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The map label for this gene is acdA [H]

Identifier: 197105483

GI number: 197105483

Start: 2261042

End: 2262220

Strand: Reverse

Name: acdA [H]

Synonym: PHZ_c2020

Alternate gene names: 197105483

Gene position: 2262220-2261042 (Counterclockwise)

Preceding gene: 197105484

Following gene: 197105482

Centisome position: 56.61

GC content: 70.74

Gene sequence:

>1179_bases
ATGGACCTGGACCTCACCCCGGAGGATCTCGCCTTCCGAGACGAGGTCCGGGCCTTTCTCGCCGCGGAGCTCACGCCCGA
GCTTCGCGAGGCGGGGGCGCGGCAGACGAGCGTGTTCGTCGAGCCGCGCCACTCGCTCGCCTGGCAGAAGATCCTGCACG
CGCGCGGCTGGGTCGCCCCCAGCTGGCCGGAGGAATACGGCGGTCCCGGCTGGACCGAGATGCAGCGGCACATCTTCGCC
GCCGAGTGCGCGGCGGCCAGCGCCCCCAGCCTCGCGCCCATGGGCCTTCGCATGGTGGGCCCCTGCATCATGCGCTACGG
CACGCCCGAGCAGAAGGCGCACTACCTCCCGCGGATCCTCTCGGGCGAGGACTACTGGTGCCAGGGCTATTCCGAGCCGG
GCTCGGGCTCGGATCTCGCCTCGCTGCAGCTTCGCGCCGTAAGCGACGGGGATCATTACGTTCTGAGCGGGTCGAAGATC
TGGACGACCCACGCCCACCACGCCAACCGCATGTTCTGCCTCGTGCGCACCAGCAGCGAGGGCAAGCCGCAGCAGGGCAT
CACCTTCCTGCTGCTCGACATGGCCACGCCGGGCCTCAAGGTCGACCCGATCATCACCCTGGCCGGCGAGCACGAGGTCA
ACCAGGTGTTCTTCGACGAGGTCCGCGTGCCCAAGTCGGGCCGGCTCGGCGAGGAGAACCAGGGCTGGACGGTGGCCAAG
TACCTGCTGGAGTTCGAGCGGGGCGGGGGCTCGGCGCCGGGCCTGAAGGTCGCCCTCGAGCGGGTGCGCGGCATGGCCGG
CGAGCTGGCGGCCGACCCGCATTTCCGCCGCCGCCTGGCCGAGCGCGAGATCGCCGTCCAGGCCGTCGAGATGAGCGAGC
TGATCGTGCTCTCGGCCCTGGCCGGGGGGCGAAATCCCGGGCCGGCCTCGTCCATGCTCAAGACGCAGGGCGCCGAGACG
ATGCAGCGGATCGACGAGCTGGCCGTGGACGCGGCCGGCGCCTACGCCGCCGTCTTCCAGCCGCACGCCCGCGAGCCGGG
CTCGAACGCCCCGGCGATCGGGCCGGAACACAGTCTGACCGCAATGGCCAGGTACCTGAACAACCGGGCCGCCTCGATCT
ACGGCGGCTCCAACGAGATCCAAAGAGACATCATCGCCCGGCTCGTGCTCGGGCTTTGA

Upstream 100 bases:

>100_bases
GTGGTGGTCGACCAGCCGCTGCAGTCGGGCACCTTCGCCGCCTTCCTCGGTTCGCCGCGGACCGTCGGGGCGACGCTGCG
GGTGAAGTTCAACTAAGCCG

Downstream 100 bases:

>100_bases
AGGGAGGAAATGCGATGTCGCTCAACCTGCGCCGGCCGCCTTACCGGACCTATTCCATCACCCAGCTGTGCCACGAGTTC
GGGGCCACGCCCCGGGCGCT

Product: acyl-CoA dehydrogenase family protein

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MDLDLTPEDLAFRDEVRAFLAAELTPELREAGARQTSVFVEPRHSLAWQKILHARGWVAPSWPEEYGGPGWTEMQRHIFA
AECAAASAPSLAPMGLRMVGPCIMRYGTPEQKAHYLPRILSGEDYWCQGYSEPGSGSDLASLQLRAVSDGDHYVLSGSKI
WTTHAHHANRMFCLVRTSSEGKPQQGITFLLLDMATPGLKVDPIITLAGEHEVNQVFFDEVRVPKSGRLGEENQGWTVAK
YLLEFERGGGSAPGLKVALERVRGMAGELAADPHFRRRLAEREIAVQAVEMSELIVLSALAGGRNPGPASSMLKTQGAET
MQRIDELAVDAAGAYAAVFQPHAREPGSNAPAIGPEHSLTAMARYLNNRAASIYGGSNEIQRDIIARLVLGL

Sequences:

>Translated_392_residues
MDLDLTPEDLAFRDEVRAFLAAELTPELREAGARQTSVFVEPRHSLAWQKILHARGWVAPSWPEEYGGPGWTEMQRHIFA
AECAAASAPSLAPMGLRMVGPCIMRYGTPEQKAHYLPRILSGEDYWCQGYSEPGSGSDLASLQLRAVSDGDHYVLSGSKI
WTTHAHHANRMFCLVRTSSEGKPQQGITFLLLDMATPGLKVDPIITLAGEHEVNQVFFDEVRVPKSGRLGEENQGWTVAK
YLLEFERGGGSAPGLKVALERVRGMAGELAADPHFRRRLAEREIAVQAVEMSELIVLSALAGGRNPGPASSMLKTQGAET
MQRIDELAVDAAGAYAAVFQPHAREPGSNAPAIGPEHSLTAMARYLNNRAASIYGGSNEIQRDIIARLVLGL
>Mature_392_residues
MDLDLTPEDLAFRDEVRAFLAAELTPELREAGARQTSVFVEPRHSLAWQKILHARGWVAPSWPEEYGGPGWTEMQRHIFA
AECAAASAPSLAPMGLRMVGPCIMRYGTPEQKAHYLPRILSGEDYWCQGYSEPGSGSDLASLQLRAVSDGDHYVLSGSKI
WTTHAHHANRMFCLVRTSSEGKPQQGITFLLLDMATPGLKVDPIITLAGEHEVNQVFFDEVRVPKSGRLGEENQGWTVAK
YLLEFERGGGSAPGLKVALERVRGMAGELAADPHFRRRLAEREIAVQAVEMSELIVLSALAGGRNPGPASSMLKTQGAET
MQRIDELAVDAAGAYAAVFQPHAREPGSNAPAIGPEHSLTAMARYLNNRAASIYGGSNEIQRDIIARLVLGL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=249, Percent_Identity=28.9156626506024, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI4557233, Length=356, Percent_Identity=26.9662921348315, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI226958414, Length=206, Percent_Identity=30.0970873786408, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI21361497, Length=242, Percent_Identity=30.9917355371901, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4501857, Length=405, Percent_Identity=23.7037037037037, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4501859, Length=242, Percent_Identity=29.3388429752066, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI7656849, Length=340, Percent_Identity=26.1764705882353, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI4557231, Length=410, Percent_Identity=24.8780487804878, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI187960098, Length=410, Percent_Identity=24.8780487804878, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4557235, Length=158, Percent_Identity=34.8101265822785, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI76496475, Length=158, Percent_Identity=34.8101265822785, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI211971008, Length=365, Percent_Identity=25.2054794520548, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI48976061, Length=365, Percent_Identity=25.2054794520548, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4503943, Length=409, Percent_Identity=24.2053789731051, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI87081958, Length=253, Percent_Identity=26.4822134387352, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17506239, Length=397, Percent_Identity=28.2115869017632, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17508101, Length=397, Percent_Identity=27.7078085642317, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17538396, Length=252, Percent_Identity=31.7460317460317, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17570075, Length=415, Percent_Identity=26.2650602409639, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI32563615, Length=232, Percent_Identity=33.1896551724138, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17569725, Length=358, Percent_Identity=27.0949720670391, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17534899, Length=360, Percent_Identity=28.0555555555556, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71990804, Length=206, Percent_Identity=31.0679611650485, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71985184, Length=197, Percent_Identity=28.4263959390863, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71985192, Length=197, Percent_Identity=28.4263959390863, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17551932, Length=212, Percent_Identity=26.8867924528302, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17505929, Length=213, Percent_Identity=26.2910798122066, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71982178, Length=195, Percent_Identity=30.7692307692308, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21355753, Length=242, Percent_Identity=32.2314049586777, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI281363737, Length=201, Percent_Identity=32.8358208955224, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356377, Length=344, Percent_Identity=28.4883720930233, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24666513, Length=207, Percent_Identity=31.4009661835749, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24660351, Length=407, Percent_Identity=25.5528255528256, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24646207, Length=396, Percent_Identity=26.5151515151515, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19920834, Length=410, Percent_Identity=25.609756097561, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42675; Mature: 42675

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLDLTPEDLAFRDEVRAFLAAELTPELREAGARQTSVFVEPRHSLAWQKILHARGWVAP
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCC
SWPEEYGGPGWTEMQRHIFAAECAAASAPSLAPMGLRMVGPCIMRYGTPEQKAHYLPRIL
CCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
SGEDYWCQGYSEPGSGSDLASLQLRAVSDGDHYVLSGSKIWTTHAHHANRMFCLVRTSSE
CCCCCEECCCCCCCCCCCEEEEEEEEECCCCEEEEECCEEEEEECCCCCEEEEEEEECCC
GKPQQGITFLLLDMATPGLKVDPIITLAGEHEVNQVFFDEVRVPKSGRLGEENQGWTVAK
CCCCCCCEEEEEECCCCCCEECCEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
YLLEFERGGGSAPGLKVALERVRGMAGELAADPHFRRRLAEREIAVQAVEMSELIVLSAL
HHHHHHCCCCCCCHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGGRNPGPASSMLKTQGAETMQRIDELAVDAAGAYAAVFQPHAREPGSNAPAIGPEHSLT
HCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCHHHH
AMARYLNNRAASIYGGSNEIQRDIIARLVLGL
HHHHHHCCCCEEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDLDLTPEDLAFRDEVRAFLAAELTPELREAGARQTSVFVEPRHSLAWQKILHARGWVAP
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCC
SWPEEYGGPGWTEMQRHIFAAECAAASAPSLAPMGLRMVGPCIMRYGTPEQKAHYLPRIL
CCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
SGEDYWCQGYSEPGSGSDLASLQLRAVSDGDHYVLSGSKIWTTHAHHANRMFCLVRTSSE
CCCCCEECCCCCCCCCCCEEEEEEEEECCCCEEEEECCEEEEEECCCCCEEEEEEEECCC
GKPQQGITFLLLDMATPGLKVDPIITLAGEHEVNQVFFDEVRVPKSGRLGEENQGWTVAK
CCCCCCCEEEEEECCCCCCEECCEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
YLLEFERGGGSAPGLKVALERVRGMAGELAADPHFRRRLAEREIAVQAVEMSELIVLSAL
HHHHHHCCCCCCCHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGGRNPGPASSMLKTQGAETMQRIDELAVDAAGAYAAVFQPHAREPGSNAPAIGPEHSLT
HCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCHHHH
AMARYLNNRAASIYGGSNEIQRDIIARLVLGL
HHHHHHCCCCEEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]