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The map label for this gene is ykoW [H]

Identifier: 197116481

GI number: 197116481

Start: 96951

End: 99365

Strand: Direct

Name: ykoW [H]

Synonym: Gbem_0081

Alternate gene names: 197116481

Gene position: 96951-99365 (Clockwise)

Preceding gene: 197116480

Following gene: 197116483

Centisome position: 2.1

GC content: 64.14

Gene sequence:

>2415_bases
ATGTCCAGGTGCAGCCTGAAAATAAAGATGAGCTTGGTCGTCTTCCTGCTGATTGGTACGGTGAGCTCGTGCGTTGCCGG
CCTGGGACTGCTGTTTTTCATGCGGGAGTTCAAGGAGACCGTCGCCGCGCGGCAGTTCGCGGTGGTGAGCGCCATGGCGG
GCGAGCTCGATGAAAAGATCCTGGCGGCGCAGCGCGAGCTGGTCGCGGTGGCGATGAGCATCCCGCCGGCCACGGGGAGA
GATGCCGCGGCCATGCAGAGTTTCCTCGACCAACGCCTCGATCTGCACCAGGTGTTCAGCGACGGCACGGCTTTCTTCAG
CGCCGACGGAAGGCTCGTAGCCTTCTCCCCGGGGCAGACCCCCGACATAGGCGACAATTTTTCCAAGCTCGATTTTTTGG
CCGCCACGCTCAGATCCGGGAAGGCGCTGATTTCCGAACCTTTCCCGTCGCAGCGAAGGCGCGGGCATCAGGTGGTGATG
TTCACCGTCCCGGTGCTGGGGGGGGGGGGGAGGATGATCGGAGTCCTGGGAGGACGCGTGGATCTTATGGAAGAAAACTT
CCTGAGCCGCGTGGCGCACCTGAACCTCCAGGACGGCGGGGAATTCTTCCTCTTCAATCGGCAAAGGCAGATAGTCGCGC
ACCGCAATCATGACAAGATCGGCAAGCCCATGCCGGCGAAGGGAATGCGGGAGCTTTTGGACCGGGCCATCGACGGATAC
CAGGGGAGCGGCGAGATGGATAACCCTGCCGGGTCGCCCTCGATCTACTCCTTCAAGAGGCTTCCCGCGCGCGGCTGGAT
ATTGGCGGCGGAACGCCCCCTCTCCGAGGCGTACGCACCGATCTACCGCGCGCAGAAACTGGCGATCTTTAGCCTCGCTT
TGCTGCTTCCTTTGGCCCTGATCACCGTTTGGCTCTTCGTCGGCCGCCTCACCGCGCCCTTGCAACTCTTCGCCGGGCGG
GTGCGCGAGATAGGGGGGGATGCCGGCAAGTACCTCCCGGTACTGGTGAATAACAACGACGAGATCGGCGACCTGGCCCA
GGCCTTCAACGCCATGATGCAGGAACTGGTGATCAACAAGCGGTCGCTGGAAAGCGAGAAGGGGTTTGCCGTGCAGCTCT
TGCAGCACTCGGCGGTCCCCTGTTTCGTCATCGACGCCGAGCACCGGGTGATCATCTGGAACAGCGCCATGGAGGAGCTG
ACCGGCGTCGCCGCAGGGGCGCAGCTGGGGCAGATCGAACCTTGGCGCGCCTTCTACGACGAGCCGCGCCGCGTTCTGGC
CGACATCGTGGTGGCGGGAACACTGTACGAGATGGCGGATCTCTATTGCTGCTACGCGGATTCCCCTCTCATCCCCGAAG
GGCTGCGGGCCGAGGGGTGGTACCGGCTCAAAGGGAAGCAGAGATACCTGGCCTTCGAGGCGGCTCCCATCCGGGACGCC
GAGGGGAGGCTGATCGCCGCCATCCAGACCATGCAGGACATGACGCTTCGGGCCAACAACGAGGAGCAGTTGAGGGGGAT
GGTGGCGGCCATAGGGGAGAGCGAGGAGCGGTTCCGGCGCCTGGTGGAGCTTTCGCTGGACGGGATCGCCATCCTGGTCG
GGCGCCGCTTCGTTTTCGTCAACCCGGCGGGGTGCGAGATGCTGGGGTACCGCTCAAGCGACGAGCTGTTGGGGAAGGAG
ATGCGCGAATTCATCCAGCGGGATTCAGAGCAGCAGTTCCTGGAGCAGGCAACCTGCGCCGAGGAAACCGGCACCACCGC
CCCCTGGATAGAGGAGCGGCTGTTGCGCCACGACCGGACCGCCGTGGAGGTGGAACTGGGGGTGGGTCCGTTCGTTTTCC
GCGGTGAAAACGCGCTGCAGGTCATCTTCAGGGATATCACCGAGAGAAAGCTCGCCAAAGCGAGGCTGGAGACCCTGGCC
CACTACGACTCGCTGACCTCGCTCCCCAACCGGGTGCTCTTCTTCGACCGGCTGCGCCACGCTGTATTCGAGGCGAAGCG
CTACCAGCACCCGATGGCGCTCATGTTCCTGGATCTGGACAGCTTCAAGCAGGTGAACGACCGGCTGGGGCATGCGGCAG
GGGACGCGGTGCTGGTGGAGGCGGGGTACCGGCTTAGGGAGTGCGTGCGGGCCTGCGACATGGTGGCCCGCATGGGCGGG
GACGAGTTCACCATCATCCTCACCAAGATGGCGGACCGGCGGGACGCGTCCCTGGTGGCCGAGAGGGTGCTAGAGGCGTT
CGCCCTCCCCTTCCTGGTGGAAGGGGAAAGCGCACAGGTGGGGGTGAGTATCGGGATCTGCGTCTATCCCGACTGCGACG
CCGATCTGGACGGGATGGTGCGCTACGCGGACTACGCCATGTACCAGGCCAAGCAGGACGGCAAGAACGTCTACCGCTTC
CACTTGGGAGGCTAG

Upstream 100 bases:

>100_bases
GCATTTCGACCCGGAGATACTGCGCGCCTTCGTTACGGCGGCACACGACTTCGAGGCCATCTACGAGAACCATAGCGATT
AGCGGGGAACCAGACGAAAC

Downstream 100 bases:

>100_bases
CCGCTAAGAGGCGCCTGCGGGGCGATGGCGGCTAGCGCCTGAGCGCCTCCACGGCCGCCTCGTCGAGAGCATTCACCGTC
TTCAGCTCCGTTTCGCTGCC

Product: HAMP/PAS domain-containing diguanylate cyclase lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 804; Mature: 803

Protein sequence:

>804_residues
MSRCSLKIKMSLVVFLLIGTVSSCVAGLGLLFFMREFKETVAARQFAVVSAMAGELDEKILAAQRELVAVAMSIPPATGR
DAAAMQSFLDQRLDLHQVFSDGTAFFSADGRLVAFSPGQTPDIGDNFSKLDFLAATLRSGKALISEPFPSQRRRGHQVVM
FTVPVLGGGGRMIGVLGGRVDLMEENFLSRVAHLNLQDGGEFFLFNRQRQIVAHRNHDKIGKPMPAKGMRELLDRAIDGY
QGSGEMDNPAGSPSIYSFKRLPARGWILAAERPLSEAYAPIYRAQKLAIFSLALLLPLALITVWLFVGRLTAPLQLFAGR
VREIGGDAGKYLPVLVNNNDEIGDLAQAFNAMMQELVINKRSLESEKGFAVQLLQHSAVPCFVIDAEHRVIIWNSAMEEL
TGVAAGAQLGQIEPWRAFYDEPRRVLADIVVAGTLYEMADLYCCYADSPLIPEGLRAEGWYRLKGKQRYLAFEAAPIRDA
EGRLIAAIQTMQDMTLRANNEEQLRGMVAAIGESEERFRRLVELSLDGIAILVGRRFVFVNPAGCEMLGYRSSDELLGKE
MREFIQRDSEQQFLEQATCAEETGTTAPWIEERLLRHDRTAVEVELGVGPFVFRGENALQVIFRDITERKLAKARLETLA
HYDSLTSLPNRVLFFDRLRHAVFEAKRYQHPMALMFLDLDSFKQVNDRLGHAAGDAVLVEAGYRLRECVRACDMVARMGG
DEFTIILTKMADRRDASLVAERVLEAFALPFLVEGESAQVGVSIGICVYPDCDADLDGMVRYADYAMYQAKQDGKNVYRF
HLGG

Sequences:

>Translated_804_residues
MSRCSLKIKMSLVVFLLIGTVSSCVAGLGLLFFMREFKETVAARQFAVVSAMAGELDEKILAAQRELVAVAMSIPPATGR
DAAAMQSFLDQRLDLHQVFSDGTAFFSADGRLVAFSPGQTPDIGDNFSKLDFLAATLRSGKALISEPFPSQRRRGHQVVM
FTVPVLGGGGRMIGVLGGRVDLMEENFLSRVAHLNLQDGGEFFLFNRQRQIVAHRNHDKIGKPMPAKGMRELLDRAIDGY
QGSGEMDNPAGSPSIYSFKRLPARGWILAAERPLSEAYAPIYRAQKLAIFSLALLLPLALITVWLFVGRLTAPLQLFAGR
VREIGGDAGKYLPVLVNNNDEIGDLAQAFNAMMQELVINKRSLESEKGFAVQLLQHSAVPCFVIDAEHRVIIWNSAMEEL
TGVAAGAQLGQIEPWRAFYDEPRRVLADIVVAGTLYEMADLYCCYADSPLIPEGLRAEGWYRLKGKQRYLAFEAAPIRDA
EGRLIAAIQTMQDMTLRANNEEQLRGMVAAIGESEERFRRLVELSLDGIAILVGRRFVFVNPAGCEMLGYRSSDELLGKE
MREFIQRDSEQQFLEQATCAEETGTTAPWIEERLLRHDRTAVEVELGVGPFVFRGENALQVIFRDITERKLAKARLETLA
HYDSLTSLPNRVLFFDRLRHAVFEAKRYQHPMALMFLDLDSFKQVNDRLGHAAGDAVLVEAGYRLRECVRACDMVARMGG
DEFTIILTKMADRRDASLVAERVLEAFALPFLVEGESAQVGVSIGICVYPDCDADLDGMVRYADYAMYQAKQDGKNVYRF
HLGG
>Mature_803_residues
SRCSLKIKMSLVVFLLIGTVSSCVAGLGLLFFMREFKETVAARQFAVVSAMAGELDEKILAAQRELVAVAMSIPPATGRD
AAAMQSFLDQRLDLHQVFSDGTAFFSADGRLVAFSPGQTPDIGDNFSKLDFLAATLRSGKALISEPFPSQRRRGHQVVMF
TVPVLGGGGRMIGVLGGRVDLMEENFLSRVAHLNLQDGGEFFLFNRQRQIVAHRNHDKIGKPMPAKGMRELLDRAIDGYQ
GSGEMDNPAGSPSIYSFKRLPARGWILAAERPLSEAYAPIYRAQKLAIFSLALLLPLALITVWLFVGRLTAPLQLFAGRV
REIGGDAGKYLPVLVNNNDEIGDLAQAFNAMMQELVINKRSLESEKGFAVQLLQHSAVPCFVIDAEHRVIIWNSAMEELT
GVAAGAQLGQIEPWRAFYDEPRRVLADIVVAGTLYEMADLYCCYADSPLIPEGLRAEGWYRLKGKQRYLAFEAAPIRDAE
GRLIAAIQTMQDMTLRANNEEQLRGMVAAIGESEERFRRLVELSLDGIAILVGRRFVFVNPAGCEMLGYRSSDELLGKEM
REFIQRDSEQQFLEQATCAEETGTTAPWIEERLLRHDRTAVEVELGVGPFVFRGENALQVIFRDITERKLAKARLETLAH
YDSLTSLPNRVLFFDRLRHAVFEAKRYQHPMALMFLDLDSFKQVNDRLGHAAGDAVLVEAGYRLRECVRACDMVARMGGD
EFTIILTKMADRRDASLVAERVLEAFALPFLVEGESAQVGVSIGICVYPDCDADLDGMVRYADYAMYQAKQDGKNVYRFH
LGG

Specific function: Probable signaling protein whose physiological role is not yet known [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=344, Percent_Identity=28.4883720930233, Blast_Score=116, Evalue=7e-27,
Organism=Escherichia coli, GI1787541, Length=212, Percent_Identity=34.9056603773585, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI87081881, Length=204, Percent_Identity=31.3725490196078, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI87082007, Length=179, Percent_Identity=34.6368715083799, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI87081977, Length=162, Percent_Identity=34.5679012345679, Blast_Score=94, Evalue=5e-20,
Organism=Escherichia coli, GI1787262, Length=170, Percent_Identity=34.1176470588235, Blast_Score=93, Evalue=9e-20,
Organism=Escherichia coli, GI145693134, Length=157, Percent_Identity=33.7579617834395, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1788956, Length=161, Percent_Identity=34.1614906832298, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1786584, Length=172, Percent_Identity=29.6511627906977, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1787802, Length=162, Percent_Identity=32.0987654320988, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1787816, Length=156, Percent_Identity=33.974358974359, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1788085, Length=169, Percent_Identity=27.810650887574, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR005330
- InterPro:   IPR000014 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF03707 MHYT [H]

EC number: NA

Molecular weight: Translated: 89370; Mature: 89239

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50885 HAMP ; PS50112 PAS ; PS50113 PAC ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRCSLKIKMSLVVFLLIGTVSSCVAGLGLLFFMREFKETVAARQFAVVSAMAGELDEKI
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAQRELVAVAMSIPPATGRDAAAMQSFLDQRLDLHQVFSDGTAFFSADGRLVAFSPGQT
HHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCCCC
PDIGDNFSKLDFLAATLRSGKALISEPFPSQRRRGHQVVMFTVPVLGGGGRMIGVLGGRV
CCCCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHCCCEEEEEEEEEECCCCEEEEEECCCH
DLMEENFLSRVAHLNLQDGGEFFLFNRQRQIVAHRNHDKIGKPMPAKGMRELLDRAIDGY
HHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC
QGSGEMDNPAGSPSIYSFKRLPARGWILAAERPLSEAYAPIYRAQKLAIFSLALLLPLAL
CCCCCCCCCCCCCCCCHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITVWLFVGRLTAPLQLFAGRVREIGGDAGKYLPVLVNNNDEIGDLAQAFNAMMQELVINK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
RSLESEKGFAVQLLQHSAVPCFVIDAEHRVIIWNSAMEELTGVAAGAQLGQIEPWRAFYD
HHCCCCCCHHHHHHHHCCCCEEEEECCCEEEEECHHHHHHHHHHCCCCCCCCCHHHHHHH
EPRRVLADIVVAGTLYEMADLYCCYADSPLIPEGLRAEGWYRLKGKQRYLAFEAAPIRDA
HHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCC
EGRLIAAIQTMQDMTLRANNEEQLRGMVAAIGESEERFRRLVELSLDGIAILVGRRFVFV
CCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCEEEEE
NPAGCEMLGYRSSDELLGKEMREFIQRDSEQQFLEQATCAEETGTTAPWIEERLLRHDRT
CCCCCCEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
AVEVELGVGPFVFRGENALQVIFRDITERKLAKARLETLAHYDSLTSLPNRVLFFDRLRH
EEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
AVFEAKRYQHPMALMFLDLDSFKQVNDRLGHAAGDAVLVEAGYRLRECVRACDMVARMGG
HHHHHHHHCCCEEEEEEEHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCC
DEFTIILTKMADRRDASLVAERVLEAFALPFLVEGESAQVGVSIGICVYPDCDADLDGMV
CCEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEEEECCCCCCCHHHHH
RYADYAMYQAKQDGKNVYRFHLGG
HHHHHHHHHHHCCCCCEEEEECCC
>Mature Secondary Structure 
SRCSLKIKMSLVVFLLIGTVSSCVAGLGLLFFMREFKETVAARQFAVVSAMAGELDEKI
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAQRELVAVAMSIPPATGRDAAAMQSFLDQRLDLHQVFSDGTAFFSADGRLVAFSPGQT
HHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCCCC
PDIGDNFSKLDFLAATLRSGKALISEPFPSQRRRGHQVVMFTVPVLGGGGRMIGVLGGRV
CCCCCCHHHHHHHHHHHHCCCHHHCCCCCHHHHCCCEEEEEEEEEECCCCEEEEEECCCH
DLMEENFLSRVAHLNLQDGGEFFLFNRQRQIVAHRNHDKIGKPMPAKGMRELLDRAIDGY
HHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC
QGSGEMDNPAGSPSIYSFKRLPARGWILAAERPLSEAYAPIYRAQKLAIFSLALLLPLAL
CCCCCCCCCCCCCCCCHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITVWLFVGRLTAPLQLFAGRVREIGGDAGKYLPVLVNNNDEIGDLAQAFNAMMQELVINK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHH
RSLESEKGFAVQLLQHSAVPCFVIDAEHRVIIWNSAMEELTGVAAGAQLGQIEPWRAFYD
HHCCCCCCHHHHHHHHCCCCEEEEECCCEEEEECHHHHHHHHHHCCCCCCCCCHHHHHHH
EPRRVLADIVVAGTLYEMADLYCCYADSPLIPEGLRAEGWYRLKGKQRYLAFEAAPIRDA
HHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCC
EGRLIAAIQTMQDMTLRANNEEQLRGMVAAIGESEERFRRLVELSLDGIAILVGRRFVFV
CCCEEHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCEEEEE
NPAGCEMLGYRSSDELLGKEMREFIQRDSEQQFLEQATCAEETGTTAPWIEERLLRHDRT
CCCCCCEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
AVEVELGVGPFVFRGENALQVIFRDITERKLAKARLETLAHYDSLTSLPNRVLFFDRLRH
EEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
AVFEAKRYQHPMALMFLDLDSFKQVNDRLGHAAGDAVLVEAGYRLRECVRACDMVARMGG
HHHHHHHHCCCEEEEEEEHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHCCC
DEFTIILTKMADRRDASLVAERVLEAFALPFLVEGESAQVGVSIGICVYPDCDADLDGMV
CCEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEEEECCCCCCCHHHHH
RYADYAMYQAKQDGKNVYRFHLGG
HHHHHHHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 11728710 [H]