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The map label for this gene is nadB [H]

Identifier: 197106069

GI number: 197106069

Start: 2998346

End: 2999866

Strand: Direct

Name: nadB [H]

Synonym: PHZ_c2608

Alternate gene names: 197106069

Gene position: 2998346-2999866 (Clockwise)

Preceding gene: 197106068

Following gene: 197106070

Centisome position: 75.03

GC content: 77.32

Gene sequence:

>1521_bases
ATGGCCGACCGCATCCGCCACGACGGGATCCTCGTCGTGGGCGCGGGCCTGGCCGGGCTGACGGCGGCGATGGCCGCCGC
GCCCGCGAGGGCGCTGGTGCTCACCGAGGCTCCCCTGAACAGCGGCTGCTCGTCGGCCTGGGCGCAGGGCGGCATGGCCG
CGGCGCTCTCGCCGGACGACGCCCCCGAACTGCACGCCGCCGACACCGTGGCCGCCGGCGCCGGCCTCGTGGACGCCGCC
ATGGCTCGCCTGCTGGCCGAGGAAGGTCCCGCCGCCGTCCACGTCCTGGCGGCGCTGGGCGCGCCGTTCGACCGCGCGGC
GGACGGCGCGTTCGTCCAGAGCCTGGAGGCCGCCCACGGCCGCGCCCGCGTCGCGCGGGTGAAGGGCGACCAGGCCGGCA
AGGCGATCATGCAGGCGGTCAGCGTCGCCGCCCTCGCCGCCCCCACCGTCCAGGTCCGCACCGGCGCGCGGCTCACCGGC
CTCCTGCAGGACGCGGGCGGCCGCATCCGTGGCGTGGTGGCCGAGCTGGACGGACGCCCGACCGAGATCCTCGCCGACGC
GGTCGTGCTGGCCACCGGCGGGATCGGCGGCCTCTACGCCGTGACCACCACCCCGGCCGAGCTGAAGGGCGAGGGTCTGG
GCCTGGCCGCCATGGCCGGCGCGGCGATCGCGGACCCCGAGTTCGTCCAGTTCCACCCGACGGCCATCGACATCGCCCGC
GACCCCGCTCCGCTCGCCACCGAGGCGCTGCGCGGCGAAGGCGCGGTGCTGGTGAACAGCGCGGGCGAGCGCTTCATGAC
CCGCTACCATCCGGCGGGCGAGCTGGCGCCGCGCGACGTGGTGGCCCGCGCCATCCACGCCGAGCGCGAGGCTGGCCGCG
GGGCCTTCCTGGACGCGCGCGAGGCGGTGGGCGCCCACTTCCCCGACGAGTTTCCGACGGTGTTCGCCGCCTGCCTCTCG
GGCGGGATCGACCCGCGCAAGCAGCTGATTCCCGTCGCTCCGGCCTGCCACTACCACATGGGCGGGATCGCCACCGACGC
CGACGGGCGCACCAGCCTTCCCGGGCTCTTCGCCGCGGGCGAATGCGCCTCGACGGGCGTTCACGGCGCCAACCGCCTGG
CGTCCAACTCGCTCCTGGAGGCGGCCGTCTTCGGCGCCCGCGCCGGCCGTGCGGCCGCGGCCGAGCCCAAGGCCGCCGGC
GCCTGCCGGGCGATCATGGGCGCCGAGCTTCCGGCGAAGGCCCTCAAGACCTTGCGCGAGGCCATGAGCCGCGAGGCGGG
GGTGATCCGCGACGAAGCGGGACTTTCGCGCCTCCTGGCCCGGATCGATGCGCTGGAGGCCGCGCACGGTCGCAGCGCCG
CCCTGGTCGCCGCCCGGCTGGTGGCCGCCGGCGCCCTGGCCCGCCGCGAGAGCCGCGGCGGCCACTTCCGCGAGGACTTC
CCCCTGTCCGGCGAGGCCCGCCGCACCCTGGCGACCCTGGCCGACGTGGAGGGCGCGGCCTTGAGGTTCGCCGCCGAATG
A

Upstream 100 bases:

>100_bases
CCACCACGTCGACGTGGAGCTGATCTGATGGCCCTGCTCCGCCAAGGCTGCGCAGGGCATGGCCCCGATCCTTCGAAGCG
CCCGAAGGGAGCGAACTAGG

Downstream 100 bases:

>100_bases
TCGAGCCGCTTCCCGACCTGCTGGTCCAGCCCATCGTCCGCGCCGCGCTCGCCGAAGACCTCGGCCGCGCCGGCGACGTC
ACCGCCCAGGCGTGCGTGCC

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO; Quinolinate synthase B [H]

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MADRIRHDGILVVGAGLAGLTAAMAAAPARALVLTEAPLNSGCSSAWAQGGMAAALSPDDAPELHAADTVAAGAGLVDAA
MARLLAEEGPAAVHVLAALGAPFDRAADGAFVQSLEAAHGRARVARVKGDQAGKAIMQAVSVAALAAPTVQVRTGARLTG
LLQDAGGRIRGVVAELDGRPTEILADAVVLATGGIGGLYAVTTTPAELKGEGLGLAAMAGAAIADPEFVQFHPTAIDIAR
DPAPLATEALRGEGAVLVNSAGERFMTRYHPAGELAPRDVVARAIHAEREAGRGAFLDAREAVGAHFPDEFPTVFAACLS
GGIDPRKQLIPVAPACHYHMGGIATDADGRTSLPGLFAAGECASTGVHGANRLASNSLLEAAVFGARAGRAAAAEPKAAG
ACRAIMGAELPAKALKTLREAMSREAGVIRDEAGLSRLLARIDALEAAHGRSAALVAARLVAAGALARRESRGGHFREDF
PLSGEARRTLATLADVEGAALRFAAE

Sequences:

>Translated_506_residues
MADRIRHDGILVVGAGLAGLTAAMAAAPARALVLTEAPLNSGCSSAWAQGGMAAALSPDDAPELHAADTVAAGAGLVDAA
MARLLAEEGPAAVHVLAALGAPFDRAADGAFVQSLEAAHGRARVARVKGDQAGKAIMQAVSVAALAAPTVQVRTGARLTG
LLQDAGGRIRGVVAELDGRPTEILADAVVLATGGIGGLYAVTTTPAELKGEGLGLAAMAGAAIADPEFVQFHPTAIDIAR
DPAPLATEALRGEGAVLVNSAGERFMTRYHPAGELAPRDVVARAIHAEREAGRGAFLDAREAVGAHFPDEFPTVFAACLS
GGIDPRKQLIPVAPACHYHMGGIATDADGRTSLPGLFAAGECASTGVHGANRLASNSLLEAAVFGARAGRAAAAEPKAAG
ACRAIMGAELPAKALKTLREAMSREAGVIRDEAGLSRLLARIDALEAAHGRSAALVAARLVAAGALARRESRGGHFREDF
PLSGEARRTLATLADVEGAALRFAAE
>Mature_505_residues
ADRIRHDGILVVGAGLAGLTAAMAAAPARALVLTEAPLNSGCSSAWAQGGMAAALSPDDAPELHAADTVAAGAGLVDAAM
ARLLAEEGPAAVHVLAALGAPFDRAADGAFVQSLEAAHGRARVARVKGDQAGKAIMQAVSVAALAAPTVQVRTGARLTGL
LQDAGGRIRGVVAELDGRPTEILADAVVLATGGIGGLYAVTTTPAELKGEGLGLAAMAGAAIADPEFVQFHPTAIDIARD
PAPLATEALRGEGAVLVNSAGERFMTRYHPAGELAPRDVVARAIHAEREAGRGAFLDAREAVGAHFPDEFPTVFAACLSG
GIDPRKQLIPVAPACHYHMGGIATDADGRTSLPGLFAAGECASTGVHGANRLASNSLLEAAVFGARAGRAAAAEPKAAGA
CRAIMGAELPAKALKTLREAMSREAGVIRDEAGLSRLLARIDALEAAHGRSAALVAARLVAAGALARRESRGGHFREDFP
LSGEARRTLATLADVEGAALRFAAE

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=526, Percent_Identity=33.0798479087452, Blast_Score=199, Evalue=4e-51,
Organism=Escherichia coli, GI1788928, Length=512, Percent_Identity=34.9609375, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1790597, Length=516, Percent_Identity=32.7519379844961, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1786942, Length=507, Percent_Identity=34.5167652859961, Blast_Score=191, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI17550100, Length=504, Percent_Identity=33.3333333333333, Blast_Score=195, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17505833, Length=524, Percent_Identity=32.0610687022901, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71986328, Length=290, Percent_Identity=28.2758620689655, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322701, Length=521, Percent_Identity=32.2456813819578, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6322416, Length=526, Percent_Identity=31.5589353612167, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6320788, Length=482, Percent_Identity=26.9709543568465, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322511, Length=312, Percent_Identity=26.6025641025641, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17137288, Length=523, Percent_Identity=32.6959847036329, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24655642, Length=523, Percent_Identity=32.6959847036329, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24655647, Length=523, Percent_Identity=32.6959847036329, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24663005, Length=526, Percent_Identity=30.6083650190114, Blast_Score=171, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 51037; Mature: 50905

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADRIRHDGILVVGAGLAGLTAAMAAAPARALVLTEAPLNSGCSSAWAQGGMAAALSPDD
CCCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHCCCEEEECCCCC
APELHAADTVAAGAGLVDAAMARLLAEEGPAAVHVLAALGAPFDRAADGAFVQSLEAAHG
CCCCCCHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHCCCHHHHHHHHHHCC
RARVARVKGDQAGKAIMQAVSVAALAAPTVQVRTGARLTGLLQDAGGRIRGVVAELDGRP
HHEEEECCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCEEEEEEECCCCC
TEILADAVVLATGGIGGLYAVTTTPAELKGEGLGLAAMAGAAIADPEFVQFHPTAIDIAR
HHHHHHHHHEEECCCCCEEEEECCCHHHCCCCCCHHHHCCCCCCCCCCEEECCCEEECCC
DPAPLATEALRGEGAVLVNSAGERFMTRYHPAGELAPRDVVARAIHAEREAGRGAFLDAR
CCCCHHHHHHCCCCEEEEECCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEHH
EAVGAHFPDEFPTVFAACLSGGIDPRKQLIPVAPACHYHMGGIATDADGRTSLPGLFAAG
HHHCCCCCCHHHHHHHHHHHCCCCCHHHEECCCCCHHHHCCCEEECCCCCCCCCCCEECC
ECASTGVHGANRLASNSLLEAAVFGARAGRAAAAEPKAAGACRAIMGAELPAKALKTLRE
CHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHH
AMSREAGVIRDEAGLSRLLARIDALEAAHGRSAALVAARLVAAGALARRESRGGHFREDF
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PLSGEARRTLATLADVEGAALRFAAE
CCCCHHHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure 
ADRIRHDGILVVGAGLAGLTAAMAAAPARALVLTEAPLNSGCSSAWAQGGMAAALSPDD
CCCCCCCCEEEEECCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHCCCEEEECCCCC
APELHAADTVAAGAGLVDAAMARLLAEEGPAAVHVLAALGAPFDRAADGAFVQSLEAAHG
CCCCCCHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHCCCHHHHHHHHHHCC
RARVARVKGDQAGKAIMQAVSVAALAAPTVQVRTGARLTGLLQDAGGRIRGVVAELDGRP
HHEEEECCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCEEEEEEECCCCC
TEILADAVVLATGGIGGLYAVTTTPAELKGEGLGLAAMAGAAIADPEFVQFHPTAIDIAR
HHHHHHHHHEEECCCCCEEEEECCCHHHCCCCCCHHHHCCCCCCCCCCEEECCCEEECCC
DPAPLATEALRGEGAVLVNSAGERFMTRYHPAGELAPRDVVARAIHAEREAGRGAFLDAR
CCCCHHHHHHCCCCEEEEECCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEHH
EAVGAHFPDEFPTVFAACLSGGIDPRKQLIPVAPACHYHMGGIATDADGRTSLPGLFAAG
HHHCCCCCCHHHHHHHHHHHCCCCCHHHEECCCCCHHHHCCCEEECCCCCCCCCCCEECC
ECASTGVHGANRLASNSLLEAAVFGARAGRAAAAEPKAAGACRAIMGAELPAKALKTLRE
CHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHH
AMSREAGVIRDEAGLSRLLARIDALEAAHGRSAALVAARLVAAGALARRESRGGHFREDF
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PLSGEARRTLATLADVEGAALRFAAE
CCCCHHHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]