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The map label for this gene is lysR [H]

Identifier: 197105838

GI number: 197105838

Start: 2694788

End: 2695705

Strand: Reverse

Name: lysR [H]

Synonym: PHZ_c2377

Alternate gene names: 197105838

Gene position: 2695705-2694788 (Counterclockwise)

Preceding gene: 197105839

Following gene: 197105837

Centisome position: 67.46

GC content: 63.07

Gene sequence:

>918_bases
ATGCGGCGTCATCTGAACCTGCGCCAGATCGAGGCCTTCAAGGCGGTCATAGAGAACGGCACCATCAGCCGCGCGGCGCA
GGTCCTCAATGTCTCGCAACCCGCCATGAGTAAGCTTGTGGCTCATCTCGAATACGACACTGGCCTCCGTTTGTTCGACC
GGGTGAAGGGCCGGCTGGCGCCGACAGAGCACGGGATGCGCCTTTATGAGGAAGTGGGCCGCATCTTCGGCGGCATCCGT
CAGGTCGAGAATGTCGTGGAGGCGATCCGGCGCGAGCAGCAGGGGCGCCTGGCGATCGGAGTGCTCCCCGCCCTGGCGAG
CTCGTTCATCCAGCAGGCGGCGACCGATTTCCTGAAGGCGAGGCCCGCCATCTTCTGCTCGGTCCAGTCCCTGAGCTCGC
AGTGGGTGGTGGACTGGCTGATCGCCCGGAAGCTCGATGTCGGGCTGGTCAGCGCAAGGGTGGACAATCCTTACGTCACG
CTCGAGCCGCTGATGCTTCAGCCCCTGGCCTGCGTCATGCCCAAGGATCACCCGCTGGCGACGAAGCGCCTGATCGAACC
CGATGACCTCGAGGGGGCGCCGTTCATCGCCTTCGACTCGGACATCTATGTGAGCCACCTGGTGAGCGAGATGTTCGAGT
CCTACAGGGTCACGCCGCAGATCGCCCTCGTCGCCAACAACGCCCTGACCGTCTGCGAATTCGTCGGAGCTGGTCTTGGC
GTGTCCCTTGTCCATCCGCTGATGGTGAGCGGTCTGGAAAGCCGGGTGACAGTCCGACGCTTCGCACCTGAGTTGCCCTA
CAACTTCCAGCTCTGCCGGAGTGCAGATAGCCGGAATGCGCATATCGTCGACGCCTTCGTTGAGGAGCTCCGGCGCAAAG
CCACGGAGATCTCTTCGTCTCTGATGATCGAGCCATAG

Upstream 100 bases:

>100_bases
CACCATCCCGGCGGATGAGGCTGCACGGCTTGACGCTACGCAGTCGGTGTATATTCGTCAAAGGCGAGACATCACCGACC
TATTCGCAAAGGTTATGGCA

Downstream 100 bases:

>100_bases
ACTTCCTCGCCGACCGGTTCCCATAACCCTGGCGAATAGGCCTCTCGCCTTTTCGACTTTGACGGAATTGTGCCGTTTGC
GCCGAATGGCGTCTCCAGAA

Product: transcriptional regulator, LysR family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MRRHLNLRQIEAFKAVIENGTISRAAQVLNVSQPAMSKLVAHLEYDTGLRLFDRVKGRLAPTEHGMRLYEEVGRIFGGIR
QVENVVEAIRREQQGRLAIGVLPALASSFIQQAATDFLKARPAIFCSVQSLSSQWVVDWLIARKLDVGLVSARVDNPYVT
LEPLMLQPLACVMPKDHPLATKRLIEPDDLEGAPFIAFDSDIYVSHLVSEMFESYRVTPQIALVANNALTVCEFVGAGLG
VSLVHPLMVSGLESRVTVRRFAPELPYNFQLCRSADSRNAHIVDAFVEELRRKATEISSSLMIEP

Sequences:

>Translated_305_residues
MRRHLNLRQIEAFKAVIENGTISRAAQVLNVSQPAMSKLVAHLEYDTGLRLFDRVKGRLAPTEHGMRLYEEVGRIFGGIR
QVENVVEAIRREQQGRLAIGVLPALASSFIQQAATDFLKARPAIFCSVQSLSSQWVVDWLIARKLDVGLVSARVDNPYVT
LEPLMLQPLACVMPKDHPLATKRLIEPDDLEGAPFIAFDSDIYVSHLVSEMFESYRVTPQIALVANNALTVCEFVGAGLG
VSLVHPLMVSGLESRVTVRRFAPELPYNFQLCRSADSRNAHIVDAFVEELRRKATEISSSLMIEP
>Mature_305_residues
MRRHLNLRQIEAFKAVIENGTISRAAQVLNVSQPAMSKLVAHLEYDTGLRLFDRVKGRLAPTEHGMRLYEEVGRIFGGIR
QVENVVEAIRREQQGRLAIGVLPALASSFIQQAATDFLKARPAIFCSVQSLSSQWVVDWLIARKLDVGLVSARVDNPYVT
LEPLMLQPLACVMPKDHPLATKRLIEPDDLEGAPFIAFDSDIYVSHLVSEMFESYRVTPQIALVANNALTVCEFVGAGLG
VSLVHPLMVSGLESRVTVRRFAPELPYNFQLCRSADSRNAHIVDAFVEELRRKATEISSSLMIEP

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=300, Percent_Identity=34.6666666666667, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI157672245, Length=235, Percent_Identity=31.063829787234, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1788887, Length=267, Percent_Identity=29.5880149812734, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1787879, Length=247, Percent_Identity=27.1255060728745, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI145693105, Length=236, Percent_Identity=23.3050847457627, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788481, Length=283, Percent_Identity=24.0282685512367, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788297, Length=249, Percent_Identity=24.4979919678715, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI87081904, Length=181, Percent_Identity=27.6243093922652, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788748, Length=303, Percent_Identity=20.7920792079208, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1790399, Length=246, Percent_Identity=21.9512195121951, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787601, Length=310, Percent_Identity=23.8709677419355, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI2367136, Length=241, Percent_Identity=24.4813278008299, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082132, Length=242, Percent_Identity=24.3801652892562, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1789173, Length=187, Percent_Identity=28.3422459893048, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1789639, Length=246, Percent_Identity=24.7967479674797, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33962; Mature: 33962

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRHLNLRQIEAFKAVIENGTISRAAQVLNVSQPAMSKLVAHLEYDTGLRLFDRVKGRLA
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCC
PTEHGMRLYEEVGRIFGGIRQVENVVEAIRREQQGRLAIGVLPALASSFIQQAATDFLKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHC
RPAIFCSVQSLSSQWVVDWLIARKLDVGLVSARVDNPYVTLEPLMLQPLACVMPKDHPLA
CCHHEEEHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEECHHHHCCHHHHCCCCCCCH
TKRLIEPDDLEGAPFIAFDSDIYVSHLVSEMFESYRVTPQIALVANNALTVCEFVGAGLG
HHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCC
VSLVHPLMVSGLESRVTVRRFAPELPYNFQLCRSADSRNAHIVDAFVEELRRKATEISSS
HHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LMIEP
CCCCC
>Mature Secondary Structure
MRRHLNLRQIEAFKAVIENGTISRAAQVLNVSQPAMSKLVAHLEYDTGLRLFDRVKGRLA
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCC
PTEHGMRLYEEVGRIFGGIRQVENVVEAIRREQQGRLAIGVLPALASSFIQQAATDFLKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHC
RPAIFCSVQSLSSQWVVDWLIARKLDVGLVSARVDNPYVTLEPLMLQPLACVMPKDHPLA
CCHHEEEHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEECHHHHCCHHHHCCCCCCCH
TKRLIEPDDLEGAPFIAFDSDIYVSHLVSEMFESYRVTPQIALVANNALTVCEFVGAGLG
HHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCC
VSLVHPLMVSGLESRVTVRRFAPELPYNFQLCRSADSRNAHIVDAFVEELRRKATEISSS
HHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LMIEP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]