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The map label for this gene is trpC

Identifier: 197105224

GI number: 197105224

Start: 1970109

End: 1970882

Strand: Direct

Name: trpC

Synonym: PHZ_c1761

Alternate gene names: 197105224

Gene position: 1970109-1970882 (Clockwise)

Preceding gene: 197105223

Following gene: 197105225

Centisome position: 49.3

GC content: 73.77

Gene sequence:

>774_bases
ATGAGCGACATCCTCGAGAAGATCGCCGCCTACAAGCGCGACGAGGTCGCCGTCCGCAAGGCCGCGCAGCCGACGATCGC
GCCGCCGGCCGAGGCCCCGCGCGGCTTCCGCGCCGCGCTGACGCGGGCGCACGCCCCCGGCCGCCTGGCCCTGATCGCCG
AGATCAAGAAGGCCTCCCCCTCCAAGGGGCTGATCCGGGAGGACTTCGATCCGCCCGCCCTCGCCCGCGCCTACGAGGCC
GGCGGCGCGGCCTGCCTGTCGGTACTGACGGACGGGCCCAGCTTCCAGGGCGACGACAGCTACCTCGCCGCGGCCCGGAG
CGCGGTGCGCCTGCCGTGCCTGCGCAAGGAGTTCCTGGTCGATCCCTGGCAGGTGGCCGAGAGCCGGTCGCTCGGGGCCG
ACGCCATCCTGGTGATCCTCGCCATGGTCGACGACGTCCTCGCCGCCGAGCTGATGGCCGAGGCCCAGCGGCTGGGCATG
GATGCCCTGGTCGAGGTGCACGACGAGGCCGAGATGGCGCGCGCCGGCGCGCTCGGCGCCGACCTGATAGGCGTGAACAA
CCGCAACCTGCGGACCTTCGAGGTCGACCTGTCCACGACCGAGCGGCTGGCCACGATGGCCCCGGCCGGCGCCCTGCTGG
TCACCGAGAGCGGCATCTTCACCCCCGCCGACGTCGCTCGCCTGGAACGCTGCGGGGCACAGGCCATGCTGGTGGGCGAG
AGCCTGATGCGGCAGGCCGACGTGACCGCCGCAACCCGCGCCCTCCTCGGCTGA

Upstream 100 bases:

>100_bases
AGGTCGAGACGCTGCGCGAGGGGGTCGAGCTGGCCGGCCGTGTCCTGGACGAAGGGCGCGCCCAGGCCGCCCTGGAGCGA
CTCGTGGAGATCACCGCCCC

Downstream 100 bases:

>100_bases
GTCGCCCGTTCCGCCGTCCGGCGCCGGGCCAGTTCTCCTGATTTTTCAGGGAGAACGGTGGTAACTTGACATTAACTAGG
AACACCTAGAGAATATCGAT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MSDILEKIAAYKRDEVAVRKAAQPTIAPPAEAPRGFRAALTRAHAPGRLALIAEIKKASPSKGLIREDFDPPALARAYEA
GGAACLSVLTDGPSFQGDDSYLAAARSAVRLPCLRKEFLVDPWQVAESRSLGADAILVILAMVDDVLAAELMAEAQRLGM
DALVEVHDEAEMARAGALGADLIGVNNRNLRTFEVDLSTTERLATMAPAGALLVTESGIFTPADVARLERCGAQAMLVGE
SLMRQADVTAATRALLG

Sequences:

>Translated_257_residues
MSDILEKIAAYKRDEVAVRKAAQPTIAPPAEAPRGFRAALTRAHAPGRLALIAEIKKASPSKGLIREDFDPPALARAYEA
GGAACLSVLTDGPSFQGDDSYLAAARSAVRLPCLRKEFLVDPWQVAESRSLGADAILVILAMVDDVLAAELMAEAQRLGM
DALVEVHDEAEMARAGALGADLIGVNNRNLRTFEVDLSTTERLATMAPAGALLVTESGIFTPADVARLERCGAQAMLVGE
SLMRQADVTAATRALLG
>Mature_256_residues
SDILEKIAAYKRDEVAVRKAAQPTIAPPAEAPRGFRAALTRAHAPGRLALIAEIKKASPSKGLIREDFDPPALARAYEAG
GAACLSVLTDGPSFQGDDSYLAAARSAVRLPCLRKEFLVDPWQVAESRSLGADAILVILAMVDDVLAAELMAEAQRLGMD
ALVEVHDEAEMARAGALGADLIGVNNRNLRTFEVDLSTTERLATMAPAGALLVTESGIFTPADVARLERCGAQAMLVGES
LMRQADVTAATRALLG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=259, Percent_Identity=41.3127413127413, Blast_Score=165, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6322638, Length=238, Percent_Identity=38.2352941176471, Blast_Score=149, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_PHEZH (B4RBX5)

Other databases:

- EMBL:   CP000747
- RefSeq:   YP_002130601.1
- GeneID:   6791274
- GenomeReviews:   CP000747_GR
- KEGG:   pzu:PHZ_c1761
- HOGENOM:   HBG540956
- OMA:   LRKDFMF
- ProtClustDB:   PRK00278
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 27118; Mature: 26987

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILEKIAAYKRDEVAVRKAAQPTIAPPAEAPRGFRAALTRAHAPGRLALIAEIKKASP
CHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCC
SKGLIREDFDPPALARAYEAGGAACLSVLTDGPSFQGDDSYLAAARSAVRLPCLRKEFLV
CCCCHHCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHCC
DPWQVAESRSLGADAILVILAMVDDVLAAELMAEAQRLGMDALVEVHDEAEMARAGALGA
CHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
DLIGVNNRNLRTFEVDLSTTERLATMAPAGALLVTESGIFTPADVARLERCGAQAMLVGE
CEEECCCCCEEEEEEECCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHH
SLMRQADVTAATRALLG
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDILEKIAAYKRDEVAVRKAAQPTIAPPAEAPRGFRAALTRAHAPGRLALIAEIKKASP
HHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHCCC
SKGLIREDFDPPALARAYEAGGAACLSVLTDGPSFQGDDSYLAAARSAVRLPCLRKEFLV
CCCCHHCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHCC
DPWQVAESRSLGADAILVILAMVDDVLAAELMAEAQRLGMDALVEVHDEAEMARAGALGA
CHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
DLIGVNNRNLRTFEVDLSTTERLATMAPAGALLVTESGIFTPADVARLERCGAQAMLVGE
CEEECCCCCEEEEEEECCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHH
SLMRQADVTAATRALLG
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA