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The map label for this gene is crt [H]

Identifier: 197105211

GI number: 197105211

Start: 1958043

End: 1958816

Strand: Direct

Name: crt [H]

Synonym: PHZ_c1748

Alternate gene names: 197105211

Gene position: 1958043-1958816 (Clockwise)

Preceding gene: 197105209

Following gene: 197105213

Centisome position: 49.0

GC content: 70.16

Gene sequence:

>774_bases
ATGCTGCTGGTGGAAAAGCCGTTCGACGGGGTCGCCGTCGTCACCCTCAACCGGCCCGAGGCGATGAACGCCCTGTCGAA
GGCCCTGCGCCAGGCGCTGCGGCAGGCCATGGTCGAGCTGGACGCCGACCCCGAGGTGAAGGTGATCGTCCTGACCGGCG
CGGGCGAGCGGGCGTTCACGGCCGGGCTCGACCTGAAGGAGCTGTCGTCCGATCCGTTGGGCATGGGCGCGGCCAACACG
ACGGACCCGGCCGAGAACCCCGCCCGCGCGCTGCTGGCCACCCGCAAGCCGATCATCGGCGCGATCAACGGCGTGGCGAT
CACCGGCGGCTTCGAGGTGGCGCTGGCCTGTGACGTGCTGATCTGCTCGACCAACGCCCGTTTCGCCGACACCCACGCGC
GGGTCGGGATCACCCCCGGCTGGGGGCTGTCGCAGAAGCTGTCGCGCGTGATCGGCCCCTATCGGGCCAAGGAACTGTCG
CTGACCGGCAACTTCCTCGACGCCAGAACCGCCTACGAATGGGGCCTTGCGAACCGCGTCGTCGAACCCGGCGAGCTGAT
GGAGGCCGCGCTGACCCTGGCCCGGCAGATGGCCGACATCGAGGCCGACATGCTGGTCGGATACAAGGCGATGATCGACG
ACGGCTACGAGACGACCCTGGCCGAGGGGCTCAAGCTGGAGCACGAGCGCTCGCTCGCGCACAACGTCGAGGTCACGCCC
GAGATGGTCGCCGCCCGCCGCGAGAAGGTGCAGGCCCGCGGGCGGAGCCAGTAG

Upstream 100 bases:

>100_bases
GCGAGCCTTAGCCACCTTCCGCGACAGGGGCAACTTGACTTCCCCGGTTGACTTGCCGCGGCGTCGGCCGGTCATGCCGG
GACGCCAAGGGAGGAAGATC

Downstream 100 bases:

>100_bases
CGCGCATGCGAACGGCCCCGCCTGTCGCCAGACGGGGCCGCGCGGAATCGCTGCCTCGGATGAGGCTTAGTCTTCCTTCG
GCGTCAGGACCTGGCGGCCT

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MLLVEKPFDGVAVVTLNRPEAMNALSKALRQALRQAMVELDADPEVKVIVLTGAGERAFTAGLDLKELSSDPLGMGAANT
TDPAENPARALLATRKPIIGAINGVAITGGFEVALACDVLICSTNARFADTHARVGITPGWGLSQKLSRVIGPYRAKELS
LTGNFLDARTAYEWGLANRVVEPGELMEAALTLARQMADIEADMLVGYKAMIDDGYETTLAEGLKLEHERSLAHNVEVTP
EMVAARREKVQARGRSQ

Sequences:

>Translated_257_residues
MLLVEKPFDGVAVVTLNRPEAMNALSKALRQALRQAMVELDADPEVKVIVLTGAGERAFTAGLDLKELSSDPLGMGAANT
TDPAENPARALLATRKPIIGAINGVAITGGFEVALACDVLICSTNARFADTHARVGITPGWGLSQKLSRVIGPYRAKELS
LTGNFLDARTAYEWGLANRVVEPGELMEAALTLARQMADIEADMLVGYKAMIDDGYETTLAEGLKLEHERSLAHNVEVTP
EMVAARREKVQARGRSQ
>Mature_257_residues
MLLVEKPFDGVAVVTLNRPEAMNALSKALRQALRQAMVELDADPEVKVIVLTGAGERAFTAGLDLKELSSDPLGMGAANT
TDPAENPARALLATRKPIIGAINGVAITGGFEVALACDVLICSTNARFADTHARVGITPGWGLSQKLSRVIGPYRAKELS
LTGNFLDARTAYEWGLANRVVEPGELMEAALTLARQMADIEADMLVGYKAMIDDGYETTLAEGLKLEHERSLAHNVEVTP
EMVAARREKVQARGRSQ

Specific function: Catalyzes The Reversible Dehydration Of L-Carnitinyl-CoA To Crotobetainyl-CoA. [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=219, Percent_Identity=35.6164383561644, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI20127408, Length=205, Percent_Identity=30.2439024390244, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI70995211, Length=185, Percent_Identity=30.8108108108108, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI31542718, Length=200, Percent_Identity=29.5, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI4502327, Length=236, Percent_Identity=33.0508474576271, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI213417737, Length=261, Percent_Identity=27.2030651340996, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI157694516, Length=261, Percent_Identity=27.2030651340996, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI37594469, Length=179, Percent_Identity=27.9329608938547, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI37594471, Length=180, Percent_Identity=27.7777777777778, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI68989263, Length=192, Percent_Identity=28.125, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI116235487, Length=194, Percent_Identity=26.8041237113402, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4757968, Length=215, Percent_Identity=25.5813953488372, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI49355787, Length=215, Percent_Identity=25.5813953488372, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI221142681, Length=256, Percent_Identity=32.8125, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1787659, Length=222, Percent_Identity=37.8378378378378, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1788597, Length=199, Percent_Identity=32.6633165829146, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1787660, Length=232, Percent_Identity=35.7758620689655, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI87082183, Length=195, Percent_Identity=31.7948717948718, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788682, Length=199, Percent_Identity=32.1608040201005, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1790281, Length=199, Percent_Identity=28.1407035175879, Blast_Score=68, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=236, Percent_Identity=35.5932203389831, Blast_Score=136, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI25145438, Length=221, Percent_Identity=35.2941176470588, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17540714, Length=224, Percent_Identity=30.3571428571429, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17560910, Length=191, Percent_Identity=32.9842931937173, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17558304, Length=183, Percent_Identity=30.6010928961749, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17534483, Length=201, Percent_Identity=27.363184079602, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17536985, Length=237, Percent_Identity=24.4725738396624, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI25144276, Length=183, Percent_Identity=28.4153005464481, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17508953, Length=183, Percent_Identity=28.4153005464481, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17508951, Length=183, Percent_Identity=28.4153005464481, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17535521, Length=226, Percent_Identity=26.1061946902655, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17540306, Length=201, Percent_Identity=26.3681592039801, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129971, Length=219, Percent_Identity=38.3561643835616, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24653477, Length=219, Percent_Identity=38.3561643835616, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24653139, Length=226, Percent_Identity=32.7433628318584, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24654903, Length=234, Percent_Identity=26.0683760683761, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI19922422, Length=190, Percent_Identity=30, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357171, Length=222, Percent_Identity=29.2792792792793, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI19920382, Length=234, Percent_Identity=28.6324786324786, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24650670, Length=253, Percent_Identity=28.4584980237154, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 27552; Mature: 27552

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLVEKPFDGVAVVTLNRPEAMNALSKALRQALRQAMVELDADPEVKVIVLTGAGERAFT
CEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEE
AGLDLKELSSDPLGMGAANTTDPAENPARALLATRKPIIGAINGVAITGGFEVALACDVL
CCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHCCCCCEEEECCEEEEEEEEEE
ICSTNARFADTHARVGITPGWGLSQKLSRVIGPYRAKELSLTGNFLDARTAYEWGLANRV
EECCCCCEECCCCEEECCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCC
VEPGELMEAALTLARQMADIEADMLVGYKAMIDDGYETTLAEGLKLEHERSLAHNVEVTP
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHCCCCCH
EMVAARREKVQARGRSQ
HHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLLVEKPFDGVAVVTLNRPEAMNALSKALRQALRQAMVELDADPEVKVIVLTGAGERAFT
CEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEE
AGLDLKELSSDPLGMGAANTTDPAENPARALLATRKPIIGAINGVAITGGFEVALACDVL
CCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHCCCCCEEEECCEEEEEEEEEE
ICSTNARFADTHARVGITPGWGLSQKLSRVIGPYRAKELSLTGNFLDARTAYEWGLANRV
EECCCCCEECCCCEEECCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCC
VEPGELMEAALTLARQMADIEADMLVGYKAMIDDGYETTLAEGLKLEHERSLAHNVEVTP
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHCCCCCH
EMVAARREKVQARGRSQ
HHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]