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The map label for this gene is yxnA [H]

Identifier: 197116691

GI number: 197116691

Start: 355610

End: 356614

Strand: Reverse

Name: yxnA [H]

Synonym: Gbem_0291

Alternate gene names: 197116691

Gene position: 356614-355610 (Counterclockwise)

Preceding gene: 197116692

Following gene: 197116690

Centisome position: 7.73

GC content: 67.36

Gene sequence:

>1005_bases
ATGACGGACTCGAAGACGAGAAACGTGGTGATTACCGGGGCGTCCGCGGGACTCGGGCGCGCCATCGCCCATGCCTTCGC
CAGCGAGGATGCCTGCATCGGGCTCATCGCCAGGAACCGGGAGCGGCTGGAGGCGGCCCGCGCCGAGGTCGAAAGGCTGG
GGGGGAAAGGGGTCGTACTGGTAGCGGACGTCGCCGACCCGCAGCAGGTGGAGCAGGCGGCGGCGCAGATGGAGCAGGAA
TTCGGCCCCATCGACGTCTGGGTCAACAACGCCATGACCTCGGTCTTCTCCCCCTTCGACCAGATGACGCCCGAGGAATT
CCGGCGGGTGACCGAGGTGACCTACCTGGGGGCGGTGCACGGAACCATGTCGGCGTTGAAGCGCATGCTGCCGCGGGACC
GGGGGATGGTGATCCAGGTGGGATCCGCGCTTTCGGAGCGGAGCATCCCGCTGCAGTCCGCCTACTGCGGCGCGAAGCAC
GGCATGCGCGGCTTCACCGACTCGATCCGCTGCGAGCTGATCCACAGCAAAAGCCGGGTGCACCTGACCATGGTGCAGCT
TCCCGCCATGAACACCCCGCAGTTCGCCTGGGTCAAGTCGAGGCTCCCCAACAAGCCGCAGCCGGTCCCCCCGATCTTCC
AGCCGGAGGTAGCCGCCGACGCCATCCTCTGGGCCTCGCACCACCGCCGCCGCGAGATCTACGTCGGTATGCCGACGGTG
AAGGCGATGTGGGGGAACAAGCTGGTGGCAGGCTTCGCCGACTTGTACCTCGGGAGAACCGGCTACCGCTCACAACAAAC
CGGTGAACCGGAAGACCCAAACCGCCCCTCCAACCTCTGGGAGAGCGTACCCGGCCCCTTCGGCGCGCACGGTAGCTTCG
ATGATCGGGCGAAGGGAAGTTCGCCCCAGGTCTGGCTGGTGCAGAACAGATGGGCGCTTTGTGCGATAGCGGCGGGGCTT
GCCGCCGGGGCGGCGCTAGGCGCGAAAGCCAGGCGCAACCGCTAG

Upstream 100 bases:

>100_bases
TATCTGTCGTTCCCGGGACGGCAGAGACTGCCGCTGTCGTGCTGTCGCGCCCCAAAGCGGCACCCTGTCGGGATCCTAAG
AGACGGAAACGGAGGTAGCT

Downstream 100 bases:

>100_bases
GTGGCAGGTGACGGCGCAAATGGTGCGCCGCGGCATGGGAGGCAGAGGCCATGTACAAAAAGATCAGCGACTACGGGATC
ATCGGCAACATGCACTCGGT

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTDSKTRNVVITGASAGLGRAIAHAFASEDACIGLIARNRERLEAARAEVERLGGKGVVLVADVADPQQVEQAAAQMEQE
FGPIDVWVNNAMTSVFSPFDQMTPEEFRRVTEVTYLGAVHGTMSALKRMLPRDRGMVIQVGSALSERSIPLQSAYCGAKH
GMRGFTDSIRCELIHSKSRVHLTMVQLPAMNTPQFAWVKSRLPNKPQPVPPIFQPEVAADAILWASHHRRREIYVGMPTV
KAMWGNKLVAGFADLYLGRTGYRSQQTGEPEDPNRPSNLWESVPGPFGAHGSFDDRAKGSSPQVWLVQNRWALCAIAAGL
AAGAALGAKARRNR

Sequences:

>Translated_334_residues
MTDSKTRNVVITGASAGLGRAIAHAFASEDACIGLIARNRERLEAARAEVERLGGKGVVLVADVADPQQVEQAAAQMEQE
FGPIDVWVNNAMTSVFSPFDQMTPEEFRRVTEVTYLGAVHGTMSALKRMLPRDRGMVIQVGSALSERSIPLQSAYCGAKH
GMRGFTDSIRCELIHSKSRVHLTMVQLPAMNTPQFAWVKSRLPNKPQPVPPIFQPEVAADAILWASHHRRREIYVGMPTV
KAMWGNKLVAGFADLYLGRTGYRSQQTGEPEDPNRPSNLWESVPGPFGAHGSFDDRAKGSSPQVWLVQNRWALCAIAAGL
AAGAALGAKARRNR
>Mature_333_residues
TDSKTRNVVITGASAGLGRAIAHAFASEDACIGLIARNRERLEAARAEVERLGGKGVVLVADVADPQQVEQAAAQMEQEF
GPIDVWVNNAMTSVFSPFDQMTPEEFRRVTEVTYLGAVHGTMSALKRMLPRDRGMVIQVGSALSERSIPLQSAYCGAKHG
MRGFTDSIRCELIHSKSRVHLTMVQLPAMNTPQFAWVKSRLPNKPQPVPPIFQPEVAADAILWASHHRRREIYVGMPTVK
AMWGNKLVAGFADLYLGRTGYRSQQTGEPEDPNRPSNLWESVPGPFGAHGSFDDRAKGSSPQVWLVQNRWALCAIAAGLA
AGAALGAKARRNR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4503817, Length=228, Percent_Identity=29.8245614035088, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI7706318, Length=169, Percent_Identity=35.5029585798817, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI20149619, Length=171, Percent_Identity=33.9181286549708, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI210032110, Length=165, Percent_Identity=29.6969696969697, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI157739938, Length=247, Percent_Identity=25.1012145748988, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI142976729, Length=227, Percent_Identity=25.5506607929515, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI32455239, Length=187, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI5031765, Length=187, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI4504505, Length=253, Percent_Identity=28.8537549407115, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI40254992, Length=173, Percent_Identity=27.7456647398844, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI7705925, Length=227, Percent_Identity=26.431718061674, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI224922801, Length=173, Percent_Identity=28.3236994219653, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI31542939, Length=179, Percent_Identity=26.8156424581006, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI40807363, Length=229, Percent_Identity=24.0174672489083, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI40548397, Length=174, Percent_Identity=29.3103448275862, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI214010158, Length=174, Percent_Identity=29.3103448275862, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI214010156, Length=174, Percent_Identity=29.3103448275862, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI22758144, Length=174, Percent_Identity=29.3103448275862, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=164, Percent_Identity=29.8780487804878, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1788459, Length=206, Percent_Identity=27.1844660194175, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787820, Length=223, Percent_Identity=25.1121076233184, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790717, Length=178, Percent_Identity=28.0898876404494, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082100, Length=176, Percent_Identity=28.9772727272727, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786701, Length=177, Percent_Identity=25.9887005649718, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=223, Percent_Identity=27.3542600896861, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI193203117, Length=219, Percent_Identity=27.3972602739726, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17564282, Length=227, Percent_Identity=27.7533039647577, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71997402, Length=194, Percent_Identity=28.8659793814433, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17567345, Length=168, Percent_Identity=27.3809523809524, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=269, Percent_Identity=26.7657992565056, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=263, Percent_Identity=27.3764258555133, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17570069, Length=194, Percent_Identity=27.8350515463918, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=194, Percent_Identity=26.2886597938144, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32563809, Length=200, Percent_Identity=27, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17507613, Length=200, Percent_Identity=27, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=238, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24644339, Length=174, Percent_Identity=31.6091954022989, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21358495, Length=176, Percent_Identity=28.9772727272727, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24581726, Length=227, Percent_Identity=26.8722466960352, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21356301, Length=228, Percent_Identity=27.1929824561404, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24640492, Length=234, Percent_Identity=25.6410256410256, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI23397609, Length=174, Percent_Identity=32.183908045977, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21355631, Length=175, Percent_Identity=25.7142857142857, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24643142, Length=184, Percent_Identity=28.2608695652174, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641232, Length=197, Percent_Identity=27.9187817258883, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI116007236, Length=225, Percent_Identity=24.8888888888889, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI28571526, Length=182, Percent_Identity=27.4725274725275, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 36437; Mature: 36306

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSKTRNVVITGASAGLGRAIAHAFASEDACIGLIARNRERLEAARAEVERLGGKGVVL
CCCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEHHHCCHHHHHHHHHHHHHCCCCCEEE
VADVADPQQVEQAAAQMEQEFGPIDVWVNNAMTSVFSPFDQMTPEEFRRVTEVTYLGAVH
EEECCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHH
GTMSALKRMLPRDRGMVIQVGSALSERSIPLQSAYCGAKHGMRGFTDSIRCELIHSKSRV
HHHHHHHHHCCCCCCEEEEECCHHHHCCCCHHHHHHCHHCCCCCCCHHHEEEEEECCCCE
HLTMVQLPAMNTPQFAWVKSRLPNKPQPVPPIFQPEVAADAILWASHHRRREIYVGMPTV
EEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCHH
KAMWGNKLVAGFADLYLGRTGYRSQQTGEPEDPNRPSNLWESVPGPFGAHGSFDDRAKGS
HHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCC
SPQVWLVQNRWALCAIAAGLAAGAALGAKARRNR
CCCEEEEECCHHHHHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
TDSKTRNVVITGASAGLGRAIAHAFASEDACIGLIARNRERLEAARAEVERLGGKGVVL
CCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEHHHCCHHHHHHHHHHHHHCCCCCEEE
VADVADPQQVEQAAAQMEQEFGPIDVWVNNAMTSVFSPFDQMTPEEFRRVTEVTYLGAVH
EEECCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHH
GTMSALKRMLPRDRGMVIQVGSALSERSIPLQSAYCGAKHGMRGFTDSIRCELIHSKSRV
HHHHHHHHHCCCCCCEEEEECCHHHHCCCCHHHHHHCHHCCCCCCCHHHEEEEEECCCCE
HLTMVQLPAMNTPQFAWVKSRLPNKPQPVPPIFQPEVAADAILWASHHRRREIYVGMPTV
EEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCHH
KAMWGNKLVAGFADLYLGRTGYRSQQTGEPEDPNRPSNLWESVPGPFGAHGSFDDRAKGS
HHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCC
SPQVWLVQNRWALCAIAAGLAAGAALGAKARRNR
CCCEEEEECCHHHHHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]