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The map label for this gene is ada [H]

Identifier: 197105718

GI number: 197105718

Start: 2555526

End: 2557031

Strand: Reverse

Name: ada [H]

Synonym: PHZ_c2256

Alternate gene names: 197105718

Gene position: 2557031-2555526 (Counterclockwise)

Preceding gene: 197105720

Following gene: 197105717

Centisome position: 63.99

GC content: 75.37

Gene sequence:

>1506_bases
ATGGATATGGACTTCGAAGCCTGCCGCCGCGCCTTCGTCACCCGCGACCCGCGGTTCGACGGCCGCATCTTCGGCGCCGT
GAAGACGACCGGCATCTACTGCCGGCCGATCTGCCCCGCGCGCACGCCGAAGCCCGAGAACATGACGTTCTACCCGACGG
CCGCGGCGGCCCAGGAGGCCGGCTACCGGCCGTGCCTGCGCTGCCGCCCGGAAGCCTCGCCCGATCTCGGCGCCTGGCGG
GGCACGTCGAACACGGTCTCGCGGGCGCTGGCCCTGATCGAGGGGGGCGCGCTGGACGGCGACGACGTGGATGCGCTCGC
GGCCCGCCTGGGCGTGGGCGAACGCCAGCTCCGCCGCCTGTTCCGCCAGCATCTCGGCGCCTCGCCGGTCTCGGTCGCCC
AGACCCGCCGCGTCCTGCTCGCCAAGCAGCTGATCCAGGAGACCCGCCTGCCGATGGGCGAGGTGGCGCTGGCGGCCGGC
TTCGGCAGCGTGCGGCGCTTCAACGAGACGTTCCAGCAGCTGTTCGGCCGCCCGCCGGGCGAGCTGCGCCGCTCGCGCCA
GGCCGACGTGCCGGCGGCCGAGGGCATCGTCGTCCGCCTGCCGTACCGGCCGCCCTACGACTGGGACGCGATCATCCGCT
TCCTCGCCGACCGTGCCATCCCGGGCGTGGAGCGGGTGGAGCCGCGCCGCTATGCGCGCACGCTGGAGGTCGACGGCGCC
CGCGGTGTCGTGATCGTGACGCCGCGCCCGGGCGACGACGCCCTGACCGCCGAGATCCGCTTCCCGAAGCTGAAGGCCCT
GCCGGCGGTGATCGCGCGCATCCGGCGGGTGTTCGACCTCGCCGCCGACCCGGGACGCATTGGAGCGCACCTGAGCCAGG
ATCCGGCGCTCGCCCCGCTGGTCGCGGCCCGGCCGGGCCTGCGAGCCCCGGGGGCGTGGGACGGCTTCGAACTGGCGGTG
CGGGCGATCCTCGGCCAGCAGATCACCGTGGCCGCCGCGCGGGCGCTGGCGGCCAAGCTGACCGACGCCTACGGCGCGTC
GGTCGACGATCCGGCCGCCGCGGAGCTGGGTCTGACACGCGTCTTCCCGCGGCCCGAGCGGCTGGTCGGCGAGGACATCG
CCGCGCTGGGCATGCCGAAGGCGCGCGGCGCGGCGCTGGAGGCCCTGGCGCGCACCGTGGCGGCCGATCCGGCGATCTTC
ACGCCGCGGGCCGACCTGGACAGCGCCATCGCGGCGCTGAAGGCGCTGCCGGGCGTCGGCGAGTGGACGGCGCAGTACAT
CGCGCTGCGCGAACTGCGCGAGCCGGACGCCTTTCCGGGCGCGGATATCGCGCTCCTGCGCGCCATGGCGGACGAGACCG
GCCGGCGGCCGACGCAGGAGGAACTGCTCGCCCGCAGCGCCGCCTGGCGGCCCTGGCGCGCCTACGCCGCCCAACATCTC
TGGGCCCACGACGCGGCCCAACCCGACCTCAAGAGGACCAAGACCGATGATCGTGCAGCCGCCTGA

Upstream 100 bases:

>100_bases
GCTGATCGCGCGCGCTTCGGCGTCCGAAAGCTGCCACGGCCGGCCATGAATGTCCGAAAACCGCGAGACTAGCCGTCCCG
CGGGGCGCATCCTGCCGAAC

Downstream 100 bases:

>100_bases
AACCCTGACCCTCGACCGCATCGCGACCCCGATCGGCACGGCCCTCGTGGTCACCGACGAGGCGGGCGTCCTGCGGGCCT
TCAACTGGACCGACTACGAG

Product: transcriptional regulator, AraC family

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MDMDFEACRRAFVTRDPRFDGRIFGAVKTTGIYCRPICPARTPKPENMTFYPTAAAAQEAGYRPCLRCRPEASPDLGAWR
GTSNTVSRALALIEGGALDGDDVDALAARLGVGERQLRRLFRQHLGASPVSVAQTRRVLLAKQLIQETRLPMGEVALAAG
FGSVRRFNETFQQLFGRPPGELRRSRQADVPAAEGIVVRLPYRPPYDWDAIIRFLADRAIPGVERVEPRRYARTLEVDGA
RGVVIVTPRPGDDALTAEIRFPKLKALPAVIARIRRVFDLAADPGRIGAHLSQDPALAPLVAARPGLRAPGAWDGFELAV
RAILGQQITVAAARALAAKLTDAYGASVDDPAAAELGLTRVFPRPERLVGEDIAALGMPKARGAALEALARTVAADPAIF
TPRADLDSAIAALKALPGVGEWTAQYIALRELREPDAFPGADIALLRAMADETGRRPTQEELLARSAAWRPWRAYAAQHL
WAHDAAQPDLKRTKTDDRAAA

Sequences:

>Translated_501_residues
MDMDFEACRRAFVTRDPRFDGRIFGAVKTTGIYCRPICPARTPKPENMTFYPTAAAAQEAGYRPCLRCRPEASPDLGAWR
GTSNTVSRALALIEGGALDGDDVDALAARLGVGERQLRRLFRQHLGASPVSVAQTRRVLLAKQLIQETRLPMGEVALAAG
FGSVRRFNETFQQLFGRPPGELRRSRQADVPAAEGIVVRLPYRPPYDWDAIIRFLADRAIPGVERVEPRRYARTLEVDGA
RGVVIVTPRPGDDALTAEIRFPKLKALPAVIARIRRVFDLAADPGRIGAHLSQDPALAPLVAARPGLRAPGAWDGFELAV
RAILGQQITVAAARALAAKLTDAYGASVDDPAAAELGLTRVFPRPERLVGEDIAALGMPKARGAALEALARTVAADPAIF
TPRADLDSAIAALKALPGVGEWTAQYIALRELREPDAFPGADIALLRAMADETGRRPTQEELLARSAAWRPWRAYAAQHL
WAHDAAQPDLKRTKTDDRAAA
>Mature_501_residues
MDMDFEACRRAFVTRDPRFDGRIFGAVKTTGIYCRPICPARTPKPENMTFYPTAAAAQEAGYRPCLRCRPEASPDLGAWR
GTSNTVSRALALIEGGALDGDDVDALAARLGVGERQLRRLFRQHLGASPVSVAQTRRVLLAKQLIQETRLPMGEVALAAG
FGSVRRFNETFQQLFGRPPGELRRSRQADVPAAEGIVVRLPYRPPYDWDAIIRFLADRAIPGVERVEPRRYARTLEVDGA
RGVVIVTPRPGDDALTAEIRFPKLKALPAVIARIRRVFDLAADPGRIGAHLSQDPALAPLVAARPGLRAPGAWDGFELAV
RAILGQQITVAAARALAAKLTDAYGASVDDPAAAELGLTRVFPRPERLVGEDIAALGMPKARGAALEALARTVAADPAIF
TPRADLDSAIAALKALPGVGEWTAQYIALRELREPDAFPGADIALLRAMADETGRRPTQEELLARSAAWRPWRAYAAQHL
WAHDAAQPDLKRTKTDDRAAA

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG2169

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=293, Percent_Identity=37.542662116041, Blast_Score=165, Evalue=7e-42,
Organism=Escherichia coli, GI1788542, Length=128, Percent_Identity=36.71875, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 54331; Mature: 54331

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMDFEACRRAFVTRDPRFDGRIFGAVKTTGIYCRPICPARTPKPENMTFYPTAAAAQEA
CCCCHHHHHHHHHCCCCCCCCEEEEEEEECCEEEECCCCCCCCCCCCEEEECCHHHHHHC
GYRPCLRCRPEASPDLGAWRGTSNTVSRALALIEGGALDGDDVDALAARLGVGERQLRRL
CCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHH
FRQHLGASPVSVAQTRRVLLAKQLIQETRLPMGEVALAAGFGSVRRFNETFQQLFGRPPG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHCCCCH
ELRRSRQADVPAAEGIVVRLPYRPPYDWDAIIRFLADRAIPGVERVEPRRYARTLEVDGA
HHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCHHHCCHHHHHHEEEECCC
RGVVIVTPRPGDDALTAEIRFPKLKALPAVIARIRRVFDLAADPGRIGAHLSQDPALAPL
CCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCHH
VAARPGLRAPGAWDGFELAVRAILGQQITVAAARALAAKLTDAYGASVDDPAAAELGLTR
HHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCHHH
VFPRPERLVGEDIAALGMPKARGAALEALARTVAADPAIFTPRADLDSAIAALKALPGVG
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHCCCCH
EWTAQYIALRELREPDAFPGADIALLRAMADETGRRPTQEELLARSAAWRPWRAYAAQHL
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHH
WAHDAAQPDLKRTKTDDRAAA
HHHCCCCCCHHHCCCCHHCCC
>Mature Secondary Structure
MDMDFEACRRAFVTRDPRFDGRIFGAVKTTGIYCRPICPARTPKPENMTFYPTAAAAQEA
CCCCHHHHHHHHHCCCCCCCCEEEEEEEECCEEEECCCCCCCCCCCCEEEECCHHHHHHC
GYRPCLRCRPEASPDLGAWRGTSNTVSRALALIEGGALDGDDVDALAARLGVGERQLRRL
CCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHH
FRQHLGASPVSVAQTRRVLLAKQLIQETRLPMGEVALAAGFGSVRRFNETFQQLFGRPPG
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHCCCCH
ELRRSRQADVPAAEGIVVRLPYRPPYDWDAIIRFLADRAIPGVERVEPRRYARTLEVDGA
HHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCHHHCCHHHHHHEEEECCC
RGVVIVTPRPGDDALTAEIRFPKLKALPAVIARIRRVFDLAADPGRIGAHLSQDPALAPL
CCEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCHH
VAARPGLRAPGAWDGFELAVRAILGQQITVAAARALAAKLTDAYGASVDDPAAAELGLTR
HHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCHHH
VFPRPERLVGEDIAALGMPKARGAALEALARTVAADPAIFTPRADLDSAIAALKALPGVG
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHCCCCH
EWTAQYIALRELREPDAFPGADIALLRAMADETGRRPTQEELLARSAAWRPWRAYAAQHL
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHH
WAHDAAQPDLKRTKTDDRAAA
HHHCCCCCCHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]