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The map label for this gene is ilvD [H]

Identifier: 197105927

GI number: 197105927

Start: 2822711

End: 2824492

Strand: Reverse

Name: ilvD [H]

Synonym: PHZ_c2466

Alternate gene names: 197105927

Gene position: 2824492-2822711 (Counterclockwise)

Preceding gene: 197105928

Following gene: 197105926

Centisome position: 70.68

GC content: 71.27

Gene sequence:

>1782_bases
ATGCCTGACCGCAAGCCCGCGCGCCCCTTCCGGTCCCGGGAGTGGTTCGCCGCCCCCGAACGCTCGGACATGACCGCCCT
CTACCTCGAGCGGTTCATGAACTACGGCATCACGCCGGAGGAGCTGCAGTCGGGCCGCCCCATCGTCGGCATCGCCCAGA
CGGGCAGCGACCTGTCGCCCTGCAACCGCATCCACCTGGACCTCGCGCGTCGGGTGCGGGATGGAATCCGCGACGCGGGC
GGCGTCCCGATGGAATTCCCGGTCCATCCAATCTTTGAGAACTGCCGCCGGCCGACCGCGGCGCTGGACCGCAACCTCGC
GTACCTCGGCCTCACCGAGATCCTCTACGGCTATCCGATCGACGCGGTGGTGCTGACCACCGGCTGCGACAAGACCACGC
CATCGGGCGTCATGGCGGCCTCGACCGTGGACATCCCGGCCATCGTGCTGTCGGGCGGGCCGATGCTGGACGGCTGGCAC
GAGGGCGAGCTGGTGGGCTCTGGGACGGTCATCTGGCGCAGCCGGCGCAAGCTGGCGGCGGGCGAGATCGACGAGGCCGA
GTTCCTGCGCCGGGCCACCGCCTCCGCGCCCTCGGCGGGCCACTGCAACACCATGGGCACGGCCTCGACCATGAACGCCG
TGGCCGAGGCCCTGGGCCTGTCGTTGCCGGGCTGCGCGGCGATCCCGGCTCCCTACCGCGAGCGCGGCCAGATGGCCTAC
GAGACCGGCCGCCGGATCGTGGACATGGCCTACGAGGACCTGCGGCCGTCGAAGATCCTGACCCGCGCCGCTTTCCTGAA
CGCGATCAAGGTGGTCAGCGCCGCGGGCGGCTCGTCCAACGCCCAGCCGCACATCGTGGCCATGGCCAGGCACGCGGGGG
TGGAGCTGTCGCCCGAGGACTGGATGGCCCACGGCTACGACGTGCCGCTGATCGTCAACATGCAGCCGGCCGGCAAGTAC
CTGGGCGAGCGCTTCCACCGCGCCGGCGGGGTGCCCGCGGTGATGTGGGAGCTGCTGCGGGCGGGCCAGCTCGACGGCGG
CTGCCTGACGGTCACCGGCCGCACCCTGGCCGAGAACCTGGAGGGCCGGGAGGCGAGCGACCGCGAGGTCATCACGCCCT
ACGATCAGCCGCTGAAGGAACGGGCCGGCTTCCTGGTGCTGAAGGGCAACCTGTTCGACTTCGCGATCATGAAGACCAGC
GTGATCTCCGAGGAGTTCCGCGCGCGCTACCTCGCCGAGCCCGGACGGGAAGGGGTGTTCGAGGCCCGCGCCGTCGTCTT
CGACGGATCGGGCGACTACCACCACCGGATCAACGACCCGGCGCTGGATATCGACGAGCGGACCATCCTCGTGATCCGCG
GCTCGGGGCCGCTGGGCTGGCCGGGCTCGGCCGAGGTGGTGAACATGCAGCCGCCGGACGCCCTGATCCAGCGCGGGATT
TCCAGCCTCCCGACCCTGGGCGACGGGCGCCAGTCGGGCACCTCCGACAGCCCCTCCATCCTCAATGCTTCGCCGGAGAG
CGCGGCCGGCGGCGGGCTGTCCTGGCTCCGCACCGGCGACGTCATCCGCATCGACCTGAACACCGGCCGGTGCGACGCCC
TGGTGGACGAGGCCGAGATCGCCCGCCGCAAGGCCGAGGCCCCGCCGCCTGTCCCGGAGAGCCGCACGCCCTGGGAGGAG
CTCTATCGCGAGAAAACCGGCCAGCTCGCCGAGGGCGCCGTGCTGGAAATGGCCGTGAAGTATCGCGGCGTCTCGGCCAA
GACCCCACGCCACAACCACTGA

Upstream 100 bases:

>100_bases
AAGGGCCTCTCGGCCGACGAGCGCGAGAAGCAGCCGCTCGCCGGCGGCCTCTTCCGGTTCGAGGTCGACGTCCCCGGCCT
GCCGCAGAACCAGATGGCCC

Downstream 100 bases:

>100_bases
AAACCCGCCAGGTCATACCATTTGGCTTGACCATGATACCGCTATCATTAAGGCTGCGCGACAAAGGTCCGTCAGAGACC
GATGCGTTACGAACCGCGGG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MPDRKPARPFRSREWFAAPERSDMTALYLERFMNYGITPEELQSGRPIVGIAQTGSDLSPCNRIHLDLARRVRDGIRDAG
GVPMEFPVHPIFENCRRPTAALDRNLAYLGLTEILYGYPIDAVVLTTGCDKTTPSGVMAASTVDIPAIVLSGGPMLDGWH
EGELVGSGTVIWRSRRKLAAGEIDEAEFLRRATASAPSAGHCNTMGTASTMNAVAEALGLSLPGCAAIPAPYRERGQMAY
ETGRRIVDMAYEDLRPSKILTRAAFLNAIKVVSAAGGSSNAQPHIVAMARHAGVELSPEDWMAHGYDVPLIVNMQPAGKY
LGERFHRAGGVPAVMWELLRAGQLDGGCLTVTGRTLAENLEGREASDREVITPYDQPLKERAGFLVLKGNLFDFAIMKTS
VISEEFRARYLAEPGREGVFEARAVVFDGSGDYHHRINDPALDIDERTILVIRGSGPLGWPGSAEVVNMQPPDALIQRGI
SSLPTLGDGRQSGTSDSPSILNASPESAAGGGLSWLRTGDVIRIDLNTGRCDALVDEAEIARRKAEAPPPVPESRTPWEE
LYREKTGQLAEGAVLEMAVKYRGVSAKTPRHNH

Sequences:

>Translated_593_residues
MPDRKPARPFRSREWFAAPERSDMTALYLERFMNYGITPEELQSGRPIVGIAQTGSDLSPCNRIHLDLARRVRDGIRDAG
GVPMEFPVHPIFENCRRPTAALDRNLAYLGLTEILYGYPIDAVVLTTGCDKTTPSGVMAASTVDIPAIVLSGGPMLDGWH
EGELVGSGTVIWRSRRKLAAGEIDEAEFLRRATASAPSAGHCNTMGTASTMNAVAEALGLSLPGCAAIPAPYRERGQMAY
ETGRRIVDMAYEDLRPSKILTRAAFLNAIKVVSAAGGSSNAQPHIVAMARHAGVELSPEDWMAHGYDVPLIVNMQPAGKY
LGERFHRAGGVPAVMWELLRAGQLDGGCLTVTGRTLAENLEGREASDREVITPYDQPLKERAGFLVLKGNLFDFAIMKTS
VISEEFRARYLAEPGREGVFEARAVVFDGSGDYHHRINDPALDIDERTILVIRGSGPLGWPGSAEVVNMQPPDALIQRGI
SSLPTLGDGRQSGTSDSPSILNASPESAAGGGLSWLRTGDVIRIDLNTGRCDALVDEAEIARRKAEAPPPVPESRTPWEE
LYREKTGQLAEGAVLEMAVKYRGVSAKTPRHNH
>Mature_592_residues
PDRKPARPFRSREWFAAPERSDMTALYLERFMNYGITPEELQSGRPIVGIAQTGSDLSPCNRIHLDLARRVRDGIRDAGG
VPMEFPVHPIFENCRRPTAALDRNLAYLGLTEILYGYPIDAVVLTTGCDKTTPSGVMAASTVDIPAIVLSGGPMLDGWHE
GELVGSGTVIWRSRRKLAAGEIDEAEFLRRATASAPSAGHCNTMGTASTMNAVAEALGLSLPGCAAIPAPYRERGQMAYE
TGRRIVDMAYEDLRPSKILTRAAFLNAIKVVSAAGGSSNAQPHIVAMARHAGVELSPEDWMAHGYDVPLIVNMQPAGKYL
GERFHRAGGVPAVMWELLRAGQLDGGCLTVTGRTLAENLEGREASDREVITPYDQPLKERAGFLVLKGNLFDFAIMKTSV
ISEEFRARYLAEPGREGVFEARAVVFDGSGDYHHRINDPALDIDERTILVIRGSGPLGWPGSAEVVNMQPPDALIQRGIS
SLPTLGDGRQSGTSDSPSILNASPESAAGGGLSWLRTGDVIRIDLNTGRCDALVDEAEIARRKAEAPPPVPESRTPWEEL
YREKTGQLAEGAVLEMAVKYRGVSAKTPRHNH

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=492, Percent_Identity=31.9105691056911, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI48994964, Length=560, Percent_Identity=28.3928571428571, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI2367371, Length=490, Percent_Identity=30.8163265306122, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI1786464, Length=452, Percent_Identity=30.3097345132743, Blast_Score=122, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6322476, Length=535, Percent_Identity=31.7757009345794, Blast_Score=218, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 64195; Mature: 64063

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDRKPARPFRSREWFAAPERSDMTALYLERFMNYGITPEELQSGRPIVGIAQTGSDLSP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCCC
CNRIHLDLARRVRDGIRDAGGVPMEFPVHPIFENCRRPTAALDRNLAYLGLTEILYGYPI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHCCCHHHHHHHHHHCCCC
DAVVLTTGCDKTTPSGVMAASTVDIPAIVLSGGPMLDGWHEGELVGSGTVIWRSRRKLAA
CEEEEECCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCEEECCEEEEECCCHHHC
GEIDEAEFLRRATASAPSAGHCNTMGTASTMNAVAEALGLSLPGCAAIPAPYRERGQMAY
CCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHH
ETGRRIVDMAYEDLRPSKILTRAAFLNAIKVVSAAGGSSNAQPHIVAMARHAGVELSPED
HHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHCCCCCCHHH
WMAHGYDVPLIVNMQPAGKYLGERFHRAGGVPAVMWELLRAGQLDGGCLTVTGRTLAENL
HHHCCCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEECHHHHHCC
EGREASDREVITPYDQPLKERAGFLVLKGNLFDFAIMKTSVISEEFRARYLAEPGREGVF
CCCCCCCCCEECCCCCCHHHCCCEEEEECCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCE
EARAVVFDGSGDYHHRINDPALDIDERTILVIRGSGPLGWPGSAEVVNMQPPDALIQRGI
EEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEECCCCHHHHHHHH
SSLPTLGDGRQSGTSDSPSILNASPESAAGGGLSWLRTGDVIRIDLNTGRCDALVDEAEI
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCHHHHHHHHH
ARRKAEAPPPVPESRTPWEELYREKTGQLAEGAVLEMAVKYRGVSAKTPRHNH
HHHHCCCCCCCCCCCCCHHHHHHHHCCCHHCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PDRKPARPFRSREWFAAPERSDMTALYLERFMNYGITPEELQSGRPIVGIAQTGSDLSP
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCCC
CNRIHLDLARRVRDGIRDAGGVPMEFPVHPIFENCRRPTAALDRNLAYLGLTEILYGYPI
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHCCCHHHHHHHHHHCCCC
DAVVLTTGCDKTTPSGVMAASTVDIPAIVLSGGPMLDGWHEGELVGSGTVIWRSRRKLAA
CEEEEECCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCEEECCEEEEECCCHHHC
GEIDEAEFLRRATASAPSAGHCNTMGTASTMNAVAEALGLSLPGCAAIPAPYRERGQMAY
CCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHH
ETGRRIVDMAYEDLRPSKILTRAAFLNAIKVVSAAGGSSNAQPHIVAMARHAGVELSPED
HHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHHCCCCCCHHH
WMAHGYDVPLIVNMQPAGKYLGERFHRAGGVPAVMWELLRAGQLDGGCLTVTGRTLAENL
HHHCCCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEECHHHHHCC
EGREASDREVITPYDQPLKERAGFLVLKGNLFDFAIMKTSVISEEFRARYLAEPGREGVF
CCCCCCCCCEECCCCCCHHHCCCEEEEECCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCE
EARAVVFDGSGDYHHRINDPALDIDERTILVIRGSGPLGWPGSAEVVNMQPPDALIQRGI
EEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEECCCCHHHHHHHH
SSLPTLGDGRQSGTSDSPSILNASPESAAGGGLSWLRTGDVIRIDLNTGRCDALVDEAEI
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCCCHHHHHHHHH
ARRKAEAPPPVPESRTPWEELYREKTGQLAEGAVLEMAVKYRGVSAKTPRHNH
HHHHCCCCCCCCCCCCCHHHHHHHHCCCHHCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA