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The map label for this gene is omp38 [H]

Identifier: 197117628

GI number: 197117628

Start: 1436878

End: 1438182

Strand: Direct

Name: omp38 [H]

Synonym: Gbem_1240

Alternate gene names: 197117628

Gene position: 1436878-1438182 (Clockwise)

Preceding gene: 197117627

Following gene: 197117629

Centisome position: 31.13

GC content: 53.49

Gene sequence:

>1305_bases
ATGAAAAAGATTGTTTCATCGATGCTAACCTGTGCTGCTGTACTTACCATGGCAACTACAGCTGTTGCCGGAGAAAGAGA
GGGGGCATTTTCAATTTCTCCTTTTGTCGGCGGTTATACGTTCGATGGGGAGCAGCACTTGGAAACGGCACCTGTGTTTG
GGCTGCGCCTGGGCTATGACCTGACAAAGAACTGGGAAGTCGAAGCTGTTGCTGATTACTTAGCGACCGAAGGGACACGT
AATGACAGAAGTGTCAATGCCTTGTCCTATCGACTGGACGTCCTCTACAACTTTTTGCCGGATGGACCGCTGGTACCGTA
CCTTGCAGTGGGAGGTGGCGGGATTACCTACGGTCACGGCCGCGATGGGCTTGAAGTCAGTGACAGAACTACTGACGCAA
CCATCAATGCCGGTGGGGGCATCAAGTACTTTGTTACCGACTCGGTCGCGTTGCGGGCTGACGCTCGCCAGCTGTTCGTA
TTGGAAAGTCCGGACAAGCCTAAATACAACTGGGAGTACACCGCCGGCCTGACCTTCCTGTTTGGCGACAAGGCAGCTCC
GGCACCGGTAAAGGCTCCGGCACCTGCACCTGCACCAAAGCCGGTTGTTGAACCCGTTCCTGTGCAAAAGCCTGTTCCGG
CTCCTGTAGTAGCTCCTGTGCCGCCTCCCGCCCCCCCCGCTCCTTCTGCAGACATGACGGTTACACCGGGTTCGATTACC
AAAGGCGAAGCCGCCATTTTGACTTGGAAGTCGAGCAACGCCACCAATTGTGAAATTCAGCCGGAAGTTGGCTCTGTTAA
GCCTCAGGGTACCGTCAAGGTTGTCCCTGCTGACAATACTGAGTACACCATAACCTGCAATGGCGCCGGTGGCACCGCTA
ATAGTGCAGCCAAAGTCGCGGTGATTGCTCCTGCTCCAGTAGTGGTTGCGCCCCCTGCTCCTGCTCCGAAGCTGTGCAGC
CCTGCTGTCATAAACATCCAGTTCGATACCAACAAGGCCGACCTCAAGCCCCAGTATCGCCCTGAATTGAAAGCTTTAGC
TGACTTCTTGAACGAGTTCCCCAATGCCACTGGTGTCATTGAGGGGCATACCGACAACGTTGGACCGAAAGCTCTTAATA
TGAAACTGTCTCAATCGCGTGCAGATACGATCCGTAATTCTCTTATCAAAGAATTCGGGATCGCACCTGAGCGGATTAAA
GCAGTAGGCTATGGTCCTACAAAGCCCGTTGCCAGCAACAAGGATAAAGCGGGGAAAGCAAAGAATCGGCGTATCGAATC
CAACTTTAACTGCAACAACAAGTAG

Upstream 100 bases:

>100_bases
GTATCCACTTGATCCTATGTATGATACACCACCAGTTATTCAGAATGCCGTGCAGCTTATATAGTTCGGCATTTAATTTT
ATTTCGGAAAAGGAGGACGT

Downstream 100 bases:

>100_bases
CAATAACGCTACGGCTGCTGACAAGCAAACACCCTTTTGGAATATTTCTAAGAGGGTGTTTTGCTATCACCATGGCATGG
CACCCTCACCCAGAAAGGAG

Product: OmpA family outer membrane protein

Products: NA

Alternate protein names: Outer membrane protein ompA; Outer membrane protein ompAb [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MKKIVSSMLTCAAVLTMATTAVAGEREGAFSISPFVGGYTFDGEQHLETAPVFGLRLGYDLTKNWEVEAVADYLATEGTR
NDRSVNALSYRLDVLYNFLPDGPLVPYLAVGGGGITYGHGRDGLEVSDRTTDATINAGGGIKYFVTDSVALRADARQLFV
LESPDKPKYNWEYTAGLTFLFGDKAAPAPVKAPAPAPAPKPVVEPVPVQKPVPAPVVAPVPPPAPPAPSADMTVTPGSIT
KGEAAILTWKSSNATNCEIQPEVGSVKPQGTVKVVPADNTEYTITCNGAGGTANSAAKVAVIAPAPVVVAPPAPAPKLCS
PAVINIQFDTNKADLKPQYRPELKALADFLNEFPNATGVIEGHTDNVGPKALNMKLSQSRADTIRNSLIKEFGIAPERIK
AVGYGPTKPVASNKDKAGKAKNRRIESNFNCNNK

Sequences:

>Translated_434_residues
MKKIVSSMLTCAAVLTMATTAVAGEREGAFSISPFVGGYTFDGEQHLETAPVFGLRLGYDLTKNWEVEAVADYLATEGTR
NDRSVNALSYRLDVLYNFLPDGPLVPYLAVGGGGITYGHGRDGLEVSDRTTDATINAGGGIKYFVTDSVALRADARQLFV
LESPDKPKYNWEYTAGLTFLFGDKAAPAPVKAPAPAPAPKPVVEPVPVQKPVPAPVVAPVPPPAPPAPSADMTVTPGSIT
KGEAAILTWKSSNATNCEIQPEVGSVKPQGTVKVVPADNTEYTITCNGAGGTANSAAKVAVIAPAPVVVAPPAPAPKLCS
PAVINIQFDTNKADLKPQYRPELKALADFLNEFPNATGVIEGHTDNVGPKALNMKLSQSRADTIRNSLIKEFGIAPERIK
AVGYGPTKPVASNKDKAGKAKNRRIESNFNCNNK
>Mature_434_residues
MKKIVSSMLTCAAVLTMATTAVAGEREGAFSISPFVGGYTFDGEQHLETAPVFGLRLGYDLTKNWEVEAVADYLATEGTR
NDRSVNALSYRLDVLYNFLPDGPLVPYLAVGGGGITYGHGRDGLEVSDRTTDATINAGGGIKYFVTDSVALRADARQLFV
LESPDKPKYNWEYTAGLTFLFGDKAAPAPVKAPAPAPAPKPVVEPVPVQKPVPAPVVAPVPPPAPPAPSADMTVTPGSIT
KGEAAILTWKSSNATNCEIQPEVGSVKPQGTVKVVPADNTEYTITCNGAGGTANSAAKVAVIAPAPVVVAPPAPAPKLCS
PAVINIQFDTNKADLKPQYRPELKALADFLNEFPNATGVIEGHTDNVGPKALNMKLSQSRADTIRNSLIKEFGIAPERIK
AVGYGPTKPVASNKDKAGKAKNRRIESNFNCNNK

Specific function: Porin. Induces apoptosis in human laryngeal epithelial HEp-2 cells through caspases-dependent and AIF-dependent pathways. Purified omp38 enters the cells and localizes to the mitochondria, which leads to a release of proapoptotic molecules such as cytochr

COG id: COG2885

COG function: function code M; Outer membrane protein and related peptidoglycan-associated (lipo)proteins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 OmpA-like domain [H]

Homologues:

Organism=Escherichia coli, GI48994946, Length=102, Percent_Identity=43.1372549019608, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI1786962, Length=99, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011250
- InterPro:   IPR006664
- InterPro:   IPR006665
- InterPro:   IPR008722 [H]

Pfam domain/function: PF00691 OmpA; PF05736 OprF [H]

EC number: NA

Molecular weight: Translated: 45677; Mature: 45677

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: PS51123 OMPA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIVSSMLTCAAVLTMATTAVAGEREGAFSISPFVGGYTFDGEQHLETAPVFGLRLGYD
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCEEECCHHHCCCCCEEEEEECCC
LTKNWEVEAVADYLATEGTRNDRSVNALSYRLDVLYNFLPDGPLVPYLAVGGGGITYGHG
CCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEECCC
RDGLEVSDRTTDATINAGGGIKYFVTDSVALRADARQLFVLESPDKPKYNWEYTAGLTFL
CCCCEECCCCCCEEEECCCCEEEEEECCEEEEECCEEEEEEECCCCCCCCEEEECCEEEE
FGDKAAPAPVKAPAPAPAPKPVVEPVPVQKPVPAPVVAPVPPPAPPAPSADMTVTPGSIT
ECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCEEECCCCCC
KGEAAILTWKSSNATNCEIQPEVGSVKPQGTVKVVPADNTEYTITCNGAGGTANSAAKVA
CCCEEEEEEECCCCCCCEECCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCEEEE
VIAPAPVVVAPPAPAPKLCSPAVINIQFDTNKADLKPQYRPELKALADFLNEFPNATGVI
EEECCCEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
EGHTDNVGPKALNMKLSQSRADTIRNSLIKEFGIAPERIKAVGYGPTKPVASNKDKAGKA
ECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHEEEECCCCCCCCCCCCCCCCCC
KNRRIESNFNCNNK
CCCEECCCCCCCCC
>Mature Secondary Structure
MKKIVSSMLTCAAVLTMATTAVAGEREGAFSISPFVGGYTFDGEQHLETAPVFGLRLGYD
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCEEECCHHHCCCCCEEEEEECCC
LTKNWEVEAVADYLATEGTRNDRSVNALSYRLDVLYNFLPDGPLVPYLAVGGGGITYGHG
CCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEECCC
RDGLEVSDRTTDATINAGGGIKYFVTDSVALRADARQLFVLESPDKPKYNWEYTAGLTFL
CCCCEECCCCCCEEEECCCCEEEEEECCEEEEECCEEEEEEECCCCCCCCEEEECCEEEE
FGDKAAPAPVKAPAPAPAPKPVVEPVPVQKPVPAPVVAPVPPPAPPAPSADMTVTPGSIT
ECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCEEECCCCCC
KGEAAILTWKSSNATNCEIQPEVGSVKPQGTVKVVPADNTEYTITCNGAGGTANSAAKVA
CCCEEEEEEECCCCCCCEECCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCEEEE
VIAPAPVVVAPPAPAPKLCSPAVINIQFDTNKADLKPQYRPELKALADFLNEFPNATGVI
EEECCCEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEE
EGHTDNVGPKALNMKLSQSRADTIRNSLIKEFGIAPERIKAVGYGPTKPVASNKDKAGKA
ECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHEEEECCCCCCCCCCCCCCCCCC
KNRRIESNFNCNNK
CCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA