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The map label for this gene is lpxC

Identifier: 197117291

GI number: 197117291

Start: 1059490

End: 1060407

Strand: Reverse

Name: lpxC

Synonym: Gbem_0901

Alternate gene names: 197117291

Gene position: 1060407-1059490 (Counterclockwise)

Preceding gene: 197117292

Following gene: 197117290

Centisome position: 22.98

GC content: 62.53

Gene sequence:

>918_bases
ATGATATTCCAGCAGACCTTGGGCAACAAAGCAACATTCAGCGGCATCGGACTGCACACGGGTAAGACCATTACCCTGAC
GCTGCGCCCGGCCGAGGCCGGAACCGGCATCGTCTTCCACAGGGTTGACCTCGCCCCCGCCGTCTCGATCGAGGCGCACG
CCTCCAACGTCGTCAACACCAGGCTCTCCACCACCATCGGCCGCGGCGACGCGAGCGTTTCGACCATAGAACACCTGATG
GCAGCCCTCTACGGCTGCGGCATCGACAACGCCCACGTCGACATTGACGGCCCGGAAGTCCCGATCATGGACGGCTCCGC
CGCCCCCTTTGTGGCCGCGATCACCAAGGCCGGGGTTAAGGTTTCCGGCAAGGCGCGCAAGTACCTCGTGGTTAAGAAAC
CGGTGACCGTCGTGGACGGGGACAAGAAAGCGACCATCATACCCTCGCGCCACTACAAGATCTCCTTCGACATGCAGTTC
GCCCACCCGGCGGTAAAGAGCCAGTTCCGCTCCCTGGAATTCAGCCAGGAAAGCTTCATCGGCGACTTCGCGGCGGCCAG
AACCTTCGGCTTTCTGGCCGAGGTGGAGATGATGAAGTCCCACGGCCTGGCGCTGGGGGGGTCCTTGGAGAACGCCGTGG
TAATCGGCGATAACGGCGTCATCAACCCGGAAGGGCTCAGGTTCCAGGACGAGTTCGTGCGCCACAAGATCCTCGACTCC
GTAGGCGACCTCTCCCTCACCGGCCACCGCCTCATCGGCCACGTGAAGGCGACCAAGTCGGGGCACGACCTGAACCACAA
GCTGGTCACCGAGCTTTTGAAGCGCCCGGACTGCTACACGCTGATCGAGTTCACCCCCCAGGCCTTCAACGCTCCGTTCA
ACATCGGCATACCGGAACTCTCCTGGCTGGAGGCTTAG

Upstream 100 bases:

>100_bases
CCGCCGGAATGTCTATACTTTTAACCCTCACGAGCAAGACCGACGCTTTGGCGCGCTCCTTGCTTGATAGTCCGCATACT
GATTATCAGGGAGCACGCAG

Downstream 100 bases:

>100_bases
AGGCAGATAGAGATAAAGATTAAGATTGAGACTAAGACAAAGATTAAGCGAATCGGAGCAGCCACCAGACAGGGGCTGCT
CTTTTCGTTTACAGCTCCTT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MIFQQTLGNKATFSGIGLHTGKTITLTLRPAEAGTGIVFHRVDLAPAVSIEAHASNVVNTRLSTTIGRGDASVSTIEHLM
AALYGCGIDNAHVDIDGPEVPIMDGSAAPFVAAITKAGVKVSGKARKYLVVKKPVTVVDGDKKATIIPSRHYKISFDMQF
AHPAVKSQFRSLEFSQESFIGDFAAARTFGFLAEVEMMKSHGLALGGSLENAVVIGDNGVINPEGLRFQDEFVRHKILDS
VGDLSLTGHRLIGHVKATKSGHDLNHKLVTELLKRPDCYTLIEFTPQAFNAPFNIGIPELSWLEA

Sequences:

>Translated_305_residues
MIFQQTLGNKATFSGIGLHTGKTITLTLRPAEAGTGIVFHRVDLAPAVSIEAHASNVVNTRLSTTIGRGDASVSTIEHLM
AALYGCGIDNAHVDIDGPEVPIMDGSAAPFVAAITKAGVKVSGKARKYLVVKKPVTVVDGDKKATIIPSRHYKISFDMQF
AHPAVKSQFRSLEFSQESFIGDFAAARTFGFLAEVEMMKSHGLALGGSLENAVVIGDNGVINPEGLRFQDEFVRHKILDS
VGDLSLTGHRLIGHVKATKSGHDLNHKLVTELLKRPDCYTLIEFTPQAFNAPFNIGIPELSWLEA
>Mature_305_residues
MIFQQTLGNKATFSGIGLHTGKTITLTLRPAEAGTGIVFHRVDLAPAVSIEAHASNVVNTRLSTTIGRGDASVSTIEHLM
AALYGCGIDNAHVDIDGPEVPIMDGSAAPFVAAITKAGVKVSGKARKYLVVKKPVTVVDGDKKATIIPSRHYKISFDMQF
AHPAVKSQFRSLEFSQESFIGDFAAARTFGFLAEVEMMKSHGLALGGSLENAVVIGDNGVINPEGLRFQDEFVRHKILDS
VGDLSLTGHRLIGHVKATKSGHDLNHKLVTELLKRPDCYTLIEFTPQAFNAPFNIGIPELSWLEA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=300, Percent_Identity=46, Blast_Score=275, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_GEOBB (B5EFL8)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002137718.1
- ProteinModelPortal:   B5EFL8
- SMR:   B5EFL8
- GeneID:   6783738
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_0901
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- ProtClustDB:   PRK13186
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 32799; Mature: 32799

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFQQTLGNKATFSGIGLHTGKTITLTLRPAEAGTGIVFHRVDLAPAVSIEAHASNVVNT
CCCHHHCCCCCEECEEEEECCCEEEEEEEECCCCCEEEEEEECCCCCEEEEHHHHHHHHH
RLSTTIGRGDASVSTIEHLMAALYGCGIDNAHVDIDGPEVPIMDGSAAPFVAAITKAGVK
HHHHEECCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEECCCCCCHHHHHHHCCEE
VSGKARKYLVVKKPVTVVDGDKKATIIPSRHYKISFDMQFAHPAVKSQFRSLEFSQESFI
EECCCEEEEEEECCEEEEECCCCEEEECCCCEEEEEEEEECCHHHHHHHHHCCCCHHHHH
GDFAAARTFGFLAEVEMMKSHGLALGGSLENAVVIGDNGVINPEGLRFQDEFVRHKILDS
HHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEECCCCEECCCCCCHHHHHHHHHHHHH
VGDLSLTGHRLIGHVKATKSGHDLNHKLVTELLKRPDCYTLIEFTPQAFNAPFNIGIPEL
HCCCEECCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECHHHHCCCCCCCCCCC
SWLEA
HHCCC
>Mature Secondary Structure
MIFQQTLGNKATFSGIGLHTGKTITLTLRPAEAGTGIVFHRVDLAPAVSIEAHASNVVNT
CCCHHHCCCCCEECEEEEECCCEEEEEEEECCCCCEEEEEEECCCCCEEEEHHHHHHHHH
RLSTTIGRGDASVSTIEHLMAALYGCGIDNAHVDIDGPEVPIMDGSAAPFVAAITKAGVK
HHHHEECCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEECCCCCCHHHHHHHCCEE
VSGKARKYLVVKKPVTVVDGDKKATIIPSRHYKISFDMQFAHPAVKSQFRSLEFSQESFI
EECCCEEEEEEECCEEEEECCCCEEEECCCCEEEEEEEEECCHHHHHHHHHCCCCHHHHH
GDFAAARTFGFLAEVEMMKSHGLALGGSLENAVVIGDNGVINPEGLRFQDEFVRHKILDS
HHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEECCCCEECCCCCCHHHHHHHHHHHHH
VGDLSLTGHRLIGHVKATKSGHDLNHKLVTELLKRPDCYTLIEFTPQAFNAPFNIGIPEL
HCCCEECCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECHHHHCCCCCCCCCCC
SWLEA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA