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The map label for this gene is parC [H]

Identifier: 197105328

GI number: 197105328

Start: 2092361

End: 2094619

Strand: Reverse

Name: parC [H]

Synonym: PHZ_c1865

Alternate gene names: 197105328

Gene position: 2094619-2092361 (Counterclockwise)

Preceding gene: 197105329

Following gene: 197105327

Centisome position: 52.41

GC content: 70.47

Gene sequence:

>2259_bases
ATGACCGTCCACACCGCACCGCCCGGCGGGGCCGAGCCCGACCGGATCATCGACGAGCCGCTGTCCGAGGCCCTGTCGCG
CCGCTACCTCGCCTACGCCCTGTCCGTCATCACCGACCGGGCGCTGCCCGACGTGCGCGACGGCCTCAAGCCCGTGCAGC
GCCGCGTGCTCTACGCCATGCGCGAGATGCGGCTGAACCCCGAGAACGCCGCGCGCAAGTGCGCCAAGGTGGTCGGCGAG
GTGATGGGCGGCTACCACCCGCACGGCGACCAGGCGATCTACGACACCCTCGTGCGCATGGCCCAGTCGTTCGCCCAGCG
CTATCCGCTGGTCGACGGCCAGGGCAACTTCGGCAACATCGACGGCGATAACGCCGCGGCCATGCGCTACACCGAGGCCA
AGCTCACGGCGGCCGCGACCCTGCTGCTGGACGGCATCGAAGAGGACGCGGTCGACTTCAAGCCCACCTACGACGGCTCC
GACGACGAGCCGGTGGTCCTGCCGGCCGGCTTCCCGAACCTCCTGGCGAACGGCTCGACCGGCATCGCCGTCGGCATGGC
CACCTCAATCCCGCCGCACAACGCCGGCGAGCTGATCGACGCCTGCCTGCTCCTGCTGGAGAATCCCGAGGCCTCCACCG
AGGCCCTGATGACCCACGTCCAGGGCCCCGACTTCCCGACCGGCGGCGTCATCGTCGAGCCGCGGCAATCGCTGGCCGAA
ACCTACGCCACCGGCCGCGGCGGCGTGCGGGTCCGGGCTCGCTGGACGAAGGAGGACCTCGGCAAGGGGACCTACCAGAT
CGTCGTCACCGAGATCCCCTACCAGGTGAAGAAGGCCGACCTGGTCGAGAAGCTGGCCGAGCTGATCGAGGCCAAGAAGG
CCCCGCTGCTGGGCGACGTGCGCGACGAGTCCGCCGAGGACGTGCGCCTCGTCCTCGAGCCCAAGAGCCGCAACGTCGAG
GCCGAGGTGCTGATGGAGAGCCTGTTCAAGCTCTCCGACCTCGAGACCCGGTTCTCGGTGAACCTCAACGTCCTGGACGC
GCGCGGCACGCCGGGCGTGATGAACCTGCGCCAGGCGCTGAAGGCGTTCCTCGACCACCGCCGCGAGGTGCTCGTCCGCC
GGGCCCGCCACCGGCTGGAGAAGATCGAGGCCCGGCTCCACATCCTCGACGGCCTGATGATCGCCTACCTCAACCTCGAC
GAGGTGATCCGCATCGTCCGCTACGAGGACAAGCCGAAGGAGAAGCTGATCGAGACCTTCTCGCTCAGCGAGATCCAGGC
CGACGCCATCCTCAACACCCGCCTGCGCCAGCTCGCCAAGCTGGAGGAGATGGAGATCCGCCGCGAGCACGCCGAGCTCG
CCGAGGAGCGCGACGGGATCCTGAAGATGCTGGCCTCCGACGCGGCCCAGTGGAAGCTGGTGGGCGAGGGGCTGCGGCAC
GTGAAGGCCGAGCTGGGCAAGCTCAACGACCGCCGCTCGACGTTCGGCGAGGCCCCGCAGGTTGACGCCGAGGCCGCCAT
CGAGGCGATGATCGTGCGCGAGCCGATCACCATCATCCTCTCCGAGCGCGGCTGGATCCGCGCCGCCAAGGGCCGCATCG
AGGACCCCTCCGAGCTGAAGTTCAAGGAGGGCGACAAGCTGCAGTTCCTGGTCCCGGCCGAGACCACCGACAAGCTGCTG
ATCTTCGCCTCGGACGGCCGCTTCTTCACCCTCGGCTGCGACAAGCTGCCGGGCGCCCGCGGCCACGGCGAGCCGCTGCG
CCTGATGATCGACCTCGACGACAAGGTCGGCATCGTCGACGTCTTCCCGCACAAGCCGGGGGCCAAGCGGCTGCTGGCCA
GCAAGCAGGGCTACGGCTTCATCCTGCCCGAGGAGGAGGCCATCGCCTTCCGCCGCGCGGGCAAGCAGGTGCTGAACGCC
GGCGATCCGGCGAAGAAGGGCGAGGGGGCCGCCGTCTGCCTGCCGGTCACGGGCGACCAGATCGCCGTCGTCGGCGACAA
CGGCAAGATCCTCGTCTTCCCGCTCGCCGAGCTGCCCGAGATGCCGCGCGGCAAGGGCGTGAAGCTGCAGAGCTACCGCG
AGGGCGGCCTGCGCGACGCCCTGGTGTTCAACGCCGCCGAGGGCGCCGCCTGGATCGACGCCGCCGGCCGCACCCGCGCC
TGGGACGGCTGGCAGGAATGGGCCGGCCGCCGGGCCGGCGCCGGCAAGCTCGCGCCCAAGGGCTTCCCCGCCACCAAGCG
CTTTCGGCCGAAGGCGTAG

Upstream 100 bases:

>100_bases
CCCCGACCTCGCCCCGCTGCCGTTCTAGGCGGTCCACGAACCCGCGCCTGCGGCGCGCTGCGACGTCGCCCCGAATCCCG
CGCCTTGCTAAGAGACGCCC

Downstream 100 bases:

>100_bases
GCGCGACGAACGGCGTCGCGTCCGGGCGCGGGGGGCGCTAGGCTTGTGGCGGGGCGCTTTCGCCTCGCCATCCTGTCCGG
ACCATGCTGCTCCTTGCGAC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 752; Mature: 751

Protein sequence:

>752_residues
MTVHTAPPGGAEPDRIIDEPLSEALSRRYLAYALSVITDRALPDVRDGLKPVQRRVLYAMREMRLNPENAARKCAKVVGE
VMGGYHPHGDQAIYDTLVRMAQSFAQRYPLVDGQGNFGNIDGDNAAAMRYTEAKLTAAATLLLDGIEEDAVDFKPTYDGS
DDEPVVLPAGFPNLLANGSTGIAVGMATSIPPHNAGELIDACLLLLENPEASTEALMTHVQGPDFPTGGVIVEPRQSLAE
TYATGRGGVRVRARWTKEDLGKGTYQIVVTEIPYQVKKADLVEKLAELIEAKKAPLLGDVRDESAEDVRLVLEPKSRNVE
AEVLMESLFKLSDLETRFSVNLNVLDARGTPGVMNLRQALKAFLDHRREVLVRRARHRLEKIEARLHILDGLMIAYLNLD
EVIRIVRYEDKPKEKLIETFSLSEIQADAILNTRLRQLAKLEEMEIRREHAELAEERDGILKMLASDAAQWKLVGEGLRH
VKAELGKLNDRRSTFGEAPQVDAEAAIEAMIVREPITIILSERGWIRAAKGRIEDPSELKFKEGDKLQFLVPAETTDKLL
IFASDGRFFTLGCDKLPGARGHGEPLRLMIDLDDKVGIVDVFPHKPGAKRLLASKQGYGFILPEEEAIAFRRAGKQVLNA
GDPAKKGEGAAVCLPVTGDQIAVVGDNGKILVFPLAELPEMPRGKGVKLQSYREGGLRDALVFNAAEGAAWIDAAGRTRA
WDGWQEWAGRRAGAGKLAPKGFPATKRFRPKA

Sequences:

>Translated_752_residues
MTVHTAPPGGAEPDRIIDEPLSEALSRRYLAYALSVITDRALPDVRDGLKPVQRRVLYAMREMRLNPENAARKCAKVVGE
VMGGYHPHGDQAIYDTLVRMAQSFAQRYPLVDGQGNFGNIDGDNAAAMRYTEAKLTAAATLLLDGIEEDAVDFKPTYDGS
DDEPVVLPAGFPNLLANGSTGIAVGMATSIPPHNAGELIDACLLLLENPEASTEALMTHVQGPDFPTGGVIVEPRQSLAE
TYATGRGGVRVRARWTKEDLGKGTYQIVVTEIPYQVKKADLVEKLAELIEAKKAPLLGDVRDESAEDVRLVLEPKSRNVE
AEVLMESLFKLSDLETRFSVNLNVLDARGTPGVMNLRQALKAFLDHRREVLVRRARHRLEKIEARLHILDGLMIAYLNLD
EVIRIVRYEDKPKEKLIETFSLSEIQADAILNTRLRQLAKLEEMEIRREHAELAEERDGILKMLASDAAQWKLVGEGLRH
VKAELGKLNDRRSTFGEAPQVDAEAAIEAMIVREPITIILSERGWIRAAKGRIEDPSELKFKEGDKLQFLVPAETTDKLL
IFASDGRFFTLGCDKLPGARGHGEPLRLMIDLDDKVGIVDVFPHKPGAKRLLASKQGYGFILPEEEAIAFRRAGKQVLNA
GDPAKKGEGAAVCLPVTGDQIAVVGDNGKILVFPLAELPEMPRGKGVKLQSYREGGLRDALVFNAAEGAAWIDAAGRTRA
WDGWQEWAGRRAGAGKLAPKGFPATKRFRPKA
>Mature_751_residues
TVHTAPPGGAEPDRIIDEPLSEALSRRYLAYALSVITDRALPDVRDGLKPVQRRVLYAMREMRLNPENAARKCAKVVGEV
MGGYHPHGDQAIYDTLVRMAQSFAQRYPLVDGQGNFGNIDGDNAAAMRYTEAKLTAAATLLLDGIEEDAVDFKPTYDGSD
DEPVVLPAGFPNLLANGSTGIAVGMATSIPPHNAGELIDACLLLLENPEASTEALMTHVQGPDFPTGGVIVEPRQSLAET
YATGRGGVRVRARWTKEDLGKGTYQIVVTEIPYQVKKADLVEKLAELIEAKKAPLLGDVRDESAEDVRLVLEPKSRNVEA
EVLMESLFKLSDLETRFSVNLNVLDARGTPGVMNLRQALKAFLDHRREVLVRRARHRLEKIEARLHILDGLMIAYLNLDE
VIRIVRYEDKPKEKLIETFSLSEIQADAILNTRLRQLAKLEEMEIRREHAELAEERDGILKMLASDAAQWKLVGEGLRHV
KAELGKLNDRRSTFGEAPQVDAEAAIEAMIVREPITIILSERGWIRAAKGRIEDPSELKFKEGDKLQFLVPAETTDKLLI
FASDGRFFTLGCDKLPGARGHGEPLRLMIDLDDKVGIVDVFPHKPGAKRLLASKQGYGFILPEEEAIAFRRAGKQVLNAG
DPAKKGEGAAVCLPVTGDQIAVVGDNGKILVFPLAELPEMPRGKGVKLQSYREGGLRDALVFNAAEGAAWIDAAGRTRAW
DGWQEWAGRRAGAGKLAPKGFPATKRFRPKA

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=447, Percent_Identity=26.3982102908277, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI19913406, Length=405, Percent_Identity=26.1728395061728, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1789396, Length=676, Percent_Identity=42.4556213017751, Blast_Score=526, Evalue=1e-150,
Organism=Escherichia coli, GI1788562, Length=717, Percent_Identity=38.9121338912134, Blast_Score=444, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI212645845, Length=478, Percent_Identity=24.4769874476987, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17535065, Length=455, Percent_Identity=25.7142857142857, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI212645657, Length=442, Percent_Identity=25.7918552036199, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=392, Percent_Identity=25.5102040816327, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17136538, Length=181, Percent_Identity=29.2817679558011, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 82652; Mature: 82521

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVHTAPPGGAEPDRIIDEPLSEALSRRYLAYALSVITDRALPDVRDGLKPVQRRVLYAM
CEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
REMRLNPENAARKCAKVVGEVMGGYHPHGDQAIYDTLVRMAQSFAQRYPLVDGQGNFGNI
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DGDNAAAMRYTEAKLTAAATLLLDGIEEDAVDFKPTYDGSDDEPVVLPAGFPNLLANGST
CCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHCCCCC
GIAVGMATSIPPHNAGELIDACLLLLENPEASTEALMTHVQGPDFPTGGVIVEPRQSLAE
CEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEECCHHHHHH
TYATGRGGVRVRARWTKEDLGKGTYQIVVTEIPYQVKKADLVEKLAELIEAKKAPLLGDV
HHHCCCCCEEEEEEECHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
RDESAEDVRLVLEPKSRNVEAEVLMESLFKLSDLETRFSVNLNVLDARGTPGVMNLRQAL
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCHHHHHHHH
KAFLDHRREVLVRRARHRLEKIEARLHILDGLMIAYLNLDEVIRIVRYEDKPKEKLIETF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHH
SLSEIQADAILNTRLRQLAKLEEMEIRREHAELAEERDGILKMLASDAAQWKLVGEGLRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKAELGKLNDRRSTFGEAPQVDAEAAIEAMIVREPITIILSERGWIRAAKGRIEDPSELK
HHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCEEECCCCCCCCCCCC
FKEGDKLQFLVPAETTDKLLIFASDGRFFTLGCDKLPGARGHGEPLRLMIDLDDKVGIVD
CCCCCEEEEEECCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCEEE
VFPHKPGAKRLLASKQGYGFILPEEEAIAFRRAGKQVLNAGDPAKKGEGAAVCLPVTGDQ
ECCCCCCHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCE
IAVVGDNGKILVFPLAELPEMPRGKGVKLQSYREGGLRDALVFNAAEGAAWIDAAGRTRA
EEEECCCCCEEEEEHHHCCCCCCCCCEEEHHHHCCCCCEEEEEECCCCCEEEECCCCCCC
WDGWQEWAGRRAGAGKLAPKGFPATKRFRPKA
CCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TVHTAPPGGAEPDRIIDEPLSEALSRRYLAYALSVITDRALPDVRDGLKPVQRRVLYAM
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
REMRLNPENAARKCAKVVGEVMGGYHPHGDQAIYDTLVRMAQSFAQRYPLVDGQGNFGNI
HHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
DGDNAAAMRYTEAKLTAAATLLLDGIEEDAVDFKPTYDGSDDEPVVLPAGFPNLLANGST
CCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHCCCCC
GIAVGMATSIPPHNAGELIDACLLLLENPEASTEALMTHVQGPDFPTGGVIVEPRQSLAE
CEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEEECCHHHHHH
TYATGRGGVRVRARWTKEDLGKGTYQIVVTEIPYQVKKADLVEKLAELIEAKKAPLLGDV
HHHCCCCCEEEEEEECHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
RDESAEDVRLVLEPKSRNVEAEVLMESLFKLSDLETRFSVNLNVLDARGTPGVMNLRQAL
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCHHHHHHHH
KAFLDHRREVLVRRARHRLEKIEARLHILDGLMIAYLNLDEVIRIVRYEDKPKEKLIETF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHH
SLSEIQADAILNTRLRQLAKLEEMEIRREHAELAEERDGILKMLASDAAQWKLVGEGLRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKAELGKLNDRRSTFGEAPQVDAEAAIEAMIVREPITIILSERGWIRAAKGRIEDPSELK
HHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHCCEEEEEECCCCEEECCCCCCCCCCCC
FKEGDKLQFLVPAETTDKLLIFASDGRFFTLGCDKLPGARGHGEPLRLMIDLDDKVGIVD
CCCCCEEEEEECCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCEEEEEEECCCCCEEE
VFPHKPGAKRLLASKQGYGFILPEEEAIAFRRAGKQVLNAGDPAKKGEGAAVCLPVTGDQ
ECCCCCCHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCE
IAVVGDNGKILVFPLAELPEMPRGKGVKLQSYREGGLRDALVFNAAEGAAWIDAAGRTRA
EEEECCCCCEEEEEHHHCCCCCCCCCEEEHHHHCCCCCEEEEEECCCCCEEEECCCCCCC
WDGWQEWAGRRAGAGKLAPKGFPATKRFRPKA
CCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9426128; 11259647 [H]