Click here to switch to the map view.

The map label for this gene is nuoM [H]

Identifier: 197105255

GI number: 197105255

Start: 2006041

End: 2007525

Strand: Reverse

Name: nuoM [H]

Synonym: PHZ_c1792

Alternate gene names: 197105255

Gene position: 2007525-2006041 (Counterclockwise)

Preceding gene: 197105256

Following gene: 197105254

Centisome position: 50.24

GC content: 66.53

Gene sequence:

>1485_bases
ATGCCGCTTCTCTCCCTCATCACCTACGCCCCGCTGGTCGGCGTCGCCGGGATCCTGGCGCTGCGCCTGTTCGGCCGGCC
CGACGACGCCAAGGCCGTTGAGGCCTCCAAGTGGATCGCGTTCGTCACCACCCTGGCGACCTTCGCGCTCTCGGTGCTGC
TGGTCGTCCAGTTCGACCCCGCCAACCCGGGCTTCCAGTTCGTGGAAGAGGTCCCGTGGTTCGCGAGCCTGTCCTACCGG
ATGGGCGTGGACGGGATCTCGGTCCTGTTCGTGCTGCTGACCGCGTTCCTGATGCCGCTCTGCATCGCCGCCTCGTGGCG
GTCGATCGAGAAGCGGGTGCCGGAATACATGATCGCCTTCCTGGTTCTCGAGACCCTGGTGATCGGCGTGTTCTGCGCGC
TGGACCTCGTGCTGTTCTACATCTTCTTCGAGTTCGGCCTGGTGCCGATGTTCCTGATCATCGGCATCTGGGGCGGGGCC
CGGCGCGTCTACGCGGCGTTCAAGTTCTTCCTCTACACGCTGCTGGGCTCGGTCCTCATGCTGGCGGCGATCCTGTTCAT
GATCGCCAGCACCGGCACCAGCTCGATCCCCGAGCTGATGGCCTACGACTTCGCGCCGGGCGTGCAGACCTGGCTGTGGC
TGGCCTTCTTCGCCTCGTTCGCGGTGAAGATGCCGATGTGGCCGGTGCACACCTGGCTGCCCGACGCCCACGTCGAGGCG
CCGACGGCCGGCTCGGTCATCCTGGCGGGCATCCTGCTGAAGATGGGCGGCTACGGCTTCATGCGCTTTAGCCTGCCGAT
GTTCCCGAACGCCTCGGACCTGTTCGCCCCGCTGGTGTTCGCGCTGTCGGTGATCGCGATCGTCTACACCTCGCTGGTCG
CCTTCCGGCAGACCGACATCAAGAAGCTGATCGCCTATTCCTCCGTGGCGCACATGGGCTTCGTGACCATGGGCATCTTC
TCGGGCAACGCCCAGGGCGAGCAGGGCGCGCTGTTCCAGATGATCAGCCACGGGGTGATCTCGGGCGCGCTCTTCCTCTG
CGTCGGCGTCGTCTACGACCGGATGCACACCCGCGAGATCGCCTTCTACGGCGGCCTCGTGAACCGCATGCCGTGGTACG
CGGCGGTGTTCATGCTGTTCACCATGGGCAACGTCGGCCTGCCGGGCACCTCGGGCTTCGTCGGCGAGATCCTGACCATG
ACGGGCGTCTACCAGGCCTCGACCTGGACGGCCCTGGTCGCGGCCACCGGCGTGATCCTGTCGGCCATGTACGCGCTGAC
CCTCTATCGCCGGGTGATCTTCGGCGAGCTGACCAATCCGAAGCTCGCCGCCATCACCGACCTCGACTGGCGGGAAGTGG
CCATCTTCGCCCCGCTGATCGTCTCCACGCTGTACCTGGGCGTCCAGCCCAACGTCGTCTTCGACCTGACCGCGGCCTCG
GTGGACCAGCTCGTCGCTGCCTACCAGGCGGCCGTCGGCGGGTGA

Upstream 100 bases:

>100_bases
CGGCTACGTCTACCACTACGCCTTCGTCATGCTGCTGGGCGTCGCGGGCCTTCTGACCTACGCCCTGTGGGCCTGGAACG
CCTGAGGGGGATAACGACCG

Downstream 100 bases:

>100_bases
GGGATCCTGGATGAACTTCGCCTCTGACCTCTCGCTCGCCTTTCCCGAGCTGATCCTCGCCGGCGGCGCCCTGATCCTGC
TGGTGATCGGCGCCTTCGCG

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MPLLSLITYAPLVGVAGILALRLFGRPDDAKAVEASKWIAFVTTLATFALSVLLVVQFDPANPGFQFVEEVPWFASLSYR
MGVDGISVLFVLLTAFLMPLCIAASWRSIEKRVPEYMIAFLVLETLVIGVFCALDLVLFYIFFEFGLVPMFLIIGIWGGA
RRVYAAFKFFLYTLLGSVLMLAAILFMIASTGTSSIPELMAYDFAPGVQTWLWLAFFASFAVKMPMWPVHTWLPDAHVEA
PTAGSVILAGILLKMGGYGFMRFSLPMFPNASDLFAPLVFALSVIAIVYTSLVAFRQTDIKKLIAYSSVAHMGFVTMGIF
SGNAQGEQGALFQMISHGVISGALFLCVGVVYDRMHTREIAFYGGLVNRMPWYAAVFMLFTMGNVGLPGTSGFVGEILTM
TGVYQASTWTALVAATGVILSAMYALTLYRRVIFGELTNPKLAAITDLDWREVAIFAPLIVSTLYLGVQPNVVFDLTAAS
VDQLVAAYQAAVGG

Sequences:

>Translated_494_residues
MPLLSLITYAPLVGVAGILALRLFGRPDDAKAVEASKWIAFVTTLATFALSVLLVVQFDPANPGFQFVEEVPWFASLSYR
MGVDGISVLFVLLTAFLMPLCIAASWRSIEKRVPEYMIAFLVLETLVIGVFCALDLVLFYIFFEFGLVPMFLIIGIWGGA
RRVYAAFKFFLYTLLGSVLMLAAILFMIASTGTSSIPELMAYDFAPGVQTWLWLAFFASFAVKMPMWPVHTWLPDAHVEA
PTAGSVILAGILLKMGGYGFMRFSLPMFPNASDLFAPLVFALSVIAIVYTSLVAFRQTDIKKLIAYSSVAHMGFVTMGIF
SGNAQGEQGALFQMISHGVISGALFLCVGVVYDRMHTREIAFYGGLVNRMPWYAAVFMLFTMGNVGLPGTSGFVGEILTM
TGVYQASTWTALVAATGVILSAMYALTLYRRVIFGELTNPKLAAITDLDWREVAIFAPLIVSTLYLGVQPNVVFDLTAAS
VDQLVAAYQAAVGG
>Mature_493_residues
PLLSLITYAPLVGVAGILALRLFGRPDDAKAVEASKWIAFVTTLATFALSVLLVVQFDPANPGFQFVEEVPWFASLSYRM
GVDGISVLFVLLTAFLMPLCIAASWRSIEKRVPEYMIAFLVLETLVIGVFCALDLVLFYIFFEFGLVPMFLIIGIWGGAR
RVYAAFKFFLYTLLGSVLMLAAILFMIASTGTSSIPELMAYDFAPGVQTWLWLAFFASFAVKMPMWPVHTWLPDAHVEAP
TAGSVILAGILLKMGGYGFMRFSLPMFPNASDLFAPLVFALSVIAIVYTSLVAFRQTDIKKLIAYSSVAHMGFVTMGIFS
GNAQGEQGALFQMISHGVISGALFLCVGVVYDRMHTREIAFYGGLVNRMPWYAAVFMLFTMGNVGLPGTSGFVGEILTMT
GVYQASTWTALVAATGVILSAMYALTLYRRVIFGELTNPKLAAITDLDWREVAIFAPLIVSTLYLGVQPNVVFDLTAASV
DQLVAAYQAAVGG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=346, Percent_Identity=35.8381502890173, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI251831117, Length=353, Percent_Identity=24.3626062322946, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1788613, Length=474, Percent_Identity=39.873417721519, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI1788827, Length=283, Percent_Identity=28.2685512367491, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1788831, Length=260, Percent_Identity=27.3076923076923, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788614, Length=376, Percent_Identity=24.468085106383, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI145693160, Length=372, Percent_Identity=26.0752688172043, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918
- InterPro:   IPR000260 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01059 Oxidored_q5_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 53786; Mature: 53654

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLSLITYAPLVGVAGILALRLFGRPDDAKAVEASKWIAFVTTLATFALSVLLVVQFDP
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
ANPGFQFVEEVPWFASLSYRMGVDGISVLFVLLTAFLMPLCIAASWRSIEKRVPEYMIAF
CCCCHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVLETLVIGVFCALDLVLFYIFFEFGLVPMFLIIGIWGGARRVYAAFKFFLYTLLGSVLM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LAAILFMIASTGTSSIPELMAYDFAPGVQTWLWLAFFASFAVKMPMWPVHTWLPDAHVEA
HHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCC
PTAGSVILAGILLKMGGYGFMRFSLPMFPNASDLFAPLVFALSVIAIVYTSLVAFRQTDI
CCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKLIAYSSVAHMGFVTMGIFSGNAQGEQGALFQMISHGVISGALFLCVGVVYDRMHTREI
HHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFYGGLVNRMPWYAAVFMLFTMGNVGLPGTSGFVGEILTMTGVYQASTWTALVAATGVIL
HHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
SAMYALTLYRRVIFGELTNPKLAAITDLDWREVAIFAPLIVSTLYLGVQPNVVFDLTAAS
HHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHH
VDQLVAAYQAAVGG
HHHHHHHHHHHCCC
>Mature Secondary Structure 
PLLSLITYAPLVGVAGILALRLFGRPDDAKAVEASKWIAFVTTLATFALSVLLVVQFDP
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECC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HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8566820 [H]