switch to the map view.

The map label for this gene is ahcY [H]

Identifier: 197117734

GI number: 197117734

Start: 1551511

End: 1552908

Strand: Direct

Name: ahcY [H]

Synonym: Gbem_1346

Alternate gene names: 197117734

Gene position: 1551511-1552908 (Clockwise)

Preceding gene: 197117733

Following gene: 197117735

Centisome position: 33.62

GC content: 62.66

Gene sequence:

>1398_bases
ATGAAAGAAAACGATTACATCGTAAAGGACATGTCGCTGGCGGCCTGGGGCCGCAAAGAGATGATCATCGCCGAGACCGA
AATGCCGGGCCTCATGGCGATCCGCGAGGAGTACGCCGCGAGCCAGCCGCTCAAAGGGGCGCGCATCGCAGGCTCGCTGC
ACATGACCATACAGACCGCAATGCTGATCGAGACCCTCACCGCTCTGGGCGCCGAGGTCCGCTGGGCTTCCTGCAACATC
TTCTCTACCCAGGATCACGCGGCTGCGGCCATCGCGGCTGCAGGGATCCCGGTCTTCGCGCACAAGGGCGAGACGCTGGC
GGAGTACTGGGATTACACCCACAAGATCTTTGAGTGGCACGACGGCGGCGCCCCCAACATGATCCTCGACGACGGCGGCG
ACGCCACCTTGCTGCTGCACCTGGGAAGCGACGCGGAGAAGAACCCCTCCGTCATCGCCAACCCCACCTGCGAGGAGGAG
CAGTTCCTCTTCGCCGCCATCAAGAAGCGCCTGGAGACAAACCCCGGCTGGTACTCGAAGACCGCGGCCAGCATCAAGGG
CGTCACCGAGGAAACCACCACCGGCGTGCACCGCCTGTACCAGATGCACGAGAAAGGGACGCTCAAGTTCCCGGCCATCA
ACGTCAACGACTCGGTGACCAAGTCCAAGTTCGACAACATCTACGGCTGCCGCGAGTCCCTCATGGACGGGATCAAGCGC
GCCACCGACGTCATGGTGGCGGGCAAGGTCGCGGTCATCTGCGGCTACGGCGACGTGGGCAAGGGTTGCTCCCAGGCGAT
GCGCGGGCTGCAGGCCCAGGTTTGGGTGACCGAGGTCGACCCGATCTGCGCGCTCCAGGCGGCGATGGAAGGCTACAAGG
TCGTGACCATGGAATGGGCCGCCGACAAGGCGGACATCTTCGTGACCACCACCGGCAACATCGACGTCATCACCCATGAC
CACATGAAGGCGATGAAGCACAACGCCATCGTCTGCAACATCGGCCACTTCGACAACGAAATCGAGGTCGCGAAACTGAA
GCAGTACCAGTGGGAGAACATCAAGCCGCAGGTGGATCACATCATCTTCCCGGACGGCAAGCGCATCATCCTCCTGGCGG
AAGGGCGTCTGGTCAACCTCGGTTGCGCCACCGGCCACCCCTCCTACGTCATGTCCTCCTCCTTCGCCAACCAGACCCTG
GCGCAGATGGAGATCTTCTGCAACCCCGGCAAGTACCCGGTCGGCGTCTACACCCTTCCGAAGGAACTGGACGAGAAGGT
GGCGCGCCTGCAGCTGAAGACACTGGGCGCCATGCTCACCGAGCTCACCGACGCTCAGGCTGACTACATCGGCGTGAAGA
AGGACGGGCCGTACAAGTCGGAGCACTACCGCTACTAA

Upstream 100 bases:

>100_bases
AGGAATAAAAGGGGACAGGCTACTTTTTCAAACGAAAAAGTAGCCTGTCCCCCTTAAATGACGAATTGTTGCAGATAACC
CACCAAAAGGAGAAGCATCG

Downstream 100 bases:

>100_bases
AACGCGGATAGACTCCCCCTCCCTTGACGGTGTATAGACTGGGGACATGGTTTACAAATGTTCGGGGACATAGTTAACAC
TTTTGCCAAGAATGACCTTT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MKENDYIVKDMSLAAWGRKEMIIAETEMPGLMAIREEYAASQPLKGARIAGSLHMTIQTAMLIETLTALGAEVRWASCNI
FSTQDHAAAAIAAAGIPVFAHKGETLAEYWDYTHKIFEWHDGGAPNMILDDGGDATLLLHLGSDAEKNPSVIANPTCEEE
QFLFAAIKKRLETNPGWYSKTAASIKGVTEETTTGVHRLYQMHEKGTLKFPAINVNDSVTKSKFDNIYGCRESLMDGIKR
ATDVMVAGKVAVICGYGDVGKGCSQAMRGLQAQVWVTEVDPICALQAAMEGYKVVTMEWAADKADIFVTTTGNIDVITHD
HMKAMKHNAIVCNIGHFDNEIEVAKLKQYQWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSYVMSSSFANQTL
AQMEIFCNPGKYPVGVYTLPKELDEKVARLQLKTLGAMLTELTDAQADYIGVKKDGPYKSEHYRY

Sequences:

>Translated_465_residues
MKENDYIVKDMSLAAWGRKEMIIAETEMPGLMAIREEYAASQPLKGARIAGSLHMTIQTAMLIETLTALGAEVRWASCNI
FSTQDHAAAAIAAAGIPVFAHKGETLAEYWDYTHKIFEWHDGGAPNMILDDGGDATLLLHLGSDAEKNPSVIANPTCEEE
QFLFAAIKKRLETNPGWYSKTAASIKGVTEETTTGVHRLYQMHEKGTLKFPAINVNDSVTKSKFDNIYGCRESLMDGIKR
ATDVMVAGKVAVICGYGDVGKGCSQAMRGLQAQVWVTEVDPICALQAAMEGYKVVTMEWAADKADIFVTTTGNIDVITHD
HMKAMKHNAIVCNIGHFDNEIEVAKLKQYQWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSYVMSSSFANQTL
AQMEIFCNPGKYPVGVYTLPKELDEKVARLQLKTLGAMLTELTDAQADYIGVKKDGPYKSEHYRY
>Mature_465_residues
MKENDYIVKDMSLAAWGRKEMIIAETEMPGLMAIREEYAASQPLKGARIAGSLHMTIQTAMLIETLTALGAEVRWASCNI
FSTQDHAAAAIAAAGIPVFAHKGETLAEYWDYTHKIFEWHDGGAPNMILDDGGDATLLLHLGSDAEKNPSVIANPTCEEE
QFLFAAIKKRLETNPGWYSKTAASIKGVTEETTTGVHRLYQMHEKGTLKFPAINVNDSVTKSKFDNIYGCRESLMDGIKR
ATDVMVAGKVAVICGYGDVGKGCSQAMRGLQAQVWVTEVDPICALQAAMEGYKVVTMEWAADKADIFVTTTGNIDVITHD
HMKAMKHNAIVCNIGHFDNEIEVAKLKQYQWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSYVMSSSFANQTL
AQMEIFCNPGKYPVGVYTLPKELDEKVARLQLKTLGAMLTELTDAQADYIGVKKDGPYKSEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=61.2554112554113, Blast_Score=535, Evalue=1e-152,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=61.1363636363636, Blast_Score=509, Evalue=1e-144,
Organism=Homo sapiens, GI298286489, Length=465, Percent_Identity=48.6021505376344, Blast_Score=457, Evalue=1e-129,
Organism=Homo sapiens, GI24308043, Length=468, Percent_Identity=48.5042735042735, Blast_Score=457, Evalue=1e-128,
Organism=Homo sapiens, GI195539337, Length=468, Percent_Identity=48.5042735042735, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI195539349, Length=465, Percent_Identity=48.6021505376344, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI21361647, Length=465, Percent_Identity=47.5268817204301, Blast_Score=433, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=58.7096774193548, Blast_Score=525, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6320882, Length=478, Percent_Identity=58.1589958158996, Blast_Score=519, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24642172, Length=467, Percent_Identity=59.9571734475375, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24656245, Length=469, Percent_Identity=49.2537313432836, Blast_Score=453, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45553387, Length=463, Percent_Identity=50.3239740820734, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45553385, Length=462, Percent_Identity=50.2164502164502, Blast_Score=444, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51249; Mature: 51249

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKENDYIVKDMSLAAWGRKEMIIAETEMPGLMAIREEYAASQPLKGARIAGSLHMTIQTA
CCCCCEEEEECEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCEEECEEEHHHHHH
MLIETLTALGAEVRWASCNIFSTQDHAAAAIAAAGIPVFAHKGETLAEYWDYTHKIFEWH
HHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHEEEC
DGGAPNMILDDGGDATLLLHLGSDAEKNPSVIANPTCEEEQFLFAAIKKRLETNPGWYSK
CCCCCCEEEECCCCEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCC
TAASIKGVTEETTTGVHRLYQMHEKGTLKFPAINVNDSVTKSKFDNIYGCRESLMDGIKR
HHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
ATDVMVAGKVAVICGYGDVGKGCSQAMRGLQAQVWVTEVDPICALQAAMEGYKVVTMEWA
HHHEEEECCEEEEECCCCCCHHHHHHHHCCEEEEEEEECCHHHHHHHHHCCCEEEEEEEC
ADKADIFVTTTGNIDVITHDHMKAMKHNAIVCNIGHFDNEIEVAKLKQYQWENIKPQVDH
CCCCCEEEEECCCEEEEECHHHHHHHCCEEEEEECCCCCCEEHHHHHHHHCCCCCCCCCE
IIFPDGKRIILLAEGRLVNLGCATGHPSYVMSSSFANQTLAQMEIFCNPGKYPVGVYTLP
EECCCCCEEEEEECCEEEEEEECCCCCCHHHHHHHHHHHHEEEEEEECCCCCCEEEEECC
KELDEKVARLQLKTLGAMLTELTDAQADYIGVKKDGPYKSEHYRY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MKENDYIVKDMSLAAWGRKEMIIAETEMPGLMAIREEYAASQPLKGARIAGSLHMTIQTA
CCCCCEEEEECEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCEEECEEEHHHHHH
MLIETLTALGAEVRWASCNIFSTQDHAAAAIAAAGIPVFAHKGETLAEYWDYTHKIFEWH
HHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHEEEC
DGGAPNMILDDGGDATLLLHLGSDAEKNPSVIANPTCEEEQFLFAAIKKRLETNPGWYSK
CCCCCCEEEECCCCEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCC
TAASIKGVTEETTTGVHRLYQMHEKGTLKFPAINVNDSVTKSKFDNIYGCRESLMDGIKR
HHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
ATDVMVAGKVAVICGYGDVGKGCSQAMRGLQAQVWVTEVDPICALQAAMEGYKVVTMEWA
HHHEEEECCEEEEECCCCCCHHHHHHHHCCEEEEEEEECCHHHHHHHHHCCCEEEEEEEC
ADKADIFVTTTGNIDVITHDHMKAMKHNAIVCNIGHFDNEIEVAKLKQYQWENIKPQVDH
CCCCCEEEEECCCEEEEECHHHHHHHCCEEEEEECCCCCCEEHHHHHHHHCCCCCCCCCE
IIFPDGKRIILLAEGRLVNLGCATGHPSYVMSSSFANQTLAQMEIFCNPGKYPVGVYTLP
EECCCCCEEEEEECCEEEEEEECCCCCCHHHHHHHHHHHHEEEEEEECCCCCCEEEEECC
KELDEKVARLQLKTLGAMLTELTDAQADYIGVKKDGPYKSEHYRY
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA