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The map label for this gene is fadA [H]

Identifier: 197105965

GI number: 197105965

Start: 2870725

End: 2871897

Strand: Reverse

Name: fadA [H]

Synonym: PHZ_c2504

Alternate gene names: 197105965

Gene position: 2871897-2870725 (Counterclockwise)

Preceding gene: 197105966

Following gene: 197105964

Centisome position: 71.86

GC content: 68.8

Gene sequence:

>1173_bases
ATGGCCGAGGCCTATATCGTCGCCGCCACCCGGACCGCGGGCGGTCGCAAGGGCGGTCGCGTGCGGGGCTGGCACCCCGC
CGACCTGGGCGCGGTGGTCCTGAACGAGCTGATGGACCGCACCGGCGTCGACCCGGCGGCCGTCGAGGACGTCGTGATGG
GCTGCGTCATGCAGGTGGGCGAGCAGTCCACCAACATCGCCCGCAACGCGGTCCTGGCCTCCAAGCTGCCGGAAAGCGTG
CCGGCCACTTCGGTCGACCGCCAGTGCGGCTCCTCGCAGCAGGCCCTCCAGTTCGCCGCCCAGGCCGTGATGAGCGGCAC
CATGGACGTGGTGATCGCCTCGGGCGTCGAGAGCATGACCCGCGTGCCCATGGGCCTGTCGGTGTCGCTGGCCGCCAAGG
AAGGCTTCGGCGTGCCGAAGAGCCCGCGGATGGAGGAGCGCTACCCCAACATCCAGTTCAGCCAGTTCATGGGCGCCGAG
ATGGTCGCCGAGAAGTACGGCCTGACCAAGGACCAGCTGGACGAGTTCGGCTACCAGTCCCACCAGCGCGCCATCGCCGC
GACCCAGGGCGGGGCGTTCAAGGACGAGATCGTCGCCATCGACGGCCTCGACGCCGAGGGCAACACCGTTCGCCATGACG
TGGACGAGGGCATCCGCTTCGATGTCAGCCTCGACGGCATGAAGGGCGTGAAGCTGCTGCGCGAGGGCGGCCGGATCACG
GCGGCCACCTCCAGCCAGATCTGCGACGGCGCCTCGGGCGTGATGATCGTCTCGGAGAAGGCGCTGAAGGAGCACAACCT
CACGCCGATGGCCCGCATCCACCACCTGTCGATCCTGGGCCACGACCCGGTGATCATGCTGGAGGCGCCGATCCCGGCGA
CCGAGCGGGCGCTGAAGAAGGCCGGCATGTCCGTCGACGACATCGACCTCTACGAAGTCAACGAGGCCTTCGCCTCGGTG
CCGGTGGCCTACCTCCAGAAGCTGGGCGTGGATCCCGAGCGGATGAACGTCAACGGCGGCGCCATCGCGCTGGGCCACCC
GCTGGGCGCCTCTGGCACCAAGCTGATGACCACGCTGCTCTATGCCCTGCAGAAGCGCGGCAAGAAGTACGGCCTGCAGA
CGATGTGCGAAGGCGGCGGCATGGCCAACGTCACCATCGTCGAGCGGCTCTAG

Upstream 100 bases:

>100_bases
AGGCGTCGCGAAGGGGTGATTGTCTTACGCTGCGGCGCCTCAATACATGTCGTCGCGACGCGCCCGAGGGGCGTAGAGGA
AGCGAAACGGAGCTGTTGAG

Downstream 100 bases:

>100_bases
GCCGGTCGAAACCGTCATCCCCGGGCCTGTCCCGGGGGTCCAGTCACGCAGGCGCTTGCGGGCTCGCCCCGAAGTGCGGT
GCTTATGGATGGCCGGGACC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MAEAYIVAATRTAGGRKGGRVRGWHPADLGAVVLNELMDRTGVDPAAVEDVVMGCVMQVGEQSTNIARNAVLASKLPESV
PATSVDRQCGSSQQALQFAAQAVMSGTMDVVIASGVESMTRVPMGLSVSLAAKEGFGVPKSPRMEERYPNIQFSQFMGAE
MVAEKYGLTKDQLDEFGYQSHQRAIAATQGGAFKDEIVAIDGLDAEGNTVRHDVDEGIRFDVSLDGMKGVKLLREGGRIT
AATSSQICDGASGVMIVSEKALKEHNLTPMARIHHLSILGHDPVIMLEAPIPATERALKKAGMSVDDIDLYEVNEAFASV
PVAYLQKLGVDPERMNVNGGAIALGHPLGASGTKLMTTLLYALQKRGKKYGLQTMCEGGGMANVTIVERL

Sequences:

>Translated_390_residues
MAEAYIVAATRTAGGRKGGRVRGWHPADLGAVVLNELMDRTGVDPAAVEDVVMGCVMQVGEQSTNIARNAVLASKLPESV
PATSVDRQCGSSQQALQFAAQAVMSGTMDVVIASGVESMTRVPMGLSVSLAAKEGFGVPKSPRMEERYPNIQFSQFMGAE
MVAEKYGLTKDQLDEFGYQSHQRAIAATQGGAFKDEIVAIDGLDAEGNTVRHDVDEGIRFDVSLDGMKGVKLLREGGRIT
AATSSQICDGASGVMIVSEKALKEHNLTPMARIHHLSILGHDPVIMLEAPIPATERALKKAGMSVDDIDLYEVNEAFASV
PVAYLQKLGVDPERMNVNGGAIALGHPLGASGTKLMTTLLYALQKRGKKYGLQTMCEGGGMANVTIVERL
>Mature_389_residues
AEAYIVAATRTAGGRKGGRVRGWHPADLGAVVLNELMDRTGVDPAAVEDVVMGCVMQVGEQSTNIARNAVLASKLPESVP
ATSVDRQCGSSQQALQFAAQAVMSGTMDVVIASGVESMTRVPMGLSVSLAAKEGFGVPKSPRMEERYPNIQFSQFMGAEM
VAEKYGLTKDQLDEFGYQSHQRAIAATQGGAFKDEIVAIDGLDAEGNTVRHDVDEGIRFDVSLDGMKGVKLLREGGRITA
ATSSQICDGASGVMIVSEKALKEHNLTPMARIHHLSILGHDPVIMLEAPIPATERALKKAGMSVDDIDLYEVNEAFASVP
VAYLQKLGVDPERMNVNGGAIALGHPLGASGTKLMTTLLYALQKRGKKYGLQTMCEGGGMANVTIVERL

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=35.7142857142857, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=35.4755784061697, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=34.1772151898734, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI4557237, Length=403, Percent_Identity=32.5062034739454, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI4504327, Length=427, Percent_Identity=30.9133489461358, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=27.6923076923077, Blast_Score=139, Evalue=4e-33,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=40.3022670025189, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI1787663, Length=403, Percent_Identity=38.4615384615385, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI87082165, Length=396, Percent_Identity=37.3737373737374, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1788554, Length=397, Percent_Identity=37.7833753148615, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=31.5403422982885, Blast_Score=175, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=35.2941176470588, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI25147385, Length=394, Percent_Identity=30.9644670050761, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17535921, Length=406, Percent_Identity=30.2955665024631, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI17535917, Length=394, Percent_Identity=28.4263959390863, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17551802, Length=421, Percent_Identity=27.3159144893112, Blast_Score=140, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=34.25, Blast_Score=203, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6322031, Length=390, Percent_Identity=33.0769230769231, Blast_Score=179, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=36.3867684478371, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI17648125, Length=394, Percent_Identity=35.5329949238579, Blast_Score=228, Evalue=5e-60,
Organism=Drosophila melanogaster, GI24640423, Length=394, Percent_Identity=32.48730964467, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI17137578, Length=428, Percent_Identity=28.0373831775701, Blast_Score=144, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41404; Mature: 41273

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAYIVAATRTAGGRKGGRVRGWHPADLGAVVLNELMDRTGVDPAAVEDVVMGCVMQVG
CCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
EQSTNIARNAVLASKLPESVPATSVDRQCGSSQQALQFAAQAVMSGTMDVVIASGVESMT
CCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCHHEEECCCHHHHH
RVPMGLSVSLAAKEGFGVPKSPRMEERYPNIQFSQFMGAEMVAEKYGLTKDQLDEFGYQS
HCCCCCEEEEEECCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCHH
HQRAIAATQGGAFKDEIVAIDGLDAEGNTVRHDVDEGIRFDVSLDGMKGVKLLREGGRIT
HHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCEEEEEECCHHHHHHHHCCCCEE
AATSSQICDGASGVMIVSEKALKEHNLTPMARIHHLSILGHDPVIMLEAPIPATERALKK
EECCCHHCCCCCCEEEEEHHHHHHCCCCHHHHHHEEEEECCCCEEEEECCCCHHHHHHHH
AGMSVDDIDLYEVNEAFASVPVAYLQKLGVDPERMNVNGGAIALGHPLGASGTKLMTTLL
CCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCHHHEECCCCEEEECCCCCCCHHHHHHHHH
YALQKRGKKYGLQTMCEGGGMANVTIVERL
HHHHHHCHHCCHHHHHCCCCEEEEEEEECC
>Mature Secondary Structure 
AEAYIVAATRTAGGRKGGRVRGWHPADLGAVVLNELMDRTGVDPAAVEDVVMGCVMQVG
CCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
EQSTNIARNAVLASKLPESVPATSVDRQCGSSQQALQFAAQAVMSGTMDVVIASGVESMT
CCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCHHEEECCCHHHHH
RVPMGLSVSLAAKEGFGVPKSPRMEERYPNIQFSQFMGAEMVAEKYGLTKDQLDEFGYQS
HCCCCCEEEEEECCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCCHH
HQRAIAATQGGAFKDEIVAIDGLDAEGNTVRHDVDEGIRFDVSLDGMKGVKLLREGGRIT
HHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHCCCCEEEEEECCHHHHHHHHCCCCEE
AATSSQICDGASGVMIVSEKALKEHNLTPMARIHHLSILGHDPVIMLEAPIPATERALKK
EECCCHHCCCCCCEEEEEHHHHHHCCCCHHHHHHEEEEECCCCEEEEECCCCHHHHHHHH
AGMSVDDIDLYEVNEAFASVPVAYLQKLGVDPERMNVNGGAIALGHPLGASGTKLMTTLL
CCCCCCCCHHHHHHHHHHHCHHHHHHHHCCCHHHEECCCCEEEECCCCCCCHHHHHHHHH
YALQKRGKKYGLQTMCEGGGMANVTIVERL
HHHHHHCHHCCHHHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA