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The map label for this gene is yuxL [H]

Identifier: 197106224

GI number: 197106224

Start: 3169960

End: 3171924

Strand: Direct

Name: yuxL [H]

Synonym: PHZ_c2763

Alternate gene names: 197106224

Gene position: 3169960-3171924 (Clockwise)

Preceding gene: 197106223

Following gene: 197106226

Centisome position: 79.32

GC content: 70.64

Gene sequence:

>1965_bases
TTGCGCGGCGCCCGCCGTTCGGGCCAAGGTCTCGCCAGGTTGGAGGGACTTTCCATGCATCGACGCGAACTGCTGGCGGG
CGCCGGCGCGCTTGGGCTTCTGGCGACGGCGGCGCCGACCGCAATGGCGCAGGGGCGCGCCGCCAAGACCTATCCGGTGC
GGGAGTTCTTCGAGACCACCAACTACCGGATGGCGGCGCCGGCGGGCTACGGCTTCTCGCCCGACGGCCAGCGGATCCTG
ATCTCCAGCGACGCGACGGGCGTGTTCAACGTCTACGCCCTGCCCGCGGCGGGCGGCGCGCCCCAGCCGCTGACCAACTC
CAAGACCGACGCCACCTTCGCGGCCAGCTGGTTTCCCAGCGACGAGCGGATCCTCTTCACCGCCGACCAGGGCGGCAACG
AGCTGAACCACCTCTATGTCCGCGAGCCGGACGGCAAGGTGCGGGATCTGACGCCCGGGGAGAAGCTGAAGGCCCAGTTT
CTCGGCTGGAACGCGGCGGGCGACACCTTCTACGTCGGGTCGAACGAGCGCGACCCGCAGACGTTCGACGTCTACGCCTA
TTCCGCCAAGGACTACGCCCGCCGGCTGGTGTTCCGGAACTCGGGCTACACGGTCGGCGCGATTTCGCGCGACGGCCGCC
GGGCGGCGCTGGTCAAGGCGCGCTCCAGCGCCGACAACGACCTCTACCTGGCGGACCTGGAAGGCGGCGGCGAGCCCAAG
CTGATCACGCCGCACCAGGGGAACATCGAGCACACCGTCTACGGCTTCACGCCGGACTCCCAGGCTCTCGTCTACGGAAC
GGACGAACACGGCGAGTTCACCCAGGCCTGGCGCTACGACCTGGCCGGCGGGGCCAAGACGCCGCTGATCCAGGCCGACT
GGGACGTGATGTACGTGATCCACGGCTGGAGCGGCCGCTACCGCGTGCACGCGGTGAACGCCGACGCCTCCACCGCCGTG
ACGATCACCGATGCGGCCGGGCGGCCGGTGACGCTATCGGGCGCGCCGGCGGGCGACCTGGGGAGCGTGCGTTTCAGCGG
CGACGAGCGGCGGATCGCCTTCACCGTCGCCTCGGACACCTCGCCGGCCGACGTCTTCGTGGCCGACCTGGCCGACGGCC
GGGCCCGGCGGCTGACCACGGCGCTCAATCCGGCGATCGACGAGGCGGACCTGGTGGAGGCGACCATCGCCCGCTTCGCC
AGCTACGACGGCCTGCAGATTCCGGGGGTGCTCTACCGGCCGAAGGGCGCGAGCGCGGCCAGGCCCGTCCCGGCGCTGGT
GTGGGTGCACGGCGGCCCGGGCGGCCAGAGCCGGCGCGGCTACATCGCCGAGGTGCAGAACCTCGTGAACAAGGGCTACG
CCGTCTACATGATCAACAACCGGGGCTCGTCCGGCTACGGCAAGACCTTCTACCACCTCGACGACAGGAAGCACGGGGAC
GTCGACCTGAAGGACGTGACCGCCGCGGCCCGCTGGCTGAAGTCGCTGGACTGGGTGGCCGACGACCGGATCGGCGTGAT
CGGCGGCTCATACGGCGGCTACATGGTGGCCGCGGCCCTGGCCTTCGAGCCCGAGGCCTTCGACGTGGGCATCGACATCT
TCGGGGTGACCAACTGGGTCCGGACGCTGAAGTCCATCCCGCCCTGGTGGGGCGACTTCAAGGCCGCGCTCTACGACGAA
ATGGGCGACCCGGCGACCGACGAGGCGCGGCACCGGGCGATCTCGCCGCTGTTCCACGCGAAGAACATCCGCAAGCCCCT
GCTGGTCGTGCAGGGGGCGAACGACCCGCGCGTGCTGAAGGTCGAGAGCGACGAGCTGGTGGCGGCGGTGAAGGCGAACG
GCGTGCCCGTCGAGTACGTGGTCTTCCCCGACGAGGGCCACGGCTTCCAACGCCGCGCCAACCGGATCACGGCGTCGGAA
GCCTACGTCCGCTTCCTGGACGCGCACCTGAAGGCGGGGGCCTGA

Upstream 100 bases:

>100_bases
TTCGCCCGCCCGCCGCTGGCCGGCGCCCTCGCCTCGTCCCGCGTACGCGCCATCGGCTGGCGCCAGCTCGCCGACGATTA
GCCGCCTCTCCGGCCGCAAG

Downstream 100 bases:

>100_bases
GCCGGCCCCGCGCCAAGGAACGGATCAGCGGGCGGGCCGGCTAGCCGTTGAGGAAGCCGTGCTCGCCCAGCACGCGGACC
TGGCAGGCGCGGCCCTCGTC

Product: dipeptidyl aminopeptidase/acylaminoacyl-peptidase

Products: Hydrolyzed protein [C]

Alternate protein names: NA

Number of amino acids: Translated: 654; Mature: 654

Protein sequence:

>654_residues
MRGARRSGQGLARLEGLSMHRRELLAGAGALGLLATAAPTAMAQGRAAKTYPVREFFETTNYRMAAPAGYGFSPDGQRIL
ISSDATGVFNVYALPAAGGAPQPLTNSKTDATFAASWFPSDERILFTADQGGNELNHLYVREPDGKVRDLTPGEKLKAQF
LGWNAAGDTFYVGSNERDPQTFDVYAYSAKDYARRLVFRNSGYTVGAISRDGRRAALVKARSSADNDLYLADLEGGGEPK
LITPHQGNIEHTVYGFTPDSQALVYGTDEHGEFTQAWRYDLAGGAKTPLIQADWDVMYVIHGWSGRYRVHAVNADASTAV
TITDAAGRPVTLSGAPAGDLGSVRFSGDERRIAFTVASDTSPADVFVADLADGRARRLTTALNPAIDEADLVEATIARFA
SYDGLQIPGVLYRPKGASAARPVPALVWVHGGPGGQSRRGYIAEVQNLVNKGYAVYMINNRGSSGYGKTFYHLDDRKHGD
VDLKDVTAAARWLKSLDWVADDRIGVIGGSYGGYMVAAALAFEPEAFDVGIDIFGVTNWVRTLKSIPPWWGDFKAALYDE
MGDPATDEARHRAISPLFHAKNIRKPLLVVQGANDPRVLKVESDELVAAVKANGVPVEYVVFPDEGHGFQRRANRITASE
AYVRFLDAHLKAGA

Sequences:

>Translated_654_residues
MRGARRSGQGLARLEGLSMHRRELLAGAGALGLLATAAPTAMAQGRAAKTYPVREFFETTNYRMAAPAGYGFSPDGQRIL
ISSDATGVFNVYALPAAGGAPQPLTNSKTDATFAASWFPSDERILFTADQGGNELNHLYVREPDGKVRDLTPGEKLKAQF
LGWNAAGDTFYVGSNERDPQTFDVYAYSAKDYARRLVFRNSGYTVGAISRDGRRAALVKARSSADNDLYLADLEGGGEPK
LITPHQGNIEHTVYGFTPDSQALVYGTDEHGEFTQAWRYDLAGGAKTPLIQADWDVMYVIHGWSGRYRVHAVNADASTAV
TITDAAGRPVTLSGAPAGDLGSVRFSGDERRIAFTVASDTSPADVFVADLADGRARRLTTALNPAIDEADLVEATIARFA
SYDGLQIPGVLYRPKGASAARPVPALVWVHGGPGGQSRRGYIAEVQNLVNKGYAVYMINNRGSSGYGKTFYHLDDRKHGD
VDLKDVTAAARWLKSLDWVADDRIGVIGGSYGGYMVAAALAFEPEAFDVGIDIFGVTNWVRTLKSIPPWWGDFKAALYDE
MGDPATDEARHRAISPLFHAKNIRKPLLVVQGANDPRVLKVESDELVAAVKANGVPVEYVVFPDEGHGFQRRANRITASE
AYVRFLDAHLKAGA
>Mature_654_residues
MRGARRSGQGLARLEGLSMHRRELLAGAGALGLLATAAPTAMAQGRAAKTYPVREFFETTNYRMAAPAGYGFSPDGQRIL
ISSDATGVFNVYALPAAGGAPQPLTNSKTDATFAASWFPSDERILFTADQGGNELNHLYVREPDGKVRDLTPGEKLKAQF
LGWNAAGDTFYVGSNERDPQTFDVYAYSAKDYARRLVFRNSGYTVGAISRDGRRAALVKARSSADNDLYLADLEGGGEPK
LITPHQGNIEHTVYGFTPDSQALVYGTDEHGEFTQAWRYDLAGGAKTPLIQADWDVMYVIHGWSGRYRVHAVNADASTAV
TITDAAGRPVTLSGAPAGDLGSVRFSGDERRIAFTVASDTSPADVFVADLADGRARRLTTALNPAIDEADLVEATIARFA
SYDGLQIPGVLYRPKGASAARPVPALVWVHGGPGGQSRRGYIAEVQNLVNKGYAVYMINNRGSSGYGKTFYHLDDRKHGD
VDLKDVTAAARWLKSLDWVADDRIGVIGGSYGGYMVAAALAFEPEAFDVGIDIFGVTNWVRTLKSIPPWWGDFKAALYDE
MGDPATDEARHRAISPLFHAKNIRKPLLVVQGANDPRVLKVESDELVAAVKANGVPVEYVVFPDEGHGFQRRANRITASE
AYVRFLDAHLKAGA

Specific function: Cleaves Peptide Bonds On The C-Terminal Side Of Lysyl And Argininyl Residues. [C]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI18450280, Length=335, Percent_Identity=25.6716417910448, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI37577089, Length=335, Percent_Identity=25.6716417910448, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI23510451, Length=261, Percent_Identity=25.6704980842912, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI194394146, Length=353, Percent_Identity=23.2294617563739, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI295849272, Length=272, Percent_Identity=24.2647058823529, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI85787627, Length=272, Percent_Identity=24.2647058823529, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI295842359, Length=272, Percent_Identity=24.2647058823529, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI52426756, Length=272, Percent_Identity=24.2647058823529, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI295842403, Length=272, Percent_Identity=24.2647058823529, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI16933540, Length=277, Percent_Identity=24.187725631769, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI18765694, Length=228, Percent_Identity=25, Blast_Score=67, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI25144540, Length=338, Percent_Identity=31.0650887573964, Blast_Score=172, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI25144537, Length=338, Percent_Identity=31.0650887573964, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI25144543, Length=247, Percent_Identity=27.9352226720648, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25149159, Length=296, Percent_Identity=28.0405405405405, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17552908, Length=232, Percent_Identity=25.8620689655172, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45551969, Length=250, Percent_Identity=27.2, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45550825, Length=250, Percent_Identity=27.2, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI45553511, Length=250, Percent_Identity=27.2, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24582257, Length=241, Percent_Identity=28.6307053941909, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR011659
- InterPro:   IPR001375 [H]

Pfam domain/function: PF07676 PD40; PF00326 Peptidase_S9 [H]

EC number: 3.4.21.83 [C]

Molecular weight: Translated: 70631; Mature: 70631

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGARRSGQGLARLEGLSMHRRELLAGAGALGLLATAAPTAMAQGRAAKTYPVREFFETT
CCCCCCCCCCHHHHHCCHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCCCCCCHHHHHHCC
NYRMAAPAGYGFSPDGQRILISSDATGVFNVYALPAAGGAPQPLTNSKTDATFAASWFPS
CEEEECCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCC
DERILFTADQGGNELNHLYVREPDGKVRDLTPGEKLKAQFLGWNAAGDTFYVGSNERDPQ
CCEEEEEECCCCCCCCEEEEECCCCCEECCCCCHHHEEEEEEEECCCCEEEECCCCCCCC
TFDVYAYSAKDYARRLVFRNSGYTVGAISRDGRRAALVKARSSADNDLYLADLEGGGEPK
EEEEEEECHHHHHHHHEEECCCCEEEEECCCCCEEEEEEECCCCCCCEEEEECCCCCCCC
LITPHQGNIEHTVYGFTPDSQALVYGTDEHGEFTQAWRYDLAGGAKTPLIQADWDVMYVI
EECCCCCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCEEEECCCEEEEE
HGWSGRYRVHAVNADASTAVTITDAAGRPVTLSGAPAGDLGSVRFSGDERRIAFTVASDT
ECCCCEEEEEEECCCCCEEEEEEECCCCEEEECCCCCCCCCCEEECCCCEEEEEEEECCC
SPADVFVADLADGRARRLTTALNPAIDEADLVEATIARFASYDGLQIPGVLYRPKGASAA
CCCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEECCCEEECCCCCCCC
RPVPALVWVHGGPGGQSRRGYIAEVQNLVNKGYAVYMINNRGSSGYGKTFYHLDDRKHGD
CCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCEEEEECCCCCCC
VDLKDVTAAARWLKSLDWVADDRIGVIGGSYGGYMVAAALAFEPEAFDVGIDIFGVTNWV
CCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEEEECCCEEEECEEEEEHHHHH
RTLKSIPPWWGDFKAALYDEMGDPATDEARHRAISPLFHAKNIRKPLLVVQGANDPRVLK
HHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEE
VESDELVAAVKANGVPVEYVVFPDEGHGFQRRANRITASEAYVRFLDAHLKAGA
ECCCCEEEEEECCCCEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRGARRSGQGLARLEGLSMHRRELLAGAGALGLLATAAPTAMAQGRAAKTYPVREFFETT
CCCCCCCCCCHHHHHCCHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCCCCCCHHHHHHCC
NYRMAAPAGYGFSPDGQRILISSDATGVFNVYALPAAGGAPQPLTNSKTDATFAASWFPS
CEEEECCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCC
DERILFTADQGGNELNHLYVREPDGKVRDLTPGEKLKAQFLGWNAAGDTFYVGSNERDPQ
CCEEEEEECCCCCCCCEEEEECCCCCEECCCCCHHHEEEEEEEECCCCEEEECCCCCCCC
TFDVYAYSAKDYARRLVFRNSGYTVGAISRDGRRAALVKARSSADNDLYLADLEGGGEPK
EEEEEEECHHHHHHHHEEECCCCEEEEECCCCCEEEEEEECCCCCCCEEEEECCCCCCCC
LITPHQGNIEHTVYGFTPDSQALVYGTDEHGEFTQAWRYDLAGGAKTPLIQADWDVMYVI
EECCCCCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCEEEECCCEEEEE
HGWSGRYRVHAVNADASTAVTITDAAGRPVTLSGAPAGDLGSVRFSGDERRIAFTVASDT
ECCCCEEEEEEECCCCCEEEEEEECCCCEEEECCCCCCCCCCEEECCCCEEEEEEEECCC
SPADVFVADLADGRARRLTTALNPAIDEADLVEATIARFASYDGLQIPGVLYRPKGASAA
CCCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEECCCEEECCCCCCCC
RPVPALVWVHGGPGGQSRRGYIAEVQNLVNKGYAVYMINNRGSSGYGKTFYHLDDRKHGD
CCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCEEEEECCCCCCC
VDLKDVTAAARWLKSLDWVADDRIGVIGGSYGGYMVAAALAFEPEAFDVGIDIFGVTNWV
CCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEEEECCCEEEECEEEEEHHHHH
RTLKSIPPWWGDFKAALYDEMGDPATDEARHRAISPLFHAKNIRKPLLVVQGANDPRVLK
HHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEE
VESDELVAAVKANGVPVEYVVFPDEGHGFQRRANRITASEAYVRFLDAHLKAGA
ECCCCEEEEEECCCCEEEEEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): 11820 [C]

Specific activity: NA

Km value (mM): 0.23 {tosyl-Arg} 0.92 {benzoyl-Lys} 0.6 {N-benzoyl-Arg} 0.47 {tosyl-Lys-methyl} 0.33 {N-benzyloxycarbonyl-Lys} 0.31 {N-benzyloxycarbonyl-Lys} 0.5 {benzoyl-Arg} 0.48 {benzoyl-Arg} 0.25 {benzoyl-Arg} 80 {acetyl-tyrosine} [C]

Substrates: Protein; H2O [C]

Specific reaction: Protein + H2O = hydrolyzed protein [C]

General reaction: Peptide bond hydrolysis [C]

Inhibitor: Antipain; Aromaticamidines; Benzamidine; Co2+; DFP; Fe2+; Hg2+; L-Arginine; Leupeptin sulfhydryl agents, trypsin inhibitors, 1, 10-phenanthroline; p-Aminobenzamidine; Tosyl -Leuchloromethyl ketone; Zn2+ [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 3098560 [H]