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The map label for this gene is nhaA [H]

Identifier: 197106305

GI number: 197106305

Start: 3259503

End: 3260687

Strand: Direct

Name: nhaA [H]

Synonym: PHZ_c2844

Alternate gene names: 197106305

Gene position: 3259503-3260687 (Clockwise)

Preceding gene: 197106301

Following gene: 197106309

Centisome position: 81.56

GC content: 73.92

Gene sequence:

>1185_bases
ATGGCCACGCGCTCGACGCTCGAATTCCTCAGGACGGAGACGGGATCGGGGCTGCTGCTGGCGTTCGTCGCCGCCTTCGC
GATCCTGTGGGCCAATTCGCCCTGGGCGGCCGAGTACGCCGCCTTCGTGGGCCGGGCGATCCCGGTCCGCATCGGCCCCT
TCGCCGAGACGCTCACCCTCGCCGCCTGGGTGAAGACGGCCCTGATGCCGATCTTCTTCCTGGTCATGGGCCTGAAGATC
AAACAGGAGATCGTCCGCGGCGAGCTCTCCAACCCCCGGCGGCTGGCCCTGCCCGTGCTGGCGGCCCTGGGCGGCGTGCT
CGCGCCGGCGGCCATCTTCCTGGCCGTGAACGCCGGCGAGGACGGCGTCGCCCTGGCCTGGCCGGCGGCCGTGCCCACCG
ACGCGGCCATCGCCCTGGCTCTCGTGGCGATCGCCGCCCCTCGCCTGCCCCAGCCGCTGCGGGTGTTCCTGCTGACCGTG
GCCATCATCCAGGACCTGATCAGCGTCGCGATGATCGCGGTGGTGTTCGCCGAGACGCTGCGTCCGGCGATGCTGGGCGG
GGCGCTCGCCACCTTCCTGGTGCTGGCCGCCATGGCTCGCTGGCGCGCCGCGCCCTACGCCTTCTGGACGGCGGGCTTCC
TGCTGCTCTGGGGCTTCGTGGTGAAGTCGGGCCTCGACCCGTCGGTGGCCGGGGTCCTGGCCGCCGCCGTCGTCCCGCTG
CAGCCCAAGCGCCCCGGCGGCCCGGGCGTGCTGGACCAGCTGCTGGCGGCCCTGCACCCCTACGTGGCCTTCCTGGTCCT
GCCGCTGTTCATCCTCACCGCGGCGGGCTTCTCGGTCCGCGACCTGCCGGCCGACACGCCCACCGCCCCGGTCGCCCTGG
GCCTGGGCCTGGCCCTCGTGCTCGGCAAGCAGCTCGGGGTGTTCGGGGCGGCCGCCCTGGCCATCGGCCTGAAGTGGGCC
CGCCGGCCGATGGGGGCCAAGTGGCTCGACCTCTACGGCGTCGCCGTCCTGTGCGGGGTCGGCTTCACGCTCAGCCTCTA
CATCGGCGAGCTGGCCTTCGATCCGGGCGACGCCCTCTCCCAGGCCAAGGTGCGGATCGGCGTGGTCGCCGGCTCCCTGG
CCTCGGCCCTGCTCGGCATGGCGGCGCTGGCCGTCTCCGACCGCCGCCGCCCGCCGGACGACTAA

Upstream 100 bases:

>100_bases
GCGGCGAGTCGCATGGGGGATCCTCCGGCCCGCAGCTTAGCGGGGCGGCGGCGGCAAGCTCCACCCTCGATTCCGCGCGG
CGGCCCTGTTAGGCAGGCGC

Downstream 100 bases:

>100_bases
GGCCCGCGATCTAGGCCAGGGCCGCCTTCAGCGCGTCCGCCGTCTCGCGCGCCGCCGCGGCCACCGCCGGCGAGACGTCG
GCCATGACGTAGAAGTCGTG

Product: Na+/H+ antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MATRSTLEFLRTETGSGLLLAFVAAFAILWANSPWAAEYAAFVGRAIPVRIGPFAETLTLAAWVKTALMPIFFLVMGLKI
KQEIVRGELSNPRRLALPVLAALGGVLAPAAIFLAVNAGEDGVALAWPAAVPTDAAIALALVAIAAPRLPQPLRVFLLTV
AIIQDLISVAMIAVVFAETLRPAMLGGALATFLVLAAMARWRAAPYAFWTAGFLLLWGFVVKSGLDPSVAGVLAAAVVPL
QPKRPGGPGVLDQLLAALHPYVAFLVLPLFILTAAGFSVRDLPADTPTAPVALGLGLALVLGKQLGVFGAAALAIGLKWA
RRPMGAKWLDLYGVAVLCGVGFTLSLYIGELAFDPGDALSQAKVRIGVVAGSLASALLGMAALAVSDRRRPPDD

Sequences:

>Translated_394_residues
MATRSTLEFLRTETGSGLLLAFVAAFAILWANSPWAAEYAAFVGRAIPVRIGPFAETLTLAAWVKTALMPIFFLVMGLKI
KQEIVRGELSNPRRLALPVLAALGGVLAPAAIFLAVNAGEDGVALAWPAAVPTDAAIALALVAIAAPRLPQPLRVFLLTV
AIIQDLISVAMIAVVFAETLRPAMLGGALATFLVLAAMARWRAAPYAFWTAGFLLLWGFVVKSGLDPSVAGVLAAAVVPL
QPKRPGGPGVLDQLLAALHPYVAFLVLPLFILTAAGFSVRDLPADTPTAPVALGLGLALVLGKQLGVFGAAALAIGLKWA
RRPMGAKWLDLYGVAVLCGVGFTLSLYIGELAFDPGDALSQAKVRIGVVAGSLASALLGMAALAVSDRRRPPDD
>Mature_393_residues
ATRSTLEFLRTETGSGLLLAFVAAFAILWANSPWAAEYAAFVGRAIPVRIGPFAETLTLAAWVKTALMPIFFLVMGLKIK
QEIVRGELSNPRRLALPVLAALGGVLAPAAIFLAVNAGEDGVALAWPAAVPTDAAIALALVAIAAPRLPQPLRVFLLTVA
IIQDLISVAMIAVVFAETLRPAMLGGALATFLVLAAMARWRAAPYAFWTAGFLLLWGFVVKSGLDPSVAGVLAAAVVPLQ
PKRPGGPGVLDQLLAALHPYVAFLVLPLFILTAAGFSVRDLPADTPTAPVALGLGLALVLGKQLGVFGAAALAIGLKWAR
RPMGAKWLDLYGVAVLCGVGFTLSLYIGELAFDPGDALSQAKVRIGVVAGSLASALLGMAALAVSDRRRPPDD

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=361, Percent_Identity=35.4570637119114, Blast_Score=197, Evalue=8e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 40903; Mature: 40772

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRSTLEFLRTETGSGLLLAFVAAFAILWANSPWAAEYAAFVGRAIPVRIGPFAETLTL
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEECCHHHHHHH
AAWVKTALMPIFFLVMGLKIKQEIVRGELSNPRRLALPVLAALGGVLAPAAIFLAVNAGE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCC
DGVALAWPAAVPTDAAIALALVAIAAPRLPQPLRVFLLTVAIIQDLISVAMIAVVFAETL
CCCEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPAMLGGALATFLVLAAMARWRAAPYAFWTAGFLLLWGFVVKSGLDPSVAGVLAAAVVPL
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
QPKRPGGPGVLDQLLAALHPYVAFLVLPLFILTAAGFSVRDLPADTPTAPVALGLGLALV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
LGKQLGVFGAAALAIGLKWARRPMGAKWLDLYGVAVLCGVGFTLSLYIGELAFDPGDALS
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHH
QAKVRIGVVAGSLASALLGMAALAVSDRRRPPDD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ATRSTLEFLRTETGSGLLLAFVAAFAILWANSPWAAEYAAFVGRAIPVRIGPFAETLTL
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEECCHHHHHHH
AAWVKTALMPIFFLVMGLKIKQEIVRGELSNPRRLALPVLAALGGVLAPAAIFLAVNAGE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCC
DGVALAWPAAVPTDAAIALALVAIAAPRLPQPLRVFLLTVAIIQDLISVAMIAVVFAETL
CCCEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPAMLGGALATFLVLAAMARWRAAPYAFWTAGFLLLWGFVVKSGLDPSVAGVLAAAVVPL
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
QPKRPGGPGVLDQLLAALHPYVAFLVLPLFILTAAGFSVRDLPADTPTAPVALGLGLALV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
LGKQLGVFGAAALAIGLKWARRPMGAKWLDLYGVAVLCGVGFTLSLYIGELAFDPGDALS
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHH
QAKVRIGVVAGSLASALLGMAALAVSDRRRPPDD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA