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The map label for this gene is ilvD [H]

Identifier: 197105441

GI number: 197105441

Start: 2208253

End: 2209992

Strand: Reverse

Name: ilvD [H]

Synonym: PHZ_c1978

Alternate gene names: 197105441

Gene position: 2209992-2208253 (Counterclockwise)

Preceding gene: 197105443

Following gene: 197105440

Centisome position: 55.3

GC content: 71.26

Gene sequence:

>1740_bases
ATGCATCGCAAACCGGACGGATCCTGGGACAAGTCGAAGCTCCCCAGCCGCCACGTGACCGAGGGGCCCTCGCGGGCGCC
GCACCGGTCGTACTTCTATGCGATGGGCCTGGGCAGCCGCGAGATCGCCCAGCCGTTCGTGGGCGTAGCCTCGTGCTGGA
ACGAGGCCGCGCCGTGCAACACCGCCCTGATGCGCCAGGCGCACGCCGCGTCCGAGGGCGTGAAGCGCGCCGGCGGCACC
CCGCGCGAGTTCTGCACCATCACCGTCACCGACGGGATCGCCATGGGCCACGAGGGCATGCGCTCGTCCCTGGTCAGCCG
GGACCTGATCGCCGACTCCGTCGAGCTGACCATGCGCGGCCACGCCTACGACGCCCTGATCGGCGTCGCCGGCTGCGACA
AGAGCCTGCCGGGCATGATGATGGCCATGCTGCGCCTGAACGTGCCCTCGGCCTTCATCTACGGCGGCTCCATCCTGCCC
GGGACCTGGCACGGGCGAGAAGTGACCGTGCAGGACGTTTTCGAGGGCGTCGGCAAGCACTCCGCCGGCCAGATGAGCCT
CGAGGATCTGTGCGACCTCGAGCAGCACGCCTGTCCGGGCGACGGGGCCTGCGGCGGCCAGTACACGGCCAACACCATGG
CCTGCGTGTCCGAGGCGATCGGCCTGGCCCTGCCGCTGTCCTCGGCGCTGCCGGCGGCCTATCTCGACCGCGACGAATAC
GCCCGCGCCACCGGCGAGGCGGTGATGGCCCTGCTGGAGCGCAACCTGCGTCCGCGCGATATCTGCACCCGCGAGGCGTT
CGAAAACGCCGCCGTGGTGGTGGCCGCGACCGGGGGGTCGACCAACGGCGGCCTGCACCTGCCGGCCATGGCCCACGAGT
GCGGCATCGAGTTCACCCTGCGCGACGTGTGCGAGATCATGAAGCGGACGCCGTACCTGGCCGACCTGATGCCGGGCGGG
CGCTATCCGGCCAAGAAGATGGGCGAGGCGGGCGGCGTGCCGATGCTGCTGCGCACCCTGCTGGACGCCGGCCTGATCCA
CGGCGACTGCATGACGGTCACCGGCAAGACGATCCGCGAGAACCTGGAAGGCGTCGTCTGGAACGACGAGCAGGACGTCA
TCCGCCCGGTCTCCAATCCGCTGTCGCCCACGGGCGGCGTCGTCGGCCTGTGGGGCTCGCTGGCCCCCGACGGCGCGATC
GTGAAGGTGGCCGGCCTCAGCCACACCAAGCACCGCGGCCCGGCCCGGGTGTTCGACGGCGAGGAGGCCTGCTTCGCCGC
CGTCGAGGCGCGCGACTACAAGGAAGGCGACGTGCTGGTCATCCGGTACGAGGGGCCCAAGGGCGGCCCCGGCATGCGCG
AGATGCTGGCCACCACGGCGGCCATCAAGGGCCAGGGCGTGGAGAACATCGCGCTCATCACCGACGGCCGGTTCTCGGGC
GCCACGCGCGGCCTCTGCGTCGGCCACATCGGTCCGGAAGCCGCGGACGGCGGCCCCATCGCGCTGGTGAAGGACGGCGA
CATCATCTCCATCGACGCCGAGGCCGGCACGATCGAGCTGGAGGTCGATCCGATCGAGCTGGAGCACCGCGCCCACCTGC
TGGCCCAGGAGGAGCCCCGCCGGACGAACTACGGCTCGGGCGCGATCTGGAAGTACGTCCAGCTCGTGGGCCCCGCGCAC
CTCGGCGCCGTGACCCATCCGGGCCACGCTGGCGAGACGCACGTCTACGCGGACATCTGA

Upstream 100 bases:

>100_bases
CGCCAGTTAGAGTAGAGTGGCCACGCGCGCGCCGCGGGGGACTTCCACCGGCGGCGAGCGGCCCTTACAGAGGGCCGGCC
TTAGTCGGGAGCGCCTGAAC

Downstream 100 bases:

>100_bases
GGTGCGGACCCTCGGCCTCATCGGCGGGATCAGCGCCGAGAGCACGGTCGTCTACTACCAGCTGCTCAACCGCCTGGTCC
GCGAGCGGCTGGGCGGCCTG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 579; Mature: 579

Protein sequence:

>579_residues
MHRKPDGSWDKSKLPSRHVTEGPSRAPHRSYFYAMGLGSREIAQPFVGVASCWNEAAPCNTALMRQAHAASEGVKRAGGT
PREFCTITVTDGIAMGHEGMRSSLVSRDLIADSVELTMRGHAYDALIGVAGCDKSLPGMMMAMLRLNVPSAFIYGGSILP
GTWHGREVTVQDVFEGVGKHSAGQMSLEDLCDLEQHACPGDGACGGQYTANTMACVSEAIGLALPLSSALPAAYLDRDEY
ARATGEAVMALLERNLRPRDICTREAFENAAVVVAATGGSTNGGLHLPAMAHECGIEFTLRDVCEIMKRTPYLADLMPGG
RYPAKKMGEAGGVPMLLRTLLDAGLIHGDCMTVTGKTIRENLEGVVWNDEQDVIRPVSNPLSPTGGVVGLWGSLAPDGAI
VKVAGLSHTKHRGPARVFDGEEACFAAVEARDYKEGDVLVIRYEGPKGGPGMREMLATTAAIKGQGVENIALITDGRFSG
ATRGLCVGHIGPEAADGGPIALVKDGDIISIDAEAGTIELEVDPIELEHRAHLLAQEEPRRTNYGSGAIWKYVQLVGPAH
LGAVTHPGHAGETHVYADI

Sequences:

>Translated_579_residues
MHRKPDGSWDKSKLPSRHVTEGPSRAPHRSYFYAMGLGSREIAQPFVGVASCWNEAAPCNTALMRQAHAASEGVKRAGGT
PREFCTITVTDGIAMGHEGMRSSLVSRDLIADSVELTMRGHAYDALIGVAGCDKSLPGMMMAMLRLNVPSAFIYGGSILP
GTWHGREVTVQDVFEGVGKHSAGQMSLEDLCDLEQHACPGDGACGGQYTANTMACVSEAIGLALPLSSALPAAYLDRDEY
ARATGEAVMALLERNLRPRDICTREAFENAAVVVAATGGSTNGGLHLPAMAHECGIEFTLRDVCEIMKRTPYLADLMPGG
RYPAKKMGEAGGVPMLLRTLLDAGLIHGDCMTVTGKTIRENLEGVVWNDEQDVIRPVSNPLSPTGGVVGLWGSLAPDGAI
VKVAGLSHTKHRGPARVFDGEEACFAAVEARDYKEGDVLVIRYEGPKGGPGMREMLATTAAIKGQGVENIALITDGRFSG
ATRGLCVGHIGPEAADGGPIALVKDGDIISIDAEAGTIELEVDPIELEHRAHLLAQEEPRRTNYGSGAIWKYVQLVGPAH
LGAVTHPGHAGETHVYADI
>Mature_579_residues
MHRKPDGSWDKSKLPSRHVTEGPSRAPHRSYFYAMGLGSREIAQPFVGVASCWNEAAPCNTALMRQAHAASEGVKRAGGT
PREFCTITVTDGIAMGHEGMRSSLVSRDLIADSVELTMRGHAYDALIGVAGCDKSLPGMMMAMLRLNVPSAFIYGGSILP
GTWHGREVTVQDVFEGVGKHSAGQMSLEDLCDLEQHACPGDGACGGQYTANTMACVSEAIGLALPLSSALPAAYLDRDEY
ARATGEAVMALLERNLRPRDICTREAFENAAVVVAATGGSTNGGLHLPAMAHECGIEFTLRDVCEIMKRTPYLADLMPGG
RYPAKKMGEAGGVPMLLRTLLDAGLIHGDCMTVTGKTIRENLEGVVWNDEQDVIRPVSNPLSPTGGVVGLWGSLAPDGAI
VKVAGLSHTKHRGPARVFDGEEACFAAVEARDYKEGDVLVIRYEGPKGGPGMREMLATTAAIKGQGVENIALITDGRFSG
ATRGLCVGHIGPEAADGGPIALVKDGDIISIDAEAGTIELEVDPIELEHRAHLLAQEEPRRTNYGSGAIWKYVQLVGPAH
LGAVTHPGHAGETHVYADI

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=615, Percent_Identity=36.0975609756098, Blast_Score=345, Evalue=4e-96,
Organism=Escherichia coli, GI1786464, Length=498, Percent_Identity=35.9437751004016, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI2367371, Length=512, Percent_Identity=33.984375, Blast_Score=228, Evalue=1e-60,
Organism=Escherichia coli, GI1788157, Length=491, Percent_Identity=31.7718940936864, Blast_Score=191, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6322476, Length=556, Percent_Identity=42.4460431654676, Blast_Score=438, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 61285; Mature: 61285

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRKPDGSWDKSKLPSRHVTEGPSRAPHRSYFYAMGLGSREIAQPFVGVASCWNEAAPCN
CCCCCCCCCCHHCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCH
TALMRQAHAASEGVKRAGGTPREFCTITVTDGIAMGHEGMRSSLVSRDLIADSVELTMRG
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHCCHHHHHHHHHHHHHHCCEEEEECC
HAYDALIGVAGCDKSLPGMMMAMLRLNVPSAFIYGGSILPGTWHGREVTVQDVFEGVGKH
CHHHHHEEECCCCCCCHHHHHHHHHHCCCCEEEECCEECCCCCCCCEEEHHHHHHHHCCC
SAGQMSLEDLCDLEQHACPGDGACGGQYTANTMACVSEAIGLALPLSSALPAAYLDRDEY
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCCHHHCCCHHH
ARATGEAVMALLERNLRPRDICTREAFENAAVVVAATGGSTNGGLHLPAMAHECGIEFTL
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEECCCHHHHCCCEEEH
RDVCEIMKRTPYLADLMPGGRYPAKKMGEAGGVPMLLRTLLDAGLIHGDCMTVTGKTIRE
HHHHHHHHCCCCEECCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHH
NLEGVVWNDEQDVIRPVSNPLSPTGGVVGLWGSLAPDGAIVKVAGLSHTKHRGPARVFDG
CCCCEEECCCHHHHHHCCCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCEECC
EEACFAAVEARDYKEGDVLVIRYEGPKGGPGMREMLATTAAIKGQGVENIALITDGRFSG
CHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
ATRGLCVGHIGPEAADGGPIALVKDGDIISIDAEAGTIELEVDPIELEHRAHLLAQEEPR
CCCCEEEECCCCCCCCCCCEEEEECCCEEEEECCCCEEEEEECCCCHHHHHHHHHCCCCC
RTNYGSGAIWKYVQLVGPAHLGAVTHPGHAGETHVYADI
CCCCCCCHHHHHHHHHCHHHHCCCCCCCCCCCCCEEEEC
>Mature Secondary Structure
MHRKPDGSWDKSKLPSRHVTEGPSRAPHRSYFYAMGLGSREIAQPFVGVASCWNEAAPCN
CCCCCCCCCCHHCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCH
TALMRQAHAASEGVKRAGGTPREFCTITVTDGIAMGHEGMRSSLVSRDLIADSVELTMRG
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHCCHHHHHHHHHHHHHHCCEEEEECC
HAYDALIGVAGCDKSLPGMMMAMLRLNVPSAFIYGGSILPGTWHGREVTVQDVFEGVGKH
CHHHHHEEECCCCCCCHHHHHHHHHHCCCCEEEECCEECCCCCCCCEEEHHHHHHHHCCC
SAGQMSLEDLCDLEQHACPGDGACGGQYTANTMACVSEAIGLALPLSSALPAAYLDRDEY
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCCHHHCCCHHH
ARATGEAVMALLERNLRPRDICTREAFENAAVVVAATGGSTNGGLHLPAMAHECGIEFTL
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCEECCCHHHHCCCEEEH
RDVCEIMKRTPYLADLMPGGRYPAKKMGEAGGVPMLLRTLLDAGLIHGDCMTVTGKTIRE
HHHHHHHHCCCCEECCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCCCCEEEECCHHHHH
NLEGVVWNDEQDVIRPVSNPLSPTGGVVGLWGSLAPDGAIVKVAGLSHTKHRGPARVFDG
CCCCEEECCCHHHHHHCCCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCCEECC
EEACFAAVEARDYKEGDVLVIRYEGPKGGPGMREMLATTAAIKGQGVENIALITDGRFSG
CHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
ATRGLCVGHIGPEAADGGPIALVKDGDIISIDAEAGTIELEVDPIELEHRAHLLAQEEPR
CCCCEEEECCCCCCCCCCCEEEEECCCEEEEECCCCEEEEEECCCCHHHHHHHHHCCCCC
RTNYGSGAIWKYVQLVGPAHLGAVTHPGHAGETHVYADI
CCCCCCCHHHHHHHHHCHHHHCCCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA