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The map label for this gene is rnd [H]

Identifier: 197116637

GI number: 197116637

Start: 281441

End: 282574

Strand: Direct

Name: rnd [H]

Synonym: Gbem_0237

Alternate gene names: 197116637

Gene position: 281441-282574 (Clockwise)

Preceding gene: 197116636

Following gene: 197116638

Centisome position: 6.1

GC content: 61.82

Gene sequence:

>1134_bases
TTGCAGAAGAAAAATAATGTGACAAACCCCGCAGCGGCACATCTGGTCACCGATCAAAAGACTTTAGACGAACTCGTTGA
GCGGCTCTCCCGGGAGTCGGTCCTTGCCTTTGACTTGGAGGCGGACTCACTCCATCACTATACAGAGAAGGTCTGCCTGA
TCCAGGTCTCCTCCACATCGGAAGACCGCCTGATCGACCCGCTCGCCCCCATCGACGTCAAGGTACTGGCGCCCATTTTC
GCCAACCCGGCGATCAAAAAGATCTTCCACGGCGCGGATTACGACATGCGCTCGCTCTACCGGGACTTCGGCATCGAGGT
GGTGAACCTGTTCGACACCATGATCGCCAGCCAGTTCCTGGGAGAGAGCGAGTTCGGCCTGGCGGCGCTTCTGAAGAAGA
GGTTCGGCGTCGAGCTGGACAAGCGCTACCAGAAGGCCGACTGGAGCAAGCGTCCCTTCTCCCAGGAGATGCTGGATTAC
GCCATGAAGGACACTTCCCTCCTGATCGAGCTCTACCGCCAGCTGGAGGCGGAGCTGAAGCAGAAAGGGAGGCTCGCCTG
GGTTGAGGAGGAGTCGGAGTTGGTGGCAGGGGTGCGTTCCCCTTCCCGCGAGGGGGAGCTGATGTGCCTGCGCTTCAAGG
GGGCCAGCAAGATGAAGCCGCGCGAGCTCGCCGTGCTGGAAGAGCTGCTGCGCTTTCGTGACGAGAAGGCACGCCTGGCG
GACGTTCCCCCCTTCAGGATCCTCAGCAACGACCTGTTGCGGGAGCTGGCAGAGAAACAGCCTAGGAACAACTTCGAGCT
GGTCGGCATCCACACCATGTCTTCTAAGCTGATCGAGCGGCTGGGGCGCGGGCTGCTGCAGGCCGTAGCCAACGGGCTGG
CGGTCCCTCAGGACAAGTTGCCGCAAGTGCATTCCGGACGCCGTCCGGTTCTGGACCGGCTGCAGGACGAAAGGGTGAAG
CGCCTCAAGGTCTGGCGCGAGGCGAAGTCGGCGCAGCTGGGTCTCGGTATCGGGCTCGTCGCCAACAACACGCTCCTGGA
GGCGCTGGCGGAGCCGGGCTCCCAGAACATAACTCTCTTGAAGCGTTGGCAGCGCGAGGCATTCGGGGACGAGCTGGCGT
CGCTCATCTCCTGA

Upstream 100 bases:

>100_bases
TTGTAATCTTTGCGGCTGGGCGCTGTCATGGTGACAGTAAGCCTTGACCTCATCGATAACCACGAAAGCATATAATAGAT
GCAGAAACGGATGGGAACTT

Downstream 100 bases:

>100_bases
CGTCGACGCTGGAGAAACGTACCGGGCGGACTCCCATTAAGGGGTCCGCTTTTTTTCGTCTTTAGATTAGAGCGCCTTGT
CGTGGTCGCTACTGTTGTGT

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MQKKNNVTNPAAAHLVTDQKTLDELVERLSRESVLAFDLEADSLHHYTEKVCLIQVSSTSEDRLIDPLAPIDVKVLAPIF
ANPAIKKIFHGADYDMRSLYRDFGIEVVNLFDTMIASQFLGESEFGLAALLKKRFGVELDKRYQKADWSKRPFSQEMLDY
AMKDTSLLIELYRQLEAELKQKGRLAWVEEESELVAGVRSPSREGELMCLRFKGASKMKPRELAVLEELLRFRDEKARLA
DVPPFRILSNDLLRELAEKQPRNNFELVGIHTMSSKLIERLGRGLLQAVANGLAVPQDKLPQVHSGRRPVLDRLQDERVK
RLKVWREAKSAQLGLGIGLVANNTLLEALAEPGSQNITLLKRWQREAFGDELASLIS

Sequences:

>Translated_377_residues
MQKKNNVTNPAAAHLVTDQKTLDELVERLSRESVLAFDLEADSLHHYTEKVCLIQVSSTSEDRLIDPLAPIDVKVLAPIF
ANPAIKKIFHGADYDMRSLYRDFGIEVVNLFDTMIASQFLGESEFGLAALLKKRFGVELDKRYQKADWSKRPFSQEMLDY
AMKDTSLLIELYRQLEAELKQKGRLAWVEEESELVAGVRSPSREGELMCLRFKGASKMKPRELAVLEELLRFRDEKARLA
DVPPFRILSNDLLRELAEKQPRNNFELVGIHTMSSKLIERLGRGLLQAVANGLAVPQDKLPQVHSGRRPVLDRLQDERVK
RLKVWREAKSAQLGLGIGLVANNTLLEALAEPGSQNITLLKRWQREAFGDELASLIS
>Mature_377_residues
MQKKNNVTNPAAAHLVTDQKTLDELVERLSRESVLAFDLEADSLHHYTEKVCLIQVSSTSEDRLIDPLAPIDVKVLAPIF
ANPAIKKIFHGADYDMRSLYRDFGIEVVNLFDTMIASQFLGESEFGLAALLKKRFGVELDKRYQKADWSKRPFSQEMLDY
AMKDTSLLIELYRQLEAELKQKGRLAWVEEESELVAGVRSPSREGELMCLRFKGASKMKPRELAVLEELLRFRDEKARLA
DVPPFRILSNDLLRELAEKQPRNNFELVGIHTMSSKLIERLGRGLLQAVANGLAVPQDKLPQVHSGRRPVLDRLQDERVK
RLKVWREAKSAQLGLGIGLVANNTLLEALAEPGSQNITLLKRWQREAFGDELASLIS

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=262, Percent_Identity=32.824427480916, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI50301240, Length=262, Percent_Identity=32.824427480916, Blast_Score=129, Evalue=3e-30,
Organism=Escherichia coli, GI1788105, Length=290, Percent_Identity=28.2758620689655, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17531757, Length=270, Percent_Identity=36.6666666666667, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32564304, Length=102, Percent_Identity=42.156862745098, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324574, Length=278, Percent_Identity=33.0935251798561, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI161078302, Length=258, Percent_Identity=33.7209302325581, Blast_Score=121, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 42755; Mature: 42755

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKNNVTNPAAAHLVTDQKTLDELVERLSRESVLAFDLEADSLHHYTEKVCLIQVSSTS
CCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCEEEEEECCCC
EDRLIDPLAPIDVKVLAPIFANPAIKKIFHGADYDMRSLYRDFGIEVVNLFDTMIASQFL
CCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHC
GESEFGLAALLKKRFGVELDKRYQKADWSKRPFSQEMLDYAMKDTSLLIELYRQLEAELK
CCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKGRLAWVEEESELVAGVRSPSREGELMCLRFKGASKMKPRELAVLEELLRFRDEKARLA
HCCCEEEEECHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
DVPPFRILSNDLLRELAEKQPRNNFELVGIHTMSSKLIERLGRGLLQAVANGLAVPQDKL
CCCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHC
PQVHSGRRPVLDRLQDERVKRLKVWREAKSAQLGLGIGLVANNTLLEALAEPGSQNITLL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCCCCCHHHH
KRWQREAFGDELASLIS
HHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MQKKNNVTNPAAAHLVTDQKTLDELVERLSRESVLAFDLEADSLHHYTEKVCLIQVSSTS
CCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCEEEEEECCCC
EDRLIDPLAPIDVKVLAPIFANPAIKKIFHGADYDMRSLYRDFGIEVVNLFDTMIASQFL
CCCCCCCCCCCCHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHC
GESEFGLAALLKKRFGVELDKRYQKADWSKRPFSQEMLDYAMKDTSLLIELYRQLEAELK
CCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKGRLAWVEEESELVAGVRSPSREGELMCLRFKGASKMKPRELAVLEELLRFRDEKARLA
HCCCEEEEECHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
DVPPFRILSNDLLRELAEKQPRNNFELVGIHTMSSKLIERLGRGLLQAVANGLAVPQDKL
CCCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHC
PQVHSGRRPVLDRLQDERVKRLKVWREAKSAQLGLGIGLVANNTLLEALAEPGSQNITLL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHCCCCCCHHHH
KRWQREAFGDELASLIS
HHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]