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The map label for this gene is comEC [H]

Identifier: 197105226

GI number: 197105226

Start: 1971710

End: 1973854

Strand: Reverse

Name: comEC [H]

Synonym: PHZ_c1763

Alternate gene names: 197105226

Gene position: 1973854-1971710 (Counterclockwise)

Preceding gene: 197105229

Following gene: 197105218

Centisome position: 49.39

GC content: 75.85

Gene sequence:

>2145_bases
ATGCGGATTCGGCGTGCTTCCAGCCTCCGCGCCCACGCGGCCTGGCTCCGCGACCAGGTCGAGGCGCAGGCCGACCGCTG
GACCCTGTGGACGCCCGTGGCCTTCGGCGCCGGATGCGGCGCCTACTTCGCGCTGATGCGGGAGCCGCAGGCCTGGGTCG
CCTGGCTGCTGCTCGGGGCGGCCGCAGCGCTGCTCCTGGCCGCGGGGCGTTGGGCGGGCCCGCGCCCCGTGGTGGTGGCC
CTCGCGCTGACGGCGTTCGGCCTCGGCGGCTTCGCCGTGGCCAAGCTGCGCACCGAGAGCGTCAAGGCGCCGGTCGCCGT
CGCGGGCGCGAGGCCGCAGCCGGTCGAAGGCTGGGTGGTGGACGTGGCCGCGCCGGGCCAGGGCGGCCAGCGCCTGCTGA
TCGCGCCCGTCCGGATCGGCTCGTGGGCGCCCGAGACCACGCCCATCCGGGTGCGCGTGACGCTCCGCCCCGGAACGCCT
GTGCCGGCGCCAGGCGAGGGCGTGCGGGTTCTGGCCATCCTCAATCCCCCGCCGCCTCCGGCCAGCCCCGGGGCCTACGA
CTTCGCGCGCGACGCCTTCTTCGAGAGCGTCGGCGGGGTCGGTCTGGCGCTGCGGCCGCCCGAGTGGTGGACGCCCGATA
CAGTGGCGCCCTGGCGGCTGCGGCTGACGATGCGGGTGAACGCTGTCCGCTGGGCGCTGACCCGGCGGATCGTCGAGACC
CTCGGCCCGGAGAGCGGCGGGCTGGCGGCGGCGATGACCACGGGCCACGAGGCGTTCATTCCGCCCGAGCAGGTGGAGAA
CCTGCGCGTCTCGGGCCTGGCGCACATCATCTCGATCAGCGGCCTGCACATGGCGATCGTGGGCGGCTTCACCTTCGCCG
CCGCCCGCCTGGCGGTGGCCGCTTGGCCGTGGCTGGCGCTGCGGGTGTCGGGCAAGAAGGTGGCGGCGCTGGTCGGTCTG
GCCGCGGTCGGCGGCTATCTTGTGCTGTCGGGCGCGCCGCCGCCGGCCGAGCGGGCGGCGATCACCGCGGCGGTGGCCTT
CGCCGCCGTCCTGGCCGACCGGCAGGCGATTAGCCTGCACGCCCTGGCCCTGGCCGCCATGGGGGTGCTCCTCCTCCAGC
CGGAAGCGGTGACCGAGCCCGGGTTCCAGATGTCGTTCGCCGCCACCGCCGCTCTGGTGGCGCTGGCCGAGGGCTGGCCC
CGGCCGATCCGCGAGATCGAGGCGCCCTGGTGGATCCGCCTGCCGCAGGCGGTCGTGACCTGGACCGCCGCCAGCCTGGC
CGTCAGCTTCGTCGCGGGCCTGGCCACGGGGCCGTTCGCCATCCAGCACTTCAACCGCGTCTCCACCTGGGGCCTGCTGG
CGAACCTGGCCGTGGCGCCGATCTCCACCTTCCTTCTGATGCCGGCCTTGGCCCTCGGCGCGGCGCTGGCCCCCTTCGGC
CTCGGGCGCATTCCGCTGGAGGCGGCGGGGCTTGCGATCGAGCTGATGAACCGCATCGCCGCAGCGGCGGCCTCGGCCCC
CATGGCCCAGACGCTGGTTCCCAGCGCGCCGGCCTGGACGCTGGCGGCTTCGTTCGTGGGCCTGCTCTTCGTCTGCCTGT
GGCGAGGACGGCTGCGCTGGGCGGGCCTGCCGCTGGCCCTGTCGGTGCTCTGGGCGCCGCGACCGGCGACGCCGGACCTG
TGGATCAGCGCCGACGGCGCCGCCGTGGCGGTCCGCGAGGGGCGCGAGGCGGTGCTGCTGCGTCCGGACGTGAAGCTGTT
CGGGGCCGAGCTGTGGGCCCGCCGCCGGGGCCTGACGCCGCTGACCTCGGAGGCCGAGCGGGACGAACGATTCGACTGCG
ACCGCTGGAGCTGTGCGCCGGGGGCGGGGGCGCCGATGCGGGTCTCCGCCGCCTGGAACCTGCGCCGGCCGCTGAAGCCG
GGCCGCCTTGACGCCCTCTGCGGCTCGGCAGAGGTGGTGATCCTGAGGAACGACTTCCGCCCGGAGAGCTGCGGGGCGCC
GCTGGTGCTGACCGGCGCCGACTTCCGCGCCGGCGGCTCGGCCGAACTCTGGCGGCGGAGCGACGGAAGCTGGCGCATCG
CCTGGAGCCAGGACCTGCGCGGACGCAGGCCCTGGACCTGGGGCTTCGACCCCAGGGGGCGCTAG

Upstream 100 bases:

>100_bases
GATCCGGGTGCGGACGGGACGGTCAGGCATCGATCTCGGAGGGGTTGGGGCGGCCCTGGCGGATAACGCCGGAGCTGAAC
ACTTGGGGGCGCCTCTTAGC

Downstream 100 bases:

>100_bases
GGCCTAGTGGTAACGGCGGATGAGGCCGACGAGGCGGCCCTGCACCGCCACGCGGTCGGGGCCGAAGATGCGGGTCTCGT
AGGCGGGGTTGGCCGCCTCG

Product: ComEC/Rec2 family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 714; Mature: 714

Protein sequence:

>714_residues
MRIRRASSLRAHAAWLRDQVEAQADRWTLWTPVAFGAGCGAYFALMREPQAWVAWLLLGAAAALLLAAGRWAGPRPVVVA
LALTAFGLGGFAVAKLRTESVKAPVAVAGARPQPVEGWVVDVAAPGQGGQRLLIAPVRIGSWAPETTPIRVRVTLRPGTP
VPAPGEGVRVLAILNPPPPPASPGAYDFARDAFFESVGGVGLALRPPEWWTPDTVAPWRLRLTMRVNAVRWALTRRIVET
LGPESGGLAAAMTTGHEAFIPPEQVENLRVSGLAHIISISGLHMAIVGGFTFAAARLAVAAWPWLALRVSGKKVAALVGL
AAVGGYLVLSGAPPPAERAAITAAVAFAAVLADRQAISLHALALAAMGVLLLQPEAVTEPGFQMSFAATAALVALAEGWP
RPIREIEAPWWIRLPQAVVTWTAASLAVSFVAGLATGPFAIQHFNRVSTWGLLANLAVAPISTFLLMPALALGAALAPFG
LGRIPLEAAGLAIELMNRIAAAAASAPMAQTLVPSAPAWTLAASFVGLLFVCLWRGRLRWAGLPLALSVLWAPRPATPDL
WISADGAAVAVREGREAVLLRPDVKLFGAELWARRRGLTPLTSEAERDERFDCDRWSCAPGAGAPMRVSAAWNLRRPLKP
GRLDALCGSAEVVILRNDFRPESCGAPLVLTGADFRAGGSAELWRRSDGSWRIAWSQDLRGRRPWTWGFDPRGR

Sequences:

>Translated_714_residues
MRIRRASSLRAHAAWLRDQVEAQADRWTLWTPVAFGAGCGAYFALMREPQAWVAWLLLGAAAALLLAAGRWAGPRPVVVA
LALTAFGLGGFAVAKLRTESVKAPVAVAGARPQPVEGWVVDVAAPGQGGQRLLIAPVRIGSWAPETTPIRVRVTLRPGTP
VPAPGEGVRVLAILNPPPPPASPGAYDFARDAFFESVGGVGLALRPPEWWTPDTVAPWRLRLTMRVNAVRWALTRRIVET
LGPESGGLAAAMTTGHEAFIPPEQVENLRVSGLAHIISISGLHMAIVGGFTFAAARLAVAAWPWLALRVSGKKVAALVGL
AAVGGYLVLSGAPPPAERAAITAAVAFAAVLADRQAISLHALALAAMGVLLLQPEAVTEPGFQMSFAATAALVALAEGWP
RPIREIEAPWWIRLPQAVVTWTAASLAVSFVAGLATGPFAIQHFNRVSTWGLLANLAVAPISTFLLMPALALGAALAPFG
LGRIPLEAAGLAIELMNRIAAAAASAPMAQTLVPSAPAWTLAASFVGLLFVCLWRGRLRWAGLPLALSVLWAPRPATPDL
WISADGAAVAVREGREAVLLRPDVKLFGAELWARRRGLTPLTSEAERDERFDCDRWSCAPGAGAPMRVSAAWNLRRPLKP
GRLDALCGSAEVVILRNDFRPESCGAPLVLTGADFRAGGSAELWRRSDGSWRIAWSQDLRGRRPWTWGFDPRGR
>Mature_714_residues
MRIRRASSLRAHAAWLRDQVEAQADRWTLWTPVAFGAGCGAYFALMREPQAWVAWLLLGAAAALLLAAGRWAGPRPVVVA
LALTAFGLGGFAVAKLRTESVKAPVAVAGARPQPVEGWVVDVAAPGQGGQRLLIAPVRIGSWAPETTPIRVRVTLRPGTP
VPAPGEGVRVLAILNPPPPPASPGAYDFARDAFFESVGGVGLALRPPEWWTPDTVAPWRLRLTMRVNAVRWALTRRIVET
LGPESGGLAAAMTTGHEAFIPPEQVENLRVSGLAHIISISGLHMAIVGGFTFAAARLAVAAWPWLALRVSGKKVAALVGL
AAVGGYLVLSGAPPPAERAAITAAVAFAAVLADRQAISLHALALAAMGVLLLQPEAVTEPGFQMSFAATAALVALAEGWP
RPIREIEAPWWIRLPQAVVTWTAASLAVSFVAGLATGPFAIQHFNRVSTWGLLANLAVAPISTFLLMPALALGAALAPFG
LGRIPLEAAGLAIELMNRIAAAAASAPMAQTLVPSAPAWTLAASFVGLLFVCLWRGRLRWAGLPLALSVLWAPRPATPDL
WISADGAAVAVREGREAVLLRPDVKLFGAELWARRRGLTPLTSEAERDERFDCDRWSCAPGAGAPMRVSAAWNLRRPLKP
GRLDALCGSAEVVILRNDFRPESCGAPLVLTGADFRAGGSAELWRRSDGSWRIAWSQDLRGRRPWTWGFDPRGR

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG0658

COG function: function code R; Predicted membrane metal-binding protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 75755; Mature: 75755

Theoretical pI: Translated: 11.52; Mature: 11.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIRRASSLRAHAAWLRDQVEAQADRWTLWTPVAFGAGCGAYFALMREPQAWVAWLLLGA
CCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECHHHCCCHHHHHHHHCCCHHHHHHHHHHH
AAALLLAAGRWAGPRPVVVALALTAFGLGGFAVAKLRTESVKAPVAVAGARPQPVEGWVV
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHEEEEEHHCCCCCEEEECCCCCCCCCEEE
DVAAPGQGGQRLLIAPVRIGSWAPETTPIRVRVTLRPGTPVPAPGEGVRVLAILNPPPPP
EEECCCCCCCEEEEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCCC
ASPGAYDFARDAFFESVGGVGLALRPPEWWTPDTVAPWRLRLTMRVNAVRWALTRRIVET
CCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHH
LGPESGGLAAAMTTGHEAFIPPEQVENLRVSGLAHIISISGLHMAIVGGFTFAAARLAVA
HCCCCCCEEEEEECCCCCCCCHHHHHCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHH
AWPWLALRVSGKKVAALVGLAAVGGYLVLSGAPPPAERAAITAAVAFAAVLADRQAISLH
HCCEEEEEECCCHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
ALALAAMGVLLLQPEAVTEPGFQMSFAATAALVALAEGWPRPIREIEAPWWIRLPQAVVT
HHHHHHHHHHEECCHHCCCCCCEEHHHHHHHHHHHHCCCCCCHHHCCCCEEEECCHHHHH
WTAASLAVSFVAGLATGPFAIQHFNRVSTWGLLANLAVAPISTFLLMPALALGAALAPFG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LGRIPLEAAGLAIELMNRIAAAAASAPMAQTLVPSAPAWTLAASFVGLLFVCLWRGRLRW
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEE
AGLPLALSVLWAPRPATPDLWISADGAAVAVREGREAVLLRPDVKLFGAELWARRRGLTP
CCCCCEEEEEECCCCCCCCEEEECCCCEEEEECCCEEEEECCCHHHHHHHHHHHHCCCCC
LTSEAERDERFDCDRWSCAPGAGAPMRVSAAWNLRRPLKPGRLDALCGSAEVVILRNDFR
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHCCCCEEEEEEECCCC
PESCGAPLVLTGADFRAGGSAELWRRSDGSWRIAWSQDLRGRRPWTWGFDPRGR
CCCCCCCEEEECCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRIRRASSLRAHAAWLRDQVEAQADRWTLWTPVAFGAGCGAYFALMREPQAWVAWLLLGA
CCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECHHHCCCHHHHHHHHCCCHHHHHHHHHHH
AAALLLAAGRWAGPRPVVVALALTAFGLGGFAVAKLRTESVKAPVAVAGARPQPVEGWVV
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHEEEEEHHCCCCCEEEECCCCCCCCCEEE
DVAAPGQGGQRLLIAPVRIGSWAPETTPIRVRVTLRPGTPVPAPGEGVRVLAILNPPPPP
EEECCCCCCCEEEEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEEECCCCCC
ASPGAYDFARDAFFESVGGVGLALRPPEWWTPDTVAPWRLRLTMRVNAVRWALTRRIVET
CCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCEEEEEEEEEHHHHHHHHHHHHHH
LGPESGGLAAAMTTGHEAFIPPEQVENLRVSGLAHIISISGLHMAIVGGFTFAAARLAVA
HCCCCCCEEEEEECCCCCCCCHHHHHCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHH
AWPWLALRVSGKKVAALVGLAAVGGYLVLSGAPPPAERAAITAAVAFAAVLADRQAISLH
HCCEEEEEECCCHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
ALALAAMGVLLLQPEAVTEPGFQMSFAATAALVALAEGWPRPIREIEAPWWIRLPQAVVT
HHHHHHHHHHEECCHHCCCCCCEEHHHHHHHHHHHHCCCCCCHHHCCCCEEEECCHHHHH
WTAASLAVSFVAGLATGPFAIQHFNRVSTWGLLANLAVAPISTFLLMPALALGAALAPFG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LGRIPLEAAGLAIELMNRIAAAAASAPMAQTLVPSAPAWTLAASFVGLLFVCLWRGRLRW
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEE
AGLPLALSVLWAPRPATPDLWISADGAAVAVREGREAVLLRPDVKLFGAELWARRRGLTP
CCCCCEEEEEECCCCCCCCEEEECCCCEEEEECCCEEEEECCCHHHHHHHHHHHHCCCCC
LTSEAERDERFDCDRWSCAPGAGAPMRVSAAWNLRRPLKPGRLDALCGSAEVVILRNDFR
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHCCCCEEEEEEECCCC
PESCGAPLVLTGADFRAGGSAELWRRSDGSWRIAWSQDLRGRRPWTWGFDPRGR
CCCCCCCEEEECCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]