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The map label for this gene is eriC [C]

Identifier: 197116692

GI number: 197116692

Start: 356920

End: 358287

Strand: Reverse

Name: eriC [C]

Synonym: Gbem_0292

Alternate gene names: 197116692

Gene position: 358287-356920 (Counterclockwise)

Preceding gene: 197116693

Following gene: 197116691

Centisome position: 7.76

GC content: 63.6

Gene sequence:

>1368_bases
ATGCGCAAAAACCTCATGGTGCAACTGACCCTTTTGGCCAGTGTCCTCAAATGGGCCTCCTACGCCACGGCGGTGGGGGT
TCTGGTGGGATGCGGCACCGCGGCCTTCCTCCGCTCCCTGGCCTGGACCTCCGACCAATACGCCCGTTTCCCTGACTATT
ACCTGCTGCTCCCCGTCACGCTGGTCGCCAGCACGCTCCTGGTGCGGTGGTTGGCGCCGGAAGCGACCGGCCACGGGACG
GAAAAGGTGATCGAGGCGGTGCACCAGCGGATGGGGAGAATCCCGCTCATGGTGGTGCCGGTGAAGCTCGCGGCCACGGT
AATCACCCTGGCAGGGGGAGGCTCCGCCGGCAAGGAGGGTCCCTGCGCACAGATAGGCGCCGGCCTTGCCTCGGGCTTCG
CCTCGCTGCTCAGGCTCAACGACGTCGACCGGCGCAAGATAGTCATCTGCGGCATCAGCGCCGGATTCGCCACCGTCTTC
GGGACCCCGATAGCCGGGGCGCTTTTCGGCGTCGAGGTCCTGGTGCTGGGTCAGGTCTTCTACGACGTGCTCTTCCCCTC
CTTCGTGGCGGGGATCGTCGGCTTCCACGTGGCTACGCTTCTGGGGGTCACCTATCCGCATCTGGCAGTGACCATCTTCC
CGAAGGTCACCGGCTGGAACTTCGCCGAGATGCTCATGCTGGGGATCTGGTGCGGCCTCATCGCGCTCATTTTCATCGAG
ATCATGCAGTGGGGGCACCGCCTGTTCGCTCGCCTTTCCTGGCACCCGGTGGCGAAGGCGCTATTTGGGGGGGGCCTGCT
GGTACTGGTGGGAAGGTTCGTGTCGCTGCGCTACCTGGGGCTTGGCGTCGATTCCATAGAGGCTGGGCTAAACGGCGCGG
TGCTCCCGATGGGCTCTACCTTCATGAAGATGTTAACTACTTCGATAACGCTCGCCTGCGGCGGGAGCGGCGGCGTGGTC
ACCCCTATCTTCTTCATAGGTACCGCGGCGGGGAACCTCTTCGCGGTGCTGCTGCACGAGCCGCTGGTGGCGACGTTTTC
GGCCATTGGGATGGCGGCGCTCCTTGCCGGGGCTGCAAACACGCCGATCGCCGCCTCAGTCATGGCCATGGAACTCTTCG
GGGCCGCCATCGCCCCACACGCCGCCATCGCCTGCATGGTCAGCTTCCTCATTGTCGGATACCGCAGCATCTATCCAAGC
CAGATCCTGGGGATCGAGAAGAGCGGCTCGCTGAAGGTGGAAACAGGCAAGCCGATGTCCCAGTTCGACCCCGAAAAGCT
GGAAAGCGCTGCGGTCTCGCTCCCTGGCTTCATTCTGAAGGGAGTAAAGGTGATCCGCCGCCGCAGCTTCGAGAAAAAAA
GAAAGTAA

Upstream 100 bases:

>100_bases
AATGTCGCAGCCGAAAAGCCCCCCCTCCCTGGCGGGAGGGGGGTGATCGATAGCACTGGTCCGCCCCCAATTTTTCACAG
GCGGCAGCCAAGGAACTGCA

Downstream 100 bases:

>100_bases
AGCCCCAACTACTACCCGCCCCCCCCAGGAACTTCCCCCGGCATCTGTGACCGCCAGTTTCCCCCTGATCCTCATGGGAC
GCTGGCTGTTTCTTCCTCAT

Product: voltage-gated chloride channel

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MRKNLMVQLTLLASVLKWASYATAVGVLVGCGTAAFLRSLAWTSDQYARFPDYYLLLPVTLVASTLLVRWLAPEATGHGT
EKVIEAVHQRMGRIPLMVVPVKLAATVITLAGGGSAGKEGPCAQIGAGLASGFASLLRLNDVDRRKIVICGISAGFATVF
GTPIAGALFGVEVLVLGQVFYDVLFPSFVAGIVGFHVATLLGVTYPHLAVTIFPKVTGWNFAEMLMLGIWCGLIALIFIE
IMQWGHRLFARLSWHPVAKALFGGGLLVLVGRFVSLRYLGLGVDSIEAGLNGAVLPMGSTFMKMLTTSITLACGGSGGVV
TPIFFIGTAAGNLFAVLLHEPLVATFSAIGMAALLAGAANTPIAASVMAMELFGAAIAPHAAIACMVSFLIVGYRSIYPS
QILGIEKSGSLKVETGKPMSQFDPEKLESAAVSLPGFILKGVKVIRRRSFEKKRK

Sequences:

>Translated_455_residues
MRKNLMVQLTLLASVLKWASYATAVGVLVGCGTAAFLRSLAWTSDQYARFPDYYLLLPVTLVASTLLVRWLAPEATGHGT
EKVIEAVHQRMGRIPLMVVPVKLAATVITLAGGGSAGKEGPCAQIGAGLASGFASLLRLNDVDRRKIVICGISAGFATVF
GTPIAGALFGVEVLVLGQVFYDVLFPSFVAGIVGFHVATLLGVTYPHLAVTIFPKVTGWNFAEMLMLGIWCGLIALIFIE
IMQWGHRLFARLSWHPVAKALFGGGLLVLVGRFVSLRYLGLGVDSIEAGLNGAVLPMGSTFMKMLTTSITLACGGSGGVV
TPIFFIGTAAGNLFAVLLHEPLVATFSAIGMAALLAGAANTPIAASVMAMELFGAAIAPHAAIACMVSFLIVGYRSIYPS
QILGIEKSGSLKVETGKPMSQFDPEKLESAAVSLPGFILKGVKVIRRRSFEKKRK
>Mature_455_residues
MRKNLMVQLTLLASVLKWASYATAVGVLVGCGTAAFLRSLAWTSDQYARFPDYYLLLPVTLVASTLLVRWLAPEATGHGT
EKVIEAVHQRMGRIPLMVVPVKLAATVITLAGGGSAGKEGPCAQIGAGLASGFASLLRLNDVDRRKIVICGISAGFATVF
GTPIAGALFGVEVLVLGQVFYDVLFPSFVAGIVGFHVATLLGVTYPHLAVTIFPKVTGWNFAEMLMLGIWCGLIALIFIE
IMQWGHRLFARLSWHPVAKALFGGGLLVLVGRFVSLRYLGLGVDSIEAGLNGAVLPMGSTFMKMLTTSITLACGGSGGVV
TPIFFIGTAAGNLFAVLLHEPLVATFSAIGMAALLAGAANTPIAASVMAMELFGAAIAPHAAIACMVSFLIVGYRSIYPS
QILGIEKSGSLKVETGKPMSQFDPEKLESAAVSLPGFILKGVKVIRRRSFEKKRK

Specific function: Selective chloride channel [C]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=385, Percent_Identity=29.6103896103896, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081943, Length=337, Percent_Identity=27.893175074184, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 48002; Mature: 48002

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKNLMVQLTLLASVLKWASYATAVGVLVGCGTAAFLRSLAWTSDQYARFPDYYLLLPVT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHCCCCHHHHHHHH
LVASTLLVRWLAPEATGHGTEKVIEAVHQRMGRIPLMVVPVKLAATVITLAGGGSAGKEG
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHEEECCCCCCCCC
PCAQIGAGLASGFASLLRLNDVDRRKIVICGISAGFATVFGTPIAGALFGVEVLVLGQVF
CHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHH
YDVLFPSFVAGIVGFHVATLLGVTYPHLAVTIFPKVTGWNFAEMLMLGIWCGLIALIFIE
HHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
IMQWGHRLFARLSWHPVAKALFGGGLLVLVGRFVSLRYLGLGVDSIEAGLNGAVLPMGST
HHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEECCCHH
FMKMLTTSITLACGGSGGVVTPIFFIGTAAGNLFAVLLHEPLVATFSAIGMAALLAGAAN
HHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TPIAASVMAMELFGAAIAPHAAIACMVSFLIVGYRSIYPSQILGIEKSGSLKVETGKPMS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEEECCCCCC
QFDPEKLESAAVSLPGFILKGVKVIRRRSFEKKRK
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKNLMVQLTLLASVLKWASYATAVGVLVGCGTAAFLRSLAWTSDQYARFPDYYLLLPVT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHCCCCHHHHHHHH
LVASTLLVRWLAPEATGHGTEKVIEAVHQRMGRIPLMVVPVKLAATVITLAGGGSAGKEG
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEHHHHHHHHHEEECCCCCCCCC
PCAQIGAGLASGFASLLRLNDVDRRKIVICGISAGFATVFGTPIAGALFGVEVLVLGQVF
CHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHH
YDVLFPSFVAGIVGFHVATLLGVTYPHLAVTIFPKVTGWNFAEMLMLGIWCGLIALIFIE
HHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
IMQWGHRLFARLSWHPVAKALFGGGLLVLVGRFVSLRYLGLGVDSIEAGLNGAVLPMGST
HHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEECCCHH
FMKMLTTSITLACGGSGGVVTPIFFIGTAAGNLFAVLLHEPLVATFSAIGMAALLAGAAN
HHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TPIAASVMAMELFGAAIAPHAAIACMVSFLIVGYRSIYPSQILGIEKSGSLKVETGKPMS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCEEEECCCCCC
QFDPEKLESAAVSLPGFILKGVKVIRRRSFEKKRK
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]