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The map label for this gene is ald [H]

Identifier: 197117564

GI number: 197117564

Start: 1368707

End: 1369822

Strand: Direct

Name: ald [H]

Synonym: Gbem_1176

Alternate gene names: 197117564

Gene position: 1368707-1369822 (Clockwise)

Preceding gene: 197117561

Following gene: 197117567

Centisome position: 29.66

GC content: 66.76

Gene sequence:

>1116_bases
ATGATCGTAGGCATTCTGAAGGAGATCAAGGTCGAAGAGAACCGGGTCAGCATGACCCCCGCAGGCGCCGAGGTGATGGC
GCACCACGGACACACGGTGCTGGTGGAACAGTCGGCTGGGGTGGGAAGCGGGTTTTCCGACGACGCCTATAGGCTCGCGG
GGGCCGAGATCGTGGCGACCCCGGCCGAGATCTACGCCCGCGCGCAGCTGGTGATGCACGTGAAGGAGCCGCAGCCGTCC
GAGTACGATCTGATCCGCGAGGGGCAGGTCCTTTTTACCTACTTCCATTTTGCAGCCAGCGAGCCTCTCACCCGTGCGAT
CATGAAGAGCAAGGCGGTAGCCATCGCCTACGAGACCATCACCGGCCCCGAGAACACGCTGCCGCTGCTCACTCCGATGA
GCGAGGTGGCGGGGCGCATGGCGGCACAGCAGGCGGCCAAATACTCGGAACGGTCCCAGGGTGGGCGCGGCATCCTCCTG
GGCGGGGTTCCGGGCGTGCCGCCGGCGACGGTCGTGGTTTTGGGCGGCGGCGTGGTGGGGACCCATGCGGCGCAGATGGC
CTGCGGGCTGGGGGCTAAGGTCTATCTCCTCGACCTGAGCCTGGAGCGCCTGCGCCACCTCTGCGAGACCATGCCCAAGA
ACTGCTTCCCGGTGATGAGCTCTCCCGCCACCATCAGGGAGCTCCTGCCGCAGGCGGACGCCGTGATCGGCGCGGTGCTG
GTGCACGGAGCCAAGGCGCCCAAGCTGGTGACGCGCGAGATGCTGAAGAGCATGAAGCCGGGCGCGGTGCTGGTGGACGT
CGCCATCGACCAAGGAGGTTGCTTCGAGACCTCGCGCCCGACTACGCACACCGACCCCACTTTCCTTTTGGACGGCGTGC
TCCATTACTGCGTGGCCAACATGCCGGGGGCGGTCCCGCTCACCTCTACGGTGGCGCTTACCAACGCCACGCTCCCGTTC
GCCGTGGCGCTCGCGGACCAGGGGTGGCAGGAGGCGTCGCGCCAAAACCCCGGCATCAAGGAAGGGATCAACATCGCGCT
GGGCCAGGTGACCTACCGCGCCGTGGCCGAGGCATTCGGGCTTCCCTATACCCCGGTCCATGCCGTCTTGATCTGA

Upstream 100 bases:

>100_bases
TGCTATGCTCCTGCCGCATCGAGGGTACGGCGCATCAGCTCATGCGGTACAATTCCATCGTGCCCACTGCTAATTAATTT
CGTCGGGGAAGGGAGCTAAC

Downstream 100 bases:

>100_bases
ATCAGGGAATGCGCAGGCGCAGCTTGCGCAGCACGCTCTCGTTGCTCTTCAGGTGCGTCTTGCGCGGGTCCAGGACGGCG
ACTCGGTGGCTTTCCCCCTT

Product: alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MIVGILKEIKVEENRVSMTPAGAEVMAHHGHTVLVEQSAGVGSGFSDDAYRLAGAEIVATPAEIYARAQLVMHVKEPQPS
EYDLIREGQVLFTYFHFAASEPLTRAIMKSKAVAIAYETITGPENTLPLLTPMSEVAGRMAAQQAAKYSERSQGGRGILL
GGVPGVPPATVVVLGGGVVGTHAAQMACGLGAKVYLLDLSLERLRHLCETMPKNCFPVMSSPATIRELLPQADAVIGAVL
VHGAKAPKLVTREMLKSMKPGAVLVDVAIDQGGCFETSRPTTHTDPTFLLDGVLHYCVANMPGAVPLTSTVALTNATLPF
AVALADQGWQEASRQNPGIKEGINIALGQVTYRAVAEAFGLPYTPVHAVLI

Sequences:

>Translated_371_residues
MIVGILKEIKVEENRVSMTPAGAEVMAHHGHTVLVEQSAGVGSGFSDDAYRLAGAEIVATPAEIYARAQLVMHVKEPQPS
EYDLIREGQVLFTYFHFAASEPLTRAIMKSKAVAIAYETITGPENTLPLLTPMSEVAGRMAAQQAAKYSERSQGGRGILL
GGVPGVPPATVVVLGGGVVGTHAAQMACGLGAKVYLLDLSLERLRHLCETMPKNCFPVMSSPATIRELLPQADAVIGAVL
VHGAKAPKLVTREMLKSMKPGAVLVDVAIDQGGCFETSRPTTHTDPTFLLDGVLHYCVANMPGAVPLTSTVALTNATLPF
AVALADQGWQEASRQNPGIKEGINIALGQVTYRAVAEAFGLPYTPVHAVLI
>Mature_371_residues
MIVGILKEIKVEENRVSMTPAGAEVMAHHGHTVLVEQSAGVGSGFSDDAYRLAGAEIVATPAEIYARAQLVMHVKEPQPS
EYDLIREGQVLFTYFHFAASEPLTRAIMKSKAVAIAYETITGPENTLPLLTPMSEVAGRMAAQQAAKYSERSQGGRGILL
GGVPGVPPATVVVLGGGVVGTHAAQMACGLGAKVYLLDLSLERLRHLCETMPKNCFPVMSSPATIRELLPQADAVIGAVL
VHGAKAPKLVTREMLKSMKPGAVLVDVAIDQGGCFETSRPTTHTDPTFLLDGVLHYCVANMPGAVPLTSTVALTNATLPF
AVALADQGWQEASRQNPGIKEGINIALGQVTYRAVAEAFGLPYTPVHAVLI

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=347, Percent_Identity=29.6829971181556, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI122939153, Length=347, Percent_Identity=29.6829971181556, Blast_Score=126, Evalue=3e-29,
Organism=Escherichia coli, GI1787887, Length=336, Percent_Identity=30.3571428571429, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17550456, Length=348, Percent_Identity=29.0229885057471, Blast_Score=131, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 39165; Mature: 39165

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVGILKEIKVEENRVSMTPAGAEVMAHHGHTVLVEQSAGVGSGFSDDAYRLAGAEIVAT
CCEECHHHHEECCCEEEECCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCEECCCEEEEC
PAEIYARAQLVMHVKEPQPSEYDLIREGQVLFTYFHFAASEPLTRAIMKSKAVAIAYETI
HHHHHHHHHHEEEECCCCCCCCHHHCCCCEEEEEEHHHHCCHHHHHHHHCCCEEEEEEEE
TGPENTLPLLTPMSEVAGRMAAQQAAKYSERSQGGRGILLGGVPGVPPATVVVLGGGVVG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECCCCHH
THAAQMACGLGAKVYLLDLSLERLRHLCETMPKNCFPVMSSPATIRELLPQADAVIGAVL
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VHGAKAPKLVTREMLKSMKPGAVLVDVAIDQGGCFETSRPTTHTDPTFLLDGVLHYCVAN
HCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
MPGAVPLTSTVALTNATLPFAVALADQGWQEASRQNPGIKEGINIALGQVTYRAVAEAFG
CCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHCCCCHHHCCCEEHHHHHHHHHHHHHC
LPYTPVHAVLI
CCCCCHHEEEC
>Mature Secondary Structure
MIVGILKEIKVEENRVSMTPAGAEVMAHHGHTVLVEQSAGVGSGFSDDAYRLAGAEIVAT
CCEECHHHHEECCCEEEECCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCEECCCEEEEC
PAEIYARAQLVMHVKEPQPSEYDLIREGQVLFTYFHFAASEPLTRAIMKSKAVAIAYETI
HHHHHHHHHHEEEECCCCCCCCHHHCCCCEEEEEEHHHHCCHHHHHHHHCCCEEEEEEEE
TGPENTLPLLTPMSEVAGRMAAQQAAKYSERSQGGRGILLGGVPGVPPATVVVLGGGVVG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECCCCHH
THAAQMACGLGAKVYLLDLSLERLRHLCETMPKNCFPVMSSPATIRELLPQADAVIGAVL
HHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VHGAKAPKLVTREMLKSMKPGAVLVDVAIDQGGCFETSRPTTHTDPTFLLDGVLHYCVAN
HCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
MPGAVPLTSTVALTNATLPFAVALADQGWQEASRQNPGIKEGINIALGQVTYRAVAEAFG
CCCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHCCCCHHHCCCEEHHHHHHHHHHHHHC
LPYTPVHAVLI
CCCCCHHEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA