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The map label for this gene is bioA [H]

Identifier: 197105839

GI number: 197105839

Start: 2695856

End: 2697094

Strand: Reverse

Name: bioA [H]

Synonym: PHZ_c2378

Alternate gene names: 197105839

Gene position: 2697094-2695856 (Counterclockwise)

Preceding gene: 197105842

Following gene: 197105838

Centisome position: 67.49

GC content: 69.01

Gene sequence:

>1239_bases
ATGAAGACCGCGCCCCCGCCTTTGCCGGTGGCCCGGACCCAGGGCGCGCAGATCGTGCTCGAGGACGGCCGGGTCCTCGT
CGATGGCGTCGCCTCCTGGTGGACGGCCTGTCACGGCTACAATCATCCGCACATCCGGGCGGCCGTCGCGCGGCAGCTGG
AGCGGGCCCCGCATGTGATGTTTGGCGGCCTCGCGCATGAGCCCGCCTATGTGCTCGCCGAGCGGCTGGCGGCGCTCCTC
CCAGGCGAGCTGGACCACGTCTTCTTCGCCGAATCCGGTTCCGTCGCCGTCGAGATCGCCATGAAGATGGCGCTGCAGTA
CTGGATCAACCGCGGGGTCGCCGGCCGGACGCGCTTCCTGTCGTTCTTTGGCGGCTATCACGGCGACACCCTGGCGACGA
TGACGGTGTGCGATCCCGAAGAGGGGATGCACGGACTGTTCGCCGGCGTGCTGCCCTCACAGGTGATCGCCCATCTGCCG
AAAGACGACGCATCCGAGGCCGAGCTCGATCGTGAGCTGTCGGCGCACGGTCGCGACATCGCCGCGATCCTGGTCGAGCC
GCGCGTGCAGGGCGCGGGCGGCATGCTGTTCCACCATGACGACGTCCTGCGCAGGCTCAGGCGCCTGGCCGATCGCCATG
ACGTCCTGCTGATCTTCGACGAGATCTTCACCGGGTTCGGGCGCACCGGAGACCTGTTCGCCTGCGCCGGGTCCGGCGTC
ACTCCGGACATCATTACGCTGTCGAAGGCGCTCACCGGCGGGACGCTGCCGCTGTCGGCGGCCGTGGCGTCGCGGCGGGT
CTTCGAAGCCTTCTGGTCCGATGACACGGGCGCCGCCCTCATGCACGGCCCCACCTACATGGCCAACCCGCTGGCCTGTG
CGGCCGCGAACGCTTCGCTCGATCTGTTCGAAGACGGCGACTGGCTCGCCAATGTGGCGCGGGTATCAGCCGGCCTGAAG
GCGGGCCTTGAACCATGTCGAGCCGCTGACGGAGTCGTGGACGTTCGGGTGCTCGGCGCGATCGGCGTCGTCGAACTCGA
GCGTGCGGCCGACGCGGGCGCGCTCTGCCGGCGATTCGCCGAACGCGGGGTCTGGATCCGCCCGTTTGGAAAGGTGGTCT
ACCTCACGCCGGCGTTCGTCATGTCGGATGACGAGCTTGGCCAGCTTACCCGCGCGATCTGCGATGAGCTCGGGCAAGAC
CGCGGCGGCCGTGACGAGGACGGCCGTCACGGTCACTGA

Upstream 100 bases:

>100_bases
TACGTAAACCAGCGCAATTCCAAAGGATCCTGAGCCCATGAACGACAGGCCTGGCTGGTACGAACGCGGCGCGCCGCATG
TCTGGCGTCCCTACTGCCAG

Downstream 100 bases:

>100_bases
CCGCTGGCGCCTGAAGGGTGCGCATGCGGGCGGAAAGAGGAGCTGACGGACACCATCCCGGCGGATGAGGCTGCACGGCT
TGACGCTACGCAGTCGGTGT

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MKTAPPPLPVARTQGAQIVLEDGRVLVDGVASWWTACHGYNHPHIRAAVARQLERAPHVMFGGLAHEPAYVLAERLAALL
PGELDHVFFAESGSVAVEIAMKMALQYWINRGVAGRTRFLSFFGGYHGDTLATMTVCDPEEGMHGLFAGVLPSQVIAHLP
KDDASEAELDRELSAHGRDIAAILVEPRVQGAGGMLFHHDDVLRRLRRLADRHDVLLIFDEIFTGFGRTGDLFACAGSGV
TPDIITLSKALTGGTLPLSAAVASRRVFEAFWSDDTGAALMHGPTYMANPLACAAANASLDLFEDGDWLANVARVSAGLK
AGLEPCRAADGVVDVRVLGAIGVVELERAADAGALCRRFAERGVWIRPFGKVVYLTPAFVMSDDELGQLTRAICDELGQD
RGGRDEDGRHGH

Sequences:

>Translated_412_residues
MKTAPPPLPVARTQGAQIVLEDGRVLVDGVASWWTACHGYNHPHIRAAVARQLERAPHVMFGGLAHEPAYVLAERLAALL
PGELDHVFFAESGSVAVEIAMKMALQYWINRGVAGRTRFLSFFGGYHGDTLATMTVCDPEEGMHGLFAGVLPSQVIAHLP
KDDASEAELDRELSAHGRDIAAILVEPRVQGAGGMLFHHDDVLRRLRRLADRHDVLLIFDEIFTGFGRTGDLFACAGSGV
TPDIITLSKALTGGTLPLSAAVASRRVFEAFWSDDTGAALMHGPTYMANPLACAAANASLDLFEDGDWLANVARVSAGLK
AGLEPCRAADGVVDVRVLGAIGVVELERAADAGALCRRFAERGVWIRPFGKVVYLTPAFVMSDDELGQLTRAICDELGQD
RGGRDEDGRHGH
>Mature_412_residues
MKTAPPPLPVARTQGAQIVLEDGRVLVDGVASWWTACHGYNHPHIRAAVARQLERAPHVMFGGLAHEPAYVLAERLAALL
PGELDHVFFAESGSVAVEIAMKMALQYWINRGVAGRTRFLSFFGGYHGDTLATMTVCDPEEGMHGLFAGVLPSQVIAHLP
KDDASEAELDRELSAHGRDIAAILVEPRVQGAGGMLFHHDDVLRRLRRLADRHDVLLIFDEIFTGFGRTGDLFACAGSGV
TPDIITLSKALTGGTLPLSAAVASRRVFEAFWSDDTGAALMHGPTYMANPLACAAANASLDLFEDGDWLANVARVSAGLK
AGLEPCRAADGVVDVRVLGAIGVVELERAADAGALCRRFAERGVWIRPFGKVVYLTPAFVMSDDELGQLTRAICDELGQD
RGGRDEDGRHGH

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=398, Percent_Identity=29.3969849246231, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI284507298, Length=309, Percent_Identity=30.42071197411, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI37574042, Length=412, Percent_Identity=25.4854368932039, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI13994255, Length=360, Percent_Identity=28.0555555555556, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI226442705, Length=412, Percent_Identity=25.2427184466019, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI226442709, Length=377, Percent_Identity=25.7294429708223, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI1786991, Length=407, Percent_Identity=50.8599508599509, Blast_Score=393, Evalue=1e-110,
Organism=Escherichia coli, GI145693181, Length=296, Percent_Identity=33.445945945946, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789759, Length=393, Percent_Identity=32.3155216284987, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789016, Length=352, Percent_Identity=33.2386363636364, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788044, Length=391, Percent_Identity=31.4578005115089, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1787560, Length=399, Percent_Identity=30.0751879699248, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1786349, Length=304, Percent_Identity=31.9078947368421, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25144271, Length=391, Percent_Identity=26.0869565217391, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI25144274, Length=212, Percent_Identity=30.188679245283, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71992977, Length=371, Percent_Identity=25.6064690026954, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324386, Length=435, Percent_Identity=35.4022988505747, Blast_Score=275, Evalue=8e-75,
Organism=Saccharomyces cerevisiae, GI6323470, Length=409, Percent_Identity=27.6283618581907, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=395, Percent_Identity=26.8354430379747, Blast_Score=107, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21357415, Length=389, Percent_Identity=27.5064267352185, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI161085790, Length=358, Percent_Identity=28.2122905027933, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574759, Length=358, Percent_Identity=28.2122905027933, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 44214; Mature: 44214

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTAPPPLPVARTQGAQIVLEDGRVLVDGVASWWTACHGYNHPHIRAAVARQLERAPHVM
CCCCCCCCCCCCCCCCEEEEECCCEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEE
FGGLAHEPAYVLAERLAALLPGELDHVFFAESGSVAVEIAMKMALQYWINRGVAGRTRFL
ECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
SFFGGYHGDTLATMTVCDPEEGMHGLFAGVLPSQVIAHLPKDDASEAELDRELSAHGRDI
HHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEE
AAILVEPRVQGAGGMLFHHDDVLRRLRRLADRHDVLLIFDEIFTGFGRTGDLFACAGSGV
EEEEEECCCCCCCCEEEECHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCEEEECCCCC
TPDIITLSKALTGGTLPLSAAVASRRVFEAFWSDDTGAALMHGPTYMANPLACAAANASL
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHCCCHHHEECCCCE
DLFEDGDWLANVARVSAGLKAGLEPCRAADGVVDVRVLGAIGVVELERAADAGALCRRFA
EEECCCHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEHHHHCHHHHHHHCCHHHHHHHHH
ERGVWIRPFGKVVYLTPAFVMSDDELGQLTRAICDELGQDRGGRDEDGRHGH
HCCCEEEECCCEEEECCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKTAPPPLPVARTQGAQIVLEDGRVLVDGVASWWTACHGYNHPHIRAAVARQLERAPHVM
CCCCCCCCCCCCCCCCEEEEECCCEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEE
FGGLAHEPAYVLAERLAALLPGELDHVFFAESGSVAVEIAMKMALQYWINRGVAGRTRFL
ECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
SFFGGYHGDTLATMTVCDPEEGMHGLFAGVLPSQVIAHLPKDDASEAELDRELSAHGRDI
HHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEE
AAILVEPRVQGAGGMLFHHDDVLRRLRRLADRHDVLLIFDEIFTGFGRTGDLFACAGSGV
EEEEEECCCCCCCCEEEECHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCEEEECCCCC
TPDIITLSKALTGGTLPLSAAVASRRVFEAFWSDDTGAALMHGPTYMANPLACAAANASL
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHCCCHHHEECCCCE
DLFEDGDWLANVARVSAGLKAGLEPCRAADGVVDVRVLGAIGVVELERAADAGALCRRFA
EEECCCHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEHHHHCHHHHHHHCCHHHHHHHHH
ERGVWIRPFGKVVYLTPAFVMSDDELGQLTRAICDELGQDRGGRDEDGRHGH
HCCCEEEECCCEEEECCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8890743 [H]