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The map label for this gene is lon1 [H]

Identifier: 197117409

GI number: 197117409

Start: 1186751

End: 1189153

Strand: Reverse

Name: lon1 [H]

Synonym: Gbem_1019

Alternate gene names: 197117409

Gene position: 1189153-1186751 (Counterclockwise)

Preceding gene: 197117412

Following gene: 308535210

Centisome position: 25.77

GC content: 62.46

Gene sequence:

>2403_bases
ATGAGCCAGAAAAATATAGAGGTACTGGAAGCAGAAACCGACGACAACACCGAAAGCAGCGGGCTGGTGCTTGCCTCAGA
AGTACTCCCGGCCGGGCTGCCGATCATACCGCTGCGGCCGCGGCCGGCATTCCCGAACATGCTGATCCCGATGGCCGTTC
AAGACCCGCAACAGGTGCAGGCAGTGAAGCGGACCATGGAGACCCCGGCGCGCGCCATAGGCCTTGCGCTGGTGAAAGAC
CCGGAGAAGCCGGATGGGCCGGCCAACCTGCACGGCGTGGGGGTGGCGGGAAAGATCGTGAAGATCATGCAGGCCGACGA
AGACGGCGTGCAGTTCCTCGTCAACACGCTGGACCGCTTTTCCATCCGGGAGTTGGACGACAACTCCGGCGTTCTCTTTG
CCAACGTAGCCTACCAGTACGGCACGGAGCTATCGGTGAACCCCGAGCTCAAGGCGTACTCGATGGCGGTCATCAGCACC
CTGAAGGAACTGGTCCAGATCAACCCGCTCTACTCGGAGGAGATCAAGCTGTTCCTGGGGCGCTCCAGCCTGGACGACCC
CGGCAGGCTGTCCGATTTCGCCGCCAGCCTCACCTCGGCCGACGGGCAGGAACTGCAGCAGGTGCTGGAGACCTTCGACG
TCCGCAAACGGATCGACATGGTGCTGAACCTGCTCAAGAAGGAGTTGGAGGTCTCCAGGCTGCAGACCAAGATCACCAAG
CAGATCGAGGAGAAGATCAGCCAGCAGCAGCGGGAGTTCTTCCTTAGGGAGCAGTTGAAGGCGATCAAGAAGGAACTGGG
GCTGGAAAAGGAAGGAAAGACCGCGGAGGTCGAGAAATTCGAGGAGCGGCTCAAGCAGTTGAAGCTGAACCCCGAGGCGC
AGCGGGCGGTGACCGACGAGCTGGAAAAATTCAAGCTGCTGGAGCCCGCCTCCGCCGAATACCACGTGACGCGGAACTAC
CTCGACTGGCTGACCATCCTTCCCTGGGGGAAGTACAGCAAGGATTCCTACAATATCGACAAGGCCCGCAGGATTCTGGA
CCGCGATCATCACGGGTTGAACGACGTGAAGGACCGCATCACCGAGTTCATCGCGGTGGGAAAGATGAAGGGGGACATCT
CCGGCTCCATCCTCTGCCTGGTCGGCCCCCCGGGGGTCGGCAAGACCTCCATCGGCAAGAGCATCGCCGATGCCCTGGGG
CGGACCTTCTACCGCTTCTCCCTGGGAGGGATGCGTGACGAGGCGGAGATCAAGGGGCACCGCCGTACCTACATCGGCGC
CATGCCCGGCAAGTTCGTGCAGGCGATGAAGAGCGCCGGGTCGTCCAACCCCGTGCTGATGCTGGACGAGATCGACAAGA
TCGGGGCCTCCTTCCAGGGGGATCCCGCGTCCGCCCTCCTAGAGGTGCTGGACCCCGAGCAAAACGGATCCTTCCGCGAC
CACTACCTGGACGTCCCCTTCGACCTTTCCAACGTCCTTTTCATCGCCACGGCCAACCAGTTGGACACCATCCCGGCGCC
GCTTCTGGACCGGATGGAGGTGATCCGGCTCTCCGGCTACGTGCTGGAGGAGAAGATGGAGATAGCCAGGCGCTACCTGA
TCCCCAAGGCGCTCAAGAACCACGGGCTCAAGAACGGGCAGGTGACCATCAGGAAGGAGGCGCTGGCGGCGCTCATCGAC
GGTTGGGCGCGCGAGGCGGGCGTGCGCACACTGGAAAACCGCATCAAGAAGCTGATGCGCAAGGCAGCCAAGGAGTTCGC
GACCGGGCGCAGCGAGCCAGTCGTCGTCACCGGGAAAGACCTTCCGGGATACCTGGGTCAGCCGGTGTTCAGCACCGAAG
AGATCTTCGAGGGGGTCCCGGGGGTCGTCACCGGGCTCGCCTGGACCAGCATGGGAGGGGCCACCCTCCCCATCGAGGCG
ACGGCGATGGCGAGCAAGAGCAAGGGGTTCAGGCAGACGGGGCAGTTGGGCAACGTCATGATCGAGAGCTCCGAGATCGC
TTATTCTTTCGTCATGGCGCATCTCAAGGAGTACGGTGCGGCGGAGGATTACTTCGATACGCACTTCGTGCATCTGCACG
TCCCCGCCGGCGCCACCCCCAAGGACGGCCCTTCCGCAGGGGTCACCATGGCGACGGCGCTGATATCCATGATGCAGGGA
AGGCCAGTAAGGAAGAAGCTCGGCATGACGGGAGAGCTGACCCTGACCGGGCGGGTGCTCCCCATCGGCGGGGTGAAGGA
AAAGACCATAGCGGCGCGGCGCGCCGGGCTGAAGGTGCTGATCTTCCCGGAAGCGAACAAGAAGGATTTCGCGGAACTTC
CCGACTACCTCAAGGAGGGGTTGGAGGTCCACTTCGCCAGGGAGTATAAGGACGTGTACAAGGTCGCCTTCGCTTCGAAG
TAA

Upstream 100 bases:

>100_bases
CCGCAGTTGGGACGGCAGCCGCAATTTGTAGCGGCAGCACGGTTGACAGCTCGTGCCGCGATGCTTAGCTTTTAATAAAT
CATCCGCTAGGAGTGTCATC

Downstream 100 bases:

>100_bases
CCGCCCTTTTCTACCCCGCACTAAAAACCCCGCCTCCTTGCCGGATGCGGGGTTTTTCTTTGCCACAAGCATTGCCGCCA
TTAAACGCGCGGGTGCTTTC

Product: DNA-binding ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 1 [H]

Number of amino acids: Translated: 800; Mature: 799

Protein sequence:

>800_residues
MSQKNIEVLEAETDDNTESSGLVLASEVLPAGLPIIPLRPRPAFPNMLIPMAVQDPQQVQAVKRTMETPARAIGLALVKD
PEKPDGPANLHGVGVAGKIVKIMQADEDGVQFLVNTLDRFSIRELDDNSGVLFANVAYQYGTELSVNPELKAYSMAVIST
LKELVQINPLYSEEIKLFLGRSSLDDPGRLSDFAASLTSADGQELQQVLETFDVRKRIDMVLNLLKKELEVSRLQTKITK
QIEEKISQQQREFFLREQLKAIKKELGLEKEGKTAEVEKFEERLKQLKLNPEAQRAVTDELEKFKLLEPASAEYHVTRNY
LDWLTILPWGKYSKDSYNIDKARRILDRDHHGLNDVKDRITEFIAVGKMKGDISGSILCLVGPPGVGKTSIGKSIADALG
RTFYRFSLGGMRDEAEIKGHRRTYIGAMPGKFVQAMKSAGSSNPVLMLDEIDKIGASFQGDPASALLEVLDPEQNGSFRD
HYLDVPFDLSNVLFIATANQLDTIPAPLLDRMEVIRLSGYVLEEKMEIARRYLIPKALKNHGLKNGQVTIRKEALAALID
GWAREAGVRTLENRIKKLMRKAAKEFATGRSEPVVVTGKDLPGYLGQPVFSTEEIFEGVPGVVTGLAWTSMGGATLPIEA
TAMASKSKGFRQTGQLGNVMIESSEIAYSFVMAHLKEYGAAEDYFDTHFVHLHVPAGATPKDGPSAGVTMATALISMMQG
RPVRKKLGMTGELTLTGRVLPIGGVKEKTIAARRAGLKVLIFPEANKKDFAELPDYLKEGLEVHFAREYKDVYKVAFASK

Sequences:

>Translated_800_residues
MSQKNIEVLEAETDDNTESSGLVLASEVLPAGLPIIPLRPRPAFPNMLIPMAVQDPQQVQAVKRTMETPARAIGLALVKD
PEKPDGPANLHGVGVAGKIVKIMQADEDGVQFLVNTLDRFSIRELDDNSGVLFANVAYQYGTELSVNPELKAYSMAVIST
LKELVQINPLYSEEIKLFLGRSSLDDPGRLSDFAASLTSADGQELQQVLETFDVRKRIDMVLNLLKKELEVSRLQTKITK
QIEEKISQQQREFFLREQLKAIKKELGLEKEGKTAEVEKFEERLKQLKLNPEAQRAVTDELEKFKLLEPASAEYHVTRNY
LDWLTILPWGKYSKDSYNIDKARRILDRDHHGLNDVKDRITEFIAVGKMKGDISGSILCLVGPPGVGKTSIGKSIADALG
RTFYRFSLGGMRDEAEIKGHRRTYIGAMPGKFVQAMKSAGSSNPVLMLDEIDKIGASFQGDPASALLEVLDPEQNGSFRD
HYLDVPFDLSNVLFIATANQLDTIPAPLLDRMEVIRLSGYVLEEKMEIARRYLIPKALKNHGLKNGQVTIRKEALAALID
GWAREAGVRTLENRIKKLMRKAAKEFATGRSEPVVVTGKDLPGYLGQPVFSTEEIFEGVPGVVTGLAWTSMGGATLPIEA
TAMASKSKGFRQTGQLGNVMIESSEIAYSFVMAHLKEYGAAEDYFDTHFVHLHVPAGATPKDGPSAGVTMATALISMMQG
RPVRKKLGMTGELTLTGRVLPIGGVKEKTIAARRAGLKVLIFPEANKKDFAELPDYLKEGLEVHFAREYKDVYKVAFASK
>Mature_799_residues
SQKNIEVLEAETDDNTESSGLVLASEVLPAGLPIIPLRPRPAFPNMLIPMAVQDPQQVQAVKRTMETPARAIGLALVKDP
EKPDGPANLHGVGVAGKIVKIMQADEDGVQFLVNTLDRFSIRELDDNSGVLFANVAYQYGTELSVNPELKAYSMAVISTL
KELVQINPLYSEEIKLFLGRSSLDDPGRLSDFAASLTSADGQELQQVLETFDVRKRIDMVLNLLKKELEVSRLQTKITKQ
IEEKISQQQREFFLREQLKAIKKELGLEKEGKTAEVEKFEERLKQLKLNPEAQRAVTDELEKFKLLEPASAEYHVTRNYL
DWLTILPWGKYSKDSYNIDKARRILDRDHHGLNDVKDRITEFIAVGKMKGDISGSILCLVGPPGVGKTSIGKSIADALGR
TFYRFSLGGMRDEAEIKGHRRTYIGAMPGKFVQAMKSAGSSNPVLMLDEIDKIGASFQGDPASALLEVLDPEQNGSFRDH
YLDVPFDLSNVLFIATANQLDTIPAPLLDRMEVIRLSGYVLEEKMEIARRYLIPKALKNHGLKNGQVTIRKEALAALIDG
WAREAGVRTLENRIKKLMRKAAKEFATGRSEPVVVTGKDLPGYLGQPVFSTEEIFEGVPGVVTGLAWTSMGGATLPIEAT
AMASKSKGFRQTGQLGNVMIESSEIAYSFVMAHLKEYGAAEDYFDTHFVHLHVPAGATPKDGPSAGVTMATALISMMQGR
PVRKKLGMTGELTLTGRVLPIGGVKEKTIAARRAGLKVLIFPEANKKDFAELPDYLKEGLEVHFAREYKDVYKVAFASK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=678, Percent_Identity=51.3274336283186, Blast_Score=726, Evalue=0.0,
Organism=Homo sapiens, GI31377667, Length=834, Percent_Identity=35.7314148681055, Blast_Score=489, Evalue=1e-138,
Organism=Escherichia coli, GI1786643, Length=770, Percent_Identity=42.3376623376623, Blast_Score=612, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI17505831, Length=697, Percent_Identity=45.3371592539455, Blast_Score=626, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI17556486, Length=625, Percent_Identity=36.48, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319449, Length=717, Percent_Identity=47.0013947001395, Blast_Score=667, Evalue=0.0,
Organism=Drosophila melanogaster, GI221513036, Length=664, Percent_Identity=52.4096385542169, Blast_Score=691, Evalue=0.0,
Organism=Drosophila melanogaster, GI24666867, Length=664, Percent_Identity=52.4096385542169, Blast_Score=691, Evalue=0.0,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88328; Mature: 88197

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKNIEVLEAETDDNTESSGLVLASEVLPAGLPIIPLRPRPAFPNMLIPMAVQDPQQVQ
CCCCCCEEEEECCCCCCCCCCEEEEHHHHCCCCCEEECCCCCCCCCCEEEEECCCHHHHH
AVKRTMETPARAIGLALVKDPEKPDGPANLHGVGVAGKIVKIMQADEDGVQFLVNTLDRF
HHHHHHHCHHHHHHHHEECCCCCCCCCCCEEECCHHHHHHHHHHCCCHHHHHHHHHHHHH
SIRELDDNSGVLFANVAYQYGTELSVNPELKAYSMAVISTLKELVQINPLYSEEIKLFLG
EHHCCCCCCCEEEEEEHHHCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEC
RSSLDDPGRLSDFAASLTSADGQELQQVLETFDVRKRIDMVLNLLKKELEVSRLQTKITK
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIEEKISQQQREFFLREQLKAIKKELGLEKEGKTAEVEKFEERLKQLKLNPEAQRAVTDE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
LEKFKLLEPASAEYHVTRNYLDWLTILPWGKYSKDSYNIDKARRILDRDHHGLNDVKDRI
HHHHCCCCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHH
TEFIAVGKMKGDISGSILCLVGPPGVGKTSIGKSIADALGRTFYRFSLGGMRDEAEIKGH
HHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
RRTYIGAMPGKFVQAMKSAGSSNPVLMLDEIDKIGASFQGDPASALLEVLDPEQNGSFRD
CEEEEECCCHHHHHHHHHCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHHCCCCCCCCCC
HYLDVPFDLSNVLFIATANQLDTIPAPLLDRMEVIRLSGYVLEEKMEIARRYLIPKALKN
CEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HGLKNGQVTIRKEALAALIDGWAREAGVRTLENRIKKLMRKAAKEFATGRSEPVVVTGKD
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
LPGYLGQPVFSTEEIFEGVPGVVTGLAWTSMGGATLPIEATAMASKSKGFRQTGQLGNVM
CCCCCCCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCEEHHHHHHHCCCCHHHCCCCCEE
IESSEIAYSFVMAHLKEYGAAEDYFDTHFVHLHVPAGATPKDGPSAGVTMATALISMMQG
EECHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCC
RPVRKKLGMTGELTLTGRVLPIGGVKEKTIAARRAGLKVLIFPEANKKDFAELPDYLKEG
CCHHHHCCCCEEEEEEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHH
LEVHFAREYKDVYKVAFASK
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SQKNIEVLEAETDDNTESSGLVLASEVLPAGLPIIPLRPRPAFPNMLIPMAVQDPQQVQ
CCCCCEEEEECCCCCCCCCCEEEEHHHHCCCCCEEECCCCCCCCCCEEEEECCCHHHHH
AVKRTMETPARAIGLALVKDPEKPDGPANLHGVGVAGKIVKIMQADEDGVQFLVNTLDRF
HHHHHHHCHHHHHHHHEECCCCCCCCCCCEEECCHHHHHHHHHHCCCHHHHHHHHHHHHH
SIRELDDNSGVLFANVAYQYGTELSVNPELKAYSMAVISTLKELVQINPLYSEEIKLFLG
EHHCCCCCCCEEEEEEHHHCCCCEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEC
RSSLDDPGRLSDFAASLTSADGQELQQVLETFDVRKRIDMVLNLLKKELEVSRLQTKITK
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIEEKISQQQREFFLREQLKAIKKELGLEKEGKTAEVEKFEERLKQLKLNPEAQRAVTDE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
LEKFKLLEPASAEYHVTRNYLDWLTILPWGKYSKDSYNIDKARRILDRDHHGLNDVKDRI
HHHHCCCCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHH
TEFIAVGKMKGDISGSILCLVGPPGVGKTSIGKSIADALGRTFYRFSLGGMRDEAEIKGH
HHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCC
RRTYIGAMPGKFVQAMKSAGSSNPVLMLDEIDKIGASFQGDPASALLEVLDPEQNGSFRD
CEEEEECCCHHHHHHHHHCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHHCCCCCCCCCC
HYLDVPFDLSNVLFIATANQLDTIPAPLLDRMEVIRLSGYVLEEKMEIARRYLIPKALKN
CEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HGLKNGQVTIRKEALAALIDGWAREAGVRTLENRIKKLMRKAAKEFATGRSEPVVVTGKD
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
LPGYLGQPVFSTEEIFEGVPGVVTGLAWTSMGGATLPIEATAMASKSKGFRQTGQLGNVM
CCCCCCCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCEEHHHHHHHCCCCHHHCCCCCEE
IESSEIAYSFVMAHLKEYGAAEDYFDTHFVHLHVPAGATPKDGPSAGVTMATALISMMQG
EECHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCC
RPVRKKLGMTGELTLTGRVLPIGGVKEKTIAARRAGLKVLIFPEANKKDFAELPDYLKEG
CCHHHHCCCCEEEEEEEEEEECCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHH
LEVHFAREYKDVYKVAFASK
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA