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The map label for this gene is ppiA [H]

Identifier: 197105903

GI number: 197105903

Start: 2790998

End: 2791582

Strand: Direct

Name: ppiA [H]

Synonym: PHZ_c2442

Alternate gene names: 197105903

Gene position: 2790998-2791582 (Clockwise)

Preceding gene: 197105902

Following gene: 197105907

Centisome position: 69.84

GC content: 63.59

Gene sequence:

>585_bases
GTGCCGACGCCTGGAAACAGGCGGGAGACTAGAATGAAAATTTCATCTGATCAGCAGCACGTCGAGTTCACGACGGCGCT
GGGCGGGATTGTCATATCTGTCGACCGCGCCGCCGCCCCCCTCACCGCCTCCAACTTCCTCACGTACGTGTGCTCCGGCT
TCTTCGATCGGACCGCCTTCTATCGGGTGGTCGCGCCCTGCAATCAAAAGGGAAACGCGGTGCCGATCTCCGTCGTCCAG
GGTGGCTGGCGCGAAGATGTGACTCCCCCCTTGCCACCGATCCCGCATGAGCCGACCTGCCAGACTGGTCTTCGCCATCG
CGACGGCGTCGTCTCCATGGCGAGGCTAGCCCCCGGCACGGCCGCGGGCGCCTTCTTCATCTGTATCGGAGATCACCCTC
AGCTCGACTACGGCGGCGCCAGAAATCCCGACCAGCACGGCTTCGCCGCTTTTGGAGAAGTCGTGCAGGGAATGGATGTC
GTGAGGGCCATCTGGGCTCGGGCGGAGCAGGAACAGTTTCTGTCCGAGCCGATCGCAATCGAGCGCGCCTTGCTCAGCAG
GCGCCGCTGGATCAGCGTTGACTAG

Upstream 100 bases:

>100_bases
GCTCTCGGCTATTCGATGTCGATCGTGGGCGGTGTGTCGGCCCTGGTGGCGACGCTGATCCTGGTGATCGGGATCAGGCC
TTACCTGTCCAGCCTGGAGC

Downstream 100 bases:

>100_bases
CCCCCATCGACGCCCGCCACAACGTCTTACCGCGGGTGGGGAAGATCTCCTGCTGAGAGCCCAGGGGGCCACAGCGTTCG
AATACCACCAGGCGCGGCCA

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MPTPGNRRETRMKISSDQQHVEFTTALGGIVISVDRAAAPLTASNFLTYVCSGFFDRTAFYRVVAPCNQKGNAVPISVVQ
GGWREDVTPPLPPIPHEPTCQTGLRHRDGVVSMARLAPGTAAGAFFICIGDHPQLDYGGARNPDQHGFAAFGEVVQGMDV
VRAIWARAEQEQFLSEPIAIERALLSRRRWISVD

Sequences:

>Translated_194_residues
MPTPGNRRETRMKISSDQQHVEFTTALGGIVISVDRAAAPLTASNFLTYVCSGFFDRTAFYRVVAPCNQKGNAVPISVVQ
GGWREDVTPPLPPIPHEPTCQTGLRHRDGVVSMARLAPGTAAGAFFICIGDHPQLDYGGARNPDQHGFAAFGEVVQGMDV
VRAIWARAEQEQFLSEPIAIERALLSRRRWISVD
>Mature_193_residues
PTPGNRRETRMKISSDQQHVEFTTALGGIVISVDRAAAPLTASNFLTYVCSGFFDRTAFYRVVAPCNQKGNAVPISVVQG
GWREDVTPPLPPIPHEPTCQTGLRHRDGVVSMARLAPGTAAGAFFICIGDHPQLDYGGARNPDQHGFAAFGEVVQGMDVV
RAIWARAEQEQFLSEPIAIERALLSRRRWISVD

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Escherichia coli, GI1789763, Length=149, Percent_Identity=38.255033557047, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1786736, Length=167, Percent_Identity=32.3353293413174, Blast_Score=75, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21201; Mature: 21070

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS00761 SPASE_I_3 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTPGNRRETRMKISSDQQHVEFTTALGGIVISVDRAAAPLTASNFLTYVCSGFFDRTAF
CCCCCCCCHHEEEECCCCHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
YRVVAPCNQKGNAVPISVVQGGWREDVTPPLPPIPHEPTCQTGLRHRDGVVSMARLAPGT
HHEECCCCCCCCEEEEHEECCCCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHHCCCC
AAGAFFICIGDHPQLDYGGARNPDQHGFAAFGEVVQGMDVVRAIWARAEQEQFLSEPIAI
CCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ERALLSRRRWISVD
HHHHHHHCCCCCCC
>Mature Secondary Structure 
PTPGNRRETRMKISSDQQHVEFTTALGGIVISVDRAAAPLTASNFLTYVCSGFFDRTAF
CCCCCCCHHEEEECCCCHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
YRVVAPCNQKGNAVPISVVQGGWREDVTPPLPPIPHEPTCQTGLRHRDGVVSMARLAPGT
HHEECCCCCCCCEEEEHEECCCCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHHCCCC
AAGAFFICIGDHPQLDYGGARNPDQHGFAAFGEVVQGMDVVRAIWARAEQEQFLSEPIAI
CCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ERALLSRRRWISVD
HHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]