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The map label for this gene is aroK-2 [H]

Identifier: 197116600

GI number: 197116600

Start: 235618

End: 236142

Strand: Direct

Name: aroK-2 [H]

Synonym: Gbem_0200

Alternate gene names: 197116600

Gene position: 235618-236142 (Clockwise)

Preceding gene: 197116599

Following gene: 197116601

Centisome position: 5.11

GC content: 57.71

Gene sequence:

>525_bases
ATGCAGACGATGGCACTTATAGGGATGCCCGGGTCGGGTAAGAGCGCTGTGGGTAGAATCATCGCCGACAGGCTGGGATG
GGATTTCCTGGACACGGACCGGCTCATAGAGCAGCGCTTTGGCCTCAAGCTGCAGGCTGTGATCGACCAGGTGGGGACTG
AGGCCTTCAGCCGGATAGAGGAGGAAACGGTACTGAGCCTGGACCCCGCGGAGCGGACCGTGATTTCCACCGGCGGGAGC
GTTGTCTACTCGGAGGCCGCCATGCGCCACCTTTGCTCCATCTCCACGGTTGTTTTTCTCGATCTTCCCATTGATGCCAT
TCGGAGCCACATATCTTTGGAAGCGCCGCGCGGCATCGTCGGAATGGATGAAGGCGGACTGGAACTACTTTATGAACAGA
GGTTCCCGCTTTACCACAGGCATGCGCAGATAGTGGTTTTGCTAGACAGCTGTACGACTGAAGAGGCGGCAGCAAGGGTA
CTGTCACAGTGGAAGGAGTATGTTGCTTCGGACCGACAGCGTTGA

Upstream 100 bases:

>100_bases
ACTGACCGAATCCTGCCTTGAGTTTGGCTAGGACTTGAGGCGGCTTCAGGGATAAGGCCTGCGGCAGCGCGTCGACAACA
ATTTCGGCGCTGGAGCGGTT

Downstream 100 bases:

>100_bases
CTTTGCTCTCAGCGTCCTCTAATATCTAGCCCATGTCATCACCCACGAATACAAATGCTCCCGCGAAGCTCAGCCTGCCA
AGGCTGACCCTGATACAGAA

Product: shikimate kinase

Products: NA

Alternate protein names: SK [H]

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MQTMALIGMPGSGKSAVGRIIADRLGWDFLDTDRLIEQRFGLKLQAVIDQVGTEAFSRIEEETVLSLDPAERTVISTGGS
VVYSEAAMRHLCSISTVVFLDLPIDAIRSHISLEAPRGIVGMDEGGLELLYEQRFPLYHRHAQIVVLLDSCTTEEAAARV
LSQWKEYVASDRQR

Sequences:

>Translated_174_residues
MQTMALIGMPGSGKSAVGRIIADRLGWDFLDTDRLIEQRFGLKLQAVIDQVGTEAFSRIEEETVLSLDPAERTVISTGGS
VVYSEAAMRHLCSISTVVFLDLPIDAIRSHISLEAPRGIVGMDEGGLELLYEQRFPLYHRHAQIVVLLDSCTTEEAAARV
LSQWKEYVASDRQR
>Mature_174_residues
MQTMALIGMPGSGKSAVGRIIADRLGWDFLDTDRLIEQRFGLKLQAVIDQVGTEAFSRIEEETVLSLDPAERTVISTGGS
VVYSEAAMRHLCSISTVVFLDLPIDAIRSHISLEAPRGIVGMDEGGLELLYEQRFPLYHRHAQIVVLLDSCTTEEAAARV
LSQWKEYVASDRQR

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate [H]

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=175, Percent_Identity=31.4285714285714, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI87082255, Length=165, Percent_Identity=30.9090909090909, Blast_Score=74, Evalue=6e-15,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000623
- InterPro:   IPR023000 [H]

Pfam domain/function: PF01202 SKI [H]

EC number: =2.7.1.71 [H]

Molecular weight: Translated: 19291; Mature: 19291

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTMALIGMPGSGKSAVGRIIADRLGWDFLDTDRLIEQRFGLKLQAVIDQVGTEAFSRIE
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
EETVLSLDPAERTVISTGGSVVYSEAAMRHLCSISTVVFLDLPIDAIRSHISLEAPRGIV
HHHEEEECCCHHEEEECCCCEEHHHHHHHHHHHHHHHEEEECCHHHHHHHHCCCCCCCEE
GMDEGGLELLYEQRFPLYHRHAQIVVLLDSCTTEEAAARVLSQWKEYVASDRQR
ECCCCCHHHHHHCCCCHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQTMALIGMPGSGKSAVGRIIADRLGWDFLDTDRLIEQRFGLKLQAVIDQVGTEAFSRIE
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
EETVLSLDPAERTVISTGGSVVYSEAAMRHLCSISTVVFLDLPIDAIRSHISLEAPRGIV
HHHEEEECCCHHEEEECCCCEEHHHHHHHHHHHHHHHEEEECCHHHHHHHHCCCCCCCEE
GMDEGGLELLYEQRFPLYHRHAQIVVLLDSCTTEEAAARVLSQWKEYVASDRQR
ECCCCCHHHHHHCCCCHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA