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The map label for this gene is kynA [H]

Identifier: 197106391

GI number: 197106391

Start: 3353179

End: 3353970

Strand: Direct

Name: kynA [H]

Synonym: PHZ_c2930

Alternate gene names: 197106391

Gene position: 3353179-3353970 (Clockwise)

Preceding gene: 197106389

Following gene: 197106392

Centisome position: 83.91

GC content: 68.43

Gene sequence:

>792_bases
ATGTCCGAACCCATGACCTATGCGCGTTACCTCGCGCTCGACGAGCTGCTCGCGGCCCAGAAGCCGCTGAGCGACCGTCA
CGACGAACTGCTGTTCATCGTCATCCACCAGACCAAGGAGCTGTGGCTCAAGGAGATCATCCACGAAGTGAACCTGGCCA
AGCGCCTGGTGGCCGCCGGCGACCTGGAGCCGGCCTACAAGGCCCTGGCGCGGGTCTCGCGCATCCAGACCATCATGACC
CTGTCGTGGGACGTGCTGGCGACCATGACGCCCGCCGACTACCTGAGCTTCCGCGGGAGCCTGGGGACCAGCTCGGGCTT
CCAGTCGCACCAGTTCCGCACGCTGGAGTACCTGCTGGGGCTGAAGGACGAGAGCTTCCTGCGCTTCCACGCCGAGCGCC
CCGAGGCCCTGGCCGAGCTGACGGCGGCGCTGGAGGCGCCCAGCCTCTACGACGTGGCCATCGCCCAGCTTCCGAAGCAC
GGCCTGCCCGTGCCCGAGACGGTGCTGAACCGCGACTTCGCCAAGGCGTACGAGGCCACGCCCTCAGTGGAGGCGGCCTG
GCTGGAGGTCTACCGCGACACGGCGAGGTACTGGGAGCTCTACCAACTGGCCGAGAAGCTGGTGGACCTGGACGACGCCC
TGGTCACCTGGCGGCACAAGCACGTGCTGACCGTCGAGCGGATCATCGGCGGGCGGCCCGGCACCGGCGGGACCGAGGGG
GTCGGCTACCTGGCCAAGACCCTGCGCCGGCGCTGCTTCCCCGAGCTGTGGTCCCTGAGGACCAGACTTTGA

Upstream 100 bases:

>100_bases
CTCTGCGGCCGGGTCGATTGCCTTAGCCCGTCTTTGTGGCGGCCTCAAGCCGTTCACGCGGCGCTTCATGCGGGGCGGGG
GCTGGCATAGGGTCCGCGCC

Downstream 100 bases:

>100_bases
CGGCTCGAAAGGACCTGTTCTCCCGCGCCCTGGCCGCAGATCCCGGGCGGCTGCACATGGCCGCCCACAGCCACCACCTG
TGGCCCGACGCCACCTACGA

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MSEPMTYARYLALDELLAAQKPLSDRHDELLFIVIHQTKELWLKEIIHEVNLAKRLVAAGDLEPAYKALARVSRIQTIMT
LSWDVLATMTPADYLSFRGSLGTSSGFQSHQFRTLEYLLGLKDESFLRFHAERPEALAELTAALEAPSLYDVAIAQLPKH
GLPVPETVLNRDFAKAYEATPSVEAAWLEVYRDTARYWELYQLAEKLVDLDDALVTWRHKHVLTVERIIGGRPGTGGTEG
VGYLAKTLRRRCFPELWSLRTRL

Sequences:

>Translated_263_residues
MSEPMTYARYLALDELLAAQKPLSDRHDELLFIVIHQTKELWLKEIIHEVNLAKRLVAAGDLEPAYKALARVSRIQTIMT
LSWDVLATMTPADYLSFRGSLGTSSGFQSHQFRTLEYLLGLKDESFLRFHAERPEALAELTAALEAPSLYDVAIAQLPKH
GLPVPETVLNRDFAKAYEATPSVEAAWLEVYRDTARYWELYQLAEKLVDLDDALVTWRHKHVLTVERIIGGRPGTGGTEG
VGYLAKTLRRRCFPELWSLRTRL
>Mature_262_residues
SEPMTYARYLALDELLAAQKPLSDRHDELLFIVIHQTKELWLKEIIHEVNLAKRLVAAGDLEPAYKALARVSRIQTIMTL
SWDVLATMTPADYLSFRGSLGTSSGFQSHQFRTLEYLLGLKDESFLRFHAERPEALAELTAALEAPSLYDVAIAQLPKHG
LPVPETVLNRDFAKAYEATPSVEAAWLEVYRDTARYWELYQLAEKLVDLDDALVTWRHKHVLTVERIIGGRPGTGGTEGV
GYLAKTLRRRCFPELWSLRTRL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=128, Percent_Identity=37.5, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17552370, Length=339, Percent_Identity=27.1386430678466, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI32564651, Length=207, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17530891, Length=143, Percent_Identity=38.4615384615385, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 29894; Mature: 29763

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPMTYARYLALDELLAAQKPLSDRHDELLFIVIHQTKELWLKEIIHEVNLAKRLVAAG
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCC
DLEPAYKALARVSRIQTIMTLSWDVLATMTPADYLSFRGSLGTSSGFQSHQFRTLEYLLG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHC
LKDESFLRFHAERPEALAELTAALEAPSLYDVAIAQLPKHGLPVPETVLNRDFAKAYEAT
CCCCHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCC
PSVEAAWLEVYRDTARYWELYQLAEKLVDLDDALVTWRHKHVLTVERIIGGRPGTGGTEG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
VGYLAKTLRRRCFPELWSLRTRL
HHHHHHHHHHHHCHHHHHHHHCC
>Mature Secondary Structure 
SEPMTYARYLALDELLAAQKPLSDRHDELLFIVIHQTKELWLKEIIHEVNLAKRLVAAG
CCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCC
DLEPAYKALARVSRIQTIMTLSWDVLATMTPADYLSFRGSLGTSSGFQSHQFRTLEYLLG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHC
LKDESFLRFHAERPEALAELTAALEAPSLYDVAIAQLPKHGLPVPETVLNRDFAKAYEAT
CCCCHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCC
PSVEAAWLEVYRDTARYWELYQLAEKLVDLDDALVTWRHKHVLTVERIIGGRPGTGGTEG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
VGYLAKTLRRRCFPELWSLRTRL
HHHHHHHHHHHHCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]