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The map label for this gene is yngJ [H]

Identifier: 197105985

GI number: 197105985

Start: 2897329

End: 2898474

Strand: Reverse

Name: yngJ [H]

Synonym: PHZ_c2524

Alternate gene names: 197105985

Gene position: 2898474-2897329 (Counterclockwise)

Preceding gene: 197105986

Following gene: 197105984

Centisome position: 72.53

GC content: 70.42

Gene sequence:

>1146_bases
ATGGACGCGGACACCCTGGGACAGTTCCGCGAGACGGTTTGGCGCTACGTCCGCGAGAAGCTCGTTCCGCTGGAGGCCGA
GGTCGCCGAGCGTGACGAGGTTCCCGAGCGCGTGCTCGCCGACTTCCGGGAGATGGGCCTCTACGGGCTGACGATCCCGG
AGGAATACGGCGGCCTCGGCCTCTCGGTCGCGGAAGAGGTCGAGGTCGTCGCCGAACTCGCCTGGGCGTCGGCAGCGTTC
CGCTCCGCGGTGAGCATGAACCTCGGGGTGGGCTCGCAAGGCATCGTTATGGACGGGACCGAAGCGCAGAAGCGCGAATG
GCTGCCGAGGCTGGCCGCCGGCGCCGTCGCGAGCTTCGCGCTGACCGAGCCGGGCTCGGGCTCCGACAGCGCCGGCCTCG
TGACCCGGGCGGTGCGCGACGGCGACCACTATGTCCTCAACGGCTCCAAGCGCTACATCACCAACGCGCCCACGGCGGAC
CTCATCACGGTCATGGCCCGGACCCATTCGGACCGTCTGCCGAAGAACGCGCACGTCACGGCCTTCCTGGTCCCCGCCGA
CACCCCCGGCGTGACGATCGGTCCGAAGGACCGGAAGATGGGGCAGGCGGGCGCGTGGTCGGCGGACGTCTATCTCCAGG
ACGTGCGCGTGCCCGCCGCCAACGTCCTGGGCGGCGTCGAGGGGCGGGGCTTCGCCACCGCCATGAAGGTGCTCGACCGC
GGCCGGCTCAATGTGACGGCCGCGTGCGTCGGTCAGGCCCGGCGCATCCTCCACGAAGCGCTCGCCTATGCACGTGAACG
TCAGCAGTTCGGCCAGGCGATCGCCGGCTTCCAGCTCGTCCAGGCCATGCTCGCGGACAGCCAGGCCGAACTCTACGCGG
CGGAGAGCATGCTGCGCGACGCCGCCCGCCGATACGACGCGGGGCAGCGGATCTCGCTCGAGGCCTCGTGCTGCAAGATG
TTCGCCGCCGAGATGGTCGGGCGCATCGCCGACCGGGCTGTGCAGATCCACGGCGGCGCCGGATACATGCGCGACACGCC
CGTCGAGCGGTTCTACCGCGACGTTCGCCTGTTCCGGATCTACGAGGGCACCACCCAGATCCAGCAGCTGGTCATCGCGC
GCGAGATGCTGCGGCGGGCCGCATGA

Upstream 100 bases:

>100_bases
AGCGCAAGGACCCGCCCTCGCTGGCGCTTTCCCACAACCTCGGCGGCATGCCGAGCCAGAACGTCAGCGCGGTGGCCATC
GTGGGCCTGGAAGGCGCCTG

Downstream 100 bases:

>100_bases
GCCTGCGCGACGTCATGGTCCATCCGGGTCCGAGGAGGGGAGTGCGATGAGCCGAGGGACCGACACGCTCGACTCGATCG
TGCGCGGCGAGGCGAGGCCC

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MDADTLGQFRETVWRYVREKLVPLEAEVAERDEVPERVLADFREMGLYGLTIPEEYGGLGLSVAEEVEVVAELAWASAAF
RSAVSMNLGVGSQGIVMDGTEAQKREWLPRLAAGAVASFALTEPGSGSDSAGLVTRAVRDGDHYVLNGSKRYITNAPTAD
LITVMARTHSDRLPKNAHVTAFLVPADTPGVTIGPKDRKMGQAGAWSADVYLQDVRVPAANVLGGVEGRGFATAMKVLDR
GRLNVTAACVGQARRILHEALAYARERQQFGQAIAGFQLVQAMLADSQAELYAAESMLRDAARRYDAGQRISLEASCCKM
FAAEMVGRIADRAVQIHGGAGYMRDTPVERFYRDVRLFRIYEGTTQIQQLVIAREMLRRAA

Sequences:

>Translated_381_residues
MDADTLGQFRETVWRYVREKLVPLEAEVAERDEVPERVLADFREMGLYGLTIPEEYGGLGLSVAEEVEVVAELAWASAAF
RSAVSMNLGVGSQGIVMDGTEAQKREWLPRLAAGAVASFALTEPGSGSDSAGLVTRAVRDGDHYVLNGSKRYITNAPTAD
LITVMARTHSDRLPKNAHVTAFLVPADTPGVTIGPKDRKMGQAGAWSADVYLQDVRVPAANVLGGVEGRGFATAMKVLDR
GRLNVTAACVGQARRILHEALAYARERQQFGQAIAGFQLVQAMLADSQAELYAAESMLRDAARRYDAGQRISLEASCCKM
FAAEMVGRIADRAVQIHGGAGYMRDTPVERFYRDVRLFRIYEGTTQIQQLVIAREMLRRAA
>Mature_381_residues
MDADTLGQFRETVWRYVREKLVPLEAEVAERDEVPERVLADFREMGLYGLTIPEEYGGLGLSVAEEVEVVAELAWASAAF
RSAVSMNLGVGSQGIVMDGTEAQKREWLPRLAAGAVASFALTEPGSGSDSAGLVTRAVRDGDHYVLNGSKRYITNAPTAD
LITVMARTHSDRLPKNAHVTAFLVPADTPGVTIGPKDRKMGQAGAWSADVYLQDVRVPAANVLGGVEGRGFATAMKVLDR
GRLNVTAACVGQARRILHEALAYARERQQFGQAIAGFQLVQAMLADSQAELYAAESMLRDAARRYDAGQRISLEASCCKM
FAAEMVGRIADRAVQIHGGAGYMRDTPVERFYRDVRLFRIYEGTTQIQQLVIAREMLRRAA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557231, Length=374, Percent_Identity=37.9679144385027, Blast_Score=258, Evalue=5e-69,
Organism=Homo sapiens, GI187960098, Length=374, Percent_Identity=37.9679144385027, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI76496475, Length=375, Percent_Identity=38.4, Blast_Score=241, Evalue=9e-64,
Organism=Homo sapiens, GI4557235, Length=375, Percent_Identity=38.4, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI4501859, Length=367, Percent_Identity=35.9673024523161, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI21361497, Length=387, Percent_Identity=35.6589147286822, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI226958412, Length=370, Percent_Identity=33.2432432432432, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=36.1702127659575, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI226958414, Length=332, Percent_Identity=34.6385542168675, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI7656849, Length=381, Percent_Identity=33.0708661417323, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI4501857, Length=371, Percent_Identity=32.0754716981132, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI4503943, Length=376, Percent_Identity=31.1170212765957, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI38505218, Length=413, Percent_Identity=28.5714285714286, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI7669494, Length=364, Percent_Identity=30.7692307692308, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI211971008, Length=393, Percent_Identity=29.2620865139949, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI48976061, Length=393, Percent_Identity=29.2620865139949, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI1786223, Length=353, Percent_Identity=32.2946175637394, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI87081958, Length=344, Percent_Identity=31.6860465116279, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI87081702, Length=334, Percent_Identity=26.6467065868263, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082384, Length=280, Percent_Identity=25.7142857142857, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=38.3202099737533, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17569725, Length=377, Percent_Identity=37.9310344827586, Blast_Score=251, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17570075, Length=378, Percent_Identity=39.1534391534392, Blast_Score=251, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71985184, Length=365, Percent_Identity=37.2602739726027, Blast_Score=245, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI17508101, Length=363, Percent_Identity=35.5371900826446, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17506239, Length=366, Percent_Identity=33.6065573770492, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17538396, Length=373, Percent_Identity=31.9034852546917, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI71985192, Length=312, Percent_Identity=35.5769230769231, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17533517, Length=372, Percent_Identity=30.1075268817204, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI71990804, Length=291, Percent_Identity=34.020618556701, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17551932, Length=375, Percent_Identity=28.8, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=28.2666666666667, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=34.4827586206897, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71982178, Length=267, Percent_Identity=33.7078651685393, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17534353, Length=362, Percent_Identity=27.9005524861878, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17531909, Length=240, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17562446, Length=362, Percent_Identity=29.0055248618785, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17531913, Length=178, Percent_Identity=29.7752808988764, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=274, Percent_Identity=27.7372262773723, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI86563381, Length=274, Percent_Identity=27.7372262773723, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24660351, Length=375, Percent_Identity=40.5333333333333, Blast_Score=264, Evalue=6e-71,
Organism=Drosophila melanogaster, GI281363737, Length=337, Percent_Identity=40.9495548961424, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24666513, Length=367, Percent_Identity=35.4223433242507, Blast_Score=222, Evalue=3e-58,
Organism=Drosophila melanogaster, GI21355753, Length=372, Percent_Identity=33.3333333333333, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI21356377, Length=348, Percent_Identity=36.4942528735632, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=36.8, Blast_Score=212, Evalue=4e-55,
Organism=Drosophila melanogaster, GI19920834, Length=382, Percent_Identity=29.8429319371728, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24652780, Length=352, Percent_Identity=24.1477272727273, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41543; Mature: 41543

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDADTLGQFRETVWRYVREKLVPLEAEVAERDEVPERVLADFREMGLYGLTIPEEYGGLG
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCEEECCCCHHHCCCC
LSVAEEVEVVAELAWASAAFRSAVSMNLGVGSQGIVMDGTEAQKREWLPRLAAGAVASFA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHE
LTEPGSGSDSAGLVTRAVRDGDHYVLNGSKRYITNAPTADLITVMARTHSDRLPKNAHVT
ECCCCCCCCCCHHHHHHHHCCCEEEECCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCEE
AFLVPADTPGVTIGPKDRKMGQAGAWSADVYLQDVRVPAANVLGGVEGRGFATAMKVLDR
EEEEECCCCCCEECCCCCCCCCCCCCCHHEEEEECCCCHHHHHCCCCCCHHHHHHHHHHC
GRLNVTAACVGQARRILHEALAYARERQQFGQAIAGFQLVQAMLADSQAELYAAESMLRD
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
AARRYDAGQRISLEASCCKMFAAEMVGRIADRAVQIHGGAGYMRDTPVERFYRDVRLFRI
HHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHEE
YEGTTQIQQLVIAREMLRRAA
ECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDADTLGQFRETVWRYVREKLVPLEAEVAERDEVPERVLADFREMGLYGLTIPEEYGGLG
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCEEECCCCHHHCCCC
LSVAEEVEVVAELAWASAAFRSAVSMNLGVGSQGIVMDGTEAQKREWLPRLAAGAVASFA
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHE
LTEPGSGSDSAGLVTRAVRDGDHYVLNGSKRYITNAPTADLITVMARTHSDRLPKNAHVT
ECCCCCCCCCCHHHHHHHHCCCEEEECCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCEE
AFLVPADTPGVTIGPKDRKMGQAGAWSADVYLQDVRVPAANVLGGVEGRGFATAMKVLDR
EEEEECCCCCCEECCCCCCCCCCCCCCHHEEEEECCCCHHHHHCCCCCCHHHHHHHHHHC
GRLNVTAACVGQARRILHEALAYARERQQFGQAIAGFQLVQAMLADSQAELYAAESMLRD
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
AARRYDAGQRISLEASCCKMFAAEMVGRIADRAVQIHGGAGYMRDTPVERFYRDVRLFRI
HHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHEE
YEGTTQIQQLVIAREMLRRAA
ECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]