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The map label for this gene is czcR [H]

Identifier: 197116643

GI number: 197116643

Start: 286662

End: 287336

Strand: Direct

Name: czcR [H]

Synonym: Gbem_0243

Alternate gene names: 197116643

Gene position: 286662-287336 (Clockwise)

Preceding gene: 197116642

Following gene: 197116644

Centisome position: 6.21

GC content: 57.33

Gene sequence:

>675_bases
ATGAGAATTTTGGTAGTTGAAGATGAGAAGAAGGTCGCCAGCTTCATCAAGCGCGGGCTGGAGGAGGAGCAGTACGAAGT
CCATACGGCCGCGGACGGAGAGGAAGGTCTCAAGCTTGCGCTCGAGAAGCCGTTCGACCTGATCGTGCTTGACTGGATGC
TCCCCAAAAAGGACGGCCTTTCCGTCCTGAAGGAGCTGAGGGAGCGGAAGAACCTCACTCCGATCCTGATGCTGACCGCC
AAAGATTCCGTGGAAGATATCGTGGCAGGCCTCGATTCCGGATCCGACGACTACCTGACCAAGCCGTTCGCTTTCGCCGA
GCTTCTGGCCCGCGTCCGTGCGCTCATGAGGAGGAGCGAGCTCGACCGCGGTGCCGAGATCCGTTTCGCCGACCTGCGCC
TCGACCTGGTTACCCACAAGGTATGGCGCAAGGATAAGGAGATCGATCTCACTGCCAAGGAGTACGGCCTGCTCGAGTAC
TTCATGCGCAACCCGCACCAGGTGCTGACCAGGACCATGATCGCGGAGCACGTCTGGGATTACACCTTCGACAGCTTCAC
CAACATCATCGATGTCTATGTCAACTACCTCAGGAAGAAGATCGACCGCGAAGCTGACAAGAAGCTGATCCACACCGTCA
GGGGCGTAGGCTACATCCTGAAGGAAGAAGAATAG

Upstream 100 bases:

>100_bases
CAAGTCCGTGGAGGAGTCTGCGGCAGAAATATTAAGCAGGCTTCATGGTGATATTAGGCACGATTAGAGGTCGACATATT
AACAAAGAGAGGAAATCAAC

Downstream 100 bases:

>100_bases
AATAGGCGCGTCACGCTCTTCATGAACAACGGACTGCTCCCGGCTCACGCCGGAGGCGGTCAGTATTAGCTTAACTCTAC
TCAAATTCCCAGGAGGTCGC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MRILVVEDEKKVASFIKRGLEEEQYEVHTAADGEEGLKLALEKPFDLIVLDWMLPKKDGLSVLKELRERKNLTPILMLTA
KDSVEDIVAGLDSGSDDYLTKPFAFAELLARVRALMRRSELDRGAEIRFADLRLDLVTHKVWRKDKEIDLTAKEYGLLEY
FMRNPHQVLTRTMIAEHVWDYTFDSFTNIIDVYVNYLRKKIDREADKKLIHTVRGVGYILKEEE

Sequences:

>Translated_224_residues
MRILVVEDEKKVASFIKRGLEEEQYEVHTAADGEEGLKLALEKPFDLIVLDWMLPKKDGLSVLKELRERKNLTPILMLTA
KDSVEDIVAGLDSGSDDYLTKPFAFAELLARVRALMRRSELDRGAEIRFADLRLDLVTHKVWRKDKEIDLTAKEYGLLEY
FMRNPHQVLTRTMIAEHVWDYTFDSFTNIIDVYVNYLRKKIDREADKKLIHTVRGVGYILKEEE
>Mature_224_residues
MRILVVEDEKKVASFIKRGLEEEQYEVHTAADGEEGLKLALEKPFDLIVLDWMLPKKDGLSVLKELRERKNLTPILMLTA
KDSVEDIVAGLDSGSDDYLTKPFAFAELLARVRALMRRSELDRGAEIRFADLRLDLVTHKVWRKDKEIDLTAKEYGLLEY
FMRNPHQVLTRTMIAEHVWDYTFDSFTNIIDVYVNYLRKKIDREADKKLIHTVRGVGYILKEEE

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=50, Blast_Score=210, Evalue=7e-56,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=44.954128440367, Blast_Score=191, Evalue=4e-50,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=37.219730941704, Blast_Score=153, Evalue=9e-39,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=37.10407239819, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=35.6828193832599, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=37.4449339207048, Blast_Score=143, Evalue=7e-36,
Organism=Escherichia coli, GI1786911, Length=219, Percent_Identity=32.8767123287671, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=34.841628959276, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=34.5291479820628, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=36.8421052631579, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=30.6306306306306, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=32.3008849557522, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=33.6283185840708, Blast_Score=103, Evalue=6e-24,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=27.7056277056277, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1788550, Length=119, Percent_Identity=36.1344537815126, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790437, Length=121, Percent_Identity=34.7107438016529, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790299, Length=136, Percent_Identity=27.2058823529412, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1788191, Length=111, Percent_Identity=31.5315315315315, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=33.6633663366337, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26131; Mature: 26131

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVEDEKKVASFIKRGLEEEQYEVHTAADGEEGLKLALEKPFDLIVLDWMLPKKDGL
CEEEEECCHHHHHHHHHHCCCHHHHEECCCCCCHHHHEEHHCCCCCEEEEECCCCCCCCH
SVLKELRERKNLTPILMLTAKDSVEDIVAGLDSGSDDYLTKPFAFAELLARVRALMRRSE
HHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LDRGAEIRFADLRLDLVTHKVWRKDKEIDLTAKEYGLLEYFMRNPHQVLTRTMIAEHVWD
CCCCCCEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
YTFDSFTNIIDVYVNYLRKKIDREADKKLIHTVRGVGYILKEEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
>Mature Secondary Structure
MRILVVEDEKKVASFIKRGLEEEQYEVHTAADGEEGLKLALEKPFDLIVLDWMLPKKDGL
CEEEEECCHHHHHHHHHHCCCHHHHEECCCCCCHHHHEEHHCCCCCEEEEECCCCCCCCH
SVLKELRERKNLTPILMLTAKDSVEDIVAGLDSGSDDYLTKPFAFAELLARVRALMRRSE
HHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LDRGAEIRFADLRLDLVTHKVWRKDKEIDLTAKEYGLLEYFMRNPHQVLTRTMIAEHVWD
CCCCCCEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
YTFDSFTNIIDVYVNYLRKKIDREADKKLIHTVRGVGYILKEEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]