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The map label for this gene is virB6 [H]

Identifier: 197105814

GI number: 197105814

Start: 2664374

End: 2665312

Strand: Direct

Name: virB6 [H]

Synonym: PHZ_c2352

Alternate gene names: 197105814

Gene position: 2664374-2665312 (Clockwise)

Preceding gene: 197105813

Following gene: 197105815

Centisome position: 66.67

GC content: 67.2

Gene sequence:

>939_bases
ATGGACGGCTCATTCCGGGTGTTCGGGCCGGCTTACCTCTTCATCGACGGCCGGCTCGACGTCTTCCTCGATCAAGGCGT
GGGTCGTGCGATTGCTGAAGTCTCCGGACCGCTACGCCTTGGTCTGGTGCTGTACGTCCTGCTCTATGGCATCGCGATCC
TGCGCGGCGCCATCGCTGAGCCGCTGATGGACTTCGCGGTGCGGTCCATCAAGCTAGCCGCGATTTACGGGCTGGCGACG
ACCCCCGCCTATGGCGACTGGATCACTCAGCCGCTGTTTCACGTCCTGCCCGAGACCCTGGCGCGCACAGTCGCCGGAAA
CTTAGCAGTGGACGTCGGCAGCGCCTTCGACGACTTCTTTGCCCGTGTGGCCTACCTTGGCGAGACGGTCTCCCGAGAGG
CATCCGCCTTCAACTGGGCGCCGCTGCTCGTCGCCGGTGGCGTCTATGTGTTCGGCGCCCTCGCCGCCGCCCTGGGTTTT
GGCATCGTCACGCTTGCCAAGGTCGCCCTGGCGTTGCTGATCGCCCTGGGGCCGATCTTTGTCGGGCTTTCCCTCTTCGA
GGCCACGCGGCGGTACTTCTTCGGCTGGCTCAGTCAGGCCGTGAACTACCTCGTGCTGTTCGCCCTGATCCTGGCGATCC
TGCAGCTCATCCTCGCCCTCGTCGCCCAGCAGTGGAGCGGGCTGGAAGGCCAGGACCCGGTTGTGGCCGGCCTCATGTTC
ATCGCGCTCTGCCTCCTGGCCGGGATTTTCTTCCTGCAGGTGCCCGCCATAGCCACGGGTATCGCCGGGGGCGCGAGCGC
CGGTCTCGCCGACTTCGGCAACGCGGCGGCCGGCGCAGGCGGCGCCCGCATGCCCTTCACCAGCCACGCCACCCGCGGCG
GTCGCACGCAGACGATGCGGGAAGGCGGCTCCGTCAGACCCGTGAGAGCCTCCGCATGA

Upstream 100 bases:

>100_bases
GTCTTGCGGACTGCGCGCCCGCCGACCGCGAGTGCCAGGCGGTCACCGCGCGGCAGGCTTCCGACGCTCGCTTGCAGCGG
TTCAAGAAGGACATCCGCTA

Downstream 100 bases:

>100_bases
GACGCGTTCCCCAGCTGCTGATCCTGGCGGCCCTTCTGACCAGCGCCTGCGCCAGCCACGGCGATGCGCCGGGCTGCCAC
GGCGCTCGTCGCCCCGCCAA

Product: type IV secretory pathway, VirB6 component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MDGSFRVFGPAYLFIDGRLDVFLDQGVGRAIAEVSGPLRLGLVLYVLLYGIAILRGAIAEPLMDFAVRSIKLAAIYGLAT
TPAYGDWITQPLFHVLPETLARTVAGNLAVDVGSAFDDFFARVAYLGETVSREASAFNWAPLLVAGGVYVFGALAAALGF
GIVTLAKVALALLIALGPIFVGLSLFEATRRYFFGWLSQAVNYLVLFALILAILQLILALVAQQWSGLEGQDPVVAGLMF
IALCLLAGIFFLQVPAIATGIAGGASAGLADFGNAAAGAGGARMPFTSHATRGGRTQTMREGGSVRPVRASA

Sequences:

>Translated_312_residues
MDGSFRVFGPAYLFIDGRLDVFLDQGVGRAIAEVSGPLRLGLVLYVLLYGIAILRGAIAEPLMDFAVRSIKLAAIYGLAT
TPAYGDWITQPLFHVLPETLARTVAGNLAVDVGSAFDDFFARVAYLGETVSREASAFNWAPLLVAGGVYVFGALAAALGF
GIVTLAKVALALLIALGPIFVGLSLFEATRRYFFGWLSQAVNYLVLFALILAILQLILALVAQQWSGLEGQDPVVAGLMF
IALCLLAGIFFLQVPAIATGIAGGASAGLADFGNAAAGAGGARMPFTSHATRGGRTQTMREGGSVRPVRASA
>Mature_312_residues
MDGSFRVFGPAYLFIDGRLDVFLDQGVGRAIAEVSGPLRLGLVLYVLLYGIAILRGAIAEPLMDFAVRSIKLAAIYGLAT
TPAYGDWITQPLFHVLPETLARTVAGNLAVDVGSAFDDFFARVAYLGETVSREASAFNWAPLLVAGGVYVFGALAAALGF
GIVTLAKVALALLIALGPIFVGLSLFEATRRYFFGWLSQAVNYLVLFALILAILQLILALVAQQWSGLEGQDPVVAGLMF
IALCLLAGIFFLQVPAIATGIAGGASAGLADFGNAAAGAGGARMPFTSHATRGGRTQTMREGGSVRPVRASA

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG3704

COG function: function code U; Type IV secretory pathway, VirB6 components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trbL/virB6 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007688 [H]

Pfam domain/function: PF04610 TrbL [H]

EC number: NA

Molecular weight: Translated: 32605; Mature: 32605

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGSFRVFGPAYLFIDGRLDVFLDQGVGRAIAEVSGPLRLGLVLYVLLYGIAILRGAIAE
CCCCEEEECCEEEEECCCHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
PLMDFAVRSIKLAAIYGLATTPAYGDWITQPLFHVLPETLARTVAGNLAVDVGSAFDDFF
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
ARVAYLGETVSREASAFNWAPLLVAGGVYVFGALAAALGFGIVTLAKVALALLIALGPIF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGLSLFEATRRYFFGWLSQAVNYLVLFALILAILQLILALVAQQWSGLEGQDPVVAGLMF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
IALCLLAGIFFLQVPAIATGIAGGASAGLADFGNAAAGAGGARMPFTSHATRGGRTQTMR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
EGGSVRPVRASA
CCCCCCCCCCCC
>Mature Secondary Structure
MDGSFRVFGPAYLFIDGRLDVFLDQGVGRAIAEVSGPLRLGLVLYVLLYGIAILRGAIAE
CCCCEEEECCEEEEECCCHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
PLMDFAVRSIKLAAIYGLATTPAYGDWITQPLFHVLPETLARTVAGNLAVDVGSAFDDFF
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
ARVAYLGETVSREASAFNWAPLLVAGGVYVFGALAAALGFGIVTLAKVALALLIALGPIF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGLSLFEATRRYFFGWLSQAVNYLVLFALILAILQLILALVAQQWSGLEGQDPVVAGLMF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
IALCLLAGIFFLQVPAIATGIAGGASAGLADFGNAAAGAGGARMPFTSHATRGGRTQTMR
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
EGGSVRPVRASA
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]