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The map label for this gene is degP [H]

Identifier: 197116644

GI number: 197116644

Start: 287438

End: 288814

Strand: Direct

Name: degP [H]

Synonym: Gbem_0244

Alternate gene names: 197116644

Gene position: 287438-288814 (Clockwise)

Preceding gene: 197116643

Following gene: 197116646

Centisome position: 6.23

GC content: 63.04

Gene sequence:

>1377_bases
ATGCAGGCAGCAATCGTTGCAAGATTTCTGGTACTTAGCGTATTTCTCTCCTCCATTTTCTCGACCGTCGCGGGCGCCTC
GGTGCTTACTCCCGACTTCGCCAAGCTGGCGAAGAAGCTGAAGCCCGCGGTGGTCAACATCAGCACCTCAAAGACCCTAG
CGGTGAAGAAGCGGCAGATCGCCCCAGGGCAAGACCCTTTCCAGGAATACTTCGACAAATTTTTCGAGGGGCCGCACCAG
CGTCCGCAAAAGCAGAGGAACCTGGGGACCGGCTTCATCATCAGCGACGACGGCTACATCATCACCAACAACCACGTGGT
GAAGGATGCCGACGAGATCAAGGTGAAGCTCTCCGACGGCAGGGAGTTCGCGGGCGATGTCAAGGGGCGCGACGAAAAGC
TGGACCTTGCCCTGGTGAAGATCGACGCCAAGGATCACCTCCCCGTGGCGCCTTTGGGGGACAGCGACAAGATGGAAGTG
GGGGACTGGGTGATGGCTATCGGCAACCCCTTCGGGCTCTCCCAGACCGTGACGGCAGGGATCATCAGCGCCCAGGGGCG
CGTGATCGGTTCCGGCCCGTATGACGACTTCATCCAGACCGACGCCTCCATCAACCCCGGCAACTCGGGGGGGCCGCTCT
TCAACACCGAAGGGGAGGTGATCGGCATAAATACGGCGATCGTCGCCGGCGGCCAGGGGATAGGATTCGCCATACCGGTC
AACATGGCGAAGGAGATCCTCCCGCAGCTGAAGTCTGCGGGCAAGGTGACCCGCGGCTGGCTCGGCGTTTCGGTGCAGCT
GGTGACCCCGGATCTCGCCAAATCCTTCGGGCTCGACACCGAGAAGGGGGCGCTGGTTGCCGACGTGGTGAAAGGCAGCC
CCGCGGAGAAGGCGGGCCTCAAGGGGGGCGACATCATCCTCGAGTACGACGGGCATCCCATCAAGGAGATGGGGGAGCTT
CCGCGCCGCGTAGCCGCCACCCCGGTAGGAAAGAAGGTGAAAGTGGTGGTGCTGCGCGAGGGGCGTCAAGAGCCGCTGCA
GGTGACCGTCGAGCAGCTGAAGGAGGGCGGCGAGGAGGATAGTGCGGTCACCAGCGACCGGCTCGGGGTGAAGGTGACGG
AGCTTACCCCGGAGCGCGCGCAGCAGTTGCGGCTGCAGGGGGACAAAGGGGTCGTGGTGACCGATGTGGAGCCGGACAGC
CTTGCCGACCGGGCCGGCATCCTGGAGGGGGACCTGATCAGGGAGATCAACGGAGTGCGTGTAAGCGGCGTGAGCGATTA
CAGCAAGTTGATCGCGGCGGCGAAGAAGGGTGGGTATCTGAAGATGCTGCTTAGGCGGGGAGAAGCCTCCCTGTTCGTCG
CGCTCAGGCTGGAATAG

Upstream 100 bases:

>100_bases
ATAGGCGCGTCACGCTCTTCATGAACAACGGACTGCTCCCGGCTCACGCCGGAGGCGGTCAGTATTAGCTTAACTCTACT
CAAATTCCCAGGAGGTCGCC

Downstream 100 bases:

>100_bases
GTAATAAGAAGGTCGTTGCGGTATCGAAGGGGGCACAGGTGACTGGCCCCCTTTTCTATTACCACAACACCTGGCCGCAT
TGCGAGCCGGCCACGGCTCT

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MQAAIVARFLVLSVFLSSIFSTVAGASVLTPDFAKLAKKLKPAVVNISTSKTLAVKKRQIAPGQDPFQEYFDKFFEGPHQ
RPQKQRNLGTGFIISDDGYIITNNHVVKDADEIKVKLSDGREFAGDVKGRDEKLDLALVKIDAKDHLPVAPLGDSDKMEV
GDWVMAIGNPFGLSQTVTAGIISAQGRVIGSGPYDDFIQTDASINPGNSGGPLFNTEGEVIGINTAIVAGGQGIGFAIPV
NMAKEILPQLKSAGKVTRGWLGVSVQLVTPDLAKSFGLDTEKGALVADVVKGSPAEKAGLKGGDIILEYDGHPIKEMGEL
PRRVAATPVGKKVKVVVLREGRQEPLQVTVEQLKEGGEEDSAVTSDRLGVKVTELTPERAQQLRLQGDKGVVVTDVEPDS
LADRAGILEGDLIREINGVRVSGVSDYSKLIAAAKKGGYLKMLLRRGEASLFVALRLE

Sequences:

>Translated_458_residues
MQAAIVARFLVLSVFLSSIFSTVAGASVLTPDFAKLAKKLKPAVVNISTSKTLAVKKRQIAPGQDPFQEYFDKFFEGPHQ
RPQKQRNLGTGFIISDDGYIITNNHVVKDADEIKVKLSDGREFAGDVKGRDEKLDLALVKIDAKDHLPVAPLGDSDKMEV
GDWVMAIGNPFGLSQTVTAGIISAQGRVIGSGPYDDFIQTDASINPGNSGGPLFNTEGEVIGINTAIVAGGQGIGFAIPV
NMAKEILPQLKSAGKVTRGWLGVSVQLVTPDLAKSFGLDTEKGALVADVVKGSPAEKAGLKGGDIILEYDGHPIKEMGEL
PRRVAATPVGKKVKVVVLREGRQEPLQVTVEQLKEGGEEDSAVTSDRLGVKVTELTPERAQQLRLQGDKGVVVTDVEPDS
LADRAGILEGDLIREINGVRVSGVSDYSKLIAAAKKGGYLKMLLRRGEASLFVALRLE
>Mature_458_residues
MQAAIVARFLVLSVFLSSIFSTVAGASVLTPDFAKLAKKLKPAVVNISTSKTLAVKKRQIAPGQDPFQEYFDKFFEGPHQ
RPQKQRNLGTGFIISDDGYIITNNHVVKDADEIKVKLSDGREFAGDVKGRDEKLDLALVKIDAKDHLPVAPLGDSDKMEV
GDWVMAIGNPFGLSQTVTAGIISAQGRVIGSGPYDDFIQTDASINPGNSGGPLFNTEGEVIGINTAIVAGGQGIGFAIPV
NMAKEILPQLKSAGKVTRGWLGVSVQLVTPDLAKSFGLDTEKGALVADVVKGSPAEKAGLKGGDIILEYDGHPIKEMGEL
PRRVAATPVGKKVKVVVLREGRQEPLQVTVEQLKEGGEEDSAVTSDRLGVKVTELTPERAQQLRLQGDKGVVVTDVEPDS
LADRAGILEGDLIREINGVRVSGVSDYSKLIAAAKKGGYLKMLLRRGEASLFVALRLE

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=297, Percent_Identity=37.7104377104377, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI24308541, Length=241, Percent_Identity=40.2489626556017, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI22129776, Length=252, Percent_Identity=40.0793650793651, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI7019477, Length=240, Percent_Identity=38.3333333333333, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1789629, Length=433, Percent_Identity=39.4919168591224, Blast_Score=281, Evalue=8e-77,
Organism=Escherichia coli, GI1786356, Length=451, Percent_Identity=37.4722838137472, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI1789630, Length=311, Percent_Identity=40.8360128617363, Blast_Score=205, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24646839, Length=305, Percent_Identity=35.7377049180328, Blast_Score=161, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 48796; Mature: 48796

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS50106 PDZ ; PS00815 AIPM_HOMOCIT_SYNTH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAAIVARFLVLSVFLSSIFSTVAGASVLTPDFAKLAKKLKPAVVNISTSKTLAVKKRQI
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCCCEEEEEHHCC
APGQDPFQEYFDKFFEGPHQRPQKQRNLGTGFIISDDGYIITNNHVVKDADEIKVKLSDG
CCCCCHHHHHHHHHHCCCCCCCHHHHCCCCEEEECCCCEEEECCEEEECCCCEEEEECCC
REFAGDVKGRDEKLDLALVKIDAKDHLPVAPLGDSDKMEVGDWVMAIGNPFGLSQTVTAG
CCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHH
IISAQGRVIGSGPYDDFIQTDASINPGNSGGPLFNTEGEVIGINTAIVAGGQGIGFAIPV
EEECCCEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCEEEECH
NMAKEILPQLKSAGKVTRGWLGVSVQLVTPDLAKSFGLDTEKGALVADVVKGSPAEKAGL
HHHHHHHHHHHHCCCCEECEEEEEEEEECHHHHHHCCCCCCCCCEEEHHHCCCCCHHCCC
KGGDIILEYDGHPIKEMGELPRRVAATPVGKKVKVVVLREGRQEPLQVTVEQLKEGGEED
CCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCC
SAVTSDRLGVKVTELTPERAQQLRLQGDKGVVVTDVEPDSLADRAGILEGDLIREINGVR
CCCCCCCCCEEEEECCHHHHHHHEECCCCCEEEEECCCHHHHHHCCCCCCHHHHHCCCEE
VSGVSDYSKLIAAAKKGGYLKMLLRRGEASLFVALRLE
EECCHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEEEC
>Mature Secondary Structure
MQAAIVARFLVLSVFLSSIFSTVAGASVLTPDFAKLAKKLKPAVVNISTSKTLAVKKRQI
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCEEEEECCCCEEEEEHHCC
APGQDPFQEYFDKFFEGPHQRPQKQRNLGTGFIISDDGYIITNNHVVKDADEIKVKLSDG
CCCCCHHHHHHHHHHCCCCCCCHHHHCCCCEEEECCCCEEEECCEEEECCCCEEEEECCC
REFAGDVKGRDEKLDLALVKIDAKDHLPVAPLGDSDKMEVGDWVMAIGNPFGLSQTVTAG
CCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHH
IISAQGRVIGSGPYDDFIQTDASINPGNSGGPLFNTEGEVIGINTAIVAGGQGIGFAIPV
EEECCCEEEECCCCHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCEEEECH
NMAKEILPQLKSAGKVTRGWLGVSVQLVTPDLAKSFGLDTEKGALVADVVKGSPAEKAGL
HHHHHHHHHHHHCCCCEECEEEEEEEEECHHHHHHCCCCCCCCCEEEHHHCCCCCHHCCC
KGGDIILEYDGHPIKEMGELPRRVAATPVGKKVKVVVLREGRQEPLQVTVEQLKEGGEED
CCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCC
SAVTSDRLGVKVTELTPERAQQLRLQGDKGVVVTDVEPDSLADRAGILEGDLIREINGVR
CCCCCCCCCEEEEECCHHHHHHHEECCCCCEEEEECCCHHHHHHCCCCCCHHHHHCCCEE
VSGVSDYSKLIAAAKKGGYLKMLLRRGEASLFVALRLE
EECCHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]