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The map label for this gene is tpiA [H]

Identifier: 197105218

GI number: 197105218

Start: 1962903

End: 1963646

Strand: Reverse

Name: tpiA [H]

Synonym: PHZ_c1755

Alternate gene names: 197105218

Gene position: 1963646-1962903 (Counterclockwise)

Preceding gene: 197105226

Following gene: 197105215

Centisome position: 49.14

GC content: 73.25

Gene sequence:

>744_bases
ATGACCGCTCCCAAGCCGCTGATCGCCGGAAACTGGAAGATGAACGGGCTGGCCGCCGCGCTGTCCGAGGCCAAGGCCGT
GGCCGCCGGGGCGGCCGCGAGCGCCGCGCGCGTGGCGATCTGTCCGCCCAGTCTGCTGGTCCACCGGATGAGCGAGGCGC
TGGCGGGGACGCCGGTGCTGGTCGGCGGTCAGGACTGCCACACGGACGAATCGGGCGCCTTCACCGGCGACGTCTCGGCC
GAGATGCTGGCCGACGCCGGCGCGAAGCTGGTGATCCTCGGCCACTCCGAGCGGCGGTCGGGCTACCGCGAGACCGACGC
CCTGGTGGCGGGCAAGGTCAAGGCGGCGCTGCGCGCGGGGCTGGAGCCGATCGTCTGCGTCGGCGAGACGCTGGAGGAGC
GTAAGGCCGGCCAGGCGCTGGCGATCGTCACGCGCCAGGTCCGCGGCTCGCTGCCGACCGAGCTGGCGGGCAAGGCCTTC
GCGGTGGCCTATGAGCCCGTGTGGGCGATCGGCACCGGCCTGACGCCCACCACGCCCGAGATCGAGGAAATGCACCGCGC
GATCCGGGCCACCCTGGTCGAGATGTTCGGCGAGGCGGGCAGGGCGGTCCCCATCCTGTACGGCGGCTCGGTGAAGCCGT
CGAACGCGGCCGAGATCCTGCACGCCGACGAGGTGGGCGGCGCGCTGGTGGGCGGCGCGTCCCTGAAGGCGCAGGACTTC
CTCGGGATCGTGAACGCCCTCTAG

Upstream 100 bases:

>100_bases
GCGGGCCGGTATAGTGGAGGCCGCTTCCGTACGGCAAGGAGGTGACAGGCCGCCCAGCTTGCCTTAACCGCGCCGGCCAT
TGCGACGTATGTGAGGCAAG

Downstream 100 bases:

>100_bases
GGCCCCCTCAGGCTCCGGGGCCCTTCAGCTCGACCGTGTTGCCCTCGGGGTCCTGCAGGTAGATCGACCAGCCGTCGCCG
TCGGCCCCGTAGCGGGGGCC

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MTAPKPLIAGNWKMNGLAAALSEAKAVAAGAAASAARVAICPPSLLVHRMSEALAGTPVLVGGQDCHTDESGAFTGDVSA
EMLADAGAKLVILGHSERRSGYRETDALVAGKVKAALRAGLEPIVCVGETLEERKAGQALAIVTRQVRGSLPTELAGKAF
AVAYEPVWAIGTGLTPTTPEIEEMHRAIRATLVEMFGEAGRAVPILYGGSVKPSNAAEILHADEVGGALVGGASLKAQDF
LGIVNAL

Sequences:

>Translated_247_residues
MTAPKPLIAGNWKMNGLAAALSEAKAVAAGAAASAARVAICPPSLLVHRMSEALAGTPVLVGGQDCHTDESGAFTGDVSA
EMLADAGAKLVILGHSERRSGYRETDALVAGKVKAALRAGLEPIVCVGETLEERKAGQALAIVTRQVRGSLPTELAGKAF
AVAYEPVWAIGTGLTPTTPEIEEMHRAIRATLVEMFGEAGRAVPILYGGSVKPSNAAEILHADEVGGALVGGASLKAQDF
LGIVNAL
>Mature_246_residues
TAPKPLIAGNWKMNGLAAALSEAKAVAAGAAASAARVAICPPSLLVHRMSEALAGTPVLVGGQDCHTDESGAFTGDVSAE
MLADAGAKLVILGHSERRSGYRETDALVAGKVKAALRAGLEPIVCVGETLEERKAGQALAIVTRQVRGSLPTELAGKAFA
VAYEPVWAIGTGLTPTTPEIEEMHRAIRATLVEMFGEAGRAVPILYGGSVKPSNAAEILHADEVGGALVGGASLKAQDFL
GIVNAL

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=244, Percent_Identity=39.344262295082, Blast_Score=161, Evalue=5e-40,
Organism=Homo sapiens, GI226529917, Length=244, Percent_Identity=39.344262295082, Blast_Score=161, Evalue=5e-40,
Organism=Escherichia coli, GI1790353, Length=248, Percent_Identity=42.3387096774194, Blast_Score=185, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17536593, Length=245, Percent_Identity=44.0816326530612, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6320255, Length=242, Percent_Identity=42.1487603305785, Blast_Score=183, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28572008, Length=245, Percent_Identity=43.265306122449, Blast_Score=174, Evalue=6e-44,
Organism=Drosophila melanogaster, GI28572006, Length=245, Percent_Identity=43.265306122449, Blast_Score=174, Evalue=6e-44,
Organism=Drosophila melanogaster, GI28572004, Length=245, Percent_Identity=43.265306122449, Blast_Score=174, Evalue=7e-44,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 25182; Mature: 25051

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPKPLIAGNWKMNGLAAALSEAKAVAAGAAASAARVAICPPSLLVHRMSEALAGTPVL
CCCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCCCEE
VGGQDCHTDESGAFTGDVSAEMLADAGAKLVILGHSERRSGYRETDALVAGKVKAALRAG
ECCCCCCCCCCCCEECCCHHHHHHCCCCEEEEEECCHHCCCCCHHHHHHHHHHHHHHHCC
LEPIVCVGETLEERKAGQALAIVTRQVRGSLPTELAGKAFAVAYEPVWAIGTGLTPTTPE
CCCEEECCCHHHHHHCCCHHHHHHHHHHCCCCHHHCCCEEEEEECCHHEECCCCCCCCCC
IEEMHRAIRATLVEMFGEAGRAVPILYGGSVKPSNAAEILHADEVGGALVGGASLKAQDF
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHEEHHHCCCEEECCCCCCHHHH
LGIVNAL
HHHHHCC
>Mature Secondary Structure 
TAPKPLIAGNWKMNGLAAALSEAKAVAAGAAASAARVAICPPSLLVHRMSEALAGTPVL
CCCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCCCEE
VGGQDCHTDESGAFTGDVSAEMLADAGAKLVILGHSERRSGYRETDALVAGKVKAALRAG
ECCCCCCCCCCCCEECCCHHHHHHCCCCEEEEEECCHHCCCCCHHHHHHHHHHHHHHHCC
LEPIVCVGETLEERKAGQALAIVTRQVRGSLPTELAGKAFAVAYEPVWAIGTGLTPTTPE
CCCEEECCCHHHHHHCCCHHHHHHHHHHCCCCHHHCCCEEEEEECCHHEECCCCCCCCCC
IEEMHRAIRATLVEMFGEAGRAVPILYGGSVKPSNAAEILHADEVGGALVGGASLKAQDF
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHEEHHHCCCEEECCCCCCHHHH
LGIVNAL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]