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The map label for this gene is crt [H]

Identifier: 197105142

GI number: 197105142

Start: 1883616

End: 1884665

Strand: Reverse

Name: crt [H]

Synonym: PHZ_c1679

Alternate gene names: 197105142

Gene position: 1884665-1883616 (Counterclockwise)

Preceding gene: 197105143

Following gene: 197105141

Centisome position: 47.16

GC content: 70.29

Gene sequence:

>1050_bases
ATGAGCGAGCCTGAAGTCCTCTGCCGCATCGAAGGCCGCGTCGGGCGCATCACCCTGAACCGGCCGCAGGCGCTGCACGC
GCTGACGACGCGGATGTGCCGGGACATCACCGACGCCCTGCTGGGCTGGAAGGACGATCCGGCGGTCGAGCTGGTGCTCC
TCGACCACTCCGGCGAGCGCGGCTTCTGCGCGGGCGGCGACATCCGCATGCTGGCCGAAAGCGGCCAGGGCGACGGCTCG
GCGGCCCGCGAGTTCTTCTTCACCGAATACCGGCTGAACGAGCTGCTGTTCCGCTATCCGAAGACCACGGTGGCGATCAT
GGACGGCGTCACCATGGGCGGCGGCGTGGGCCTGTCGCGGCCCTGCCGCTTCCGGGTGGCGACCGAGCGCACCACCTTCG
CCATGCCCGAGACCGGCATCGGCCTGTTCCCTGACGTCGGCGGCGGCTGGTACCTTTCCCGGATGCCCGACCACATCGGC
CTGTGGCTGGCGCTGACCGGCGCGCGGATCAAGGCGGCCGACTGCGAGCTGATCGGCGTCGCCACCGACTATGTCGAGAG
CGCCAAGGTCGCCGAGCTGAAGGCGGGGATCCTCGCCGATCCGTCCGGCGCCGAGACCCTGCTGACCGAGCTGGAGGGCG
ATGCGGGCCGCCCGCCGATCGCCGCCCACCAGGACGAGATAGCCAGGCTCTTCTCCGGCGACAGCGTCGAGGCGATCGTG
GCCGCCCTGGAGGGCGCCGGGACCGAATGGGCCGCCGAGCAGCTGAAGATCCTGCGAACCAAGTCGCCACAGACGATGAA
GGTCGCCTTCCGCCAGCTGCGGCTCGGCGCGCGCTGCGCGACCTTCGCCGAGAACATGGCCATGGAGTACCGGATCGGCG
CCCGCGTCGTTCAGAAGCACGACTTCATCGAGGGCGTGCGGGCGGTGATCGTCGAAAAGGACAACGCCCCCAGGTGGAAC
CCCGCCAGCCTCGAGGGCGTCACCGAGGCCATGCTGGACGAGATCTTCGCGCCGCTGCCGGCCGACCAGGAATGGTCGCC
GCTGCCCTGA

Upstream 100 bases:

>100_bases
ATCCGCTGGAGCGGATCGTCCGCGACCTGCGCGTCCACCAGATCCTCGAAGGCGCCAACGAGGTCATGCGCGTGATCACC
GCCCGGGAGCTGTTCCGTCC

Downstream 100 bases:

>100_bases
GGATTCGGCCGCCAACAGACTGAAATTCATGAGGAAGCCATGACCCGTATCGCATTCATCGGCCTGGGCAACATGGGCGG
GGGCATGGCGGCGAACCAGG

Product: enoyl-CoA hydratase/isomerase family protein

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MSEPEVLCRIEGRVGRITLNRPQALHALTTRMCRDITDALLGWKDDPAVELVLLDHSGERGFCAGGDIRMLAESGQGDGS
AAREFFFTEYRLNELLFRYPKTTVAIMDGVTMGGGVGLSRPCRFRVATERTTFAMPETGIGLFPDVGGGWYLSRMPDHIG
LWLALTGARIKAADCELIGVATDYVESAKVAELKAGILADPSGAETLLTELEGDAGRPPIAAHQDEIARLFSGDSVEAIV
AALEGAGTEWAAEQLKILRTKSPQTMKVAFRQLRLGARCATFAENMAMEYRIGARVVQKHDFIEGVRAVIVEKDNAPRWN
PASLEGVTEAMLDEIFAPLPADQEWSPLP

Sequences:

>Translated_349_residues
MSEPEVLCRIEGRVGRITLNRPQALHALTTRMCRDITDALLGWKDDPAVELVLLDHSGERGFCAGGDIRMLAESGQGDGS
AAREFFFTEYRLNELLFRYPKTTVAIMDGVTMGGGVGLSRPCRFRVATERTTFAMPETGIGLFPDVGGGWYLSRMPDHIG
LWLALTGARIKAADCELIGVATDYVESAKVAELKAGILADPSGAETLLTELEGDAGRPPIAAHQDEIARLFSGDSVEAIV
AALEGAGTEWAAEQLKILRTKSPQTMKVAFRQLRLGARCATFAENMAMEYRIGARVVQKHDFIEGVRAVIVEKDNAPRWN
PASLEGVTEAMLDEIFAPLPADQEWSPLP
>Mature_348_residues
SEPEVLCRIEGRVGRITLNRPQALHALTTRMCRDITDALLGWKDDPAVELVLLDHSGERGFCAGGDIRMLAESGQGDGSA
AREFFFTEYRLNELLFRYPKTTVAIMDGVTMGGGVGLSRPCRFRVATERTTFAMPETGIGLFPDVGGGWYLSRMPDHIGL
WLALTGARIKAADCELIGVATDYVESAKVAELKAGILADPSGAETLLTELEGDAGRPPIAAHQDEIARLFSGDSVEAIVA
ALEGAGTEWAAEQLKILRTKSPQTMKVAFRQLRLGARCATFAENMAMEYRIGARVVQKHDFIEGVRAVIVEKDNAPRWNP
ASLEGVTEAMLDEIFAPLPADQEWSPLP

Specific function: Catalyzes The Reversible Dehydration Of L-Carnitinyl-CoA To Crotobetainyl-CoA. [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=344, Percent_Identity=44.1860465116279, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI37594469, Length=297, Percent_Identity=43.7710437710438, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI194097323, Length=170, Percent_Identity=32.9411764705882, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI31542718, Length=249, Percent_Identity=24.4979919678715, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI221142681, Length=193, Percent_Identity=30.0518134715026, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788597, Length=148, Percent_Identity=27.027027027027, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787659, Length=184, Percent_Identity=27.1739130434783, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI25144157, Length=353, Percent_Identity=39.943342776204, Blast_Score=268, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI25144160, Length=353, Percent_Identity=39.943342776204, Blast_Score=268, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI25145438, Length=175, Percent_Identity=30.8571428571429, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554946, Length=175, Percent_Identity=29.1428571428571, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320241, Length=376, Percent_Identity=30.0531914893617, Blast_Score=145, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28571729, Length=346, Percent_Identity=42.7745664739884, Blast_Score=278, Evalue=5e-75,
Organism=Drosophila melanogaster, GI28571730, Length=346, Percent_Identity=42.7745664739884, Blast_Score=277, Evalue=6e-75,
Organism=Drosophila melanogaster, GI20129971, Length=177, Percent_Identity=31.0734463276836, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24653477, Length=177, Percent_Identity=31.0734463276836, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 37961; Mature: 37830

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPEVLCRIEGRVGRITLNRPQALHALTTRMCRDITDALLGWKDDPAVELVLLDHSGER
CCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCC
GFCAGGDIRMLAESGQGDGSAAREFFFTEYRLNELLFRYPKTTVAIMDGVTMGGGVGLSR
CEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEECCCCCCCC
PCRFRVATERTTFAMPETGIGLFPDVGGGWYLSRMPDHIGLWLALTGARIKAADCELIGV
CEEEEEEECCEEEECCCCCCCCCCCCCCCEECCCCCCHHEEEEEEECCEEEECCCEEEEE
ATDYVESAKVAELKAGILADPSGAETLLTELEGDAGRPPIAAHQDEIARLFSGDSVEAIV
EHHHHHHHHHHHHHCCCEECCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHH
AALEGAGTEWAAEQLKILRTKSPQTMKVAFRQLRLGARCATFAENMAMEYRIGARVVQKH
HHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
DFIEGVRAVIVEKDNAPRWNPASLEGVTEAMLDEIFAPLPADQEWSPLP
HHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SEPEVLCRIEGRVGRITLNRPQALHALTTRMCRDITDALLGWKDDPAVELVLLDHSGER
CCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCC
GFCAGGDIRMLAESGQGDGSAAREFFFTEYRLNELLFRYPKTTVAIMDGVTMGGGVGLSR
CEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEECCCCCCCC
PCRFRVATERTTFAMPETGIGLFPDVGGGWYLSRMPDHIGLWLALTGARIKAADCELIGV
CEEEEEEECCEEEECCCCCCCCCCCCCCCEECCCCCCHHEEEEEEECCEEEECCCEEEEE
ATDYVESAKVAELKAGILADPSGAETLLTELEGDAGRPPIAAHQDEIARLFSGDSVEAIV
EHHHHHHHHHHHHHCCCEECCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHH
AALEGAGTEWAAEQLKILRTKSPQTMKVAFRQLRLGARCATFAENMAMEYRIGARVVQKH
HHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
DFIEGVRAVIVEKDNAPRWNPASLEGVTEAMLDEIFAPLPADQEWSPLP
HHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]