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The map label for this gene is yxbG [H]

Identifier: 197105469

GI number: 197105469

Start: 2243656

End: 2244447

Strand: Reverse

Name: yxbG [H]

Synonym: PHZ_c2006

Alternate gene names: 197105469

Gene position: 2244447-2243656 (Counterclockwise)

Preceding gene: 197105470

Following gene: 197105468

Centisome position: 56.16

GC content: 72.35

Gene sequence:

>792_bases
ATGAAGATCGATTCCAGCGTTGCGGCCGTCGTGACGGGCGGGGCGTCGGGCCTGGGGCGGGCGACCGCCGCGGCCCTGCG
TGACCTCGGGGCCAGGGTCGCCCTGTTCGACAAGAACAAGGAGCTCGGCGAGCAGACGGCGGCCGAGCTCGGCGCGCTGT
TCTGCGAGGTGGACGTCATGGACGAGGCCTCGGTGGACGCCGGCTTCGCCAAGGCGCGGGCGGCCCACGGCCAGGAGCGC
GTCCTGGTCAACTGCGCCGGCGGCGGCCGGGGCGGCAAGACCATCGCCCGGGACAAGCAGACGGGCGAGATCGTCCCCTA
CAAGACCGACGACTTCCAATGGGTGCTGGGGCTGAACACGGTCGGCACCTTCCGCTGCACCGTGAAGAGCGCCGCCGGCA
TGGCCGCCCTCGAGCCCACCCCCGAGGGCGAGCGGGGCGCGATCGTCAACACGGGCTCGGTGGCCGCCGAGGAGGGCCAG
ATCGGCCAGGTCGCCTACGCCGCCGCGAAGGCGGCCATCAAGGGCATGACCATCGTCCTGGCCCGCGACCTGTCCTCGGA
GGGGATCCGGGTGAACACCATCCTGCCGGGGATCATGGACACGCCGCTGCTGGGCGGCCTGAAGACCCGCGCGCCCCAGG
TCTACGAGGGCCTTGCCCGGTCGGTGCCGTTCCCCCGCCGCCTGGGCACGGCCGAGGAATACGCGGACCTGGCGCTGACC
ATGATCCGCAACGGCTACCTGAACGGCGAGACGGTGCGCTTGGACGGGGCGATCCGCATGGCCCCGCGCTAG

Upstream 100 bases:

>100_bases
GGCGAGGGAACCGCGGCAAGGCGTTCACAGACGAGCCTCGCCCAACGTCAGGCGCTTCCGCTGCTATGCGGGCTGAAAAT
CCTATCGGGAGGCATATGGG

Downstream 100 bases:

>100_bases
GGGCCCGACCTGAGCCCCGGGGCGCGGCGGCGACCCTGCTCCGGCCGACGGCTGCTCCTCCTGCGCGAGCCACGGCTCGT
GGGCGTCGGGCGCTGTCGGG

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MKIDSSVAAVVTGGASGLGRATAAALRDLGARVALFDKNKELGEQTAAELGALFCEVDVMDEASVDAGFAKARAAHGQER
VLVNCAGGGRGGKTIARDKQTGEIVPYKTDDFQWVLGLNTVGTFRCTVKSAAGMAALEPTPEGERGAIVNTGSVAAEEGQ
IGQVAYAAAKAAIKGMTIVLARDLSSEGIRVNTILPGIMDTPLLGGLKTRAPQVYEGLARSVPFPRRLGTAEEYADLALT
MIRNGYLNGETVRLDGAIRMAPR

Sequences:

>Translated_263_residues
MKIDSSVAAVVTGGASGLGRATAAALRDLGARVALFDKNKELGEQTAAELGALFCEVDVMDEASVDAGFAKARAAHGQER
VLVNCAGGGRGGKTIARDKQTGEIVPYKTDDFQWVLGLNTVGTFRCTVKSAAGMAALEPTPEGERGAIVNTGSVAAEEGQ
IGQVAYAAAKAAIKGMTIVLARDLSSEGIRVNTILPGIMDTPLLGGLKTRAPQVYEGLARSVPFPRRLGTAEEYADLALT
MIRNGYLNGETVRLDGAIRMAPR
>Mature_263_residues
MKIDSSVAAVVTGGASGLGRATAAALRDLGARVALFDKNKELGEQTAAELGALFCEVDVMDEASVDAGFAKARAAHGQER
VLVNCAGGGRGGKTIARDKQTGEIVPYKTDDFQWVLGLNTVGTFRCTVKSAAGMAALEPTPEGERGAIVNTGSVAAEEGQ
IGQVAYAAAKAAIKGMTIVLARDLSSEGIRVNTILPGIMDTPLLGGLKTRAPQVYEGLARSVPFPRRLGTAEEYADLALT
MIRNGYLNGETVRLDGAIRMAPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=259, Percent_Identity=47.8764478764479, Blast_Score=198, Evalue=4e-51,
Organism=Homo sapiens, GI83715985, Length=259, Percent_Identity=45.1737451737452, Blast_Score=177, Evalue=8e-45,
Organism=Homo sapiens, GI15277342, Length=271, Percent_Identity=31.3653136531365, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI40254992, Length=252, Percent_Identity=30.952380952381, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI31542939, Length=272, Percent_Identity=28.6764705882353, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI59889578, Length=203, Percent_Identity=31.5270935960591, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=31.9066147859922, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI87082100, Length=261, Percent_Identity=31.8007662835249, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI2367175, Length=259, Percent_Identity=32.4324324324324, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1787905, Length=261, Percent_Identity=28.3524904214559, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=28.0155642023346, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788459, Length=261, Percent_Identity=26.0536398467433, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786812, Length=194, Percent_Identity=31.4432989690722, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=257, Percent_Identity=44.7470817120623, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17555706, Length=261, Percent_Identity=32.5670498084291, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25147288, Length=260, Percent_Identity=29.2307692307692, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17538480, Length=219, Percent_Identity=31.9634703196347, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17560332, Length=267, Percent_Identity=30.3370786516854, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=206, Percent_Identity=31.0679611650485, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=268, Percent_Identity=26.4925373134328, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=267, Percent_Identity=26.5917602996255, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=276, Percent_Identity=27.1739130434783, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI17737361, Length=256, Percent_Identity=48.828125, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24639444, Length=257, Percent_Identity=34.2412451361868, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28571526, Length=202, Percent_Identity=29.7029702970297, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357041, Length=210, Percent_Identity=30.952380952381, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI23397609, Length=201, Percent_Identity=30.8457711442786, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 27350; Mature: 27350

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIDSSVAAVVTGGASGLGRATAAALRDLGARVALFDKNKELGEQTAAELGALFCEVDVM
CCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHEEEEEEC
DEASVDAGFAKARAAHGQERVLVNCAGGGRGGKTIARDKQTGEIVPYKTDDFQWVLGLNT
CCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEECCCCEEEEECCC
VGTFRCTVKSAAGMAALEPTPEGERGAIVNTGSVAAEEGQIGQVAYAAAKAAIKGMTIVL
CEEEEEEEECCCCCEEECCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCEEEEE
ARDLSSEGIRVNTILPGIMDTPLLGGLKTRAPQVYEGLARSVPFPRRLGTAEEYADLALT
EECCCCCCEEEEEECCCCCCCCCCCCHHCCCCHHHHHHHHCCCCCHHCCCHHHHHHHHHH
MIRNGYLNGETVRLDGAIRMAPR
HHHCCCCCCCEEEECCEEEECCC
>Mature Secondary Structure
MKIDSSVAAVVTGGASGLGRATAAALRDLGARVALFDKNKELGEQTAAELGALFCEVDVM
CCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHEEEEEEC
DEASVDAGFAKARAAHGQERVLVNCAGGGRGGKTIARDKQTGEIVPYKTDDFQWVLGLNT
CCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCEECCCCEEEEECCC
VGTFRCTVKSAAGMAALEPTPEGERGAIVNTGSVAAEEGQIGQVAYAAAKAAIKGMTIVL
CEEEEEEEECCCCCEEECCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCEEEEE
ARDLSSEGIRVNTILPGIMDTPLLGGLKTRAPQVYEGLARSVPFPRRLGTAEEYADLALT
EECCCCCCEEEEEECCCCCCCCCCCCHHCCCCHHHHHHHHCCCCCHHCCCHHHHHHHHHH
MIRNGYLNGETVRLDGAIRMAPR
HHHCCCCCCCEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377 [H]