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The map label for this gene is mutL [H]

Identifier: 197117368

GI number: 197117368

Start: 1135193

End: 1137136

Strand: Direct

Name: mutL [H]

Synonym: Gbem_0978

Alternate gene names: 197117368

Gene position: 1135193-1137136 (Clockwise)

Preceding gene: 197117365

Following gene: 197117369

Centisome position: 24.6

GC content: 62.14

Gene sequence:

>1944_bases
TTGGCAACGAAGATTCGCATACTCCCTGAGAATTTAACCAACAAGATCGCCGCTGGAGAGGTGGTGGAGCGTCCGGCCTC
CGTCGCGAAGGAACTGGTGGAGAATGCACTCGACGCAGGTTCCAAGGAAGTCGTGGTCGAGATAGAGTCGGGTGGCAGGC
GGCTCATCAAGGTCTCCGATACCGGTTGCGGCATGTCCCGGGACGACGCCTTGCTCGCCCTGGAACGTCACGCAACCAGC
AAGATCGCGACAGACGAAGATCTCTTCTCCCTCTGCACTCTCGGCTTCCGAGGCGAGGCGCTGCCATCTGTCGCCTCGGT
TTCCCGCCTCACCATCTCTACCCGGACCAGCGACTCGGTCGAGGGGACGGAGATTTACGCCGAAGGGGGACGGATCAAGG
AAGTGAAGGAATGCGGCATGGCGGTCGGGACTGTGATCTCGGTGCGGAATCTTTTCTTCAACACGCCGGCGCGGCTTAAA
TTCATGAAGAGCGCCGAGACGGAGGGGGGGCACGTCGGGGAGTTGCTGACCCGCCTCGCCATCTCCAGGCCGGAGGTCCG
CTTCACTTATAAAAACGACGGCAAGGTGGTGTTCCGTGCGCTGGATGCGGACCTGAAGGAGCGGGTCGCTACTATGCTGG
GGCGTTCCATCGCCTCCTTTTTGTACCCCGTTTCCTACCAGGAGGGGGGGCTCAAGGTGAGCGGATTGGTTGCGGCGCCG
GAGTGCAGCCGCAGTGCCGGGAGCCATCTCTACACCTACATAAACGGACGTTTCATCAAGGACAAGGTGGTGCAGCACGC
CATCCTCCAGGCGTACCGCAACTTCCTGGAGCGCGGACGTTACCCTGTCGTCGCCGTTTTTATCGAGATAGCACCGGGCG
AAGTCGATGTGAACGTGCATCCGACCAAGCATGAGGTTCGTTTCCGAGAGCAGGGGCGGGTGCACGACGCCATCCAGAAC
GCGGTGGAGTCGGTGCTCAAGGAAACGCCGTGGCTAAAGCGCCCTGCAGTCGCAGCAGTATCCCGGCCGACGGAGAAGGA
CGCGGCAGCGGCGCGAGCAGTCCTGGAGGGGTCGCAAGCTCCGCTGCCCGTGACGCCGCAGCCCCGGCCGGCGCTGACGT
CTGAAAAACCGGTTCCCGCACCGCAGGCTCAACCGCAGCAGTCGTCGATCAGCGAAGCGCGGGTGGCAGAGGTAAGGGAG
CTCCTGGTGGATTTTCAGCCGAGGCCGCAGCCTTCGCTTCGACCGCAGTATCAGGGATCTGTGACGTCCAAGGAGGCGTT
GCCCTATGCCCCCATGGCTGCGCCGGTGCCGGTCCGTGAACCCGAGACGGCGGCGCCTGAACCGGACCCCGCTGCAGCGG
GATACTTCTCTTCGCTCGGCGTCATAGGGCAATTCAACGCCTCCTATATCCTCTGTCAAAGAGGGACCGACCTCGTTCTC
ATCGACCAGCACGCAGCGCACGAGCGGGTCGCGTTCGAAAAGCTGAAAGGGCAGTTCGCCGGGAGGGAGGTGGACAGCCA
GGGGCTTCTCTTTCCGGAGACCATGGAATTCTCCTTCCGCGAGTCGGCCGTATTGCGGGAACACCTGGCGGAGCTTGCCC
GCCTGGGGTTCGAGTTCGAAGAGTTCGGGGGGAATACCTGGCTGTTGAAGGGAGTCCCGCAGGTGCTGTCGGCGACGCGG
TATGTGGACACGATTCGCGACATACTCGAGGAGCTGGGAAGCCTCAGCCGCAGCCGCGCCTTCAGCGATATCCAGGAGGA
CCTGCTCGCTCGCATCGCCTGCCACAGCGTGGTTCGTGGGAAGCGCACCCTGAGCCAAGTGGAGATAACGGCACTCTTCA
AGCAGATGGATGAGACCGATTTCTCCAGTAACTGCCCTCACGGCAGGCCGGTGATGCAGACCCTCACGCTCGCCGAAGTA
GAGAAGATGTTCAAGAGAATCTAG

Upstream 100 bases:

>100_bases
CATGAGCGTGACGTGTGAGAGAAAGCCCAATCTTGGATTTACAAACAGGCGCCGGTTAAGGTATCTTGGCTCACCCTACA
ACGCTTGTGAGAGGAATGGC

Downstream 100 bases:

>100_bases
CGGTGTCGACCGTTACGCAGAAGTGAGGCACCTGTTGCAGGATAAGGAAAAAAAGATCAAGGTCATCGTCCTTGGAGGCC
CCACCGGTTCCGGCAAGAGC

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 647; Mature: 646

Protein sequence:

>647_residues
MATKIRILPENLTNKIAAGEVVERPASVAKELVENALDAGSKEVVVEIESGGRRLIKVSDTGCGMSRDDALLALERHATS
KIATDEDLFSLCTLGFRGEALPSVASVSRLTISTRTSDSVEGTEIYAEGGRIKEVKECGMAVGTVISVRNLFFNTPARLK
FMKSAETEGGHVGELLTRLAISRPEVRFTYKNDGKVVFRALDADLKERVATMLGRSIASFLYPVSYQEGGLKVSGLVAAP
ECSRSAGSHLYTYINGRFIKDKVVQHAILQAYRNFLERGRYPVVAVFIEIAPGEVDVNVHPTKHEVRFREQGRVHDAIQN
AVESVLKETPWLKRPAVAAVSRPTEKDAAAARAVLEGSQAPLPVTPQPRPALTSEKPVPAPQAQPQQSSISEARVAEVRE
LLVDFQPRPQPSLRPQYQGSVTSKEALPYAPMAAPVPVREPETAAPEPDPAAAGYFSSLGVIGQFNASYILCQRGTDLVL
IDQHAAHERVAFEKLKGQFAGREVDSQGLLFPETMEFSFRESAVLREHLAELARLGFEFEEFGGNTWLLKGVPQVLSATR
YVDTIRDILEELGSLSRSRAFSDIQEDLLARIACHSVVRGKRTLSQVEITALFKQMDETDFSSNCPHGRPVMQTLTLAEV
EKMFKRI

Sequences:

>Translated_647_residues
MATKIRILPENLTNKIAAGEVVERPASVAKELVENALDAGSKEVVVEIESGGRRLIKVSDTGCGMSRDDALLALERHATS
KIATDEDLFSLCTLGFRGEALPSVASVSRLTISTRTSDSVEGTEIYAEGGRIKEVKECGMAVGTVISVRNLFFNTPARLK
FMKSAETEGGHVGELLTRLAISRPEVRFTYKNDGKVVFRALDADLKERVATMLGRSIASFLYPVSYQEGGLKVSGLVAAP
ECSRSAGSHLYTYINGRFIKDKVVQHAILQAYRNFLERGRYPVVAVFIEIAPGEVDVNVHPTKHEVRFREQGRVHDAIQN
AVESVLKETPWLKRPAVAAVSRPTEKDAAAARAVLEGSQAPLPVTPQPRPALTSEKPVPAPQAQPQQSSISEARVAEVRE
LLVDFQPRPQPSLRPQYQGSVTSKEALPYAPMAAPVPVREPETAAPEPDPAAAGYFSSLGVIGQFNASYILCQRGTDLVL
IDQHAAHERVAFEKLKGQFAGREVDSQGLLFPETMEFSFRESAVLREHLAELARLGFEFEEFGGNTWLLKGVPQVLSATR
YVDTIRDILEELGSLSRSRAFSDIQEDLLARIACHSVVRGKRTLSQVEITALFKQMDETDFSSNCPHGRPVMQTLTLAEV
EKMFKRI
>Mature_646_residues
ATKIRILPENLTNKIAAGEVVERPASVAKELVENALDAGSKEVVVEIESGGRRLIKVSDTGCGMSRDDALLALERHATSK
IATDEDLFSLCTLGFRGEALPSVASVSRLTISTRTSDSVEGTEIYAEGGRIKEVKECGMAVGTVISVRNLFFNTPARLKF
MKSAETEGGHVGELLTRLAISRPEVRFTYKNDGKVVFRALDADLKERVATMLGRSIASFLYPVSYQEGGLKVSGLVAAPE
CSRSAGSHLYTYINGRFIKDKVVQHAILQAYRNFLERGRYPVVAVFIEIAPGEVDVNVHPTKHEVRFREQGRVHDAIQNA
VESVLKETPWLKRPAVAAVSRPTEKDAAAARAVLEGSQAPLPVTPQPRPALTSEKPVPAPQAQPQQSSISEARVAEVREL
LVDFQPRPQPSLRPQYQGSVTSKEALPYAPMAAPVPVREPETAAPEPDPAAAGYFSSLGVIGQFNASYILCQRGTDLVLI
DQHAAHERVAFEKLKGQFAGREVDSQGLLFPETMEFSFRESAVLREHLAELARLGFEFEEFGGNTWLLKGVPQVLSATRY
VDTIRDILEELGSLSRSRAFSDIQEDLLARIACHSVVRGKRTLSQVEITALFKQMDETDFSSNCPHGRPVMQTLTLAEVE
KMFKRI

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=332, Percent_Identity=34.9397590361446, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI4505911, Length=368, Percent_Identity=29.3478260869565, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI189458898, Length=368, Percent_Identity=29.3478260869565, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI4505913, Length=340, Percent_Identity=29.1176470588235, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI310128478, Length=340, Percent_Identity=29.1176470588235, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI189458896, Length=362, Percent_Identity=28.7292817679558, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI263191589, Length=234, Percent_Identity=29.9145299145299, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI310128480, Length=290, Percent_Identity=28.6206896551724, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI91992160, Length=358, Percent_Identity=23.7430167597765, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI91992162, Length=358, Percent_Identity=23.7430167597765, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1790612, Length=625, Percent_Identity=36, Blast_Score=314, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI71991825, Length=317, Percent_Identity=35.0157728706625, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17562796, Length=340, Percent_Identity=27.3529411764706, Blast_Score=124, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=335, Percent_Identity=33.134328358209, Blast_Score=183, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=356, Percent_Identity=23.876404494382, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=153, Percent_Identity=31.3725490196078, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136968, Length=327, Percent_Identity=34.8623853211009, Blast_Score=209, Evalue=7e-54,
Organism=Drosophila melanogaster, GI17136970, Length=354, Percent_Identity=25.4237288135593, Blast_Score=101, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 70976; Mature: 70845

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATKIRILPENLTNKIAAGEVVERPASVAKELVENALDAGSKEVVVEIESGGRRLIKVSD
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEC
TGCGMSRDDALLALERHATSKIATDEDLFSLCTLGFRGEALPSVASVSRLTISTRTSDSV
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHEEEEECCCCCC
EGTEIYAEGGRIKEVKECGMAVGTVISVRNLFFNTPARLKFMKSAETEGGHVGELLTRLA
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHH
ISRPEVRFTYKNDGKVVFRALDADLKERVATMLGRSIASFLYPVSYQEGGLKVSGLVAAP
CCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECC
ECSRSAGSHLYTYINGRFIKDKVVQHAILQAYRNFLERGRYPVVAVFIEIAPGEVDVNVH
CCCCCCCCEEEEEECCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEC
PTKHEVRFREQGRVHDAIQNAVESVLKETPWLKRPAVAAVSRPTEKDAAAARAVLEGSQA
CCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCC
PLPVTPQPRPALTSEKPVPAPQAQPQQSSISEARVAEVRELLVDFQPRPQPSLRPQYQGS
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
VTSKEALPYAPMAAPVPVREPETAAPEPDPAAAGYFSSLGVIGQFNASYILCQRGTDLVL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEECCCCEEEEECCCCEEE
IDQHAAHERVAFEKLKGQFAGREVDSQGLLFPETMEFSFRESAVLREHLAELARLGFEFE
ECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCHH
EFGGNTWLLKGVPQVLSATRYVDTIRDILEELGSLSRSRAFSDIQEDLLARIACHSVVRG
HHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRTLSQVEITALFKQMDETDFSSNCPHGRPVMQTLTLAEVEKMFKRI
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ATKIRILPENLTNKIAAGEVVERPASVAKELVENALDAGSKEVVVEIESGGRRLIKVSD
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEC
TGCGMSRDDALLALERHATSKIATDEDLFSLCTLGFRGEALPSVASVSRLTISTRTSDSV
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHEEEEECCCCCC
EGTEIYAEGGRIKEVKECGMAVGTVISVRNLFFNTPARLKFMKSAETEGGHVGELLTRLA
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHH
ISRPEVRFTYKNDGKVVFRALDADLKERVATMLGRSIASFLYPVSYQEGGLKVSGLVAAP
CCCCCEEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECC
ECSRSAGSHLYTYINGRFIKDKVVQHAILQAYRNFLERGRYPVVAVFIEIAPGEVDVNVH
CCCCCCCCEEEEEECCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEC
PTKHEVRFREQGRVHDAIQNAVESVLKETPWLKRPAVAAVSRPTEKDAAAARAVLEGSQA
CCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCC
PLPVTPQPRPALTSEKPVPAPQAQPQQSSISEARVAEVRELLVDFQPRPQPSLRPQYQGS
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
VTSKEALPYAPMAAPVPVREPETAAPEPDPAAAGYFSSLGVIGQFNASYILCQRGTDLVL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCEEECCCCEEEEECCCCEEE
IDQHAAHERVAFEKLKGQFAGREVDSQGLLFPETMEFSFRESAVLREHLAELARLGFEFE
ECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCHH
EFGGNTWLLKGVPQVLSATRYVDTIRDILEELGSLSRSRAFSDIQEDLLARIACHSVVRG
HHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRTLSQVEITALFKQMDETDFSSNCPHGRPVMQTLTLAEVEKMFKRI
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA