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The map label for this gene is 197105986

Identifier: 197105986

GI number: 197105986

Start: 2898474

End: 2899679

Strand: Reverse

Name: 197105986

Synonym: PHZ_c2525

Alternate gene names: NA

Gene position: 2899679-2898474 (Counterclockwise)

Preceding gene: 197105987

Following gene: 197105985

Centisome position: 72.56

GC content: 69.32

Gene sequence:

>1206_bases
ATGGCGAGCGGCATCAAGGACCGGGTTGCGATCCTGGGTATGGGCTGCGCCCGCTTCGGTGAGCGCTGGAACGACGACGC
CGAGACCCTGATGGTGGAGGCCTTCGACGAGGCCATCGCCGATGCGGGCATCGACGTTTCCCAGATCGACGCGGCGTGGC
TGTCCGTGGGCTTCGACGCCCAGAACATCGGCCCCAGCGGCATCCCGCTGGCGATGGCGCTGAGGTTGCCGAACATCGGG
GTGACCAAGGTCGAGAACTACTGCGCCTCGGGCACCGACGGCTTCCGTGGCGCGGTCTACGCCGTGGCCTCGGGGGCCTG
CGACATCGCGCTGGCTGTTGGCGTCGAGAAGCTGAAGGACACCGGATACGGCGGCCTGCCCGTGCGCACCCGGGGCACGA
CCTACGACATGGTCAATGTGACGGGCTCTGCGCCGGGCTTCTTCGCCCAGCTGGCCGGCGCCTACCGGGCCAAGCACGGC
GTCGGCTACGACGACCTGAAGCGGGCCATGGCCCACGTCTCGGTGAAGAGCCACGCGAACGGCGCCAGGAACCCCAAGGC
GCACCTGCGCAAGCCGATCACCGAGGAGCAGGCGCTCAACGCGCCGATGATCGCCGCGCCGCTGGGCCTCTTCGACTGCT
GCGGCGTGTCGGACGGCGCGGCCTGCGCCATCGTGACGACGCCCGAGATCGCCCGGGCGCTCGGCAAGACCGACCTCGTG
ACCGTCAAGGCGCTGCAGATTTCCACCTCCAACGGCTGGGAGCTGCAGGGCGGCGGCTGGGACGGCAGCTACTTCCACAC
CACGCGGATCGCGGCCCAGAAGGCCTATGCCGAAGCCGGCGTCACCGACCCGCGCAAGCAGCTGTCCCTGACGGAGGTGC
ACGACTGCTTCTCGGTCACCGAGCTGGTGACGATGGAGGACCTGGGGCTCTCCGCGGAGGGCGAGGCCTGGAAGGACGTG
CTGGACGGGGTGTTCGACGCCGACGGCCAGATTCCCTGCCAGATCGACGGCGGCCTGAAGTGCTTCGGCCACCCCATCGG
CGCCTCGGGTCTTCGGATGATCTACGAGAACTATCTGCAGCTGCTTGGCCGCGCCGGCGAACGCCAGCGCAAGGACCCGC
CCTCGCTGGCGCTTTCCCACAACCTCGGCGGCATGCCGAGCCAGAACGTCAGCGCGGTGGCCATCGTGGGCCTGGAAGGC
GCCTGA

Upstream 100 bases:

>100_bases
TCGACGATCGGCGGGGCTTCACGAAGTACTTCTGGAAAGCGGTCCCGGACTACCTGGCGGGCAACCCCGCGCAGCTGGCG
GCGGAATAGGAGCGAAGGTC

Downstream 100 bases:

>100_bases
TGGACGCGGACACCCTGGGACAGTTCCGCGAGACGGTTTGGCGCTACGTCCGCGAGAAGCTCGTTCCGCTGGAGGCCGAG
GTCGCCGAGCGTGACGAGGT

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MASGIKDRVAILGMGCARFGERWNDDAETLMVEAFDEAIADAGIDVSQIDAAWLSVGFDAQNIGPSGIPLAMALRLPNIG
VTKVENYCASGTDGFRGAVYAVASGACDIALAVGVEKLKDTGYGGLPVRTRGTTYDMVNVTGSAPGFFAQLAGAYRAKHG
VGYDDLKRAMAHVSVKSHANGARNPKAHLRKPITEEQALNAPMIAAPLGLFDCCGVSDGAACAIVTTPEIARALGKTDLV
TVKALQISTSNGWELQGGGWDGSYFHTTRIAAQKAYAEAGVTDPRKQLSLTEVHDCFSVTELVTMEDLGLSAEGEAWKDV
LDGVFDADGQIPCQIDGGLKCFGHPIGASGLRMIYENYLQLLGRAGERQRKDPPSLALSHNLGGMPSQNVSAVAIVGLEG
A

Sequences:

>Translated_401_residues
MASGIKDRVAILGMGCARFGERWNDDAETLMVEAFDEAIADAGIDVSQIDAAWLSVGFDAQNIGPSGIPLAMALRLPNIG
VTKVENYCASGTDGFRGAVYAVASGACDIALAVGVEKLKDTGYGGLPVRTRGTTYDMVNVTGSAPGFFAQLAGAYRAKHG
VGYDDLKRAMAHVSVKSHANGARNPKAHLRKPITEEQALNAPMIAAPLGLFDCCGVSDGAACAIVTTPEIARALGKTDLV
TVKALQISTSNGWELQGGGWDGSYFHTTRIAAQKAYAEAGVTDPRKQLSLTEVHDCFSVTELVTMEDLGLSAEGEAWKDV
LDGVFDADGQIPCQIDGGLKCFGHPIGASGLRMIYENYLQLLGRAGERQRKDPPSLALSHNLGGMPSQNVSAVAIVGLEG
A
>Mature_400_residues
ASGIKDRVAILGMGCARFGERWNDDAETLMVEAFDEAIADAGIDVSQIDAAWLSVGFDAQNIGPSGIPLAMALRLPNIGV
TKVENYCASGTDGFRGAVYAVASGACDIALAVGVEKLKDTGYGGLPVRTRGTTYDMVNVTGSAPGFFAQLAGAYRAKHGV
GYDDLKRAMAHVSVKSHANGARNPKAHLRKPITEEQALNAPMIAAPLGLFDCCGVSDGAACAIVTTPEIARALGKTDLVT
VKALQISTSNGWELQGGGWDGSYFHTTRIAAQKAYAEAGVTDPRKQLSLTEVHDCFSVTELVTMEDLGLSAEGEAWKDVL
DGVFDADGQIPCQIDGGLKCFGHPIGASGLRMIYENYLQLLGRAGERQRKDPPSLALSHNLGGMPSQNVSAVAIVGLEGA

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=391, Percent_Identity=29.923273657289, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI302344760, Length=391, Percent_Identity=28.1329923273657, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI302344767, Length=317, Percent_Identity=29.9684542586751, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI302344762, Length=391, Percent_Identity=27.8772378516624, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI55956775, Length=358, Percent_Identity=26.2569832402235, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17537653, Length=392, Percent_Identity=27.2959183673469, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI19921506, Length=395, Percent_Identity=28.1012658227848, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24585051, Length=396, Percent_Identity=28.5353535353535, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42019; Mature: 41888

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASGIKDRVAILGMGCARFGERWNDDAETLMVEAFDEAIADAGIDVSQIDAAWLSVGFDA
CCCCHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
QNIGPSGIPLAMALRLPNIGVTKVENYCASGTDGFRGAVYAVASGACDIALAVGVEKLKD
CCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCHHEEEEECCCCHHHHHHHHHHHHH
TGYGGLPVRTRGTTYDMVNVTGSAPGFFAQLAGAYRAKHGVGYDDLKRAMAHVSVKSHAN
CCCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
GARNPKAHLRKPITEEQALNAPMIAAPLGLFDCCGVSDGAACAIVTTPEIARALGKTDLV
CCCCCHHHHHCCCCHHHHCCCCHHHHCCCHHHHCCCCCCCEEEEEECHHHHHHHCCCCEE
TVKALQISTSNGWELQGGGWDGSYFHTTRIAAQKAYAEAGVTDPRKQLSLTEVHDCFSVT
EEEEEEEECCCCEEECCCCCCCCCEEHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHH
ELVTMEDLGLSAEGEAWKDVLDGVFDADGQIPCQIDGGLKCFGHPIGASGLRMIYENYLQ
HHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCHHHHHHHHHHHHH
LLGRAGERQRKDPPSLALSHNLGGMPSQNVSAVAIVGLEGA
HHHCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
ASGIKDRVAILGMGCARFGERWNDDAETLMVEAFDEAIADAGIDVSQIDAAWLSVGFDA
CCCHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
QNIGPSGIPLAMALRLPNIGVTKVENYCASGTDGFRGAVYAVASGACDIALAVGVEKLKD
CCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCHHEEEEECCCCHHHHHHHHHHHHH
TGYGGLPVRTRGTTYDMVNVTGSAPGFFAQLAGAYRAKHGVGYDDLKRAMAHVSVKSHAN
CCCCCCEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
GARNPKAHLRKPITEEQALNAPMIAAPLGLFDCCGVSDGAACAIVTTPEIARALGKTDLV
CCCCCHHHHHCCCCHHHHCCCCHHHHCCCHHHHCCCCCCCEEEEEECHHHHHHHCCCCEE
TVKALQISTSNGWELQGGGWDGSYFHTTRIAAQKAYAEAGVTDPRKQLSLTEVHDCFSVT
EEEEEEEECCCCEEECCCCCCCCCEEHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHH
ELVTMEDLGLSAEGEAWKDVLDGVFDADGQIPCQIDGGLKCFGHPIGASGLRMIYENYLQ
HHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCCHHHHHHHHHHHHH
LLGRAGERQRKDPPSLALSHNLGGMPSQNVSAVAIVGLEGA
HHHCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]