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The map label for this gene is yngJ [H]

Identifier: 197105959

GI number: 197105959

Start: 2863144

End: 2864217

Strand: Reverse

Name: yngJ [H]

Synonym: PHZ_c2498

Alternate gene names: 197105959

Gene position: 2864217-2863144 (Counterclockwise)

Preceding gene: 197105960

Following gene: 197105956

Centisome position: 71.67

GC content: 75.42

Gene sequence:

>1074_bases
ATGAGGTTCGCGCTCTCCGAGGACCAGGTCCTGCTGCAGGACAGCCTGGCGAAGGCCCTGGCCGAGCTCGCGCCCCTGGA
GCGGGTGCGGCGCTTCGCCGACGACAACGAGCCCTGCGCCGGGGACATCTGGGCCGGACTGGCCGAGCTGGGCCTGCCCG
GGCTGCTGATCGACGAGGCCCACGGCGGCCTGGGACTGGGGCTCATCGAGGCCGCGCTGGCCGCCGAGGCCCTGGGCCGC
ACGGTCGCCCCGACGCCGTTCCTCGGATCGGCGGTGCTGGCCCCCCTCGCGCTGAAGCTGGCCGGCTCGGCCGAGCAGCA
GGCCCGCTGGCTGCCGAGTCTGGCGGCCGGCGAGATCACCGCGGGCGTGGCCATCGCCGAGCCGATCGCCGGCGCCCGGG
ACGGCGCGGGCGTCGACGCCGTGGCCGGCCGGCTGACGGGCAGGGCGCTCTTCGCCGTGGGGGCAGAGGGCGCGGACCTG
CTGGTGGTCGCCGACCGGACCGGCGGCCTGCACCTCGCCGAGAGCGCCGAGGCCACGGCGCCGATGCGCACCATCGACGC
CACCCGGCGGCTCACCGAGATTTCGTTCAAGGCCACGCCCGCCGAGCCGCTCGCCTCGAACGGGGCGCTGGAGCGGCTGC
GCGACGCGGCGTGGGTCATGCTGGCCGCCGACACGGTCGGCGCGGCCGGAGCCATGCTCGGCAAGGCCGTCGGCTACGCC
CAGGAACGGCGCCAGTTCGGCCGGGTGATCGGCTCGTTCCAGGCGGTGAAGCACCTCTGCGCCGAAATGGCCGCCGAGAT
CGAGCCGGCGCGGGCCCTGGTCTGGTACGCGGCCTACGCCTTCGACCACGCGCCGGACGAAGCGCCGCTGATGGCGGCCC
ACGCCAAGGCGCACACATCGGAGATCGGCCGCTTCGTCGCGCGTACGGCCACCGAGGTGCACGGCGGCATCGGCATCACC
GACCTGCTGGGCCTGCACTACTGGTTCAAGCGCATCGGCCTGAACCGGCAGCTGTTCGGCGGACCCGAGCGGGTGCGCGA
GACCGCCGCGCGCCTGCAGGGGCTGGCGGCCTAG

Upstream 100 bases:

>100_bases
GGCCTCATCATCGGCGGCGGCACGGCGCAGATCCAGAAGAACATCATCGCCGAGCGGGGCCTTGGCCTGCCGCGCGAACC
CAAGACGGTGGGGGCCTGAC

Downstream 100 bases:

>100_bases
AGCGCGCGGACCGGCGGCAGGCGGCCGGCCCAGGGCTGGGCCGCCTCGAGCTGGTAGGCGAGCTGGAACAGCAGGGCCTC
GTGGCCGACGCGGGCGGCGA

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MRFALSEDQVLLQDSLAKALAELAPLERVRRFADDNEPCAGDIWAGLAELGLPGLLIDEAHGGLGLGLIEAALAAEALGR
TVAPTPFLGSAVLAPLALKLAGSAEQQARWLPSLAAGEITAGVAIAEPIAGARDGAGVDAVAGRLTGRALFAVGAEGADL
LVVADRTGGLHLAESAEATAPMRTIDATRRLTEISFKATPAEPLASNGALERLRDAAWVMLAADTVGAAGAMLGKAVGYA
QERRQFGRVIGSFQAVKHLCAEMAAEIEPARALVWYAAYAFDHAPDEAPLMAAHAKAHTSEIGRFVARTATEVHGGIGIT
DLLGLHYWFKRIGLNRQLFGGPERVRETAARLQGLAA

Sequences:

>Translated_357_residues
MRFALSEDQVLLQDSLAKALAELAPLERVRRFADDNEPCAGDIWAGLAELGLPGLLIDEAHGGLGLGLIEAALAAEALGR
TVAPTPFLGSAVLAPLALKLAGSAEQQARWLPSLAAGEITAGVAIAEPIAGARDGAGVDAVAGRLTGRALFAVGAEGADL
LVVADRTGGLHLAESAEATAPMRTIDATRRLTEISFKATPAEPLASNGALERLRDAAWVMLAADTVGAAGAMLGKAVGYA
QERRQFGRVIGSFQAVKHLCAEMAAEIEPARALVWYAAYAFDHAPDEAPLMAAHAKAHTSEIGRFVARTATEVHGGIGIT
DLLGLHYWFKRIGLNRQLFGGPERVRETAARLQGLAA
>Mature_357_residues
MRFALSEDQVLLQDSLAKALAELAPLERVRRFADDNEPCAGDIWAGLAELGLPGLLIDEAHGGLGLGLIEAALAAEALGR
TVAPTPFLGSAVLAPLALKLAGSAEQQARWLPSLAAGEITAGVAIAEPIAGARDGAGVDAVAGRLTGRALFAVGAEGADL
LVVADRTGGLHLAESAEATAPMRTIDATRRLTEISFKATPAEPLASNGALERLRDAAWVMLAADTVGAAGAMLGKAVGYA
QERRQFGRVIGSFQAVKHLCAEMAAEIEPARALVWYAAYAFDHAPDEAPLMAAHAKAHTSEIGRFVARTATEVHGGIGIT
DLLGLHYWFKRIGLNRQLFGGPERVRETAARLQGLAA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501859, Length=371, Percent_Identity=25.8760107816712, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI226958412, Length=352, Percent_Identity=25.2840909090909, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI7656849, Length=344, Percent_Identity=23.8372093023256, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17533517, Length=339, Percent_Identity=22.7138643067847, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17534899, Length=352, Percent_Identity=26.9886363636364, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646207, Length=362, Percent_Identity=27.3480662983425, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24660351, Length=357, Percent_Identity=26.890756302521, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 37152; Mature: 37152

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFALSEDQVLLQDSLAKALAELAPLERVRRFADDNEPCAGDIWAGLAELGLPGLLIDEA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEECC
HGGLGLGLIEAALAAEALGRTVAPTPFLGSAVLAPLALKLAGSAEQQARWLPSLAAGEIT
CCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHCCHHH
AGVAIAEPIAGARDGAGVDAVAGRLTGRALFAVGAEGADLLVVADRTGGLHLAESAEATA
CCHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCEEECCCCCCCC
PMRTIDATRRLTEISFKATPAEPLASNGALERLRDAAWVMLAADTVGAAGAMLGKAVGYA
CHHHHHHHHHHHHHEECCCCCCCHHCCCHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHH
QERRQFGRVIGSFQAVKHLCAEMAAEIEPARALVWYAAYAFDHAPDEAPLMAAHAKAHTS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
EIGRFVARTATEVHGGIGITDLLGLHYWFKRIGLNRQLFGGPERVRETAARLQGLAA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRFALSEDQVLLQDSLAKALAELAPLERVRRFADDNEPCAGDIWAGLAELGLPGLLIDEA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEECC
HGGLGLGLIEAALAAEALGRTVAPTPFLGSAVLAPLALKLAGSAEQQARWLPSLAAGEIT
CCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHCCHHH
AGVAIAEPIAGARDGAGVDAVAGRLTGRALFAVGAEGADLLVVADRTGGLHLAESAEATA
CCHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCEEECCCCCCCC
PMRTIDATRRLTEISFKATPAEPLASNGALERLRDAAWVMLAADTVGAAGAMLGKAVGYA
CHHHHHHHHHHHHHEECCCCCCCHHCCCHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHH
QERRQFGRVIGSFQAVKHLCAEMAAEIEPARALVWYAAYAFDHAPDEAPLMAAHAKAHTS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
EIGRFVARTATEVHGGIGITDLLGLHYWFKRIGLNRQLFGGPERVRETAARLQGLAA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]