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The map label for this gene is ethA [H]

Identifier: 197105377

GI number: 197105377

Start: 2142694

End: 2144223

Strand: Direct

Name: ethA [H]

Synonym: PHZ_c1914

Alternate gene names: 197105377

Gene position: 2142694-2144223 (Clockwise)

Preceding gene: 197105372

Following gene: 197105384

Centisome position: 53.62

GC content: 67.25

Gene sequence:

>1530_bases
ATGAACGATGCCGCCATGCCGAAGGGGCCCGCGACCGCCCTCGAACACTTCGACGTCCTGATCGTGGGCGCCGGGATCTC
CGGGATCGGCGGCGCCTACCACCTGAAGCAGCAGTGCCCCGGCAAGAGCTTCGTGGTGCTGGAGACGCTGGAGAGCTTCG
GCGGCACCTGGCTGACCCACACGTACCCGGGCATCCGCTCGGACAGCGACCTCTACACCTTCGGCTACCGCTTCAAGCCC
TGGGTCGGCCCGCCCATCGCCACGGCGGACGAGATCCTGAAGTACATGGGCGAGGTGATCGAGGAGAACGACCTCTCCCC
GCACATCCGCTACCGCCACCGGATCACCAACGCGACCTGGTCCAGCCGCGACAACCTCTGGACCGTCGAGGCCGAGCGCC
TCGACACGGGTCAGGCCGTGGCGTTCACCTGCAACTTCCTGTGGATGTGCCAGGGCTACTACCGTCACTCCGAGGGCTAC
ACCCCCGAGTGGCCGGGCATGGCCGACTTCAAGGGCCGCATCGTCCATCCGCAGACCTGGCCGGACGACCTGGACCTTAA
GGACAAGAAGGTGGTGGTGATCGGCTCGGGGGCCACGGCGGCGACGCTGGTGCCGGCCATCGCCGACGACTGCGGCCACG
TCACCCTGCTGCAGCGCTCGCCGACCTACTTCATCCCCGGCCGCAACGCCAACGAGCTGGCCGACATCCTGCGCGAGCTG
AAGATCGACGAGGCCTGGATCCACGAGATCGTCCGCCGCAAGATCCTGCACGACCAGGACCTGTTCACCCGCCGCTCGTT
CGAGGAGCCCGAGGCGGTGAAGCAGGAGCTGCTGGCTGGCGTCAGCGCCTTCGTCGGACCCGAGATCACCGAGAAGCACT
TCACGCCCTCGTACCGGCCGTGGCGGCAGCGGATCGCGTTCGTGCCGGACGGCGACATCTTCCAGTGCGTGAACCGCGGC
AAGGCCTCGGTGGTCACCGACGAGATCGAGCGCTTCACCGAGCAGGGCATCCTGCTGAAGTCCGGCCAGGAGCTGGAGGC
GGACATCGTCATCACCGCCACGGGCTTCAACCTGAACGTCCTGGGCGACATCAGCTTCGCGGTCGACGGCAAGCCGCTGA
ACTTCGCCGACACGGTGACCTATCGGGGGATGATGTTCACGGGCGTGCCGAACCTCGTCTGGGTGTTCGGCTACTTCCGG
GCCAGCTGGACGCTGCGGGCGGACCTCGTCGCCGACTTCGTCTGCCGCCTTCTGACCCACATGGACGAGAAGGGCGCGCG
GAAGGTCACGGTCGAGCTGAGGCCCGAGGACAAGGACATGCCGCTCTCCGCCTGGATCGACCCGGAGAACTTCAATCCCG
GCTACCTGATGCGCGGCATGCACCTCCTGCCCAAGCGCGGCGACAAGCCGGAGTGGCAGCACAGCCAGGACTACTGGCGC
GAGAAGGAGGAGCTGCCGCTGATCGACCTGGACGACAGCGCGTTCGTCTACGCGGGGACCAAGGCACGGACGCCCGAGCC
GGTCGGCTGA

Upstream 100 bases:

>100_bases
GGATCAATTGGGGGAACGGCCCGCCGCCCGATGCTGCGGCCGAAGCAGAGCCGCGCCGTCCGAGCGCCGCCGGGACAGGG
AACGGGACAGGGAAGACGCC

Downstream 100 bases:

>100_bases
GGCGCTCGCCTCAACCGAACAGGAAGTCCGAGGCGCCGAGGCTGGCGCCCGGCACGCCGAGGAGCGTGATCACCTCGCCC
GTCGGCAGCAGGATGGTGGC

Product: flavin binding monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MNDAAMPKGPATALEHFDVLIVGAGISGIGGAYHLKQQCPGKSFVVLETLESFGGTWLTHTYPGIRSDSDLYTFGYRFKP
WVGPPIATADEILKYMGEVIEENDLSPHIRYRHRITNATWSSRDNLWTVEAERLDTGQAVAFTCNFLWMCQGYYRHSEGY
TPEWPGMADFKGRIVHPQTWPDDLDLKDKKVVVIGSGATAATLVPAIADDCGHVTLLQRSPTYFIPGRNANELADILREL
KIDEAWIHEIVRRKILHDQDLFTRRSFEEPEAVKQELLAGVSAFVGPEITEKHFTPSYRPWRQRIAFVPDGDIFQCVNRG
KASVVTDEIERFTEQGILLKSGQELEADIVITATGFNLNVLGDISFAVDGKPLNFADTVTYRGMMFTGVPNLVWVFGYFR
ASWTLRADLVADFVCRLLTHMDEKGARKVTVELRPEDKDMPLSAWIDPENFNPGYLMRGMHLLPKRGDKPEWQHSQDYWR
EKEELPLIDLDDSAFVYAGTKARTPEPVG

Sequences:

>Translated_509_residues
MNDAAMPKGPATALEHFDVLIVGAGISGIGGAYHLKQQCPGKSFVVLETLESFGGTWLTHTYPGIRSDSDLYTFGYRFKP
WVGPPIATADEILKYMGEVIEENDLSPHIRYRHRITNATWSSRDNLWTVEAERLDTGQAVAFTCNFLWMCQGYYRHSEGY
TPEWPGMADFKGRIVHPQTWPDDLDLKDKKVVVIGSGATAATLVPAIADDCGHVTLLQRSPTYFIPGRNANELADILREL
KIDEAWIHEIVRRKILHDQDLFTRRSFEEPEAVKQELLAGVSAFVGPEITEKHFTPSYRPWRQRIAFVPDGDIFQCVNRG
KASVVTDEIERFTEQGILLKSGQELEADIVITATGFNLNVLGDISFAVDGKPLNFADTVTYRGMMFTGVPNLVWVFGYFR
ASWTLRADLVADFVCRLLTHMDEKGARKVTVELRPEDKDMPLSAWIDPENFNPGYLMRGMHLLPKRGDKPEWQHSQDYWR
EKEELPLIDLDDSAFVYAGTKARTPEPVG
>Mature_509_residues
MNDAAMPKGPATALEHFDVLIVGAGISGIGGAYHLKQQCPGKSFVVLETLESFGGTWLTHTYPGIRSDSDLYTFGYRFKP
WVGPPIATADEILKYMGEVIEENDLSPHIRYRHRITNATWSSRDNLWTVEAERLDTGQAVAFTCNFLWMCQGYYRHSEGY
TPEWPGMADFKGRIVHPQTWPDDLDLKDKKVVVIGSGATAATLVPAIADDCGHVTLLQRSPTYFIPGRNANELADILREL
KIDEAWIHEIVRRKILHDQDLFTRRSFEEPEAVKQELLAGVSAFVGPEITEKHFTPSYRPWRQRIAFVPDGDIFQCVNRG
KASVVTDEIERFTEQGILLKSGQELEADIVITATGFNLNVLGDISFAVDGKPLNFADTVTYRGMMFTGVPNLVWVFGYFR
ASWTLRADLVADFVCRLLTHMDEKGARKVTVELRPEDKDMPLSAWIDPENFNPGYLMRGMHLLPKRGDKPEWQHSQDYWR
EKEELPLIDLDDSAFVYAGTKARTPEPVG

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 57519; Mature: 57519

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDAAMPKGPATALEHFDVLIVGAGISGIGGAYHLKQQCPGKSFVVLETLESFGGTWLTH
CCCCCCCCCCHHHHHCCEEEEEECCCCCCCCHHHHHHHCCCCCEEHHEEHHHHCCEEEEE
TYPGIRSDSDLYTFGYRFKPWVGPPIATADEILKYMGEVIEENDLSPHIRYRHRITNATW
CCCCCCCCCCEEEECEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEHEEECCCCC
SSRDNLWTVEAERLDTGQAVAFTCNFLWMCQGYYRHSEGYTPEWPGMADFKGRIVHPQTW
CCCCCEEEEEHHHCCCCCEEEEEEHHHEEHHHHHCCCCCCCCCCCCCCCCCCEEECCCCC
PDDLDLKDKKVVVIGSGATAATLVPAIADDCGHVTLLQRSPTYFIPGRNANELADILREL
CCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEECCCEEEECCCCHHHHHHHHHHH
KIDEAWIHEIVRRKILHDQDLFTRRSFEEPEAVKQELLAGVSAFVGPEITEKHFTPSYRP
CCCHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
WRQRIAFVPDGDIFQCVNRGKASVVTDEIERFTEQGILLKSGQELEADIVITATGFNLNV
HHHEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHCCEEEECCCCCCEEEEEEEECCEEEE
LGDISFAVDGKPLNFADTVTYRGMMFTGVPNLVWVFGYFRASWTLRADLVADFVCRLLTH
EEEEEEEECCCCCCCHHHHEECCEEECCCCHHHHHHHHHHHCEEEHHHHHHHHHHHHHHH
MDEKGARKVTVELRPEDKDMPLSAWIDPENFNPGYLMRGMHLLPKRGDKPEWQHSQDYWR
CCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCCHHHHCCHHCCCCCCCCCCCCCHHHHH
EKEELPLIDLDDSAFVYAGTKARTPEPVG
HHHCCCEEECCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MNDAAMPKGPATALEHFDVLIVGAGISGIGGAYHLKQQCPGKSFVVLETLESFGGTWLTH
CCCCCCCCCCHHHHHCCEEEEEECCCCCCCCHHHHHHHCCCCCEEHHEEHHHHCCEEEEE
TYPGIRSDSDLYTFGYRFKPWVGPPIATADEILKYMGEVIEENDLSPHIRYRHRITNATW
CCCCCCCCCCEEEECEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEHEEECCCCC
SSRDNLWTVEAERLDTGQAVAFTCNFLWMCQGYYRHSEGYTPEWPGMADFKGRIVHPQTW
CCCCCEEEEEHHHCCCCCEEEEEEHHHEEHHHHHCCCCCCCCCCCCCCCCCCEEECCCCC
PDDLDLKDKKVVVIGSGATAATLVPAIADDCGHVTLLQRSPTYFIPGRNANELADILREL
CCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCEEEEECCCEEEECCCCHHHHHHHHHHH
KIDEAWIHEIVRRKILHDQDLFTRRSFEEPEAVKQELLAGVSAFVGPEITEKHFTPSYRP
CCCHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCC
WRQRIAFVPDGDIFQCVNRGKASVVTDEIERFTEQGILLKSGQELEADIVITATGFNLNV
HHHEEEECCCCHHHHHHCCCCCHHHHHHHHHHHHCCEEEECCCCCCEEEEEEEECCEEEE
LGDISFAVDGKPLNFADTVTYRGMMFTGVPNLVWVFGYFRASWTLRADLVADFVCRLLTH
EEEEEEEECCCCCCCHHHHEECCEEECCCCHHHHHHHHHHHCEEEHHHHHHHHHHHHHHH
MDEKGARKVTVELRPEDKDMPLSAWIDPENFNPGYLMRGMHLLPKRGDKPEWQHSQDYWR
CCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCCHHHHCCHHCCCCCCCCCCCCCHHHHH
EKEELPLIDLDDSAFVYAGTKARTPEPVG
HHHCCCEEECCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]