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The map label for this gene is aqpZ [H]

Identifier: 197117629

GI number: 197117629

Start: 1438290

End: 1438982

Strand: Direct

Name: aqpZ [H]

Synonym: Gbem_1241

Alternate gene names: 197117629

Gene position: 1438290-1438982 (Clockwise)

Preceding gene: 197117628

Following gene: 197117630

Centisome position: 31.16

GC content: 52.81

Gene sequence:

>693_bases
ATGTCAAAGCGACTTTGCGCTGAGTTCATCGGTACATTCTGGTTGGTTCTTGGAGGTTGTGGTAGTGCGGTACTTGCTGC
GGCATTCCCGAATGTCGGGATTGGATTGCATGGTGTCGCGCTGGCTTTCGGATTGACTGTTCTCACTATGGCCTACGCCA
TTGGGCATATTTCGGGGTGCCATCTTAACCCAGCTGTTTCCATCGGCCTCTTCGCCGGAGGACGCTTCCCGGCTAAAGAA
CTTCTGCCGTACATCATAGCCCAAGTGCTTGGAGGCATTGCAGGTGCTGCTGTACTGTTCCTCATTGCCAGCGGGAAAAT
AGGGTTCGATGTTGCTGCCGGCTTTGCTTCAAATGGCTATGGGGAGCATTCTCCGGGTGGGTATTCGCTATTAGCCGGGT
TCGTTACAGAGATCGTGATGACCATGATGTTCCTATTTATCATCATGGGCGCGACCGACAAACGTGCACCACAAGGGTTT
GCGCCGATAGCCATCGGTTTGGGACTTACCTTGATCCACCTCATAAGCATTCCGATCACCAATACGTCGGTAAATCCGGC
ACGCAGTACCGGGGTTGCCATATTCGTCGGAGGATGGGCCATTTCACAATTGTGGCTCTTTTGGGTGGCCCCAATTATCG
GAGCAATAGCTGGCGGCAGTATTTACCGGTTTATCGGCTCCGGCGATGAATAG

Upstream 100 bases:

>100_bases
GCTACGGCTGCTGACAAGCAAACACCCTTTTGGAATATTTCTAAGAGGGTGTTTTGCTATCACCATGGCATGGCACCCTC
ACCCAGAAAGGAGAAGTACA

Downstream 100 bases:

>100_bases
ATGCCGCTAAACACTCATCTTGTCGAATTGCGAATGGATTTTCACCCATACTTCTTTCGGAGGTAGTGACTATGAGCATC
GTTAAAGAGTTCAAGGAATT

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MSKRLCAEFIGTFWLVLGGCGSAVLAAAFPNVGIGLHGVALAFGLTVLTMAYAIGHISGCHLNPAVSIGLFAGGRFPAKE
LLPYIIAQVLGGIAGAAVLFLIASGKIGFDVAAGFASNGYGEHSPGGYSLLAGFVTEIVMTMMFLFIIMGATDKRAPQGF
APIAIGLGLTLIHLISIPITNTSVNPARSTGVAIFVGGWAISQLWLFWVAPIIGAIAGGSIYRFIGSGDE

Sequences:

>Translated_230_residues
MSKRLCAEFIGTFWLVLGGCGSAVLAAAFPNVGIGLHGVALAFGLTVLTMAYAIGHISGCHLNPAVSIGLFAGGRFPAKE
LLPYIIAQVLGGIAGAAVLFLIASGKIGFDVAAGFASNGYGEHSPGGYSLLAGFVTEIVMTMMFLFIIMGATDKRAPQGF
APIAIGLGLTLIHLISIPITNTSVNPARSTGVAIFVGGWAISQLWLFWVAPIIGAIAGGSIYRFIGSGDE
>Mature_229_residues
SKRLCAEFIGTFWLVLGGCGSAVLAAAFPNVGIGLHGVALAFGLTVLTMAYAIGHISGCHLNPAVSIGLFAGGRFPAKEL
LPYIIAQVLGGIAGAAVLFLIASGKIGFDVAAGFASNGYGEHSPGGYSLLAGFVTEIVMTMMFLFIIMGATDKRAPQGFA
PIAIGLGLTLIHLISIPITNTSVNPARSTGVAIFVGGWAISQLWLFWVAPIIGAIAGGSIYRFIGSGDE

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI37694062, Length=231, Percent_Identity=37.2294372294372, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI4502179, Length=226, Percent_Identity=34.070796460177, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI4755125, Length=234, Percent_Identity=31.6239316239316, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI4502181, Length=234, Percent_Identity=31.6239316239316, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI4502183, Length=240, Percent_Identity=32.9166666666667, Blast_Score=110, Evalue=7e-25,
Organism=Homo sapiens, GI6912506, Length=229, Percent_Identity=32.7510917030568, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI86792455, Length=229, Percent_Identity=30.5676855895196, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI157266307, Length=242, Percent_Identity=31.8181818181818, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI45446752, Length=224, Percent_Identity=32.1428571428571, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI22538420, Length=249, Percent_Identity=27.710843373494, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI4826645, Length=248, Percent_Identity=27.8225806451613, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI4502187, Length=247, Percent_Identity=30.3643724696356, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI297307120, Length=91, Percent_Identity=40.6593406593407, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI297307116, Length=113, Percent_Identity=37.1681415929204, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI297307118, Length=91, Percent_Identity=40.6593406593407, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787101, Length=224, Percent_Identity=74.5535714285714, Blast_Score=308, Evalue=1e-85,
Organism=Escherichia coli, GI1790362, Length=252, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71993722, Length=234, Percent_Identity=30.7692307692308, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17558372, Length=238, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71992966, Length=244, Percent_Identity=30.327868852459, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531431, Length=240, Percent_Identity=30, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17531429, Length=240, Percent_Identity=30, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24652747, Length=233, Percent_Identity=35.6223175965665, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI45551084, Length=233, Percent_Identity=35.6223175965665, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24652751, Length=222, Percent_Identity=32.8828828828829, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922038, Length=222, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136672, Length=224, Percent_Identity=28.5714285714286, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI45550503, Length=228, Percent_Identity=28.0701754385965, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24762342, Length=198, Percent_Identity=29.2929292929293, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24762344, Length=220, Percent_Identity=28.1818181818182, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24762346, Length=220, Percent_Identity=28.1818181818182, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24762348, Length=220, Percent_Identity=28.1818181818182, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI20130305, Length=220, Percent_Identity=28.1818181818182, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 23559; Mature: 23428

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRLCAEFIGTFWLVLGGCGSAVLAAAFPNVGIGLHGVALAFGLTVLTMAYAIGHISGC
CCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
HLNPAVSIGLFAGGRFPAKELLPYIIAQVLGGIAGAAVLFLIASGKIGFDVAAGFASNGY
CCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCC
GEHSPGGYSLLAGFVTEIVMTMMFLFIIMGATDKRAPQGFAPIAIGLGLTLIHLISIPIT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
NTSVNPARSTGVAIFVGGWAISQLWLFWVAPIIGAIAGGSIYRFIGSGDE
CCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCC
>Mature Secondary Structure 
SKRLCAEFIGTFWLVLGGCGSAVLAAAFPNVGIGLHGVALAFGLTVLTMAYAIGHISGC
CHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
HLNPAVSIGLFAGGRFPAKELLPYIIAQVLGGIAGAAVLFLIASGKIGFDVAAGFASNGY
CCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCC
GEHSPGGYSLLAGFVTEIVMTMMFLFIIMGATDKRAPQGFAPIAIGLGLTLIHLISIPIT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
NTSVNPARSTGVAIFVGGWAISQLWLFWVAPIIGAIAGGSIYRFIGSGDE
CCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]