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The map label for this gene is clpP

Identifier: 197117660

GI number: 197117660

Start: 1469390

End: 1469989

Strand: Direct

Name: clpP

Synonym: Gbem_1272

Alternate gene names: 197117660

Gene position: 1469390-1469989 (Clockwise)

Preceding gene: 197117659

Following gene: 197117661

Centisome position: 31.84

GC content: 60.83

Gene sequence:

>600_bases
ATGCTTGTACCGATAGTAGTGGAGCAGACCGGCCGGGGCGAGAGGTCGTACGACATCTACTCGCGCCTGCTGAAGGACAG
GATCATCTTCCTGGGCGGCGGCATCGACGATAACGTCGCGAACCTGGTGATAGCGCAGCTCCTCTTCCTCGAGGCCGAGG
ACCCGGACAAGGATATCCACCTCTACATCAACTCCCCCGGCGGCGTGGTTACCGCCGGCATGGCCATCTACGACACCATG
CGCTACATCAAGGCGCCGGTCTCCACCATCTGCGTCGGGCAGGCCGCCTCCATGGGCGCGTTCCTTCTGTCCGGCGGCGA
GAAGGGGAAACGGTACTCGCTGGTCAACTCGCGCATCATGATCCACCAGCCCCTGGGCGGTTTCCAGGGGCAGGCGACGG
ACATCCATATCCACGCCAAAGAGATCCTGCGCATGAAGGATCAACTGAACGCGCTTCTGGCCGAGCACACCGGCCAGAGC
GTGGAAAAGGTAGCGGCCGATACCGAGCGCGACTACTTCATGTCGGGCGAAGAGGCCAAGAATTACGGCATCATAGATGC
CATTGTGACTAGAAACGTCGTCACCGGAGGTGCCAATTGA

Upstream 100 bases:

>100_bases
ACCTGATGGCCCAGATGAGGGAAGACAAGGCGGTGCAGTTCATCCTTGACCGCGCCAAGGTGACCGAAGTCCCCAAGGCG
GAAATTAAATAGGAGTGTCC

Downstream 100 bases:

>100_bases
GCAGAAGAGATGACCGTTCCGACACGCTGATCTGTTCCTTTTGCGGGAAGAGCCAGGAAGAGGTAAAGAAGTTGATTGCG
GGGCCTACGGTCTACATCTG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MLVPIVVEQTGRGERSYDIYSRLLKDRIIFLGGGIDDNVANLVIAQLLFLEAEDPDKDIHLYINSPGGVVTAGMAIYDTM
RYIKAPVSTICVGQAASMGAFLLSGGEKGKRYSLVNSRIMIHQPLGGFQGQATDIHIHAKEILRMKDQLNALLAEHTGQS
VEKVAADTERDYFMSGEEAKNYGIIDAIVTRNVVTGGAN

Sequences:

>Translated_199_residues
MLVPIVVEQTGRGERSYDIYSRLLKDRIIFLGGGIDDNVANLVIAQLLFLEAEDPDKDIHLYINSPGGVVTAGMAIYDTM
RYIKAPVSTICVGQAASMGAFLLSGGEKGKRYSLVNSRIMIHQPLGGFQGQATDIHIHAKEILRMKDQLNALLAEHTGQS
VEKVAADTERDYFMSGEEAKNYGIIDAIVTRNVVTGGAN
>Mature_199_residues
MLVPIVVEQTGRGERSYDIYSRLLKDRIIFLGGGIDDNVANLVIAQLLFLEAEDPDKDIHLYINSPGGVVTAGMAIYDTM
RYIKAPVSTICVGQAASMGAFLLSGGEKGKRYSLVNSRIMIHQPLGGFQGQATDIHIHAKEILRMKDQLNALLAEHTGQS
VEKVAADTERDYFMSGEEAKNYGIIDAIVTRNVVTGGAN

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=63.2978723404255, Blast_Score=253, Evalue=7e-68,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=69.2708333333333, Blast_Score=293, Evalue=8e-81,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=55.7894736842105, Blast_Score=225, Evalue=1e-59,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=62.2340425531915, Blast_Score=254, Evalue=4e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_GEOBB (B5EI27)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002138087.1
- MEROPS:   S14.001
- GeneID:   6781256
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_1272
- HOGENOM:   HBG558421
- OMA:   KFGLVDN
- ProtClustDB:   PRK00277
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21641; Mature: 21641

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 97-97 ACT_SITE 122-122

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVPIVVEQTGRGERSYDIYSRLLKDRIIFLGGGIDDNVANLVIAQLLFLEAEDPDKDIH
CEEEEEEECCCCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEE
LYINSPGGVVTAGMAIYDTMRYIKAPVSTICVGQAASMGAFLLSGGEKGKRYSLVNSRIM
EEEECCCCEEEHHHHHHHHHHHHHCCHHHHHHCCCHHCCEEEECCCCCCCEEEEECCEEE
IHQPLGGFQGQATDIHIHAKEILRMKDQLNALLAEHTGQSVEKVAADTERDYFMSGEEAK
EECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEECCCCCC
NYGIIDAIVTRNVVTGGAN
CCCHHHHHHHHHEECCCCC
>Mature Secondary Structure
MLVPIVVEQTGRGERSYDIYSRLLKDRIIFLGGGIDDNVANLVIAQLLFLEAEDPDKDIH
CEEEEEEECCCCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEEE
LYINSPGGVVTAGMAIYDTMRYIKAPVSTICVGQAASMGAFLLSGGEKGKRYSLVNSRIM
EEEECCCCEEEHHHHHHHHHHHHHCCHHHHHHCCCHHCCEEEECCCCCCCEEEEECCEEE
IHQPLGGFQGQATDIHIHAKEILRMKDQLNALLAEHTGQSVEKVAADTERDYFMSGEEAK
EECCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEECCCCCC
NYGIIDAIVTRNVVTGGAN
CCCHHHHHHHHHEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA