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The map label for this gene is ubiB [H]

Identifier: 197117292

GI number: 197117292

Start: 1060600

End: 1062282

Strand: Reverse

Name: ubiB [H]

Synonym: Gbem_0902

Alternate gene names: 197117292

Gene position: 1062282-1060600 (Counterclockwise)

Preceding gene: 197117293

Following gene: 197117291

Centisome position: 23.02

GC content: 63.64

Gene sequence:

>1683_bases
GTGTATAGAATCCTGAACATCAACCGTAACGTCCGGAGCATCCGGCGTTACCGGCAAATCATCACCGTGATGGGCGGGTA
TGGCCTCGGTCAGTTGCTGGAGTACCTGAACCTGGGGCACGTCGTGGCCCTGTCGCGCCGTATGCTGCGCCGCCCCAACA
AGGCGGCTAACCTCTCGGCACCCGAGCGCCTGCGCCTAGCCCTGGAAGAACTCGGGCCGACCTTCATCAAACTGGGGCAG
CTCCTCTCCACCCGCGCCGACATCATACCCCCCGCATTCGTGCAGGAACTGGCGCGCCTGCAGGACGAGATACCCTGCAT
CGACTTCGAGGAGATAAAGGTACAGATCGAGCACGAACTGGGGGTCCCGCTGGAAAGCCGGTTTCTCCACGTGGATCAGG
TGGCGATCGCCGGGGCGTCGATTGCGCAGGTGCACCGGGCCACGCTGATCACCGGCGAGGACGTGGTGGTGAAGGTGCGC
CGTCCGGGCGTGATTGAGGCGGTCGAGACCGACATCGACATCCTGATGGGAGTGGCGCTGCTTTTGGAGCGCCACATGGC
CAGAAGCGACATCTACGACCCGGTTGGGGTGGTGCGGGAATTCTCCTACACCATCCGGCGGGAGATGGACCTCTCCCGCG
AGGGGCACGCCATCGAGCGCATCCGCGACAACTTCAAGGGGGGGCCCGACCTTTATTTCCCGCAGGTCTACTGGGAGGCG
ACCGCCAAGGGTGTGCTCACCACCGAGTACGTGGACGGCATCAAGGTGAGCGACATCTGCGCCATCGAGAAGGCGGGGCT
GGACCGGCGCGAGATTGCGCGGCGCGGCGCGACGGCGTTTCTGAAGATGGTATTGGAGCACGGTTTCTTCCATGGCGACC
CACACCCGGGCAATGTGATGATCCTCCCCAACAACGTGATCTGCCTGCTCGACTACGGCATGGTGGGAAGACTCGACCCC
GCGGTGAAGCGCTACCTGACCGACGTCCTCGGCGCGGTGATACACCGGGACGTCGAAGGGCTCGCCTATATCGTGGCGGA
GGCCGGCGACGCGGGCGAGAACGTCAACATGCACGCGCTCAAAAAGGGGCTCGCCGAGTTCATCGACAGCTACTTCGAGA
TCCCGCTCAAGGAGATCGTGGTGGGGCGCATGCTCCTGGAGTTCATCGACCTGATCTCCACGCATCGCATCAAGGTGCAC
CCGGACCTCACCATGCTGGTCAAGGTGCTGGTAGTGGTGGAGGGGATGGGGAGAAAGCTCGATCCCGATTTCGACATGGT
CGGGCACCTGCGGCCGTTCCTGGAGAGGGAGTACAGGGAGCAGCGCTCCCCTGGGCGACTGCTGCGCGAGATGGAACAGG
GGCTGGAGGGATACCTGACCCTGGCGCGCAACCTGCCGCGGGAGCTGAAGGAGATCCTGAACAAGATCAACCGGAACAAG
TTCCGCATCGACCTGGAACACCGGGGGCTGGACCGCTTCAGCCGTGAGCTCGACCGCTCCGCGAACCGGGTCTGCCTGAG
CCTCATCATAGCGGCGCTCCTGATCGGCTCCTCCATCGCCATGCAGACCAACCACGGCCCGATGCTCTGGGGGCTCCCCG
TATTCGCCTTTTTCGGCTACAGCTGCGCCGGAGTAGTCGGCATCTGGTGGATGATCGCCATCCTCCGCTCCGGCAGACTG
TAG

Upstream 100 bases:

>100_bases
TGGGAATGGTGTCCCGCGAGGAGTACGACCGCCTGGAGCGGCGCGTGCGGGCGCTTGAGGCGCTCCAGGTGCAAAACCTG
AGCGTCGAGGCGGAGGAAGA

Downstream 100 bases:

>100_bases
CAAAAAAGCCACACCCGCCGTTGCTTTTCCACCACACGGGCATTTTCGCCACAGCTCCCGCGAGCCCCCCGTCCCTGCCC
CACACCTCTATACCGCCGGA

Product: ubiquinone biosynthesis protein AarF

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MYRILNINRNVRSIRRYRQIITVMGGYGLGQLLEYLNLGHVVALSRRMLRRPNKAANLSAPERLRLALEELGPTFIKLGQ
LLSTRADIIPPAFVQELARLQDEIPCIDFEEIKVQIEHELGVPLESRFLHVDQVAIAGASIAQVHRATLITGEDVVVKVR
RPGVIEAVETDIDILMGVALLLERHMARSDIYDPVGVVREFSYTIRREMDLSREGHAIERIRDNFKGGPDLYFPQVYWEA
TAKGVLTTEYVDGIKVSDICAIEKAGLDRREIARRGATAFLKMVLEHGFFHGDPHPGNVMILPNNVICLLDYGMVGRLDP
AVKRYLTDVLGAVIHRDVEGLAYIVAEAGDAGENVNMHALKKGLAEFIDSYFEIPLKEIVVGRMLLEFIDLISTHRIKVH
PDLTMLVKVLVVVEGMGRKLDPDFDMVGHLRPFLEREYREQRSPGRLLREMEQGLEGYLTLARNLPRELKEILNKINRNK
FRIDLEHRGLDRFSRELDRSANRVCLSLIIAALLIGSSIAMQTNHGPMLWGLPVFAFFGYSCAGVVGIWWMIAILRSGRL

Sequences:

>Translated_560_residues
MYRILNINRNVRSIRRYRQIITVMGGYGLGQLLEYLNLGHVVALSRRMLRRPNKAANLSAPERLRLALEELGPTFIKLGQ
LLSTRADIIPPAFVQELARLQDEIPCIDFEEIKVQIEHELGVPLESRFLHVDQVAIAGASIAQVHRATLITGEDVVVKVR
RPGVIEAVETDIDILMGVALLLERHMARSDIYDPVGVVREFSYTIRREMDLSREGHAIERIRDNFKGGPDLYFPQVYWEA
TAKGVLTTEYVDGIKVSDICAIEKAGLDRREIARRGATAFLKMVLEHGFFHGDPHPGNVMILPNNVICLLDYGMVGRLDP
AVKRYLTDVLGAVIHRDVEGLAYIVAEAGDAGENVNMHALKKGLAEFIDSYFEIPLKEIVVGRMLLEFIDLISTHRIKVH
PDLTMLVKVLVVVEGMGRKLDPDFDMVGHLRPFLEREYREQRSPGRLLREMEQGLEGYLTLARNLPRELKEILNKINRNK
FRIDLEHRGLDRFSRELDRSANRVCLSLIIAALLIGSSIAMQTNHGPMLWGLPVFAFFGYSCAGVVGIWWMIAILRSGRL
>Mature_560_residues
MYRILNINRNVRSIRRYRQIITVMGGYGLGQLLEYLNLGHVVALSRRMLRRPNKAANLSAPERLRLALEELGPTFIKLGQ
LLSTRADIIPPAFVQELARLQDEIPCIDFEEIKVQIEHELGVPLESRFLHVDQVAIAGASIAQVHRATLITGEDVVVKVR
RPGVIEAVETDIDILMGVALLLERHMARSDIYDPVGVVREFSYTIRREMDLSREGHAIERIRDNFKGGPDLYFPQVYWEA
TAKGVLTTEYVDGIKVSDICAIEKAGLDRREIARRGATAFLKMVLEHGFFHGDPHPGNVMILPNNVICLLDYGMVGRLDP
AVKRYLTDVLGAVIHRDVEGLAYIVAEAGDAGENVNMHALKKGLAEFIDSYFEIPLKEIVVGRMLLEFIDLISTHRIKVH
PDLTMLVKVLVVVEGMGRKLDPDFDMVGHLRPFLEREYREQRSPGRLLREMEQGLEGYLTLARNLPRELKEILNKINRNK
FRIDLEHRGLDRFSRELDRSANRVCLSLIIAALLIGSSIAMQTNHGPMLWGLPVFAFFGYSCAGVVGIWWMIAILRSGRL

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=271, Percent_Identity=29.8892988929889, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI41393593, Length=271, Percent_Identity=32.1033210332103, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI32261307, Length=335, Percent_Identity=26.865671641791, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI217035081, Length=217, Percent_Identity=29.9539170506912, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI34147522, Length=329, Percent_Identity=25.8358662613982, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI27363457, Length=269, Percent_Identity=24.907063197026, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI217416386, Length=228, Percent_Identity=25.8771929824561, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI2367309, Length=545, Percent_Identity=33.7614678899083, Blast_Score=268, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17555620, Length=474, Percent_Identity=25.3164556962025, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17559152, Length=302, Percent_Identity=28.1456953642384, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI32565180, Length=245, Percent_Identity=32.6530612244898, Blast_Score=104, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325148, Length=432, Percent_Identity=22.6851851851852, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323282, Length=361, Percent_Identity=26.5927977839335, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321319, Length=241, Percent_Identity=26.1410788381743, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI22024280, Length=283, Percent_Identity=28.6219081272085, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24662575, Length=272, Percent_Identity=29.4117647058824, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI18859849, Length=245, Percent_Identity=29.7959183673469, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63359; Mature: 63359

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRILNINRNVRSIRRYRQIITVMGGYGLGQLLEYLNLGHVVALSRRMLRRPNKAANLSA
CEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC
PERLRLALEELGPTFIKLGQLLSTRADIIPPAFVQELARLQDEIPCIDFEEIKVQIEHEL
HHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHEEEEHHC
GVPLESRFLHVDQVAIAGASIAQVHRATLITGEDVVVKVRRPGVIEAVETDIDILMGVAL
CCCHHHHHEEHHHHHHCCHHHHHHHHHHEEECCCEEEEECCCCCHHHHHHHHHHHHHHHH
LLERHMARSDIYDPVGVVREFSYTIRREMDLSREGHAIERIRDNFKGGPDLYFPQVYWEA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHH
TAKGVLTTEYVDGIKVSDICAIEKAGLDRREIARRGATAFLKMVLEHGFFHGDPHPGNVM
HHCCCEEHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
ILPNNVICLLDYGMVGRLDPAVKRYLTDVLGAVIHRDVEGLAYIVAEAGDAGENVNMHAL
EECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHH
KKGLAEFIDSYFEIPLKEIVVGRMLLEFIDLISTHRIKVHPDLTMLVKVLVVVEGMGRKL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCCCC
DPDFDMVGHLRPFLEREYREQRSPGRLLREMEQGLEGYLTLARNLPRELKEILNKINRNK
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCE
FRIDLEHRGLDRFSRELDRSANRVCLSLIIAALLIGSSIAMQTNHGPMLWGLPVFAFFGY
EEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCEEHHHHHHHHHHH
SCAGVVGIWWMIAILRSGRL
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYRILNINRNVRSIRRYRQIITVMGGYGLGQLLEYLNLGHVVALSRRMLRRPNKAANLSA
CEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCC
PERLRLALEELGPTFIKLGQLLSTRADIIPPAFVQELARLQDEIPCIDFEEIKVQIEHEL
HHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHEEEEHHC
GVPLESRFLHVDQVAIAGASIAQVHRATLITGEDVVVKVRRPGVIEAVETDIDILMGVAL
CCCHHHHHEEHHHHHHCCHHHHHHHHHHEEECCCEEEEECCCCCHHHHHHHHHHHHHHHH
LLERHMARSDIYDPVGVVREFSYTIRREMDLSREGHAIERIRDNFKGGPDLYFPQVYWEA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHH
TAKGVLTTEYVDGIKVSDICAIEKAGLDRREIARRGATAFLKMVLEHGFFHGDPHPGNVM
HHCCCEEHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
ILPNNVICLLDYGMVGRLDPAVKRYLTDVLGAVIHRDVEGLAYIVAEAGDAGENVNMHAL
EECCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHH
KKGLAEFIDSYFEIPLKEIVVGRMLLEFIDLISTHRIKVHPDLTMLVKVLVVVEGMGRKL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHCCCCC
DPDFDMVGHLRPFLEREYREQRSPGRLLREMEQGLEGYLTLARNLPRELKEILNKINRNK
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCE
FRIDLEHRGLDRFSRELDRSANRVCLSLIIAALLIGSSIAMQTNHGPMLWGLPVFAFFGY
EEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCEEHHHHHHHHHHH
SCAGVVGIWWMIAILRSGRL
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]