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The map label for this gene is cirA [H]

Identifier: 197116511

GI number: 197116511

Start: 133141

End: 135186

Strand: Direct

Name: cirA [H]

Synonym: Gbem_0111

Alternate gene names: 197116511

Gene position: 133141-135186 (Clockwise)

Preceding gene: 197116510

Following gene: 197116512

Centisome position: 2.88

GC content: 64.22

Gene sequence:

>2046_bases
ATGGGTACCTGCATCTCCCGCCTTGTTACGGGGATCTTTCTTCTGACCACGCTGGGCGCTCCCCTGGCCTTTGCGCAGCA
GGAGGGGGAGGGAGCCGCCGCCCCGGCGCTGGGGGAAATGGACCTGGAACAGTTGACCAACCTCAAGGTGGAGCAGGTGT
ACGGGGTCTCGAAGTTCGAACAGGCGGTAACGGAGGCTCCTGCCTCGGTCTCGGTGATCACCGCCGACGAGATCAAGCAC
TATGGGTGGCGTACCCTTGCCGACGTGATCAGGTCGAGCCGCGGGTTCTTCACGAGCTATGACCGCAACTACAGCTACAT
CGGGACGCGGGGCTTCAGCCGCCCCGGGGACTACAACACCCGCGTGCTCCTTCTGATCGACGGGCACCGGATCAACGACG
CCATCTACGAGACCGCCGCGATCGGAACCGAGTTCATACTCGATCTGGCGCTCATCGACAGGATCGAGATCATCCGCGGG
CCCAGTTCCTCGCTTTACGGTGCGGGCGCCTTCTTCGGGGTGATCAACGTCATCACCCGCAGCGCCAAACAGATCGAGGG
GGGGGAGGCGGCGGCCTCGGGGGGAAGCCAGCGGACCGGAGCCGGGCGCCTGACCTACGGGAAGAGTTTCGACGGCGGAG
AGTTCGTCGCCTCCGGGTCGGCCTACAAAAGCCGCGGCAACGACTCGCTCTTCTACCCCGAGTTCAACGACCCCGCCACC
AACAACGGCATCGCAAGCAACATGGACCGGGACCGGAATTATTCCCTGTTCGCTTCCGGGCGCCTGCACGACTTCACCCT
GACCGGGGCGCTGATTTCCCGGGATAAACGGATCCCCACCGCTTCGTTCAACACCATCTTCAACGACCCACGGACCCATT
CCGTCGACCGGCGCAGCTACCTCGACCTCAAGTACGACAAGGCGTTGGAAGGGGGGACCGGCGTCACCGCCAGGCTCTTC
TACGACGAGTACCGCTACCAGGGGAATTTCGCCTACGAAAAAGGCCTGGACGACCCCGGTTTCTACCCGCCCACCTACCT
GAACCGGGACGATCATCTGGCGCGCTGGTGGGGGGGGGAGGCCCAGGCGAGCCGCCAGGTCCTGCCGCGCCTGCAGCTTA
CCGCCGGCGCCAGCTTCCGGGACAGCTTCCTAAAGCTTCCCAACTACGACGCAGTGCCACAGGGGCGCAGAGTGGAGAAC
GACCACAGCGACCTCTTCTTGGCCCTGTTCGGGCAGGGGGAGCTGCGCCTTTTCGAGCACCTGATCGTCAACGTCGGGGT
CCGCCACGACCACTACCAGACCTTCGGCGGCGCGACCAGCCCGCGCCTGGCGGTCATCTACACGCCGGTCGAAGGGACCG
TCTTCAAGTACATCGAGGGAAAGGCGTTTCGCGCCCCCAACGCCTACGAGCTCTACTACAACGACGTCTTCGACACCAAC
GTCGCCAATCCGCGCCTGGCGCCCGAGACGGTCAGGACCAGGGAGCTGATCTACGAGCAGTACCTGGGCGAGGTGCTTAG
AACCAGCCTGAGCCTGTTCCAGAACAAGATAGAGAACCTGATCAGTTACCAGAACCTTCCTTCAGGAGAGGTATCCTTCG
GCAACGCCGGCCGGGTGAAGGCGGTGGGAGGGGAGTTCGAGGTAGAGGGGCAGTGGGCAAGCGGCTTCGCGGCGAGGACC
AGCTACAGCTTCGTCTCGGCCCGCGACGAGGGGCAGGACCAGCGGCTGGACTACTCGCCGCGTCAACTGGCCAAGCTGAA
CCTGACCGCGCCGCTTTACCGCAAGAAGCTTTTCGCTGGGGTGGAACTGCAGGGGACGGCCCGCCGCGACTTCTCCCATA
ACGGCGTGCAGACCGCGGCGCCGGGATACCTGATCGCCAACGCCACCCTGTTCTCCACCGGGATACTCCCGTCGCTGGAC
CTCTCTTTATCCGTCTACAACTTCCTGGACCGGCGCTACCAGGACCCGGCCACGACCGACCACAGGCAGAGCCTGATTGC
GCAGGACGGCCGGACCTTCAGGGTCCAGGCCACCTACGGTTTCTGA

Upstream 100 bases:

>100_bases
ATTGTCACGTTGCTAAGATAGTGATCGCCTCTTGCTAAATTGAGTCTGTCGACTTTGCTGCGGGGGGACCGGATGAAACG
GTTTCTCCAGGAGGACGCTG

Downstream 100 bases:

>100_bases
AAGGAGGAGAGCCCTGATTCGACGCCACTGTCCCATACCGGCTGCAGCCGGACTACGCTGTCTGCCGATACTGCTGGCTC
TTCTTTTCCTGCACGCCTTT

Product: ligand-gated porin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 681; Mature: 680

Protein sequence:

>681_residues
MGTCISRLVTGIFLLTTLGAPLAFAQQEGEGAAAPALGEMDLEQLTNLKVEQVYGVSKFEQAVTEAPASVSVITADEIKH
YGWRTLADVIRSSRGFFTSYDRNYSYIGTRGFSRPGDYNTRVLLLIDGHRINDAIYETAAIGTEFILDLALIDRIEIIRG
PSSSLYGAGAFFGVINVITRSAKQIEGGEAAASGGSQRTGAGRLTYGKSFDGGEFVASGSAYKSRGNDSLFYPEFNDPAT
NNGIASNMDRDRNYSLFASGRLHDFTLTGALISRDKRIPTASFNTIFNDPRTHSVDRRSYLDLKYDKALEGGTGVTARLF
YDEYRYQGNFAYEKGLDDPGFYPPTYLNRDDHLARWWGGEAQASRQVLPRLQLTAGASFRDSFLKLPNYDAVPQGRRVEN
DHSDLFLALFGQGELRLFEHLIVNVGVRHDHYQTFGGATSPRLAVIYTPVEGTVFKYIEGKAFRAPNAYELYYNDVFDTN
VANPRLAPETVRTRELIYEQYLGEVLRTSLSLFQNKIENLISYQNLPSGEVSFGNAGRVKAVGGEFEVEGQWASGFAART
SYSFVSARDEGQDQRLDYSPRQLAKLNLTAPLYRKKLFAGVELQGTARRDFSHNGVQTAAPGYLIANATLFSTGILPSLD
LSLSVYNFLDRRYQDPATTDHRQSLIAQDGRTFRVQATYGF

Sequences:

>Translated_681_residues
MGTCISRLVTGIFLLTTLGAPLAFAQQEGEGAAAPALGEMDLEQLTNLKVEQVYGVSKFEQAVTEAPASVSVITADEIKH
YGWRTLADVIRSSRGFFTSYDRNYSYIGTRGFSRPGDYNTRVLLLIDGHRINDAIYETAAIGTEFILDLALIDRIEIIRG
PSSSLYGAGAFFGVINVITRSAKQIEGGEAAASGGSQRTGAGRLTYGKSFDGGEFVASGSAYKSRGNDSLFYPEFNDPAT
NNGIASNMDRDRNYSLFASGRLHDFTLTGALISRDKRIPTASFNTIFNDPRTHSVDRRSYLDLKYDKALEGGTGVTARLF
YDEYRYQGNFAYEKGLDDPGFYPPTYLNRDDHLARWWGGEAQASRQVLPRLQLTAGASFRDSFLKLPNYDAVPQGRRVEN
DHSDLFLALFGQGELRLFEHLIVNVGVRHDHYQTFGGATSPRLAVIYTPVEGTVFKYIEGKAFRAPNAYELYYNDVFDTN
VANPRLAPETVRTRELIYEQYLGEVLRTSLSLFQNKIENLISYQNLPSGEVSFGNAGRVKAVGGEFEVEGQWASGFAART
SYSFVSARDEGQDQRLDYSPRQLAKLNLTAPLYRKKLFAGVELQGTARRDFSHNGVQTAAPGYLIANATLFSTGILPSLD
LSLSVYNFLDRRYQDPATTDHRQSLIAQDGRTFRVQATYGF
>Mature_680_residues
GTCISRLVTGIFLLTTLGAPLAFAQQEGEGAAAPALGEMDLEQLTNLKVEQVYGVSKFEQAVTEAPASVSVITADEIKHY
GWRTLADVIRSSRGFFTSYDRNYSYIGTRGFSRPGDYNTRVLLLIDGHRINDAIYETAAIGTEFILDLALIDRIEIIRGP
SSSLYGAGAFFGVINVITRSAKQIEGGEAAASGGSQRTGAGRLTYGKSFDGGEFVASGSAYKSRGNDSLFYPEFNDPATN
NGIASNMDRDRNYSLFASGRLHDFTLTGALISRDKRIPTASFNTIFNDPRTHSVDRRSYLDLKYDKALEGGTGVTARLFY
DEYRYQGNFAYEKGLDDPGFYPPTYLNRDDHLARWWGGEAQASRQVLPRLQLTAGASFRDSFLKLPNYDAVPQGRRVEND
HSDLFLALFGQGELRLFEHLIVNVGVRHDHYQTFGGATSPRLAVIYTPVEGTVFKYIEGKAFRAPNAYELYYNDVFDTNV
ANPRLAPETVRTRELIYEQYLGEVLRTSLSLFQNKIENLISYQNLPSGEVSFGNAGRVKAVGGEFEVEGQWASGFAARTS
YSFVSARDEGQDQRLDYSPRQLAKLNLTAPLYRKKLFAGVELQGTARRDFSHNGVQTAAPGYLIANATLFSTGILPSLDL
SLSVYNFLDRRYQDPATTDHRQSLIAQDGRTFRVQATYGF

Specific function: Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=589, Percent_Identity=25.8064516129032, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1790405, Length=610, Percent_Identity=22.9508196721311, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 75484; Mature: 75353

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS01156 TONB_DEPENDENT_REC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTCISRLVTGIFLLTTLGAPLAFAQQEGEGAAAPALGEMDLEQLTNLKVEQVYGVSKFE
CCHHHHHHHHHHHHHHHHCCCCEEHHCCCCCCCCCCCCCCCHHHHHCCCHHHHHCHHHHH
QAVTEAPASVSVITADEIKHYGWRTLADVIRSSRGFFTSYDRNYSYIGTRGFSRPGDYNT
HHHHCCCCCEEEEEHHHHHHCCHHHHHHHHHCCCCCEEECCCCCEEEECCCCCCCCCCCC
RVLLLIDGHRINDAIYETAAIGTEFILDLALIDRIEIIRGPSSSLYGAGAFFGVINVITR
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHH
SAKQIEGGEAAASGGSQRTGAGRLTYGKSFDGGEFVASGSAYKSRGNDSLFYPEFNDPAT
HHHHCCCCCHHCCCCCCCCCCCEEEECCCCCCCCEEECCCHHHCCCCCCEECCCCCCCCC
NNGIASNMDRDRNYSLFASGRLHDFTLTGALISRDKRIPTASFNTIFNDPRTHSVDRRSY
CCCCCCCCCCCCCEEEEECCCEEEEEEEHHHHHCCCCCCCCCCHHHCCCCCCCCCCCHHC
LDLKYDKALEGGTGVTARLFYDEYRYQGNFAYEKGLDDPGFYPPTYLNRDDHLARWWGGE
CCEEHHHCCCCCCCCEEEEEEEHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHCCCC
AQASRQVLPRLQLTAGASFRDSFLKLPNYDAVPQGRRVENDHSDLFLALFGQGELRLFEH
HHHHHHHHCCEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHH
LIVNVGVRHDHYQTFGGATSPRLAVIYTPVEGTVFKYIEGKAFRAPNAYELYYNDVFDTN
HHHHCCCCCCCHHHCCCCCCCEEEEEEECCCCCEEEEECCCEECCCCCEEEEECCCCCCC
VANPRLAPETVRTRELIYEQYLGEVLRTSLSLFQNKIENLISYQNLPSGEVSFGNAGRVK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
AVGGEFEVEGQWASGFAARTSYSFVSARDEGQDQRLDYSPRQLAKLNLTAPLYRKKLFAG
EECCEEEECCCCCCCCCHHCCCEEEECCCCCCCCCCCCCHHHHEEECCCCHHHHHHHHCC
VELQGTARRDFSHNGVQTAAPGYLIANATLFSTGILPSLDLSLSVYNFLDRRYQDPATTD
CEECCCCCCCCCCCCCCCCCCCEEEECCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCH
HRQSLIAQDGRTFRVQATYGF
HHHHHHHCCCCEEEEEEECCC
>Mature Secondary Structure 
GTCISRLVTGIFLLTTLGAPLAFAQQEGEGAAAPALGEMDLEQLTNLKVEQVYGVSKFE
CHHHHHHHHHHHHHHHHCCCCEEHHCCCCCCCCCCCCCCCHHHHHCCCHHHHHCHHHHH
QAVTEAPASVSVITADEIKHYGWRTLADVIRSSRGFFTSYDRNYSYIGTRGFSRPGDYNT
HHHHCCCCCEEEEEHHHHHHCCHHHHHHHHHCCCCCEEECCCCCEEEECCCCCCCCCCCC
RVLLLIDGHRINDAIYETAAIGTEFILDLALIDRIEIIRGPSSSLYGAGAFFGVINVITR
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHH
SAKQIEGGEAAASGGSQRTGAGRLTYGKSFDGGEFVASGSAYKSRGNDSLFYPEFNDPAT
HHHHCCCCCHHCCCCCCCCCCCEEEECCCCCCCCEEECCCHHHCCCCCCEECCCCCCCCC
NNGIASNMDRDRNYSLFASGRLHDFTLTGALISRDKRIPTASFNTIFNDPRTHSVDRRSY
CCCCCCCCCCCCCEEEEECCCEEEEEEEHHHHHCCCCCCCCCCHHHCCCCCCCCCCCHHC
LDLKYDKALEGGTGVTARLFYDEYRYQGNFAYEKGLDDPGFYPPTYLNRDDHLARWWGGE
CCEEHHHCCCCCCCCEEEEEEEHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHCCCC
AQASRQVLPRLQLTAGASFRDSFLKLPNYDAVPQGRRVENDHSDLFLALFGQGELRLFEH
HHHHHHHHCCEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHH
LIVNVGVRHDHYQTFGGATSPRLAVIYTPVEGTVFKYIEGKAFRAPNAYELYYNDVFDTN
HHHHCCCCCCCHHHCCCCCCCEEEEEEECCCCCEEEEECCCEECCCCCEEEEECCCCCCC
VANPRLAPETVRTRELIYEQYLGEVLRTSLSLFQNKIENLISYQNLPSGEVSFGNAGRVK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEE
AVGGEFEVEGQWASGFAARTSYSFVSARDEGQDQRLDYSPRQLAKLNLTAPLYRKKLFAG
EECCEEEECCCCCCCCCHHCCCEEEECCCCCCCCCCCCCHHHHEEECCCCHHHHHHHHCC
VELQGTARRDFSHNGVQTAAPGYLIANATLFSTGILPSLDLSLSVYNFLDRRYQDPATTD
CEECCCCCCCCCCCCCCCCCCCEEEECCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCH
HRQSLIAQDGRTFRVQATYGF
HHHHHHHCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2644220; 9278503; 3316180; 1315732; 2160948 [H]