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The map label for this gene is acsA [H]

Identifier: 197106285

GI number: 197106285

Start: 3239382

End: 3241328

Strand: Direct

Name: acsA [H]

Synonym: PHZ_c2824

Alternate gene names: 197106285

Gene position: 3239382-3241328 (Clockwise)

Preceding gene: 197106284

Following gene: 197106286

Centisome position: 81.06

GC content: 71.44

Gene sequence:

>1947_bases
ATGAGCCACGACCAGTCCTTCCCGCCTCCCGCCGCCTGGGCCCGCGACGCCCTGGTGGACCGGCGGCGATACGAGGACCT
CGTGGCCCTGGAGGCCCGCGACCCCGACGCCTTCTGGCGCGAGGTGGCCGGGCGGCTCGACTGGGAGACGCCCTTCACCA
AGGTGAAGGACGTCAGCTTCGACCTTACGGACTTCCGCATCCGCTGGTTCGAGGACGGGCGGCTCAACGCGTCGGTCAAC
TGCATCGACCGGCACCTGGCGGCGCGCGGCGACCAGACGGCGATCATCTGGGAGGGGGACGATCCCGCCGCGAGCCGCCG
CATCACCTACCGCGAGCTGCACCGCCAGGTGTGCCGGATGGCCAACGTCCTCAAGCGGAGGGGCGTCCGCCGGGGCGACC
GGGTGACGATCTACCTGCCGATGATCCCGGAGGCGGCCTACGCCATGCTGGCCTGCGCCCGGATCGGCGCGATCCACTCG
GTCGTCTTCGCGGGCTTCTCGCCCGACAGCCTGGCGGGACGGATCAACGACTGCGACTCCCGCCTCGTCATCACCGCCGA
CGAAGGCGTTCGCGGCGGCAAGCGCGTCCCGCTGAAGGCGAATGTGGACGAGGCGCTGGAGCATGCGCCCGGGGTCGAGA
CCGTGCTGGTCGTCACCCGCACCGGCGTCGCCACCTCGCTGAAAGCCGGCCGCGACTTCGTCTACGAGGCCGAGGCCGCC
GAGGTCGCCGACGACTGCCCCGCCGAGGCGATGGGCGCCGAGGATCCCCTGTTCATCCTCTACACCTCGGGCTCGACGGG
CCGTCCCAAGGGCGTGCTGCACACCACCGGCGGCTATCTCGCCTGGGCTGCCTGGACCCACGAGGCGGTCTTCGACTACC
GCCCGGGCCAGGTCTACTGGTGCACCGCGGACGTGGGCTGGGTGACCGGCCACAGCTACATCGTCTACGGCCCCCTCGCG
AACGGGGCCACGACCCTGATGTTCGAGGGCGTGCCGAACTATCCCTCGCTCAGCCGCTGCTGGCAGGTGATCGACAAGCA
CCAGGTCGAGATCTTCTACACCGCCCCGACCGCCATCCGCGCCCTGATGCGCGAGGGCGAGGCGCCGGTGGCCCGCACGT
CCCGCAGGTCGCTGCGCCTGCTGGGCTCGGTGGGCGAGCCGATCAACCCCGAGGCCTGGCTCTGGTACCATCGCGTGGTG
GGCGAGCACCGCTGCCCGATCGTCGACACCTGGTGGCAGACCGAGACCGGCGGAATCCTGATCTCGCCCCTGCCCGGCGC
CACGACGCTGAAGCCCGGCTCGGCCACCCGGCCGCTGCCCGGCGTGAAGCTGGCCCTGGTGGACGCCGACGGACGGCCGC
TCGAGGGCGCGGGCGAGGGCAACCTGTGCCTGACCGACAGCTGGCCAGGCCAGATGCGCACGGTCTGGAACGACCACGAG
CGCTTCCTGCAGACCTATTTCTCCACCTATCCGGGGAAGTACTTCACCGGCGACGGCTGCCGCCGCGACGCCGACGGGGA
CTACTGGATCACCGGCCGGGTGGACGACGTGCTGAACGTCTCGGGCCACCGGCTGGGCACGGCCGAGGTGGAGAGCGCCC
TCGTCGCCCATCCGAAGGTGGCCGAGGCCGCGGTGGTCGGCTTCCCGCACGAGGTGAAGGGTCAGGGGATCTACTGCTAC
GTCACCCTCAAGGCCGGCGAGCAGCCCGGCCCGGCGCTGGAGAAGGCGCTGGTGGACTGGGTGCGGCGCGAGATCGGTCC
CATCGCCACGCCCGACGTGATCCAGTGGGCCCCCGGCCTGCCCAAGACCCGCTCGGGCAAGATCATGCGCCGCATCCTGC
GCAAGATCGCCGAGGGCGACACCGCCAACCTCGGCGACACCTCGACCCTGGCCGATCCGGGGGTGGTGGACGACCTCGTC
GCACGCAAGCGCCTCGAGCCCGCCTGA

Upstream 100 bases:

>100_bases
AGATCATGCGGGCCCGGCGCGAGCTGGAGTCCGGCGCCAAGGGCGACCTCAACCGCATCCAGGCCTTCGCCAAGTACAGC
TTCTGAGTCCGGAGTTTCCC

Downstream 100 bases:

>100_bases
GGCGCCCTTAGGGCCCCTGAGGCTCCGATCCGTTTGGGGAGAGGTGGTGCGGGCGGTCGGAATCGAACCGACATGACCGA
AGTCGCGGCATTTTGAGTGC

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 648; Mature: 647

Protein sequence:

>648_residues
MSHDQSFPPPAAWARDALVDRRRYEDLVALEARDPDAFWREVAGRLDWETPFTKVKDVSFDLTDFRIRWFEDGRLNASVN
CIDRHLAARGDQTAIIWEGDDPAASRRITYRELHRQVCRMANVLKRRGVRRGDRVTIYLPMIPEAAYAMLACARIGAIHS
VVFAGFSPDSLAGRINDCDSRLVITADEGVRGGKRVPLKANVDEALEHAPGVETVLVVTRTGVATSLKAGRDFVYEAEAA
EVADDCPAEAMGAEDPLFILYTSGSTGRPKGVLHTTGGYLAWAAWTHEAVFDYRPGQVYWCTADVGWVTGHSYIVYGPLA
NGATTLMFEGVPNYPSLSRCWQVIDKHQVEIFYTAPTAIRALMREGEAPVARTSRRSLRLLGSVGEPINPEAWLWYHRVV
GEHRCPIVDTWWQTETGGILISPLPGATTLKPGSATRPLPGVKLALVDADGRPLEGAGEGNLCLTDSWPGQMRTVWNDHE
RFLQTYFSTYPGKYFTGDGCRRDADGDYWITGRVDDVLNVSGHRLGTAEVESALVAHPKVAEAAVVGFPHEVKGQGIYCY
VTLKAGEQPGPALEKALVDWVRREIGPIATPDVIQWAPGLPKTRSGKIMRRILRKIAEGDTANLGDTSTLADPGVVDDLV
ARKRLEPA

Sequences:

>Translated_648_residues
MSHDQSFPPPAAWARDALVDRRRYEDLVALEARDPDAFWREVAGRLDWETPFTKVKDVSFDLTDFRIRWFEDGRLNASVN
CIDRHLAARGDQTAIIWEGDDPAASRRITYRELHRQVCRMANVLKRRGVRRGDRVTIYLPMIPEAAYAMLACARIGAIHS
VVFAGFSPDSLAGRINDCDSRLVITADEGVRGGKRVPLKANVDEALEHAPGVETVLVVTRTGVATSLKAGRDFVYEAEAA
EVADDCPAEAMGAEDPLFILYTSGSTGRPKGVLHTTGGYLAWAAWTHEAVFDYRPGQVYWCTADVGWVTGHSYIVYGPLA
NGATTLMFEGVPNYPSLSRCWQVIDKHQVEIFYTAPTAIRALMREGEAPVARTSRRSLRLLGSVGEPINPEAWLWYHRVV
GEHRCPIVDTWWQTETGGILISPLPGATTLKPGSATRPLPGVKLALVDADGRPLEGAGEGNLCLTDSWPGQMRTVWNDHE
RFLQTYFSTYPGKYFTGDGCRRDADGDYWITGRVDDVLNVSGHRLGTAEVESALVAHPKVAEAAVVGFPHEVKGQGIYCY
VTLKAGEQPGPALEKALVDWVRREIGPIATPDVIQWAPGLPKTRSGKIMRRILRKIAEGDTANLGDTSTLADPGVVDDLV
ARKRLEPA
>Mature_647_residues
SHDQSFPPPAAWARDALVDRRRYEDLVALEARDPDAFWREVAGRLDWETPFTKVKDVSFDLTDFRIRWFEDGRLNASVNC
IDRHLAARGDQTAIIWEGDDPAASRRITYRELHRQVCRMANVLKRRGVRRGDRVTIYLPMIPEAAYAMLACARIGAIHSV
VFAGFSPDSLAGRINDCDSRLVITADEGVRGGKRVPLKANVDEALEHAPGVETVLVVTRTGVATSLKAGRDFVYEAEAAE
VADDCPAEAMGAEDPLFILYTSGSTGRPKGVLHTTGGYLAWAAWTHEAVFDYRPGQVYWCTADVGWVTGHSYIVYGPLAN
GATTLMFEGVPNYPSLSRCWQVIDKHQVEIFYTAPTAIRALMREGEAPVARTSRRSLRLLGSVGEPINPEAWLWYHRVVG
EHRCPIVDTWWQTETGGILISPLPGATTLKPGSATRPLPGVKLALVDADGRPLEGAGEGNLCLTDSWPGQMRTVWNDHER
FLQTYFSTYPGKYFTGDGCRRDADGDYWITGRVDDVLNVSGHRLGTAEVESALVAHPKVAEAAVVGFPHEVKGQGIYCYV
TLKAGEQPGPALEKALVDWVRREIGPIATPDVIQWAPGLPKTRSGKIMRRILRKIAEGDTANLGDTSTLADPGVVDDLVA
RKRLEPA

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=673, Percent_Identity=53.1946508172363, Blast_Score=682, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=686, Percent_Identity=52.1865889212828, Blast_Score=677, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=623, Percent_Identity=51.5248796147673, Blast_Score=648, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=628, Percent_Identity=37.4203821656051, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI31982927, Length=630, Percent_Identity=24.7619047619048, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI42544132, Length=539, Percent_Identity=27.6437847866419, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI38505220, Length=533, Percent_Identity=29.0806754221388, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI122937307, Length=510, Percent_Identity=26.8627450980392, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI115511026, Length=539, Percent_Identity=27.0871985157699, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI58082049, Length=510, Percent_Identity=26.4705882352941, Blast_Score=146, Evalue=7e-35,
Organism=Homo sapiens, GI157311624, Length=510, Percent_Identity=25.6862745098039, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI157311622, Length=510, Percent_Identity=25.6862745098039, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI187761345, Length=400, Percent_Identity=29.25, Blast_Score=110, Evalue=6e-24,
Organism=Homo sapiens, GI187761343, Length=400, Percent_Identity=29.25, Blast_Score=110, Evalue=6e-24,
Organism=Homo sapiens, GI195947378, Length=435, Percent_Identity=24.8275862068966, Blast_Score=100, Evalue=8e-21,
Organism=Homo sapiens, GI42544134, Length=371, Percent_Identity=23.989218328841, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI156151445, Length=541, Percent_Identity=23.1053604436229, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1790505, Length=646, Percent_Identity=64.5510835913313, Blast_Score=870, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=637, Percent_Identity=37.9905808477237, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI221142682, Length=535, Percent_Identity=24.1121495327103, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1788107, Length=596, Percent_Identity=23.8255033557047, Blast_Score=114, Evalue=3e-26,
Organism=Escherichia coli, GI145693145, Length=528, Percent_Identity=24.2424242424242, Blast_Score=113, Evalue=4e-26,
Organism=Escherichia coli, GI1786810, Length=549, Percent_Identity=22.4043715846995, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786801, Length=446, Percent_Identity=24.4394618834081, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71983001, Length=655, Percent_Identity=50.0763358778626, Blast_Score=616, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI71982997, Length=658, Percent_Identity=49.5440729483283, Blast_Score=616, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI17569507, Length=619, Percent_Identity=21.9709208400646, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17557194, Length=567, Percent_Identity=24.1622574955908, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17538037, Length=604, Percent_Identity=23.6754966887417, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17560308, Length=545, Percent_Identity=24.0366972477064, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323182, Length=640, Percent_Identity=50.15625, Blast_Score=620, Evalue=1e-178,
Organism=Saccharomyces cerevisiae, GI6319264, Length=638, Percent_Identity=48.7460815047022, Blast_Score=591, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6319699, Length=551, Percent_Identity=23.2304900181488, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24667955, Length=660, Percent_Identity=54.2424242424242, Blast_Score=696, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=565, Percent_Identity=58.7610619469027, Blast_Score=652, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=523, Percent_Identity=58.6998087954111, Blast_Score=603, Evalue=1e-172,
Organism=Drosophila melanogaster, GI21355225, Length=626, Percent_Identity=36.4217252396166, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI18859661, Length=529, Percent_Identity=23.6294896030246, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21355181, Length=544, Percent_Identity=22.7941176470588, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24581924, Length=538, Percent_Identity=22.4907063197026, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24656500, Length=543, Percent_Identity=23.572744014733, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71380; Mature: 71248

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHDQSFPPPAAWARDALVDRRRYEDLVALEARDPDAFWREVAGRLDWETPFTKVKDVSF
CCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHCCCEE
DLTDFRIRWFEDGRLNASVNCIDRHLAARGDQTAIIWEGDDPAASRRITYRELHRQVCRM
ECEEEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHCCCHHHHHHHHHHHH
ANVLKRRGVRRGDRVTIYLPMIPEAAYAMLACARIGAIHSVVFAGFSPDSLAGRINDCDS
HHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCC
RLVITADEGVRGGKRVPLKANVDEALEHAPGVETVLVVTRTGVATSLKAGRDFVYEAEAA
EEEEEECCCCCCCCCCCEECCHHHHHHHCCCCEEEEEEEECCCHHHHHCCCCEEEECCHH
EVADDCPAEAMGAEDPLFILYTSGSTGRPKGVLHTTGGYLAWAAWTHEAVFDYRPGQVYW
HHHHCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEECCCHHEECCCCEEEE
CTADVGWVTGHSYIVYGPLANGATTLMFEGVPNYPSLSRCWQVIDKHQVEIFYTAPTAIR
EECCCCEEECCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHCCCEEEEEEECHHHHH
ALMREGEAPVARTSRRSLRLLGSVGEPINPEAWLWYHRVVGEHRCPIVDTWWQTETGGIL
HHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHCCCCCCEEECCCCCCCCCEE
ISPLPGATTLKPGSATRPLPGVKLALVDADGRPLEGAGEGNLCLTDSWPGQMRTVWNDHE
EECCCCCCEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH
RFLQTYFSTYPGKYFTGDGCRRDADGDYWITGRVDDVLNVSGHRLGTAEVESALVAHPKV
HHHHHHHHHCCCCEECCCCCCCCCCCCEEEECCCHHHHCCCCCCCCHHHHHHHHHCCCCH
AEAAVVGFPHEVKGQGIYCYVTLKAGEQPGPALEKALVDWVRREIGPIATPDVIQWAPGL
HHHEEECCCHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCC
PKTRSGKIMRRILRKIAEGDTANLGDTSTLADPGVVDDLVARKRLEPA
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
SHDQSFPPPAAWARDALVDRRRYEDLVALEARDPDAFWREVAGRLDWETPFTKVKDVSF
CCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHCCCEE
DLTDFRIRWFEDGRLNASVNCIDRHLAARGDQTAIIWEGDDPAASRRITYRELHRQVCRM
ECEEEEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHCCCHHHHHHHHHHHH
ANVLKRRGVRRGDRVTIYLPMIPEAAYAMLACARIGAIHSVVFAGFSPDSLAGRINDCDS
HHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCC
RLVITADEGVRGGKRVPLKANVDEALEHAPGVETVLVVTRTGVATSLKAGRDFVYEAEAA
EEEEEECCCCCCCCCCCEECCHHHHHHHCCCCEEEEEEEECCCHHHHHCCCCEEEECCHH
EVADDCPAEAMGAEDPLFILYTSGSTGRPKGVLHTTGGYLAWAAWTHEAVFDYRPGQVYW
HHHHCCCHHHCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEECCCHHEECCCCEEEE
CTADVGWVTGHSYIVYGPLANGATTLMFEGVPNYPSLSRCWQVIDKHQVEIFYTAPTAIR
EECCCCEEECCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHCCCEEEEEEECHHHHH
ALMREGEAPVARTSRRSLRLLGSVGEPINPEAWLWYHRVVGEHRCPIVDTWWQTETGGIL
HHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHCCCCCCEEECCCCCCCCCEE
ISPLPGATTLKPGSATRPLPGVKLALVDADGRPLEGAGEGNLCLTDSWPGQMRTVWNDHE
EECCCCCCEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHH
RFLQTYFSTYPGKYFTGDGCRRDADGDYWITGRVDDVLNVSGHRLGTAEVESALVAHPKV
HHHHHHHHHCCCCEECCCCCCCCCCCCEEEECCCHHHHCCCCCCCCHHHHHHHHHCCCCH
AEAAVVGFPHEVKGQGIYCYVTLKAGEQPGPALEKALVDWVRREIGPIATPDVIQWAPGL
HHHEEECCCHHHCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCC
PKTRSGKIMRRILRKIAEGDTANLGDTSTLADPGVVDDLVARKRLEPA
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA