Click here to switch to the map view.

The map label for this gene is clpX

Identifier: 197117661

GI number: 197117661

Start: 1469986

End: 1471239

Strand: Direct

Name: clpX

Synonym: Gbem_1273

Alternate gene names: 197117661

Gene position: 1469986-1471239 (Clockwise)

Preceding gene: 197117660

Following gene: 197117662

Centisome position: 31.85

GC content: 59.89

Gene sequence:

>1254_bases
TTGAGCAGAAGAGATGACCGTTCCGACACGCTGATCTGTTCCTTTTGCGGGAAGAGCCAGGAAGAGGTAAAGAAGTTGAT
TGCGGGGCCTACGGTCTACATCTGCGACGAGTGCATCGAGCTTTGCAACGACATCATCGCGGAGGAGTCCAAACTGGAGG
ATGCCACCGCTACCGATGTGAGGAAACTTCCCAAGCCGCAGGAGATCAAGGAAGTCCTCGATGAATACGTGATCGGCCAG
TCCAGGGCGAAGAAGGTACTGGCTGTCGCCGTGTACAACCATTACAAGAGGGTCGAGGCCGCGGTCAAGCCGGGCGACGT
CGAGATGCAGAAGAGCAACATCCTGCTTCTTGGCCCCACCGGCAGCGGCAAAACGCTCCTGGCGCAGACCCTGGCCCGCA
TCCTCAAGGTGCCTTTCGCCATGGCGGACGCCACCAACTTGACCGAGGCGGGTTACGTCGGCGAGGACGTGGAGAACATC
ATCCTGACCCTTTTGCAGGCGTCCGACTACGACGTGGAGAAGGCGCAGAAGGGGATCATCTACATCGACGAGATCGACAA
GATCGCCAGGAAGTCCGACTCCCCCTCCATCACCCGCGACGTGTCGGGCGAGGGGGTGCAGCAGGCCCTTTTGAAGATCA
TCGAAGGTACCGTGGCGAGCGTACCCCCCAAGGGTGGCCGCAAGCACCCGCAGCAGGAATTCCTCAAGGTGGACACCACC
AACATCCTGTTCATCTGCGGCGGGGCCTTCCCCGGGTTGGACAGCATCATCCAGCAGAGGATCGGGGTCAAGACGCTCGG
CTTCGGCGCGGACGTCAAGAAGAAGGTGGAGAAGAAGGCGGGCGAACTGCTGGCCGGGGTGACCCCTGAGGATCTCCTCA
AGTTCGGCTTCATCCCCGAGTTCGTGGGGCGCCTTCCCATGCTCGCCTCGCTTTCCGAGCTCGACGAGGAGGCGATGGTC
CAGATCCTCAAGGAGCCGAAGAACGCGCTGATCAAGCAGTACCAGAAGCTCTTCGATATGGAGCACGTGAAGCTGAAGTT
CACCGACGGCTCCCTGGTCGCCATAGCCCGCGAGGCCCTGAAGAGAAAGACCGGCGCCCGCGGCCTGCGCTCCATCCTCG
AAAACGCCATGCTGGACATCATGTACGAGATCCCTTCCCAGAGCATGGTGAAGGAAGTGGTCATCAACGAAGAGGTGATC
TACAGCAAGGAAAAGCCGATCATCGTCTACGAGAACGTGGCGGAAAGCGCCTGA

Upstream 100 bases:

>100_bases
CCGATACCGAGCGCGACTACTTCATGTCGGGCGAAGAGGCCAAGAATTACGGCATCATAGATGCCATTGTGACTAGAAAC
GTCGTCACCGGAGGTGCCAA

Downstream 100 bases:

>100_bases
GCATACAGGAAAACATGACTGAGAAAGCCAGAACCAGAGGTAAAAGGAGGGGGAATCCGGAAAGATTCCCTCTCTTTCCA
TTAAGGGACATAGTTATCTT

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MSRRDDRSDTLICSFCGKSQEEVKKLIAGPTVYICDECIELCNDIIAEESKLEDATATDVRKLPKPQEIKEVLDEYVIGQ
SRAKKVLAVAVYNHYKRVEAAVKPGDVEMQKSNILLLGPTGSGKTLLAQTLARILKVPFAMADATNLTEAGYVGEDVENI
ILTLLQASDYDVEKAQKGIIYIDEIDKIARKSDSPSITRDVSGEGVQQALLKIIEGTVASVPPKGGRKHPQQEFLKVDTT
NILFICGGAFPGLDSIIQQRIGVKTLGFGADVKKKVEKKAGELLAGVTPEDLLKFGFIPEFVGRLPMLASLSELDEEAMV
QILKEPKNALIKQYQKLFDMEHVKLKFTDGSLVAIAREALKRKTGARGLRSILENAMLDIMYEIPSQSMVKEVVINEEVI
YSKEKPIIVYENVAESA

Sequences:

>Translated_417_residues
MSRRDDRSDTLICSFCGKSQEEVKKLIAGPTVYICDECIELCNDIIAEESKLEDATATDVRKLPKPQEIKEVLDEYVIGQ
SRAKKVLAVAVYNHYKRVEAAVKPGDVEMQKSNILLLGPTGSGKTLLAQTLARILKVPFAMADATNLTEAGYVGEDVENI
ILTLLQASDYDVEKAQKGIIYIDEIDKIARKSDSPSITRDVSGEGVQQALLKIIEGTVASVPPKGGRKHPQQEFLKVDTT
NILFICGGAFPGLDSIIQQRIGVKTLGFGADVKKKVEKKAGELLAGVTPEDLLKFGFIPEFVGRLPMLASLSELDEEAMV
QILKEPKNALIKQYQKLFDMEHVKLKFTDGSLVAIAREALKRKTGARGLRSILENAMLDIMYEIPSQSMVKEVVINEEVI
YSKEKPIIVYENVAESA
>Mature_416_residues
SRRDDRSDTLICSFCGKSQEEVKKLIAGPTVYICDECIELCNDIIAEESKLEDATATDVRKLPKPQEIKEVLDEYVIGQS
RAKKVLAVAVYNHYKRVEAAVKPGDVEMQKSNILLLGPTGSGKTLLAQTLARILKVPFAMADATNLTEAGYVGEDVENII
LTLLQASDYDVEKAQKGIIYIDEIDKIARKSDSPSITRDVSGEGVQQALLKIIEGTVASVPPKGGRKHPQQEFLKVDTTN
ILFICGGAFPGLDSIIQQRIGVKTLGFGADVKKKVEKKAGELLAGVTPEDLLKFGFIPEFVGRLPMLASLSELDEEAMVQ
ILKEPKNALIKQYQKLFDMEHVKLKFTDGSLVAIAREALKRKTGARGLRSILENAMLDIMYEIPSQSMVKEVVINEEVIY
SKEKPIIVYENVAESA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=337, Percent_Identity=51.0385756676558, Blast_Score=317, Evalue=2e-86,
Organism=Escherichia coli, GI1786642, Length=410, Percent_Identity=68.5365853658537, Blast_Score=569, Evalue=1e-163,
Organism=Escherichia coli, GI1790366, Length=103, Percent_Identity=41.747572815534, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71982908, Length=324, Percent_Identity=46.6049382716049, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI71982905, Length=324, Percent_Identity=46.6049382716049, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI71988663, Length=418, Percent_Identity=38.0382775119617, Blast_Score=254, Evalue=7e-68,
Organism=Caenorhabditis elegans, GI71988660, Length=248, Percent_Identity=39.9193548387097, Blast_Score=168, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6319704, Length=426, Percent_Identity=40.8450704225352, Blast_Score=270, Evalue=4e-73,
Organism=Drosophila melanogaster, GI24648291, Length=318, Percent_Identity=45.9119496855346, Blast_Score=284, Evalue=7e-77,
Organism=Drosophila melanogaster, GI24648289, Length=318, Percent_Identity=45.9119496855346, Blast_Score=284, Evalue=7e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_GEOBB (B5EI28)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002138088.1
- GeneID:   6781257
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_1273
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- ProtClustDB:   PRK05342
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 45944; Mature: 45813

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRDDRSDTLICSFCGKSQEEVKKLIAGPTVYICDECIELCNDIIAEESKLEDATATDV
CCCCCCCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RKLPKPQEIKEVLDEYVIGQSRAKKVLAVAVYNHYKRVEAAVKPGDVEMQKSNILLLGPT
HHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCC
GSGKTLLAQTLARILKVPFAMADATNLTEAGYVGEDVENIILTLLQASDYDVEKAQKGII
CCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCE
YIDEIDKIARKSDSPSITRDVSGEGVQQALLKIIEGTVASVPPKGGRKHPQQEFLKVDTT
EEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCHHHHHEECCC
NILFICGGAFPGLDSIIQQRIGVKTLGFGADVKKKVEKKAGELLAGVTPEDLLKFGFIPE
EEEEEECCCCCCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHH
FVGRLPMLASLSELDEEAMVQILKEPKNALIKQYQKLFDMEHVKLKFTDGSLVAIAREAL
HHHHCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
KRKTGARGLRSILENAMLDIMYEIPSQSMVKEVVINEEVIYSKEKPIIVYENVAESA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
SRRDDRSDTLICSFCGKSQEEVKKLIAGPTVYICDECIELCNDIIAEESKLEDATATDV
CCCCCCCCEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
RKLPKPQEIKEVLDEYVIGQSRAKKVLAVAVYNHYKRVEAAVKPGDVEMQKSNILLLGPT
HHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCC
GSGKTLLAQTLARILKVPFAMADATNLTEAGYVGEDVENIILTLLQASDYDVEKAQKGII
CCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCE
YIDEIDKIARKSDSPSITRDVSGEGVQQALLKIIEGTVASVPPKGGRKHPQQEFLKVDTT
EEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCHHHHHEECCC
NILFICGGAFPGLDSIIQQRIGVKTLGFGADVKKKVEKKAGELLAGVTPEDLLKFGFIPE
EEEEEECCCCCCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHH
FVGRLPMLASLSELDEEAMVQILKEPKNALIKQYQKLFDMEHVKLKFTDGSLVAIAREAL
HHHHCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHH
KRKTGARGLRSILENAMLDIMYEIPSQSMVKEVVINEEVIYSKEKPIIVYENVAESA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA