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The map label for this gene is phbA [H]

Identifier: 197105470

GI number: 197105470

Start: 2244563

End: 2245783

Strand: Reverse

Name: phbA [H]

Synonym: PHZ_c2007

Alternate gene names: 197105470

Gene position: 2245783-2244563 (Counterclockwise)

Preceding gene: 197105472

Following gene: 197105469

Centisome position: 56.2

GC content: 72.07

Gene sequence:

>1221_bases
ATGGCCCAGAGCCTCCGCCGCGCCGCCATCGTCAGCCCGATCCGCACCGCCGTGGGCAAGTATCTCGGCGCCCTGTCGGG
CGTGACCGCCGGCGACCTCGGGGCGGTGGTGATCCGAGCCCTCGTGGACCGCACCGGGGTGGATCCGGAGCGGATCGACG
ACGTGATCTTCGCCCAGGGCTACGCCAACGGCGAGGCGCCCTGCATCGCCCGTTGGTCGGCCCTGGCCGCCGACCTGCCG
ATCAAGGTGCCGGGCTACCAGCTCGACCGCCGCTGCGGCTCGGGCCTCCAGGCGGTGGTGGACGCCGCCATGATGATCCA
GACGGGCGCGGCCGACGTGGTCATCGCCGGCGGCTGCGAGAGCATGAGCAACGCCGAGTACTACACCCTCGACATGCGCA
AGGGCGCGCGCGCGGGGTCGACGACCATGCACGACCGCCTGGCCCGCGGCCGGGTGATGTCGCAGCCGATCTCCCGCTTC
GGGGTGATCACCGGGATGATCGAAACCGCCGAGAACCTGGCCAAGGACTACGGCATCAGCCGCGAGGCCTGCGACGAGTA
CGCCCTGATGAGCCACACCCGGGCGGCCGAGGCCTGGGCCGCCGGAAAGTTCGACGACGAGCTGGTGCCGGTCTCGGTGC
CCCAGCGCAAGGGCGATCCGATCCTGTTCGATCGCGACGAGGGCGTGCGCGGCGACGTGACCATGGAGAGCCTGTCGAAG
CTGCCGGCCATCGAGAAGGGCGGGGTGGTCACGGCCGGCAACGCCAGCCAGCAGAACGACGCCGGCGCCGCCTGCCTAGT
GGTGGCCGAGGACAAGCTGGCCGAGCTGGGGCTGGAGCCGATGGGCTGGTTCACCGGCTGGGCGGCCGCCGGCTGCGACC
CGGCGCGCATGGGCATCGGCCCGGTGCCGGCGGTGGAGCGGCTGTTCGCCCGCACCGGGCTGTCCTGGGACGACATCGAC
CTCGTGGAGCTGAACGAGGCCTTCGCGCCGCAGGTCCTGGCGGTGCTGAAGGGCTGGGGCTGGCCAGAAAATGGGGACTG
GCGCGACCGGCTGAACGTCAACGGCTCGGGCATCTCGCTGGGCCACCCCATCGGCGCCACTGGCGGCCGCATCCTGGCCA
ACCTGCTGCGCGAGCTGAAGCGCCGCGACGGCCGTTACGGCCTGGAGACCATGTGCATCGGCGGCGGCCAGGGAATCGCG
GCCGTCTTCGAGCGGGCGTGA

Upstream 100 bases:

>100_bases
CGGGCGCCCCTGCGCTGCAGGAACACCCCGACATCCCTTCGCCGGCGCGCGCCCTGAGCGCCGCGCCGGACCATCCACGC
CTCAGCAGGAGACCACCCCC

Downstream 100 bases:

>100_bases
CGCGCGATCCTGACGGGCGAGGGAACCGCGGCAAGGCGTTCACAGACGAGCCTCGCCCAACGTCAGGCGCTTCCGCTGCT
ATGCGGGCTGAAAATCCTAT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MAQSLRRAAIVSPIRTAVGKYLGALSGVTAGDLGAVVIRALVDRTGVDPERIDDVIFAQGYANGEAPCIARWSALAADLP
IKVPGYQLDRRCGSGLQAVVDAAMMIQTGAADVVIAGGCESMSNAEYYTLDMRKGARAGSTTMHDRLARGRVMSQPISRF
GVITGMIETAENLAKDYGISREACDEYALMSHTRAAEAWAAGKFDDELVPVSVPQRKGDPILFDRDEGVRGDVTMESLSK
LPAIEKGGVVTAGNASQQNDAGAACLVVAEDKLAELGLEPMGWFTGWAAAGCDPARMGIGPVPAVERLFARTGLSWDDID
LVELNEAFAPQVLAVLKGWGWPENGDWRDRLNVNGSGISLGHPIGATGGRILANLLRELKRRDGRYGLETMCIGGGQGIA
AVFERA

Sequences:

>Translated_406_residues
MAQSLRRAAIVSPIRTAVGKYLGALSGVTAGDLGAVVIRALVDRTGVDPERIDDVIFAQGYANGEAPCIARWSALAADLP
IKVPGYQLDRRCGSGLQAVVDAAMMIQTGAADVVIAGGCESMSNAEYYTLDMRKGARAGSTTMHDRLARGRVMSQPISRF
GVITGMIETAENLAKDYGISREACDEYALMSHTRAAEAWAAGKFDDELVPVSVPQRKGDPILFDRDEGVRGDVTMESLSK
LPAIEKGGVVTAGNASQQNDAGAACLVVAEDKLAELGLEPMGWFTGWAAAGCDPARMGIGPVPAVERLFARTGLSWDDID
LVELNEAFAPQVLAVLKGWGWPENGDWRDRLNVNGSGISLGHPIGATGGRILANLLRELKRRDGRYGLETMCIGGGQGIA
AVFERA
>Mature_405_residues
AQSLRRAAIVSPIRTAVGKYLGALSGVTAGDLGAVVIRALVDRTGVDPERIDDVIFAQGYANGEAPCIARWSALAADLPI
KVPGYQLDRRCGSGLQAVVDAAMMIQTGAADVVIAGGCESMSNAEYYTLDMRKGARAGSTTMHDRLARGRVMSQPISRFG
VITGMIETAENLAKDYGISREACDEYALMSHTRAAEAWAAGKFDDELVPVSVPQRKGDPILFDRDEGVRGDVTMESLSKL
PAIEKGGVVTAGNASQQNDAGAACLVVAEDKLAELGLEPMGWFTGWAAAGCDPARMGIGPVPAVERLFARTGLSWDDIDL
VELNEAFAPQVLAVLKGWGWPENGDWRDRLNVNGSGISLGHPIGATGGRILANLLRELKRRDGRYGLETMCIGGGQGIAA
VFERA

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=403, Percent_Identity=40.6947890818859, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI148539872, Length=401, Percent_Identity=38.1546134663342, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=38.2871536523929, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI4557237, Length=406, Percent_Identity=33.743842364532, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI4504327, Length=428, Percent_Identity=31.0747663551402, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=28.0612244897959, Blast_Score=126, Evalue=3e-29,
Organism=Escherichia coli, GI87082165, Length=403, Percent_Identity=43.9205955334988, Blast_Score=297, Evalue=9e-82,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=44.0594059405941, Blast_Score=291, Evalue=4e-80,
Organism=Escherichia coli, GI1787663, Length=406, Percent_Identity=43.8423645320197, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI48994986, Length=413, Percent_Identity=38.7409200968523, Blast_Score=251, Evalue=8e-68,
Organism=Escherichia coli, GI1788683, Length=411, Percent_Identity=33.8199513381995, Blast_Score=198, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI133906874, Length=398, Percent_Identity=40.2010050251256, Blast_Score=278, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI25147385, Length=421, Percent_Identity=33.0166270783848, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17535921, Length=401, Percent_Identity=33.1670822942643, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17551802, Length=429, Percent_Identity=30.7692307692308, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=407, Percent_Identity=26.2899262899263, Blast_Score=121, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6325229, Length=403, Percent_Identity=34.9875930521092, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6322031, Length=401, Percent_Identity=34.9127182044888, Blast_Score=198, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24655093, Length=398, Percent_Identity=43.21608040201, Blast_Score=305, Evalue=5e-83,
Organism=Drosophila melanogaster, GI17648125, Length=408, Percent_Identity=37.2549019607843, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24640423, Length=399, Percent_Identity=33.3333333333333, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI17137578, Length=428, Percent_Identity=32.9439252336449, Blast_Score=182, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 42990; Mature: 42859

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQSLRRAAIVSPIRTAVGKYLGALSGVTAGDLGAVVIRALVDRTGVDPERIDDVIFAQG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHEECC
YANGEAPCIARWSALAADLPIKVPGYQLDRRCGSGLQAVVDAAMMIQTGAADVVIAGGCE
CCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECCCC
SMSNAEYYTLDMRKGARAGSTTMHDRLARGRVMSQPISRFGVITGMIETAENLAKDYGIS
CCCCCCEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
REACDEYALMSHTRAAEAWAAGKFDDELVPVSVPQRKGDPILFDRDEGVRGDVTMESLSK
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHH
LPAIEKGGVVTAGNASQQNDAGAACLVVAEDKLAELGLEPMGWFTGWAAAGCDPARMGIG
CCCCCCCCEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCCCHHHHHHHCCCCHHHCCCC
PVPAVERLFARTGLSWDDIDLVELNEAFAPQVLAVLKGWGWPENGDWRDRLNVNGSGISL
CCHHHHHHHHHCCCCCCCEEHEECCHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCEEC
GHPIGATGGRILANLLRELKRRDGRYGLETMCIGGGQGIAAVFERA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHCC
>Mature Secondary Structure 
AQSLRRAAIVSPIRTAVGKYLGALSGVTAGDLGAVVIRALVDRTGVDPERIDDVIFAQG
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHEECC
YANGEAPCIARWSALAADLPIKVPGYQLDRRCGSGLQAVVDAAMMIQTGAADVVIAGGCE
CCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECCCC
SMSNAEYYTLDMRKGARAGSTTMHDRLARGRVMSQPISRFGVITGMIETAENLAKDYGIS
CCCCCCEEEEECCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
REACDEYALMSHTRAAEAWAAGKFDDELVPVSVPQRKGDPILFDRDEGVRGDVTMESLSK
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHH
LPAIEKGGVVTAGNASQQNDAGAACLVVAEDKLAELGLEPMGWFTGWAAAGCDPARMGIG
CCCCCCCCEEEECCCCCCCCCCCEEEEEECHHHHHCCCCCCCHHHHHHHCCCCHHHCCCC
PVPAVERLFARTGLSWDDIDLVELNEAFAPQVLAVLKGWGWPENGDWRDRLNVNGSGISL
CCHHHHHHHHHCCCCCCCEEHEECCHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCEEC
GHPIGATGGRILANLLRELKRRDGRYGLETMCIGGGQGIAAVFERA
CCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2670935; 2670936 [H]