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The map label for this gene is hemA [H]

Identifier: 197105140

GI number: 197105140

Start: 1881270

End: 1882499

Strand: Reverse

Name: hemA [H]

Synonym: PHZ_c1677

Alternate gene names: 197105140

Gene position: 1882499-1881270 (Counterclockwise)

Preceding gene: 197105141

Following gene: 197105138

Centisome position: 47.11

GC content: 69.51

Gene sequence:

>1230_bases
ATGGATTACAGGGTCGCCTTCCGCACCGCCTTGGAGAACATCCGTTCCGAGGGCCGTTACCGGGTGTTCGCGGACCTGAA
GCGGCATCGCGGGGCGTTCCCGCGGGCGACCTGGACGCGGGCCGACGGCTCCGAATCGGACGTCGTGGTCTGGTGCTCGA
ACGACTACCTGGGCCAGGGCCAGAACCCGGTGGTGCTGGACGCCATGCACCGGGCGATCGAGGCGGCCGGGGCCGGCTCG
GGCGGCACCCGCAACATCTCGGGCACGACGCACTATCACGTGGAGCTGGAGCGCGAGCTCGCCGACCTGCACGGCAAGGA
GGCGGCGCTGCTGTTCACCTCGGGCTACGTCTCCAACGAGGCGACGCTGTCGACGCTCTACAAGATCCTGCCGGGCCTGG
TGGTCTTCTCCGACGCCCTGAACCACAACTCGATGATCTCGGGCATCCGGGCGGGCAAGCGCGAGCAGCGGCACGTCTTC
CGCCACAACGACCTGGCGCACCTGGAGGAGCTGCTGGCCGCCGCCGATCCGGCCGCGCCCAAGCTGATCGCCTTCGAGAG
CGTCTATTCCATGGACGGCGACATCGCCGACCTGCCGGCCATGGTGGCCCTGGCCCGGAAGTACGGCGCCATGACCTACC
TGGACGAGGTCCATGCGGTGGGCATGTACGGCCCCCGCGGCGCGGGCGTGGCCGAGCGTGACGGGGTGATGGACCAGATC
GACATCGTCGAGGGCACCCTGGGCAAGGCCTTCGGGGTGATGGGCGGCTACATCGCCGCCGACGCGGTGATCGTCGACGC
CATCCGCAGCTACGCCGACGGCTTCATCTTCACGACCTCGCTGCCGCCCGCGCTGGCCGCAGGCGCCGCCGCCTCGATCC
GCTGGCTGAAGGAACACGACGAGGTCCGAACCGCCCACCAGGAGCGCGCCGCGACCCTGAAGGCCAAGATGCGCGCCGCC
GGCCTGCCGGTGATGGACAGCGTCTCCCACATCGTGCCGGTGCTGGTGGGCGATCCCGTCCACTGCAAGATGATCAGCGA
CATCCTGCTGGAAGACCACGGGATCTACGTCCAGCCGATCAATTACCCCACCGTGCCGCGCGGAACCGAGCGGCTGCGCT
TCACGCCCAGCCCCGCCCATACCGACGCCATGATGGACGCCCTCGTCGCCGCCCTCGAAACGCTGTGGGTCCGCTGCAAC
GTCAAGCGCGTGGGCGGCGTCGCGGCCTAG

Upstream 100 bases:

>100_bases
TTATGGACAATGTGAAATCGCGGCGCCAAAAGGCGGGCATATTTCAGGGGCCGGTCCTCAGCGCGAGATCGTCGAACGCG
GCGGGCCGGGATTGAAGTCC

Downstream 100 bases:

>100_bases
CGGCCGCACCGGATCAGAAGACGTCGGTCACCCGGCAGACGGCGCTCCAGCCGCCCTTGAACGTGGCGAGCTGGACGACC
GCCACCTCGTGCACCACCCC

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MDYRVAFRTALENIRSEGRYRVFADLKRHRGAFPRATWTRADGSESDVVVWCSNDYLGQGQNPVVLDAMHRAIEAAGAGS
GGTRNISGTTHYHVELERELADLHGKEAALLFTSGYVSNEATLSTLYKILPGLVVFSDALNHNSMISGIRAGKREQRHVF
RHNDLAHLEELLAAADPAAPKLIAFESVYSMDGDIADLPAMVALARKYGAMTYLDEVHAVGMYGPRGAGVAERDGVMDQI
DIVEGTLGKAFGVMGGYIAADAVIVDAIRSYADGFIFTTSLPPALAAGAAASIRWLKEHDEVRTAHQERAATLKAKMRAA
GLPVMDSVSHIVPVLVGDPVHCKMISDILLEDHGIYVQPINYPTVPRGTERLRFTPSPAHTDAMMDALVAALETLWVRCN
VKRVGGVAA

Sequences:

>Translated_409_residues
MDYRVAFRTALENIRSEGRYRVFADLKRHRGAFPRATWTRADGSESDVVVWCSNDYLGQGQNPVVLDAMHRAIEAAGAGS
GGTRNISGTTHYHVELERELADLHGKEAALLFTSGYVSNEATLSTLYKILPGLVVFSDALNHNSMISGIRAGKREQRHVF
RHNDLAHLEELLAAADPAAPKLIAFESVYSMDGDIADLPAMVALARKYGAMTYLDEVHAVGMYGPRGAGVAERDGVMDQI
DIVEGTLGKAFGVMGGYIAADAVIVDAIRSYADGFIFTTSLPPALAAGAAASIRWLKEHDEVRTAHQERAATLKAKMRAA
GLPVMDSVSHIVPVLVGDPVHCKMISDILLEDHGIYVQPINYPTVPRGTERLRFTPSPAHTDAMMDALVAALETLWVRCN
VKRVGGVAA
>Mature_409_residues
MDYRVAFRTALENIRSEGRYRVFADLKRHRGAFPRATWTRADGSESDVVVWCSNDYLGQGQNPVVLDAMHRAIEAAGAGS
GGTRNISGTTHYHVELERELADLHGKEAALLFTSGYVSNEATLSTLYKILPGLVVFSDALNHNSMISGIRAGKREQRHVF
RHNDLAHLEELLAAADPAAPKLIAFESVYSMDGDIADLPAMVALARKYGAMTYLDEVHAVGMYGPRGAGVAERDGVMDQI
DIVEGTLGKAFGVMGGYIAADAVIVDAIRSYADGFIFTTSLPPALAAGAAASIRWLKEHDEVRTAHQERAATLKAKMRAA
GLPVMDSVSHIVPVLVGDPVHCKMISDILLEDHGIYVQPINYPTVPRGTERLRFTPSPAHTDAMMDALVAALETLWVRCN
VKRVGGVAA

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=400, Percent_Identity=51.25, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI83977440, Length=400, Percent_Identity=51.25, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI83977444, Length=400, Percent_Identity=51.25, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI4502025, Length=408, Percent_Identity=49.5098039215686, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI40316939, Length=408, Percent_Identity=49.5098039215686, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI7657118, Length=383, Percent_Identity=35.7702349869452, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=37.0689655172414, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI4758668, Length=364, Percent_Identity=30.4945054945055, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI119220554, Length=368, Percent_Identity=30.7065217391304, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI5454084, Length=304, Percent_Identity=29.2763157894737, Blast_Score=122, Evalue=9e-28,
Organism=Escherichia coli, GI1790046, Length=374, Percent_Identity=36.6310160427808, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1786993, Length=359, Percent_Identity=33.1476323119777, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71994529, Length=404, Percent_Identity=32.6732673267327, Blast_Score=221, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI32566772, Length=377, Percent_Identity=31.2997347480106, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17560912, Length=380, Percent_Identity=30.2631578947368, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17560914, Length=380, Percent_Identity=30.2631578947368, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71982617, Length=246, Percent_Identity=30.4878048780488, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71982625, Length=246, Percent_Identity=30.4878048780488, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320438, Length=427, Percent_Identity=48.0093676814988, Blast_Score=396, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6320267, Length=377, Percent_Identity=30.5039787798408, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323954, Length=291, Percent_Identity=25.4295532646048, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17137420, Length=398, Percent_Identity=49.4974874371859, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24662918, Length=360, Percent_Identity=37.7777777777778, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI17136286, Length=381, Percent_Identity=29.6587926509186, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24653280, Length=306, Percent_Identity=27.4509803921569, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24653276, Length=306, Percent_Identity=27.4509803921569, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24653278, Length=306, Percent_Identity=27.4509803921569, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 44275; Mature: 44275

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYRVAFRTALENIRSEGRYRVFADLKRHRGAFPRATWTRADGSESDVVVWCSNDYLGQG
CCCHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCEEECCCCCCCCEEEEECCCCCCCC
QNPVVLDAMHRAIEAAGAGSGGTRNISGTTHYHVELERELADLHGKEAALLFTSGYVSNE
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHHHHHHCCCCCEEEEEECCCCCCH
ATLSTLYKILPGLVVFSDALNHNSMISGIRAGKREQRHVFRHNDLAHLEELLAAADPAAP
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCC
KLIAFESVYSMDGDIADLPAMVALARKYGAMTYLDEVHAVGMYGPRGAGVAERDGVMDQI
CEEEHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHCCCHHHH
DIVEGTLGKAFGVMGGYIAADAVIVDAIRSYADGFIFTTSLPPALAAGAAASIRWLKEHD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHCHHHHHHHHHHHH
EVRTAHQERAATLKAKMRAAGLPVMDSVSHIVPVLVGDPVHCKMISDILLEDHGIYVQPI
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEC
NYPTVPRGTERLRFTPSPAHTDAMMDALVAALETLWVRCNVKRVGGVAA
CCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHEECHHHCCCCCC
>Mature Secondary Structure
MDYRVAFRTALENIRSEGRYRVFADLKRHRGAFPRATWTRADGSESDVVVWCSNDYLGQG
CCCHHHHHHHHHHHHCCCCEEEHHHHHHHCCCCCCCEEECCCCCCCCEEEEECCCCCCCC
QNPVVLDAMHRAIEAAGAGSGGTRNISGTTHYHVELERELADLHGKEAALLFTSGYVSNE
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHHHHHHCCCCCEEEEEECCCCCCH
ATLSTLYKILPGLVVFSDALNHNSMISGIRAGKREQRHVFRHNDLAHLEELLAAADPAAP
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCC
KLIAFESVYSMDGDIADLPAMVALARKYGAMTYLDEVHAVGMYGPRGAGVAERDGVMDQI
CEEEHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHCCCHHHH
DIVEGTLGKAFGVMGGYIAADAVIVDAIRSYADGFIFTTSLPPALAAGAAASIRWLKEHD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCHHHHHCHHHHHHHHHHHH
EVRTAHQERAATLKAKMRAAGLPVMDSVSHIVPVLVGDPVHCKMISDILLEDHGIYVQPI
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEC
NYPTVPRGTERLRFTPSPAHTDAMMDALVAALETLWVRCNVKRVGGVAA
CCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHEECHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2381418; 1904045 [H]