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The map label for this gene is hisC

Identifier: 197116636

GI number: 197116636

Start: 280211

End: 281263

Strand: Direct

Name: hisC

Synonym: Gbem_0236

Alternate gene names: 197116636

Gene position: 280211-281263 (Clockwise)

Preceding gene: 197116635

Following gene: 197116637

Centisome position: 6.07

GC content: 63.06

Gene sequence:

>1053_bases
ATGATCGCCCTGCGGGAAAACATCGCAGAAATGGCAGGCTATGTCCCCGGTTTCCAGCCGCTCGATGTGGATTCGTACAT
CAAGCTGAACACCAACGAGAATCCTTATCCCCCCTCACCGAAGGTGTTGGAGGCGATCGCCAAGGAGGCCGGAGAGGGCC
TGCGCCGGTACCCCGACGCCGCGAGCCGCCTGGCGCGGGAGGAGGCGGCGAAGGTGTACGGCTTCGATCCCTCCTGGATC
ATCATGGCCAACGGCTCGGACGAGGTCCTCAACAACCTGATCCGCGCCTGTGCCGGCGAAGGGGAGGAAATCGCCTTCAT
AAACCCCTCCTACTCGTACTACGGCACCCTCGCGGAAGTTCAGGGCGCGCGCGTCAGGACCTTCGGGCTTTCCGAGAGCT
TTGAGCCGGAAGGGATCCCGGAGCATTACGACGGCAAGCTCTTCTTTCTGACCAACCCCAATGCACCGCTTGGTTTCACC
TACAGCCAGCGCTACATCGCTGACCTGGCGGGGCGCCTCTCCGGGGTGCTGGTGGTGGACGAGGCGTACGTGGATTTCGC
CGAAGAGACTTCGCTGGAACTGGTGCGCAGCTTCGACAACGTCGTGGTGACCCGCACCTTCTCCAAGAGCTATTCCCTGG
CCGGCATGCGGCTTGGTCTCGCGATCGCCCGCCCGGAGATCATCGCGGCGCTGAACAAGATTCGCGACCACTACAACCTG
GACCGCCTGGCGCAGGCCGCTGCCGCCGCGGCGCTCGCGGACCAGCCGTATTTCCAGGAGTGCGTAAGGAAGATCAAGGA
GACCCGCGCCTGGTTCACGGCGGAACTGCAGCAGCTGGGGTATCAGGTGATACCTTCCAGCGGCAATTTCGTCTTTGCCA
GCCCGCCCGACCGAGACGGTACCCGTATCTACCAGGGGCTTTACGACAGGAAGATCCTGGTGCGCCACTTCACCGACCCG
AAGCTGGCCCACGGTCTCAGGATCAGTATCGGCTCCAGGGAGGAGATGGAGCAGACTGTCAAGGCGCTACGCGAACTGGG
TCCCGGGCGGTAG

Upstream 100 bases:

>100_bases
GGCTCTATCGCCTCTTCGTTGTCAATTGTCAATTGTCCATTGTCAATTGCCTTTGCCTCTTGTTATATTCACCTGATCTT
TTGCCCTGAAAGGAGTTGCC

Downstream 100 bases:

>100_bases
CAAAGAGCGTTCTGTCTGTGCAGGGAAGAAAATTTTACTCTGAACGGCACCTTGGACTTGTACTGAAAGTGAAAAGGTTG
TAATCTTTGCGGCTGGGCGC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MIALRENIAEMAGYVPGFQPLDVDSYIKLNTNENPYPPSPKVLEAIAKEAGEGLRRYPDAASRLAREEAAKVYGFDPSWI
IMANGSDEVLNNLIRACAGEGEEIAFINPSYSYYGTLAEVQGARVRTFGLSESFEPEGIPEHYDGKLFFLTNPNAPLGFT
YSQRYIADLAGRLSGVLVVDEAYVDFAEETSLELVRSFDNVVVTRTFSKSYSLAGMRLGLAIARPEIIAALNKIRDHYNL
DRLAQAAAAAALADQPYFQECVRKIKETRAWFTAELQQLGYQVIPSSGNFVFASPPDRDGTRIYQGLYDRKILVRHFTDP
KLAHGLRISIGSREEMEQTVKALRELGPGR

Sequences:

>Translated_350_residues
MIALRENIAEMAGYVPGFQPLDVDSYIKLNTNENPYPPSPKVLEAIAKEAGEGLRRYPDAASRLAREEAAKVYGFDPSWI
IMANGSDEVLNNLIRACAGEGEEIAFINPSYSYYGTLAEVQGARVRTFGLSESFEPEGIPEHYDGKLFFLTNPNAPLGFT
YSQRYIADLAGRLSGVLVVDEAYVDFAEETSLELVRSFDNVVVTRTFSKSYSLAGMRLGLAIARPEIIAALNKIRDHYNL
DRLAQAAAAAALADQPYFQECVRKIKETRAWFTAELQQLGYQVIPSSGNFVFASPPDRDGTRIYQGLYDRKILVRHFTDP
KLAHGLRISIGSREEMEQTVKALRELGPGR
>Mature_350_residues
MIALRENIAEMAGYVPGFQPLDVDSYIKLNTNENPYPPSPKVLEAIAKEAGEGLRRYPDAASRLAREEAAKVYGFDPSWI
IMANGSDEVLNNLIRACAGEGEEIAFINPSYSYYGTLAEVQGARVRTFGLSESFEPEGIPEHYDGKLFFLTNPNAPLGFT
YSQRYIADLAGRLSGVLVVDEAYVDFAEETSLELVRSFDNVVVTRTFSKSYSLAGMRLGLAIARPEIIAALNKIRDHYNL
DRLAQAAAAAALADQPYFQECVRKIKETRAWFTAELQQLGYQVIPSSGNFVFASPPDRDGTRIYQGLYDRKILVRHFTDP
KLAHGLRISIGSREEMEQTVKALRELGPGR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=353, Percent_Identity=29.1784702549575, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1788722, Length=246, Percent_Identity=29.2682926829268, Blast_Score=76, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322075, Length=354, Percent_Identity=29.3785310734463, Blast_Score=114, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_GEOBB (B5E9W9)

Other databases:

- EMBL:   CP001124
- RefSeq:   YP_002137063.1
- ProteinModelPortal:   B5E9W9
- GeneID:   6783061
- GenomeReviews:   CP001124_GR
- KEGG:   gbm:Gbem_0236
- HOGENOM:   HBG646350
- OMA:   AEMAGYV
- ProtClustDB:   CLSK829109
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 38905; Mature: 38905

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIALRENIAEMAGYVPGFQPLDVDSYIKLNTNENPYPPSPKVLEAIAKEAGEGLRRYPDA
CCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCHH
ASRLAREEAAKVYGFDPSWIIMANGSDEVLNNLIRACAGEGEEIAFINPSYSYYGTLAEV
HHHHHHHHHHHEECCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCHHHEEHHHH
QGARVRTFGLSESFEPEGIPEHYDGKLFFLTNPNAPLGFTYSQRYIADLAGRLSGVLVVD
CCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCEEEEE
EAYVDFAEETSLELVRSFDNVVVTRTFSKSYSLAGMRLGLAIARPEIIAALNKIRDHYNL
HHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCH
DRLAQAAAAAALADQPYFQECVRKIKETRAWFTAELQQLGYQVIPSSGNFVFASPPDRDG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEECCCCCCCH
TRIYQGLYDRKILVRHFTDPKLAHGLRISIGSREEMEQTVKALRELGPGR
HHHHHHHHHHHHHHHCCCCHHHHCCEEEECCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIALRENIAEMAGYVPGFQPLDVDSYIKLNTNENPYPPSPKVLEAIAKEAGEGLRRYPDA
CCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCHH
ASRLAREEAAKVYGFDPSWIIMANGSDEVLNNLIRACAGEGEEIAFINPSYSYYGTLAEV
HHHHHHHHHHHEECCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCHHHEEHHHH
QGARVRTFGLSESFEPEGIPEHYDGKLFFLTNPNAPLGFTYSQRYIADLAGRLSGVLVVD
CCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCEEEEE
EAYVDFAEETSLELVRSFDNVVVTRTFSKSYSLAGMRLGLAIARPEIIAALNKIRDHYNL
HHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCH
DRLAQAAAAAALADQPYFQECVRKIKETRAWFTAELQQLGYQVIPSSGNFVFASPPDRDG
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEECCCCCCCH
TRIYQGLYDRKILVRHFTDPKLAHGLRISIGSREEMEQTVKALRELGPGR
HHHHHHHHHHHHHHHCCCCHHHHCCEEEECCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA