Click here to switch to the map view.

The map label for this gene is virB8 [H]

Identifier: 197105815

GI number: 197105815

Start: 2665482

End: 2666162

Strand: Direct

Name: virB8 [H]

Synonym: PHZ_c2353

Alternate gene names: 197105815

Gene position: 2665482-2666162 (Clockwise)

Preceding gene: 197105814

Following gene: 197105816

Centisome position: 66.7

GC content: 68.72

Gene sequence:

>681_bases
ATGACGGGCGTCCCGTCTCCGGACCTGAAGGCCTACTTCGCCGAGGCGCGTAGCTGGGACGCCGATCGCCTGCGCCAGGC
GAACCGCTCCCGCCGCGTGGCCTGGAGCGTGGCCGCTGGCGCGTCCGCGCTCGCCACAGCCGCAGTGTGCGCCGTCGCCG
CGCTCTCGCCGCTCAAGACCGTGGAGCCCTACGTGGTCCGGGTCGACCGGAGCACGGGCGCCGTCGAGGTGATGACAGGG
CTCAACGAGGCCGGTGACCTGACTTACGAAGAGGCGGTCACCAAGTCCTTCCTGGCGACCTATGTCCGGGCGCGGGAGTC
GTGGCTGCCGCCTGCCGCCGAGGCGAACTTCCGTCAGGTTTCAATCATGTCGACGCCAGCCGAGCAGCAGCGCTGGGCAG
AGCGCTTCCGACCATCGAACCCCCTGAGCCCTCAGGTGGCCTGGGGACCGAACGCGGAAGCTGAGGCGCGGGTCCGCGCC
ATAACCTTCGTCGCCCCCCAGGTCGCCAGTGTGAGGTTCCACCGGACCTTAAGACAGCAAGGTCAGCTGACCGAAAGCGA
CTGGATCGCAACCGTGGCCTTCGGCTACGCCCGGGCGCCGATGTCGGAGTCCGACAGGTTGCGCAATCCGCTGGGCTTCC
AGGTTTCGAGCTACCGCGCGGACCCGGAGGTCATCCAATGA

Upstream 100 bases:

>100_bases
CGGGCTGCCACGGCGCTCGTCGCCCCGCCAATCCGCACGGCTCCGTCCTGGCGCCGGACGCCCAGCAACCGCCGCTTCCG
GCTGGCAAGGGAGGGTGCGC

Downstream 100 bases:

>100_bases
CGCTAAGGAACCTCATCCTTGTGGCCAGCCTGCTCGGCGCAGCGCCGGCCGTCGCCGCATCACCCCCGAAGACCCCGGCC
AGCGACCCGCGCATCCGAAC

Product: Type IV secretory pathway, component VirB8

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MTGVPSPDLKAYFAEARSWDADRLRQANRSRRVAWSVAAGASALATAAVCAVAALSPLKTVEPYVVRVDRSTGAVEVMTG
LNEAGDLTYEEAVTKSFLATYVRARESWLPPAAEANFRQVSIMSTPAEQQRWAERFRPSNPLSPQVAWGPNAEAEARVRA
ITFVAPQVASVRFHRTLRQQGQLTESDWIATVAFGYARAPMSESDRLRNPLGFQVSSYRADPEVIQ

Sequences:

>Translated_226_residues
MTGVPSPDLKAYFAEARSWDADRLRQANRSRRVAWSVAAGASALATAAVCAVAALSPLKTVEPYVVRVDRSTGAVEVMTG
LNEAGDLTYEEAVTKSFLATYVRARESWLPPAAEANFRQVSIMSTPAEQQRWAERFRPSNPLSPQVAWGPNAEAEARVRA
ITFVAPQVASVRFHRTLRQQGQLTESDWIATVAFGYARAPMSESDRLRNPLGFQVSSYRADPEVIQ
>Mature_225_residues
TGVPSPDLKAYFAEARSWDADRLRQANRSRRVAWSVAAGASALATAAVCAVAALSPLKTVEPYVVRVDRSTGAVEVMTGL
NEAGDLTYEEAVTKSFLATYVRARESWLPPAAEANFRQVSIMSTPAEQQRWAERFRPSNPLSPQVAWGPNAEAEARVRAI
TFVAPQVASVRFHRTLRQQGQLTESDWIATVAFGYARAPMSESDRLRNPLGFQVSSYRADPEVIQ

Specific function: Component of the type IV secretion system virB/virD4 which could be a major virulence determinant for subversion of human endothelial cell (HEC) function [H]

COG id: COG3736

COG function: function code U; Type IV secretory pathway, component VirB8

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the virB8 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007430 [H]

Pfam domain/function: PF04335 VirB8 [H]

EC number: NA

Molecular weight: Translated: 24843; Mature: 24712

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGVPSPDLKAYFAEARSWDADRLRQANRSRRVAWSVAAGASALATAAVCAVAALSPLKT
CCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHEEEEEHHHCHHHHHHHHHHHHHHHHHHHC
VEPYVVRVDRSTGAVEVMTGLNEAGDLTYEEAVTKSFLATYVRARESWLPPAAEANFRQV
CCCEEEEEECCCCEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
SIMSTPAEQQRWAERFRPSNPLSPQVAWGPNAEAEARVRAITFVAPQVASVRFHRTLRQQ
EEECCCHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHEEEEEEECCHHHHHHHHHHHHHH
GQLTESDWIATVAFGYARAPMSESDRLRNPLGFQVSSYRADPEVIQ
CCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCEECCCCCCCCCCC
>Mature Secondary Structure 
TGVPSPDLKAYFAEARSWDADRLRQANRSRRVAWSVAAGASALATAAVCAVAALSPLKT
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHEEEEEHHHCHHHHHHHHHHHHHHHHHHHC
VEPYVVRVDRSTGAVEVMTGLNEAGDLTYEEAVTKSFLATYVRARESWLPPAAEANFRQV
CCCEEEEEECCCCEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
SIMSTPAEQQRWAERFRPSNPLSPQVAWGPNAEAEARVRAITFVAPQVASVRFHRTLRQQ
EEECCCHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHEEEEEEECCHHHHHHHHHHHHHH
GQLTESDWIATVAFGYARAPMSESDRLRNPLGFQVSSYRADPEVIQ
CCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA